JP2006262888A - Health food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a health food intended for increasing use of Peuraria flower through finding out the new function of the Peuraria flower. <P>SOLUTION: The food and an antiobestic agent contain an Peuraria flower processed product and dietary fiber. As for the dietary fiber, hardly digestible dextrin is preferably used. The food and the antiobestic agent are excellent in antiobestic effect and stability in humidity. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a health food containing a processed kuzu flower and dietary fiber.

  Kuzu is a large vine plant of the legume family, and katsu starch collected from its roots has long been used as a raw material for Japanese confectionery. The roots and flowers are referred to as kudzu and kuzuka, respectively, and are used as raw materials for traditional Chinese medicines such as antipyretic drugs, analgesics, antispasmodics, and drugs for symptoms such as sweating. In particular, unlike other legumes, Kuzuka has been shown to have various effects such as an action for improving liver damage, an action for preventing hangover, and an action for improving urinary nitrogen metabolism (Patent Documents 1 to 3). .

Kuzuka contains various components that may be useful, such as flavonoids. However, since only a limited function has been revealed, it is not fully utilized at present.
Japanese Patent No. 3454718 Japanese Patent Publication No. 8-32632 JP-A 64-68318

  An object of the present invention is to expand the use of Kuzuka by finding a new function of Kuzuka.

  The present inventor conducted various studies on the use of kuzuka and found that when the kuzuka processed product and dietary fiber were combined, synergistically excellent anti-obesity effect was exhibited.

  This invention provides the foodstuff containing a kuzu flower processed material and dietary fiber.

  Furthermore, this invention provides the anti-obesity agent containing a kuzu flower processed material and dietary fiber.

  In a preferred embodiment, the dietary fiber is an indigestible dextrin.

  The food and anti-obesity agent of the present invention exhibit an excellent anti-obesity effect. And the foodstuff and anti-obesity agent of this invention are excellent in the stability with respect to humidity at the point of storage. Therefore, according to the present invention, the use of Kuzuka can be expanded by finding a new function that Kuzuka has an anti-obesity effect.

  The food and anti-obesity agent of the present invention contain processed kuzuka and dietary fiber, and contain additives as necessary. Hereinafter, the components of the food of the present invention will be described individually. The present invention should not be construed as being limited by the following embodiments, and various modifications can be made within the scope of the claims.

(Katsuhana treatment product)
Kuzuka, the flower part of Kuzu, contains flavonoids, saponins, and tryptophan glycosides. Kuzuka includes flowers collected at the stage from buds to fully opened flowers. In the present invention, it is particularly preferable to use soot.

  The processed Kuzuka product used in the food and anti-obesity agent of the present invention is not particularly limited as long as it is a processed Kuzuka product. In the present specification, the “Kuzuhana processed product” refers to a product obtained by subjecting Kuzuka to at least one of a drying process, a pulverizing process, and an extracting process.

  In this specification, in particular, the term “dried kuzuka” refers to a product obtained by drying kuzuka, a dry powder obtained by crushing kuzuka after drying, and the following kuzuka. Contains no flower extract.

  In this specification, when describing as "Kuzuhana extract", the juice of Kuzuka, the extract extracted from Kuzuka, the concentrate obtained by concentrating these juice or extract, the juice of these juices or A dry powder (extract powder) obtained by drying the extract.

  Hereinafter, a method for preparing a kuzu flower dried product, kuzu flower powder (dry powder and extract powder), and a kuzu flower extract, which are processed kuzu flowers, will be described.

  The dried kuzu flower is obtained by drying kuzu flowers, preferably kuzu flowers in the cocoon stage, by sun drying, hot air drying or the like. Preferably, it is dried until the water content is 10% by mass or less.

  Kuzuka powder (dry powder) is obtained by pulverizing the dried Kuzuka product. The powderization is performed by a method commonly used by those skilled in the art, for example, a ball mill, a hammer mill, a roller mill or the like.

  Alternatively, the Kuzuka powder (dried powder) is obtained by crushing the collected Kuzuka using a mass colloider, a slicer, a Komitrol, etc. to obtain a Kuzuka crushed product, and drying this Kuzuka crushed product .

  The kuzu flower extract is prepared by adding a solvent to a kuzu flower dried product such as kuzu flower, kuzu flower crushed product, kuzu flower dried product, or kuzu flower powder (dried powder), preferably kuzu flower dried powder, for example. Accordingly, the extraction is performed by heating, and the extract is collected by centrifugation or filtration.

  Examples of the solvent that can be used to obtain the Kuzuhana extract include water, organic solvents, and hydrous organic solvents. Examples of the organic solvent include methanol, ethanol, n-propanol, n-butanol, acetone, hexane, cyclohexane, propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1, Examples include 1,1,2-tetrafluoroethane, 1,1,2-trichloroethene and the like. Among these, a polar organic solvent, preferably ethanol, n-butanol, methanol, acetone, propylene glycol, and ethyl acetate are preferable, and ethanol is most preferable.

  Examples of the extraction method include a warm extraction method such as heating reflux, a supercritical extraction method, and the like. In these extraction methods, heating may be performed by applying pressure as necessary. When heating, it is necessary to prevent the solvent added to Kuzuka from volatilizing. When heating, the extraction temperature is preferably 50 ° C. or higher, more preferably 70 ° C. or higher, preferably 130 ° C. or lower, more preferably 100 ° C. or lower.

  The extraction time may be a time for sufficiently extracting soluble components from the extraction raw material, and may be set as appropriate according to the extraction temperature and the like. Preferably, it is 30 minutes to 48 hours. For example, when the extraction temperature is less than 50 ° C., it can be 6 hours to 48 hours, and when it is 50 ° C. or more, it can be 30 minutes to 24 hours.

  The obtained extract may be concentrated or dried by a method such as concentration under reduced pressure or freeze-drying, if necessary, to form a liquid, a paste, or a powder (extract powder).

  The processed Kuzuka product thus obtained may contain isoflavones, saponins and the like. The isoflavones contained in the processed kuzuhana product are preferably 3% by mass or more, more preferably 5% by mass to 90% by mass with respect to the dry mass of the extract. The saponin contained is preferably 1% by mass or more, more preferably 2% by mass to 50% by mass.

(Dietary fiber)
The dietary fiber used in the food and anti-obesity agent of the present invention includes insoluble dietary fiber, water-soluble dietary fiber, and derivatives of these dietary fibers. Specific examples of the insoluble dietary fiber include cellulose, hemicellulose, lignin, agar, chitin, collagen, carrageenan and the like. Specific examples of water-soluble dietary fiber include pectin, guar gum, psyllium, galactomannan, xyloglucan, locust bean gum, glucomannan, sodium alginate, chondroitin sulfate, low molecular alginic acid, low molecular guar gum, indigestible dextrin, Examples include pullulan and fipalon. Specific examples of these dietary fiber derivatives include cellulose derivatives such as methylcellulose, hydroxypropylcellulose, and carboxymethylcellulose, carboxymethylated products of chitin or chitosan, phosphoric oxides, sulfates, dihydroxypropylated products, and the like. Derivatives, starch derivatives such as polydextrose. In this specification, the simple description of “dietary fiber” includes derivatives of dietary fiber unless otherwise specified.

  In the present invention, the indigestible dextrin preferably used is an indigestible polysaccharide obtained from starch. For example, starch is hydrolyzed by heating and then hydrolyzed by amylase. The indigestibility is derived from the α-1,4 bond of starch. Indigestible dextrin has a blood glucose elevation-inhibiting effect, a blood lipid improving effect, and an intestinal regulating effect. Indigestible dextrin is commercially available in the form of powder, fine granules, granules and the like, and any form can be used in the present invention. Since indigestible dextrin is water-soluble, it may be used in the form of an aqueous solution.

  In the present invention, as a dietary fiber, a food material containing the above insoluble dietary fiber, water-soluble dietary fiber, derivatives of these dietary fibers, or the like may be used. Examples of food materials containing these dietary fibers include extracts of brown algae including giant kelp, pyrolysates of this extract, hydrolysates of shells such as crabs and shrimps, corn hulls, rice bran, rice Of rice husk, wheat bran, soybean bran, crow bran, pigeon bran, rye bran, oat bran, milo husk, oyster husk, cereal husk, soybeans, red beans, peas, peanuts Hulls, hulls of food seeds such as Indian psyllium, konjac koji, konjac powder, sugar-extracted beet (sugar beet sugar), apples and other fruits; konjac mannan; brewer's yeast dietary fiber; pine fiber; Banana fiber; citrus fiber; plant seed fiber; fruit vegetable fiber; root vegetable fiber.

  As a food material containing dietary fiber, a material prepared from wheat leaf, kale, or the like can be used as the dietary fiber-containing material. Examples of such materials include dry powders of young leaves of barley, wheat, oats, and other wheat. Such dry wheat powder is prepared, for example, by the following production method.

  The wheat leaves harvested from the start of splitting to the heading start (the height is about 20 cm to 40 cm) are washed with water and cut into an appropriate length (for example, about 10 cm). If necessary, a blanching (hot water) treatment, a microwave treatment, a steam treatment, or the like may be performed in order to prevent alteration of the material (green discoloration and flavor change). Next, it is dried and powdered so that the water content is 5% by mass or less.

  When the blanching treatment is performed, the time is preferably a short time, preferably 0.5 to 10 minutes, more preferably 0.5 to 5 minutes, from the viewpoint of nutrient retention. Drying is preferably freeze-drying or low-temperature heat drying at 70 ° C. or lower (for example, hot air drying). Unlike the wheat young leaf extract obtained by squeezing the wheat young leaves and removing most of the dietary fibers contained in the wheat young leaves, the wheat young leaves are obtained by pulverizing the wheat young leaves as they are. Therefore, the dry powder of young wheat leaves contains abundant dietary fibers (cellulose, hemicellulose, lignin, etc.), and therefore can be suitably used as a material containing dietary fibers. Furthermore, since wheat young leaves themselves are rich in vitamins, minerals, and the like, combining them with the processed kuzuhana product provides a bowel movement improving effect synergistically in addition to the anti-obesity effect.

  Kale is a kind of cruciferous plant and contains a lot of dietary fiber (cellulose, pectin, etc.) in addition to vitamins and minerals such as vitamin U and vitamin C, and has attracted attention as a health food material. Kale dry powder can be prepared by the same production method as wheat young powder.

  Among the food materials containing the above dietary fiber, food materials prepared from brown algae extracts or pyrolysates of the extracts are extracted from, for example, brown algae with sodium carbonate aqueous solution and then precipitated with hydrochloric acid or calcium chloride. To obtain an alginate fraction. Further, the alginic acid fraction may be reduced in molecular weight by enzymatic decomposition, acid hydrolysis, pressurized thermal decomposition, thermal decomposition or the like.

Among the food materials containing the above dietary fiber, food materials prepared from crab, shrimp and other shell hydrolysates are demineralized using hydrochloric acid and then used caustic soda. Obtained as a chitin fraction obtained by deproteinization. Specifically, decalcification using hydrochloric acid is decomposition and removal of CaCO ₃ , for example, using 2N HCl for 2 days at room temperature. For example, deproteinization using caustic soda is performed by treating with 1N NaOH at 100 ° C. for 36 hours.

  Among the food materials containing the above-mentioned dietary fiber, as food materials prepared from cereal hulls, legume hulls, plant seed hulls, etc., these hulls are subjected to enzyme treatment, chemical treatment, physical treatment, etc. Examples include materials that are used alone or in combination. Enzymatic treatment is performed using, for example, starch-degrading enzymes such as α-amylase and glucoamylase, proteolytic enzymes such as protease, lipid-degrading enzymes such as lipase, or fibrinolytic enzymes such as cellulase, pH 3 to 9, temperature 30 to 100 ° C. It is performed by adding to these outer skins and carrying out an enzyme reaction under these conditions. The chemical treatment is performed, for example, by adding an aqueous solution of a mineral acid or an organic acid to these shells and heat-treating them under the conditions of pH 2-5. Moreover, you may carry out by adding the surfactant for food to these outer skins, and heat-processing on the conditions of pH 3-8. The physical treatment is performed, for example, by pulverizing these skins with a pulverizer such as a homogenizer or a hammer mill and then sieving them.

  Of the materials containing the above-mentioned dietary fiber, the material prepared from konjac koji or konjac flour may be konjac koji strips or konjac flour itself. Examples of raw materials of these konjac meal pieces or konjac flour include materials obtained by separation and purification with water or alcohol.

  Among the materials containing the above-mentioned dietary fiber, a material prepared from beet (sugar beet sugar radish) after sugar extraction is obtained by dehydrating the beet cozette after sugar extraction, drying it, and then crushing it. Alternatively, the beet cosette after sugar extraction may be colloidally ground using shearing force under water.

  Among the materials containing the above dietary fiber, materials prepared from fruits such as apples are obtained by drying and pulverizing by-products (residues) obtained after squeezing fruit juice from fruits such as apples. It is done.

(Other additives)
The food and anti-obesity agent of the present invention include excipients, extenders, binders, thickeners, emulsifiers, colorants, fragrances, other food ingredients, seasonings, pharmaceutical ingredients, etc., as necessary. May be added. Furthermore, you may shape | mold into forms, such as a granule and a tablet, according to a use. The form of the food of the present invention is not particularly limited, and may be formed into capsules such as hard capsules and soft capsules, tablets, pills, or the like, or in the form of powder, granules, or tea as necessary. It may be in the form of a tea bag or bowl, or it may be in the form of a beverage. Depending on these shapes or preferences, the food and anti-obesity agent of the present invention may be eaten as they are, or may be taken by dissolving in water, hot water, milk or the like. For example, it may be pulverized into a tea bag shape, and the ingredients may be leached before drinking.

  Examples of food materials that can be added to the food of the present invention include royal jelly, propolis, vitamins (A, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.), minerals (iron, magnesium) , Calcium, zinc, selenium, etc.), α-lipoic acid, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (eg caffeine), fatty acids, proteins (Collagen, elastin, etc.), mucopolysaccharide (hyaluronic acid, etc.), amino sugar (glucosamine, acetylglucosamine, galactosamine, acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine, salts thereof), oligosaccharide (isomaltoo Sucrose, cyclic oligosaccharides, etc.), phospholipids and their derivatives (phosphatidylcholine, sphingomyelin, ceramide, etc.), sulfur-containing compounds (eg, alliin, sepaene, taurine, glutathione, methylsulfonylmethane), sugar alcohols, lignans (Sesamin etc.), animal and plant extracts containing these, root vegetables (turmeric, ginger etc.) and the like.

  In particular, if a lipid absorption inhibitory component and / or a lipid metabolism promoting component is added to the food of the present invention, a lipid accumulation inhibitory effect or a body fat reducing effect can be obtained synergistically. As a result, an effect of preventing various symptoms caused by obesity can be expected.

  Examples of the lipid absorption inhibitory component include components having an action of excreting bile acids (chitosan and its derivatives, psyllium, proanthocyanidins and the like) and components having a lipase inhibitory action (gallotannins and the like). In this invention, you may use the raw material containing these components instead of these components. Examples of such raw materials include plant extracts and loquat leaves, and preferably pine bark extracts and loquat leaf extracts.

  Examples of lipid metabolism promoting components include riboflavin, tea catechins, isomerized linoleic acid, caffeine, capsaicin, carnitine, coenzyme Q10, soybean peptide, branched amino acid, phosphatidylcholine, allyl sulfide compound, forskolin, bergenin, quercetin, astilbine, Examples include hydroxycitric acid and salts thereof. In this invention, you may use the raw material containing these components instead of these components. Examples of such raw materials include extracts such as tea, coleus foliage, red pepper, yellow potato, soybean, chili, buckwheat, garlic, onion, and coffee.

  The lipid absorption suppressing component and the lipid metabolism promoting component are appropriately blended in the food and anti-obesity agent of the present invention according to the purpose. These components may be used alone or in combination of two or more.

(Anti-obesity agent)
The anti-obesity agent of the present invention contains a processed kuzuka product and dietary fiber, and contains additives and the like as necessary.

  There is no restriction | limiting in particular in content of each of these components. For example, the content of Kuzuka extract (dry mass) is preferably formulated so that the intake of Kuzuka extract (dry mass) per adult day is preferably 10 mg or more, preferably Is preferably not more than 3000 mg, more preferably not more than 1000 mg.

  In the case of dried katsuhana, the amount of dried kuzuka per day is preferably 0.1 g or more, preferably 30 g or less, more preferably 10 g or less. It is good to mix | blend so that it may become.

  Since the content of the processed kuzuhana product differs depending on the form or dosage form, it may be appropriately adjusted. For example, in the case of Kuzuhana extract, the Kuzuka extract (dry mass) in the anti-obesity agent is preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, preferably Is 50% by mass or less, more preferably 30% by mass or less. In the case of dried katsuhana, the dried kuzuka is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, preferably 80% by mass or less. More preferably, it is good to set it as 50 mass% or less.

  The content of dietary fiber in the anti-obesity agent of the present invention is not particularly limited. For example, the dietary fiber is preferably 50 parts by mass or more, more preferably 100 parts by mass or more, preferably 30,000 parts by mass or less, more preferably 20 parts per 100 parts by mass of the processed kuzuhana product. 000 parts by mass or less. When using the food material containing the above dietary fiber, the food material may be used so that the content of the dietary fiber in the food material is within the above range.

(Food)
The food of the present invention contains processed kuzuka and dietary fiber, and contains additives as necessary. Preferably, the above anti-obesity agent can be used as the food of the present invention.

  The content of the processed kuzuka and dietary fiber in the food of the present invention is not particularly limited. Therefore, the content of processed kuzuhana and dietary fiber should just be in said range.

  Furthermore, the food of the present invention may be in the form of a beverage such as fermented plant juice, vegetable juice (eg, carrot juice), plant extract, fruit juice and the like containing the anti-obesity agent of the present invention. By setting it as such a form, not only the functionality or nutritional value of these drinks is improved, but also palatability is improved. These beverages can be enhanced in sweetness by adding sugar solution, sugar alcohol, seasoning or the like.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to this range.

(Example 1: Examination of anti-obesity effect)
About the foodstuff of this invention, the effect with respect to a body weight increase was examined with the following method.

  Twenty-one 7-week-old female ICR mice were acclimated for one week by feeding a standard feed (MF feed, Oriental Yeast Co., Ltd.). Subsequently, it was divided into 3 groups of 7 animals per group so that the average body weight per group was uniform.

  Next, 5% by weight of Kuzuhana extract (containing 10% by weight of isoflavones and 1% by weight of saponin, Ota Gassan Co., Ltd.), 4% by weight of indigestible dextrin, 40% by weight of beef tallow, and granulated sugar Test feed 1 was prepared by adding to the standard feed so as to contain 9% by mass.

  Comparative feed 1 was prepared in the same procedure as test feed 1 except that the kuzu flower extract was not added.

  Control feed 1 was prepared in the same manner as test feed 1 except that the kuzu flower extract and the indigestible dextrin were not added.

  One group of mice received test feed 1, the other group received comparative feed 1, and the other group of mice received control feed 1 ad libitum.

  On the 25th day from the start of free intake, the weight of each mouse was measured. After the measurement, the weight gain rate (%) was calculated from the following formula (I). The results are shown in Table 1.

  As shown in Table 1, the mice in the group that ingested the test feed 1 were suppressed in weight gain compared to the mice in the group that ingested the control diet 1 and the mice in the group that ingested the comparative diet 1 Recognize. Therefore, it turns out that the foodstuff of this invention has an anti-obesity action.

(Example 2: Examination of body fat reduction effect)
About the test feed 1 prepared in Example 1, the influence on fat accumulation in subcutaneous fat and visceral fat was examined by the following method.

  Fourteen-week-old female ICR mice were acclimated for one week by feeding a standard feed (MF feed, Oriental Yeast Co., Ltd.). Subsequently, the group was divided into two groups of seven per group so that the average body weight per group was uniform. One group of mice received the test diet 1 prepared in Example 1 and the remaining one group of mice received the control diet 1 prepared in Example 1 freely.

  On the 25th day from the start of free intake, the subcutaneous fat of each mouse was measured by X-ray CT for experimental animals (trade name: LATheata, manufactured by Aloka). Each mouse was then dissected and the retroperitoneal fat and peruterine fat removed. The total mass of these fats, that is, the mass of visceral fat was measured. The results are shown in Table 2.

  As shown in Table 2, it can be seen that the mice in the group that ingested the test feed 1 both suppressed the accumulation of subcutaneous fat and visceral fat, compared to the mice in the group that ingested the control diet 1. Accordingly, it was found that the food of the present invention has an excellent anti-obesity effect since it has an excellent body fat reducing action.

(Production Example 1)
Tablets (200 mg per tablet) were produced using the following raw materials.

<Tablet ingredients> Amount (% by mass)
Kuzuhana extract (Ota gassan) 5
Pine bark extract (Toyo Shinyaku Co., Ltd.) 1
Ascorbic acid 10
Crystalline cellulose 14
Sucrose ester 4
Reduced maltose 30
Silicon dioxide 1
Trehalose 25
Indigestible dextrin 10

(Production Example 2)
Granules were produced using the following raw materials.

<Blend ingredients> Blending amount (% by mass)
Kuzuhana extract (Ota gassan) 2
Soy peptide 25
Tea catechin 10
Crystalline cellulose 10
Reduced maltose 20
Indigestible dextrin 33

(Comparative Production Example 1)
Comparative tablets (200 mg per tablet) were produced using the following raw materials.

<Blend ingredients> Blending amount (% by mass)
Kuzuhana extract (Ota gassan) 5
Pine bark extract (Toyo Shinyaku Co., Ltd.) 1
Ascorbic acid 10
Crystalline cellulose 24
Sucrose ester 4
Reduced maltose 30
Silicon dioxide 1
Trehalose 25

(Example 3: Evaluation of stability against humidity)
The stability against humidity of the test tablet 1 obtained in Production Example 1 and the comparative tablet 1 containing no indigestible dextrin obtained in Comparative Production Example 1 was evaluated by the following method.

  Ten tablets were sealed in an aluminum pouch and stored in a constant temperature and humidity chamber (50 ° C., relative humidity 75%). Two weeks later, changes in the appearance of each tablet were observed. As a result, the test tablet 1 did not change in shape. However, the comparative tablet 1 containing no indigestible dextrin was hygroscopic and changed in shape. Therefore, it turns out that the foodstuff (test tablet 1) of this invention is excellent in stability with respect to humidity.

  Since the food and anti-obesity agent of the present invention exhibit an excellent anti-obesity effect, they are useful for preventing various symptoms caused by obesity. Furthermore, since the food and anti-obesity agent of the present invention are excellent in stability against humidity, they can be stored for a long time and are easy to use on a daily basis.

Claims (3)

  A food containing processed kuzuhana and dietary fiber.   An anti-obesity agent containing processed kuzuhana and dietary fiber.   The food or anti-obesity agent according to claim 1 or 2, wherein the dietary fiber is an indigestible dextrin.