JP2006083113A - Skin-beautifying composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin-beautifying composition exhibiting high skin-beautifying effects and preventing ageing symptoms such as wrinkles, sag or rough skin. <P>SOLUTION: The skin-beautifying composition comprises holothurians and/or extracts thereof. The composition is used for preparing external preparations and foods and drinks, which are applied to cosmetics, quasi-drugs, pharmaceuticals, foods, healthy foods and functional foods. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a skin-beautifying composition derived from sea cucumber, which is applied to external preparations, foods and drinks and the like.

  Skin troubles such as rough skin and fine lines are particularly serious problems for women. In skin tissue, acidic mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and proteins such as collagen and elastin are known as components that are largely involved in water retention and elasticity.

  The acidic mucopolysaccharide has high water retention, binds to collagen that plays the role of the matrix of the intercellular substance matrix, and is distributed in connective tissue, cartilage tissue, skin tissue, etc. Helps to maintain. If these amounts are reduced due to aging, ultraviolet rays, etc., the water retention and elasticity of the skin are lost, which causes rough skin and fine lines.

  Therefore, in order to prevent and improve rough skin and fine lines, it is important to maintain the moisture and tension of the skin.

  Conventionally, cosmetics and beauty health foods containing various ingredients having an effect of maintaining skin moisture and elasticity have been commercially available. Examples of such components include mucopolysaccharides such as hyaluronic acid and chondroitin sulfate described above, proteins such as collagen, low molecular sugars such as trehalose and sorbitol, vitamins, amino acid derivatives, ceramide, α-oryzanol, and purification. Examples include oils and fats such as camellia oil, and recently, there is a tendency to respect highly safe and naturally derived ingredients.

  Specifically, beauty and health food (see Patent Document 1) characterized by containing mucopolysaccharides containing hyaluronic acid and chondroitin sulfate, collagen and nucleic acid, improving active oxygen scavenging factor, antiallergic factor, skin, etc. Processed foods (see Patent Document 2) containing a mixture of two or more of food materials having factors and antioxidant factors (see Patent Document 2), foods composed of conchiolin or processed products thereof (see Patent Document 3), mucopolysaccharides and peptides Health foods having complex mucopolysaccharides bound to each other (see Patent Document 4), health foods containing ceramide (see Patent Document 5), and the like.

JP-A-10-165138 JP 10-000070 A JP-A-8-173091 JP-A-9-98739 JP-A-11-113530

  An object of the present invention is to provide a skin-beautifying composition that exhibits a high skin-beautifying effect and prevents skin aging symptoms such as wrinkles, sagging, and rough skin.

  In this situation, the present inventor has conducted earnest research, and as a result, by taking sea cucumber and / or its extract orally or externally, it exhibits a high skin beautifying effect, and causes skin aging symptoms such as wrinkles, sagging and rough skin. The present invention has been completed.

  In the present invention, a sea cucumber and / or an extract thereof is taken orally or externally to exert a high skin beautifying effect and prevent skin aging symptoms such as wrinkles, sagging and rough skin.

The sea cucumber used in the present invention may be any animal belonging to the marine species, such as sea cucumber ( Stichopus japonicus Selenka), deer sea cucumber ( Stichopus chloronotus Brandt), sea cucumber ( Holothuria pervicax Selenka), sea cucumber ( Holothuria monacaria Lesson), Examples include black sea cucumber ( Holothuri a Leucospilota Brandt) and quince ( Cucumaria frondosa var. J aponica Semper), and it is preferable to use these because they are available. In addition, it is preferable to use these marine animals as they are, or those that have been chopped and dried.

  The use part of the sea cucumber in the skin beautifying composition of the present invention is not particularly limited, and the whole or a part excluding the internal organs and internal organs can be used.

  In the skin-beautifying composition of the present invention, the sea cucumber may be used as it is, but it may be dried for ease of processing. Moreover, you may use what was extracted with the solvent with the raw | natural or dried thing.

  The method for drying sea cucumber is not particularly limited, and it can be dried by methods such as sun-drying, heat drying, etc., but it is preferable to dry using a freeze-drying method that can be dried while retaining the content components. .

  The method for extracting from sea cucumber using a solvent is described below, but is not limited to these extraction solvents and extraction methods. Extraction solvents include water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methyl amyl alcohol, 2-ethylbutanol, n-octyl alcohol and other alcohols, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol Polyethyl alcohol such as monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol or derivatives thereof, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl -Ketones such as n-propyl ketone, esters such as ethyl acetate and isopropyl acetate, ethyl ether, isop Pills ether, one or more mixed solvents selected from polar solvents such as ethers such as n- butyl ether can be preferably used, also can be used in phosphate buffered saline. Or low polarity or non-polarity such as petroleum ether, n-hexane, n-pentane, n-butane, n-octane, cyclohexane, squalane and other hydrocarbons, carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, toluene One or two or more kinds of mixed solvents selected from solvents can also be suitably used. Furthermore, 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia, can also be used.

  As extraction methods, extraction is performed by impregnation under normal pressure or under pressure or reduced pressure at room temperature, in a cooled or heated state, extraction using a distillation method such as steam distillation, extraction by squeezing sea cucumber An example is a squeezing method for obtaining a product, and these methods can be used alone or in combination of two or more.

  The sea cucumber extract thus obtained can be used as it is, but within the range where the effect is not lost, purification operations such as deodorization, decolorization and concentration are added, and further column chromatography is performed. May be used as a fraction. These extracts, purified products, and fractions thereof can be dried by removing the solvent from them, and further used in a form solubilized in a solvent such as alcohol or in the form of an emulsion. be able to.

  The skin beautifying composition of the present invention can be contained in external preparations such as cosmetics, pharmaceuticals, and quasi drugs. Cosmetics include emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shaving cream, shaving lotion, cosmetic oil, sunscreen lotion, funny powder, foundation, perfume, pack, nails Creams, enamels, enamel removers, eyebrows, blushers, eye creams, eye shadows, mascaras, eye liners, lipsticks, lip balms, shampoos, rinses, hair dyes, dispersions, cleaning agents and the like. Examples of the medicinal product or quasi-drug include medicinal products such as ointments, creams, and liquids for external use.

  In addition to the above essential components, the external preparation for skin of the present invention contains ingredients that are blended in external preparations for skin such as cosmetics and quasi-drugs, oils, higher alcohols, fatty acids, ultraviolet absorbers, in addition to the above essential components. Powders, pigments, surfactants, polyhydric alcohols, sugars, polysaccharides, amino acids, peptides, proteins, polymer compounds, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like can be blended.

  Moreover, the composition for beautiful skin of this invention can be contained in food-drinks. For example, confectionery (gum, candy, caramel, chocolate, cookies, snack confectionery, jelly, gummy, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasoning (Miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) and other general and health foods (tablets, capsules, etc.), nutritional supplements (nutrient drinks, etc.) ) And the like.

  You may add the skin beautifying composition of this invention to an instant food. For example, a composition for beautifying skin that is spray-dried or freeze-dried together with powdered cellulose can be easily contained in a food or drink by making it into powder, granule, tableting or solution.

  The skin beautifying composition of the present invention is not limited to a skin external preparation, but can be contained in drugs (including pharmaceuticals and quasi drugs) used for oral administration. For example, it can be in the form of products such as soft / hard capsules or tablets, granules, fine granules, powders, liquids and the like.

  The present invention will be described in more detail with reference to examples.

[Preparation Example 1] Manamako viscera freeze-dried product Manamako viscera viscera 203.1 g was dried by freeze-drying to obtain 78.4 g of manamako viscera freeze-dried product.

[Preparation Example 2] Manamako (excluding internal organs) freeze-dried product 2351.9 g of manamaco (excluding internal organs) was dried by freeze drying to obtain 421.6 g of manamaco (excluding internal organs) freeze-dried product.

[Preparation Example 3] Manamako (excluding viscera) supercritical extract Preparation Example 2 9.85 g of the lyophilized manamaco (excluding viscera) was separated into 25 MPa carbon dioxide at 40 ° C. using a supercritical extraction apparatus. The supercritical carbon dioxide was supplied for 3 hours while adjusting the flow rate of carbon dioxide at atmospheric pressure at the outlet to 3 mL / min. Thereafter, the pressure in the extraction tank was reduced, and the extract and the residue were taken out. The yield of the extract was 1.36 g.

[Preparation Example 4] Supercritical extract of viscera viscera 14.45 g of the lyophilized manamako viscera obtained in Preparation Example 1 was subjected to atmospheric pressure at 40 ° C. and 25 MPa of carbon dioxide at 40 ° C. at the outlet of the separation tank. The supercritical carbon dioxide was supplied for 3 hours while adjusting the flow rate of carbon dioxide below to be 3 mL / min. Thereafter, the pressure in the extraction tank was reduced, and the extract and the residue were taken out. The yield of the extract was 1.38 g.

[Preparation Example 5] Manamako Hydrophilic Solvent Extract All parts of Manamako dried in the sun were pulverized and immersed in a 50 vol% ethanol aqueous solution for 1 week with occasional stirring. The supernatant was collected and dried under reduced pressure to remove the solvent. Removal of manamaco hydrophilic solvent extract was obtained.

[Preparation Example 6] Manamako (excluding viscera) hot water extract The manamaco (excluding viscera) freeze-dried product obtained in Preparation Example 2 was pulverized, heated in 10 times the amount of hot water for 4 hours, and then the supernatant. Was collected, dried under reduced pressure to remove the solvent, and a hot water extract of manamako (excluding viscera) was obtained.

  Then, the Example of the cosmetic composition using the sea cucumber prepared in the preparation example is shown.

[Examples 1-6, Comparative Example 1] Granules (1) Sea cucumber preparation examples shown in Table 1 5.0 (wt%)
(2) Citric acid 2.5
(3) Powdered sugar 50.0
(4) Ascorbic acid 1.0
(5) Fragrance 0.1
(6) Lactose 41.4
Manufacturing method: (1) to (6) are mixed, an appropriate amount of an 80% by volume ethanol aqueous solution is added, and extrusion granulation is performed, followed by drying.

[Examples 7 to 12, Comparative Example 2] Tablet (1) Sea cucumber preparation example shown in Table 1 5.00 (% by weight)
(2) Citric acid 4.00
(3) Powdered sugar 50.00
(4) Lactose 37.49
(5) Saflower Yellow 0.01
(6) Fragrance 0.10
(7) Sucrose fatty acid ester 3.00
Production method: An appropriate amount of an 80% by volume aqueous ethanol solution is added to the mixture of (1) to (5), granulated, and then dried. Next, (6) and (7) are added and tableted.

[Examples 13 to 18, Comparative Example 3] Skin cream
(1) Beeswah 6.00 (wt%)
(2) Cetanol 5.00
(3) Reduced lanolin 8.00
(4) Squalane 37.50
(5) Fatty acid glycerin 4.00
(6) Lipophilic glyceryl monostearate 2.00
(7) Polyoxyethylene (20E.O.) sorbitan
Monolauric acid ester 2.00
(8) Propylene glycol 5.00
(9) Methyl parahydroxybenzoate 0.10
(10) Amount with 100% purified water
(11) Sea cucumber preparation examples shown in Table 1 0.50
(12) Fragrance 0.20
Production method: The oil phase components (1) to (7) are mixed, dissolved and made uniform, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Subsequently, after adding an oil phase component to the said water phase component and pre-emulsifying, it emulsifies uniformly with a homomixer. Thereafter, the mixture is cooled, and (11) to (12) are added and mixed at 50 ° C.

  A use test was performed on the examples and comparative examples of the present invention. In the use test, 20 female panelists in their 30s to 60s exhibiting skin aging symptoms such as fine lines, sagging skin, and rough skin were used as one group, and each of the examples and comparative examples was blinded to each group. Ingested. For Examples 1 to 6 and Comparative Example 1, 5g twice a day, for Examples 7 to 12 and Comparative Example 2, 2 tablets twice a day, Examples 13 to 18 And about the comparative example 3, the normal usage-amount was ingested or apply | coated twice a day for two months. The condition of the skin was observed before and after the use test, and a questionnaire survey was conducted on skin texture, elasticity, dryness, skin color, spots, fine lines, and makeup paste. The results are shown in Tables 2 to 4 in terms of the number of panelists who answered that there was an effect.

  As is clear from Tables 2 to 4, in the group using the examples of the present invention, the number of panelists who answered that there was an effect of improving the skin condition was higher than in the comparative examples, and improvements such as dryness, wrinkles, and elasticity The effect was recognized.

Example 19 Beverage (1) Preparation Example 5 3.00 (% by weight)
(2) Fragrance 0.10
(3) Ethanol 0.50
(4) Citric acid 0.70
(5) Glucose 6.00
(6) Purified water 89.70
Production method: Dissolve (1) and (2) in (3), add to (6) together with (4) and (5), mix, dissolve, filter, heat sterilize, and fill into bottles.

[Example 20] Beverage (1) Preparation Example 6 5.0 (wt%)
(2) Fragrance 0.1
(3) Citric acid 0.7
(4) Reduced maltose starch syrup 6.0
(5) Purified water 88.2
Manufacturing method: (1) to (4) are sequentially added to (5), mixed, dissolved, filtered, heat-sterilized, and filled into a bottle.

[Example 21] Granule (1) Preparation Example 1 5.0 (wt%)
(2) Preparation Example 2 5.0
(3) Citric acid 2.5
(4) Powdered sugar 50.0
(5) Vitamin E 1.0
(6) Fragrance 0.1
(7) Lactose 36.4
Production method: (1) to (7) are mixed, an appropriate amount of 80% by volume ethanol aqueous solution is added, extrusion granulation is performed, and then drying is performed.

[Example 22] Emulsion
(1) Squalane 5.0 (% by weight)
(2) White petrolatum 2.0
(3) Beeswax 0.5
(4) Sorbitan sesquioleate 0.8
(5) Polyoxyethylene (20E.O.) oleyl ether 1.2
(6) Phytosteryl isostearate 3.0
(7) Methyl paraoxybenzoate 0.1
(8) Propylene glycol 5.0
(9) Purified water Amount of 100
(10) Carboxyvinyl polymer (1 wt% aqueous solution) 20.0
(11) Potassium hydroxide (10% by weight aqueous solution) 1.0
(12) Preparation Example 5 0.5
(13) Ethanol 5.0
(14) Fragrance 0.2
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed and dissolved, heated to 75 ° C., and the oil phase component is added and pre-emulsified. After (10) is added, the mixture is uniformly emulsified with a homomixer, and (11) is added to adjust the pH. After cooling, add and mix (12) to (14) at 40 ° C.

[Example 23] Skin lotion
(1) Ethanol 10.0 (wt%)
(2) Hydroxyethyl cellulose 1.0
(3) Preparation Example 6 0.5
(4) Methyl paraoxybenzoate 0.1
(5) Glycerin 10.0
(6) 1,3-Butylene glycol 10.0
(7) Purified water Mass production method with a total amount of 100: (1) to (7) are mixed and made uniform.

[Example 24] Emulsion for skin
(1) Stearic acid 0.2 (% by weight)
(2) Cetanol 1.5
(3) Vaseline 3.0
(4) Liquid paraffin 7.0
(5) Polyoxyethylene (10E.O.) monooleate 1.5
(6) Tocopherol acetate 0.5
(7) Glycerin 5.0
(8) Methyl paraoxybenzoate 0.1
(9) Triethanolamine 1.0
(10) Purified water 79.2
(11) Preparation Example 3 0.5
(12) Preparation Example 4 0.5
Production method: The oil phase components (1) to (6) are mixed, heated and uniformly dissolved, and kept at 70 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and heated to be uniform, and set to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring and emulsified. After cooling, the components (11) and (12) are added and mixed at 40 ° C.

[Example 25] Gel for skin
(1) Purified water 78.5 (wt%)
(2) Carboxyvinyl polymer 0.5
(3) Dipropylene glycol 20.0
(4) Methyl paraoxybenzoate 0.1
(5) Potassium hydroxide 0.1
(6) Preparation Example 6 0.8
Manufacturing method: (2) is uniformly dissolved in (1), (4) is dissolved and added to (3), and then (5) is added to increase the viscosity. Added.

[Example 26] Cream for skin
(1) Beeswaw 6.0 (wt%)
(2) Cetanol 5.0
(3) Reduced lanolin 8.0
(4) Squalane 29.5
(5) Lipophilic glycerin monostearate 4.0
(6) Polyoxyethylene (20E.O.)
Sorbitan monolaurate 5.0
(7) Propylene glycol 8.0
(8) Glycerin 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 28.4
(11) Preparation Example 5 1.0
Production method: The oil phase components (1) to (6) are mixed, dissolved, and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer. After cooling, the component (11) is added and mixed at 40 ° C.

Example 27 Oil-in-water emulsion ointment
(1) White petrolatum 25.0 (wt%)
(2) Stearyl alcohol 25.0
(3) Glycerin 15.0
(4) Sodium lauryl sulfate 1.0
(5) Methyl paraoxybenzoate 0.1
(6) Purified water 32.9
(7) Preparation Example 6 1.0
Production method: The oil phase components (1) to (4) are mixed, dissolved and made uniform, and heated to 75 ° C. On the other hand, (5) is dissolved in (6) and heated to 75 ° C., the oil phase component is added thereto to emulsify, and after cooling, (7) is added and mixed at 40 ° C.

[Example 28] Lotion
(1) Ethanol 10.0 (wt%)
(2) 1,3-butylene glycol 20.0
(3) Preparation Example 5 0.5
(4) Fragrance 0.1
(5) Purified water 69.4
Production method: (1) to (4) are sequentially added to (5) and mixed and dissolved uniformly.

[Example 29] Water-in-oil emulsified emollient cream
(1) Liquid paraffin 30.0 (wt%)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium L-glutamate 1.6
(6) L-serine 0.4
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 47.3
(11) Fragrance 0.1
(12) Preparation Example 4 0.5
Production method: (5) and (6) are dissolved in a part of (10) to 50 ° C., and gradually added to (4) heated to 50 ° C. with stirring. This was mixed in advance and uniformly dispersed in (1) to (3) dissolved at 70 ° C., and (7) to (9) were dissolved in the remainder of (10) and heated to 70 ° C. Is added with stirring and emulsified with a homomixer. After cooling, add and mix components (11) and (12) at 40 ° C.

[Example 30] Makeup base cream
(1) Stearic acid 12.0 (wt%)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Self-emulsifying glycerin monostearate 2.0
(5) Propylene glycol 11.0
(6) Potassium hydroxide 0.3
(7) Purified water 68.1
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Preparation Example 5 0.5
Production method: The oil phase components (1) to (4) are mixed and heated to 75 ° C. to be uniform. On the other hand, the aqueous phase components (5) to (7) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (8) to (10) are added to this and dispersed uniformly with a homomixer. Let The oil phase component is added to the water phase component, emulsified with a homomixer, cooled, and the components (11) and (12) are added and mixed at 40 ° C.

[Example 31] Emulsion foundation
(1) Stearic acid 2.0 (wt%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Decaglycerin monoisopalmitate 9.0
(6) Macadamia nut fatty acid phytosteryl 0.5
(7) 1,3-butylene glycol 8.0
(8) Potassium hydroxide 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 50.6
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Preparation Example 6 0.5
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to be uniform. On the other hand, the water phase components (7) to (10) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (11) to (15) are added thereto and uniformly emulsified with a homomixer. After cooling, add components (16) and (17) at 40 ° C and mix.

[Example 32] Hand cream
(1) Cetanol 4.0 (wt%)
(2) Vaseline 2.0
(3) Liquid paraffin 10.0
(4) Glycerin monostearate 1.5
(5) Polyoxyethylene (20E.O.)
Glycerol isostearate 2.5
(6) Tocopherol acetate 0.5
(7) Soybean phospholipid 0.5
(8) Glycerin 20.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 58.4
(11) Preparation Example 5 0.5
Production method: The oil phase components (1) to (7) are mixed, dissolved, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer and cooled, and the component (11) is added and mixed at 40 ° C.

Claims (3)

A composition for beautifying skin containing sea cucumber and / or an extract thereof. An external preparation containing sea cucumber and / or an extract thereof as a beautifying skin composition. A food or drink containing sea cucumber and / or an extract thereof as a beautifying skin composition.