JP2006076898A - External skin care preparation in emulsion dosage form - Google Patents
External skin care preparation in emulsion dosage form Download PDFInfo
- Publication number
- JP2006076898A JP2006076898A JP2004260348A JP2004260348A JP2006076898A JP 2006076898 A JP2006076898 A JP 2006076898A JP 2004260348 A JP2004260348 A JP 2004260348A JP 2004260348 A JP2004260348 A JP 2004260348A JP 2006076898 A JP2006076898 A JP 2006076898A
- Authority
- JP
- Japan
- Prior art keywords
- alginic acid
- mass
- skin
- polyhydric alcohol
- external preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000002552 dosage form Substances 0.000 title abstract description 6
- 239000000839 emulsion Substances 0.000 title abstract description 6
- 229920000615 alginic acid Polymers 0.000 claims abstract description 43
- -1 propylene glycol ester Chemical class 0.000 claims abstract description 43
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 42
- 239000000783 alginic acid Substances 0.000 claims abstract description 36
- 229960001126 alginic acid Drugs 0.000 claims abstract description 36
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 34
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 33
- 150000002148 esters Chemical class 0.000 claims abstract description 28
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000007864 aqueous solution Substances 0.000 claims abstract description 12
- 230000032050 esterification Effects 0.000 claims abstract description 9
- 238000005886 esterification reaction Methods 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000003995 emulsifying agent Substances 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 4
- 239000000243 solution Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 description 30
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 18
- 238000012360 testing method Methods 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 13
- 239000000203 mixture Substances 0.000 description 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 235000019437 butane-1,3-diol Nutrition 0.000 description 9
- 229920001296 polysiloxane Polymers 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 229940072056 alginate Drugs 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 6
- 239000006096 absorbing agent Substances 0.000 description 6
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 6
- 229940032094 squalane Drugs 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 4
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- 229920002907 Guar gum Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 235000010417 guar gum Nutrition 0.000 description 3
- 239000000665 guar gum Substances 0.000 description 3
- 229960002154 guar gum Drugs 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 229940015975 1,2-hexanediol Drugs 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
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- 238000003756 stirring Methods 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、皮膚外用剤に関し、更に詳細には、アルギン酸の多価アルコールエステルを用いた乳化剤形の皮膚外用剤に関する。 The present invention relates to a skin external preparation, and more particularly to an emulsifier type skin external preparation using a polyhydric alcohol ester of alginic acid.
乳化組成物は、水性成分と油性成分が、連続相と乳化粒子に分かれて含有される為、油溶性成分の担体としても、水溶性成分の担体としても好適である為、複数の有効成分を含有する、化粧料や皮膚外用医薬などの分野で有用な製剤として使用されている。この様な乳化組成物は、成分としては、主として親水性成分、油性成分及び界面活性剤から構成されている。中でも界面活性剤は、互いには混じらない親水性成分と油性成分とを均一な分散状態に分散させるには必須の成分である。界面活性剤としては、石けんやアルキル硫酸エステル塩などのアニオン界面活性剤やポリオキシエチレン付加型、或いは多価アルコールの部分エステル型の非イオン界面活性剤が、皮膚外用剤の分野では広く使用されている。この内、アニオン界面活性剤には、一時刺激性の面で改善すべきがあり、非イオン界面活性剤では、経時的なホルマリン発生の面で改善すべき点があった。更に、生分解されにくい特性から、環境科学的には、「持続可能な発展」の京都議定書の主旨とは相容れない面があり、改善される余地を残している。この為、界面活性剤を使用しない乳化系の開発が、皮膚外用剤の分野では長年の課題となっていた。この様な背景から、本発明者らは、アルギン酸の塩、アルギン酸の多価アルコールのエステル及び塩を用いることにより、界面活性剤フリーの水中油乳化系が具現化出来ることを見出した。（例えば、特許文献１を参照）この技術においては、アルギン酸の塩を必須成分として用いているが、この成分の持っている被膜性が、化粧膜をフレーキングさせたりする場合が存し、その改良が望まれるようになっていた。又、陰イオン性の物質が存する場合には、カルシウムイオン等のアルギン酸の対イオンと不溶体を形成する場合も存し、その意味で、応用範囲に限度が存している技術と言える。言い換えれば、アルギン酸の多価アルコールエステルを含有する乳化剤形の皮膚外用剤において、アルギン酸塩フリーのものの開発が望まれていたと言える。 Since the emulsified composition contains an aqueous component and an oily component separately in a continuous phase and emulsified particles, it is suitable as a carrier for an oil-soluble component and a carrier for a water-soluble component. It is used as a formulation useful in the fields of cosmetics and external medicine for skin. Such an emulsified composition is mainly composed of a hydrophilic component, an oily component and a surfactant as components. Above all, the surfactant is an essential component for dispersing a hydrophilic component and an oil component that are not mixed with each other in a uniform dispersion state. As surfactants, anionic surfactants such as soap and alkyl sulfate esters, polyoxyethylene addition type, or partial ester type nonionic surfactants of polyhydric alcohols are widely used in the field of topical skin preparations. ing. Of these, anionic surfactants should be improved in terms of temporary irritation, and nonionic surfactants should be improved in terms of generation of formalin over time. Furthermore, because of its characteristics that are not easily biodegradable, environmental science is incompatible with the main points of the Sustainable Development Protocol in Kyoto, leaving room for improvement. For this reason, the development of an emulsifying system that does not use a surfactant has been a long-standing problem in the field of topical skin preparations. From such a background, the present inventors have found that a surfactant-free oil-in-water emulsion system can be realized by using a salt of alginic acid, an ester and a salt of a polyhydric alcohol of alginic acid. (For example, refer to Patent Document 1) In this technique, a salt of alginic acid is used as an essential component. However, there is a case where the coating property of this component flakes a decorative film. Improvements have come to be desired. In addition, when an anionic substance exists, it may form an insoluble substance with a counter ion of alginic acid such as calcium ion, and in this sense, it can be said that the application range is limited. In other words, it can be said that development of an alginate-free external preparation in the emulsifier form containing a polyhydric alcohol ester of alginic acid has been desired.
一方、アルギン酸の多価アルコールエステルとしては、アルギン酸プロピレングリコール、アルギン酸グリセリンなどが知られており、乳化剤形などで使用されているが、（例えば、特許文献１或いは特許文献２を参照）アルギン酸の多価アルコールエステルであって、エステル化度が７０％以上であり、１％水溶液に於ける粘度が、２０℃の測定条件において、１００ｍＰａｓｃａｌ秒以下であるものを皮膚外用剤全量に対して２〜５質量％含有する乳化剤形の皮膚外用剤は全く知られていないし、かかる構成を取ることにより、アルギン酸の塩を使用せずに、微細な乳化粒子の乳化系が得られることも全く知られていない。 On the other hand, as polyhydric alcohol esters of alginic acid, propylene glycol alginate, glycerin alginate and the like are known and used in an emulsifier form or the like (see, for example, Patent Document 1 or Patent Document 2). A monohydric alcohol ester having an esterification degree of 70% or more and a viscosity in a 1% aqueous solution of 100 mPascal seconds or less under the measurement condition of 20 ° C. is 2 to 5 with respect to the total amount of the external preparation for skin. No emulsifier type skin external preparation containing mass% is known at all, and it is not known at all that an emulsified system of fine emulsified particles can be obtained without using a salt of alginic acid by taking such a constitution. .
本発明は、この様な状況下為されたものであり、アルギン酸の多価アルコールエステルを含有する乳化剤形の皮膚外用剤において、アルギン酸塩フリーの剤形を提供することを課題とする。 The present invention has been made under such circumstances, and an object of the present invention is to provide an alginate-free dosage form in an emulsifier-type skin external preparation containing a polyhydric alcohol ester of alginic acid.
この様な状況に鑑みて、本発明者らは、アルギン酸の多価アルコールエステルを含有する乳化剤形の皮膚外用剤において、アルギン酸塩フリーの剤形を求めて、鋭意研究努力を重ねた結果、アルギン酸の多価アルコールエステルであって、エステル化度が７０％以上であり、１％水溶液に於ける粘度が、２０℃の測定条件において、１００ｍＰａｓｃａｌ秒以下であるものを皮膚外用剤全量に対して２〜５質量％含有する乳化剤形の皮膚外用剤がその様な特性を備えていることを見出し、発明を完成させるに至った。即ち、本発明は以下に示すとおりである。
（１）アルギン酸の多価アルコールエステルであって、エステル化度が７０％以上であり、１％水溶液に於ける粘度が、２０℃の測定条件において、１００ｍＰａｓｃａｌ秒以下であるものを皮膚外用剤全量に対して２〜５質量％含有することを特徴とする、乳化剤形の皮膚外用剤。
（２）前記アルギン酸の多価アルコールエステルが、アルギン酸プロピレングリコールエステルであることを特徴とする、（１）に記載の乳化剤形の皮膚外用剤。
（３）前記アルギン酸の多価アルコールエステルの含有量が、１〜５質量％であることを特徴とする、（１）又は（２）に記載の乳化剤形の皮膚外用剤。
（４）水中油乳化剤形であることを特徴とする、（１）〜（３）何れか１項に記載の乳化剤形の皮膚外用剤。
（５）実質的に界面活性剤を含有しないことを特徴とする、（１）〜（４）何れか１項に記載の乳化剤形の皮膚外用剤。
In view of such a situation, the present inventors have sought for an alginate-free dosage form in an emulsifier-type skin external preparation containing a polyhydric alcohol ester of alginic acid. A polyhydric alcohol ester of which the degree of esterification is 70% or more and the viscosity in a 1% aqueous solution is 100 mPascal seconds or less under the measurement condition of 20 ° C. is 2% relative to the total amount of the external preparation for skin. The present inventors have found that an emulsifier-type skin external preparation containing ˜5% by mass has such characteristics, and has completed the invention. That is, the present invention is as follows.
(1) Alginate polyhydric alcohol ester having a degree of esterification of 70% or more and a viscosity in a 1% aqueous solution of 100 mPascal seconds or less under the measurement conditions of 20 ° C. An emulsifier-type skin external preparation characterized by containing 2-5 mass% with respect to this.
(2) The emulsifier-type skin external preparation according to (1), wherein the polyhydric alcohol ester of alginic acid is a propylene glycol ester of alginic acid.
(3) The emulsifier-type skin external preparation according to (1) or (2), wherein the content of the polyhydric alcohol ester of alginic acid is 1 to 5% by mass.
(4) The emulsifier-type skin external preparation according to any one of (1) to (3), which is an oil-in-water emulsifier type.
(5) The skin external preparation in the form of an emulsifier according to any one of (1) to (4), which is substantially free of a surfactant.
（１）本発明の乳化組成物の必須成分であるアルギン酸の多価アルコールエステル
本発明の乳化組成物は、アルギン酸の多価アルコールのエステルを必須成分として含有する。ここで、アルギン酸の多価アルコールのエステルを構成する多価アルコールとしては、皮膚外用剤などで使用されているものであれば特段の限定なく使用することが出来、炭素数２〜４のものが好ましく、エーテル結合を持たないものが好ましい。具体的には、プロピレングリコール、グリセリン、１，３−ブタンジオール、エチレングリコール等が好ましく例示でき、中でも親水性と親油性のバランスから、プロピレングリコールが特に好ましく例示できる。これらのアルギン酸の多価アルコールのエステルは何れも既知化合物であり、その製造方法は既に知られている。かかるアルギン酸の多価アルコールのエステルの製造法としては、アルギン酸ナトリウム等のアルギン酸の塩と、対応する多価アルコールのモノハロゲン化物を、アルカリ存在下反応させることが例示できる。例えば、アルギン酸プロピレングリコール エステルであれば、アルギン酸ナトリウムと１−クロル−２−プロパノールを含水アルコール中で炭酸カリウムなどを存在させて反応させればよいし、アルギン酸グリセリルエステルであれば、前記の反応の１−クロル−ープロパノールを１−クロル−２，３−プロパンジオールに代えて同様に処理すれば製造することが出来る。本発明の皮膚外用剤で使用できるアルギン酸の多価アルコールエステルとしては、の特性を有するものが使用できる。
(1) Polyhydric alcohol ester of alginic acid which is an essential component of the emulsified composition of the present invention The emulsified composition of the present invention contains an ester of polyhydric alcohol of alginic acid as an essential component. Here, the polyhydric alcohol constituting the polyhydric alcohol ester of alginic acid can be used without particular limitation as long as it is used in a skin external preparation or the like, and those having 2 to 4 carbon atoms. Those having no ether bond are preferred. Specifically, propylene glycol, glycerin, 1,3-butanediol, ethylene glycol and the like can be preferably exemplified, and propylene glycol can be particularly preferably exemplified from the balance between hydrophilicity and lipophilicity. All of these polyhydric alcohol esters of alginic acid are known compounds, and their production methods are already known. Examples of the method for producing an ester of a polyhydric alcohol of alginic acid include a reaction of a salt of alginic acid such as sodium alginate with a monohalide of the corresponding polyhydric alcohol in the presence of an alkali. For example, in the case of propylene glycol alginate, sodium alginate and 1-chloro-2-propanol may be reacted in the presence of aqueous alcohol in the presence of potassium carbonate or the like, and in the case of glyceryl alginate, It can be produced by treating 1-chloro-propanol in the same manner in place of 1-chloro-2,3-propanediol. As the polyhydric alcohol ester of alginic acid that can be used in the external preparation for skin of the present invention, those having the following characteristics can be used.
（アルギン酸の多価アルコールエステルの特性）
１）エステル化度が７０％以上、より好ましくは８０％以上であること。
２）１％水溶液の水溶液の２０℃における粘度がＢ型粘度計で１号ローターでの測定で、１０〜１００ｍＰａｓｃａｌ・秒、より好ましくは１０〜３０ｍＰａｓｃａｌ・秒であること。
(Characteristics of polyhydric alcohol ester of alginic acid)
1) The degree of esterification is 70% or more, more preferably 80% or more.
2) The viscosity of an aqueous solution of 1% aqueous solution at 20 ° C. is 10 to 100 mPascal · second, more preferably 10 to 30 mPascal · second as measured with a No. 1 rotor with a B-type viscometer.
この様な特性を有するアルギン酸の多価アルコールエステルの中には既に市販されているものが存し、これを購入して利用することも出来る。この様なアルギン酸の多価アルコールエステルとしては、株式会社キミカから販売されている、「キミロイドＬＬＶ」（１％水溶液、２０℃の粘度が１０〜３０ｍＰａｓｃａｌ・秒で、エステル化度８０％）、「キミロイドＮＬＳ−Ｋ」（１％水溶液、２０℃の粘度が３０〜６０ｍＰａｓｃａｌ・秒で、エステル化度８０％）、「キミロイドＬＶ」（１％水溶液、２０℃の粘度が６０〜１００ｍＰａｓｃａｌ・秒で、エステル化度８０％）等が好ましく例示できる。これらの内、特に好ましいものは、「キミロイドＬＬＶ」である。これらは唯一種を含有させることも出来るし、二種以上を組み合わせて含有させることも出来る。かかるアルギン酸の多価アルコールエステルの好ましい含有量は、下限値としては、総量で、化粧料全量に対して２〜３質量％であり、上限値としては、４〜５質量％である。これは少なすぎると、乳化が出来ない場合が存し、多すぎると硬度が大きくなりすぎるなどして、使用性が損なわれるためである。 Among the polyhydric alcohol esters of alginic acid having such properties, there are already commercially available ones that can be purchased and used. As such a polyhydric alcohol ester of alginic acid, “Kimiloid LLV” (1% aqueous solution, viscosity at 20 ° C. of 10 to 30 mPascal · sec, esterification degree 80%) sold by Kimika Co., Ltd., “ “Chimiloid NLS-K” (1% aqueous solution, viscosity at 20 ° C. is 30 to 60 mPascal · second, esterification degree 80%), “Chimiloid LV” (1% aqueous solution, viscosity at 20 ° C. is 60 to 100 mPascal · second, A preferred example is an esterification degree of 80%. Among these, “Chimiloid LLV” is particularly preferable. These can contain only the seed | species, and can also be made to contain in combination of 2 or more type. The preferable content of the polyhydric alcohol ester of alginic acid is the total amount as the lower limit, and is 2-3% by mass relative to the total amount of the cosmetic, and the upper limit is 4-5% by mass. If the amount is too small, there are cases where emulsification cannot be performed. If the amount is too large, the hardness becomes too high, and the usability is impaired.
（２）本発明の皮膚外用剤
本発明の皮膚外用剤は、前記必須成分を含有し、乳化剤形であることを特徴とする。かかる乳化剤形に於ける乳化の形態としては、外相に水相が存する乳化剤形が好ましく、この様な形態の単純エマルション、複合エマルションの何れもが適用可能であるが、単純エマルションである、Ｏ／Ｗ乳化剤形（水中油乳化剤形）が特に好ましく例示できる。本発明の、皮膚外用剤では、その開発主旨から、界面活性剤の含有量は出来る限り低減することが好ましく、少なくとも環境負荷の少ない０．５質量以下であることが好ましく、界面活性剤フリーであることがより好ましい。又、フレーキングなどの使用性の面から、アルギン酸塩も極力少なくすることが好ましく、０．０５質量％以下であることが好ましく、アルギン酸塩フリーであることがより好ましい。
(2) The external preparation for skin of the present invention The external preparation for skin of the present invention contains the essential components and is in the form of an emulsifier. As the form of emulsification in such an emulsifier form, an emulsifier form in which an aqueous phase is present in the external phase is preferable, and both simple emulsions and complex emulsions of such form can be applied. The W emulsifier type (oil-in-water emulsifier type) can be particularly preferably exemplified. In the external preparation for skin according to the present invention, the content of the surfactant is preferably reduced as much as possible from the gist of the development, and it is preferably at least 0.5 mass or less with a low environmental load, and is free of surfactant. More preferably. Also, from the viewpoint of usability such as flaking, it is preferable to reduce the alginate as much as possible, preferably 0.05% by mass or less, and more preferably alginate free.
本発明の皮膚外用剤においては、前記の成分以外に、通常皮膚外用剤で使用される任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類、流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等、イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−２−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−２−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−２−ヘプチルウンデカン酸グリセリン、トリ−２−エチルヘキサン酸グリセリン、トリ−２−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−２−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類、ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン、オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン、アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類、脂肪酸セッケン（ラウリン酸ナトリウム、パルミチン酸ナトリウム等）、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類、塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類、イミダゾリン系両性界面活性剤（２−ココイル−２−イミダゾリニウムヒドロキサイド−１−カルボキシエチロキシ２ナトリウム塩等）、ベタイン系界面活性剤（アルキルベタイン、アミドベタイン、スルホベタイン等）、アシルメチルタウリン等の両性界面活性剤類、ソルビタン脂肪酸エステル類（ソルビタンモノステアレート、セスキオレイン酸ソルビタン等）、グリセリン脂肪酸類（モノステアリン酸グリセリン等）、プロピレングリコール脂肪酸エステル類（モノステアリン酸プロピレングリコール等）、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、ＰＯＥソルビタン脂肪酸エステル類（ＰＯＥソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等）、ＰＯＥソルビット脂肪酸エステル類（ＰＯＥ−ソルビットモノラウレート等）、ＰＯＥグリセリン脂肪酸エステル類（ＰＯＥ−グリセリンモノイソステアレート等）、ＰＯＥ脂肪酸エステル類（ポリエチレングリコールモノオレート、ＰＯＥジステアレート等）、ＰＯＥアルキルエーテル類（ＰＯＥ２−オクチルドデシルエーテル等）、ＰＯＥアルキルフェニルエーテル類（ＰＯＥノニルフェニルエーテル等）、プルロニック型類、ＰＯＥ・ＰＯＰアルキルエーテル類（ＰＯＥ・ＰＯＰ２−デシルテトラデシルエーテル等）、テトロニック類、ＰＯＥヒマシ油・硬化ヒマシ油誘導体（ＰＯＥヒマシ油、ＰＯＥ硬化ヒマシ油等）、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン、１，３−ブチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、１，２−ペンタンジオール、２，４−ヘキシレングリコール、１，２−ヘキサンジオール、１，２−オクタンジオール等の多価アルコール類、ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類、グアガム、クインスシード、カラギーナン、ガラクタン、アラビアガム、ペクチン、マンナン、デンプン、キサンタンガム、カードラン、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルセルロース、メチルヒドロキシプロピルセルロース、コンドロイチン硫酸、デルマタン硫酸、グリコーゲン、ヘパラン硫酸、ヒアルロン酸、ヒアルロン酸ナトリウム、トラガントガム、ケラタン硫酸、コンドロイチン、ムコイチン硫酸、ヒドロキシエチルグアガム、カルボキシメチルグアガム、デキストラン、ケラト硫酸，ローカストビーンガム，サクシノグルカン，カロニン酸，キチン，キトサン、カルボキシメチルキチン、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、ポリアクリル酸ナトリウム、ポリエチレングリコール、ベントナイト等の増粘剤、表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸（シリカ）、酸化アルミニウム、硫酸バリウム等の粉体類、表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類、表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類、レーキ化されていても良い赤色２０２号、赤色２２８号、赤色２２６号、黄色４号、青色４０４号、黄色５号、赤色５０５号、赤色２３０号、赤色２２３号、橙色２０１号、赤色２１３号、黄色２０４号、黄色２０３号、青色１号、緑色２０１号、紫色２０１号、赤色２０４号等の有機色素類、ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類、パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、２−（２’−ヒドロキシ−５’−ｔ−オクチルフェニル)ベンゾトリアゾール、４−メトキシ−４’−ｔ−ブチルジベンゾイルメタン等の紫外線吸収剤類、エタノール、イソプロパノール等の低級アルコール類、ビタミンＡ又はその誘導体、ビタミンＢ6塩酸塩，ビタミンＢ6トリパルミテート，ビタミンＢ6ジオクタノエート，ビタミンＢ2又はその誘導体，ビタミンＢ12，ビタミンＢ15又はその誘導体等のビタミンＢ類、α−トコフェロール，β−トコフェロール，γ−トコフェロール，ビタミンＥアセテート等のビタミンＥ類、ビタミンＤ類、ビタミンＨ、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類などが好ましく例示できる。特に、本発明の皮膚外用剤において、含有することが好ましい成分としては、多価アルコールが例示でき、中でも、１，３−ブタンジオール、１，２−ペンタンジオール、１，２−ヘキサンジオールなどの抗菌性多価アルコールが好ましく例示できる。これらは唯一種含有することも出来るし、二種以上を組み合わせて含有することも出来る。かかる多価アルコールの好ましい含有量は、総量で、皮膚外用剤全量に対して、１〜１０質量％であり、より好ましくは３〜８質量％である。本発明の皮膚外用剤は、これらの成分を常法に従って処理することにより製造することが出来る。 In the external preparation for skin of the present invention, in addition to the above-mentioned components, optional components usually used in external preparations for skin can be contained. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, pyrrolidone carboxylic acid Moisturizing ingredients such as sodium, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate , Dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hyaluronan Droxyethyl guar gum, carboxymethyl guar gum, dextran, keratosulfuric acid, locust bean gum, succinoglucan, carolinic acid, chitin, chitosan, carboxymethylchitin, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene glycol , Thickeners such as bentonite, surface may be treated, powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, The surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, the surface may be treated, mica titanium, fish phosphorus Foil, bismuth oxychloride, etc. Red, No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201 Organic dyes such as red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc. Organic powders, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2 UV light such as' -hydroxy-5'-t-octylphenyl) benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane Collectors, lower alcohols such as ethanol and isopropanol, vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof, etc. Vitamin E such as vitamin B, α-tocopherol, β-tocopherol, γ-tocopherol and vitamin E acetate, vitamin D such as vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like can be preferably exemplified. In particular, in the external preparation for skin of the present invention, examples of the component preferably contained include polyhydric alcohols, among which 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, etc. An antibacterial polyhydric alcohol can be illustrated preferably. These can be contained alone or in combination of two or more. The preferable content of the polyhydric alcohol is 1 to 10% by mass, more preferably 3 to 8% by mass, based on the total amount of the external preparation for skin, in total. The external preparation for skin of the present invention can be produced by treating these components according to a conventional method.
本発明の皮膚外用剤は、皮膚に外用で投与されるものであれば特段の限定無く適用することが出来る。この様な皮膚外用剤としては、例えば、皮膚外用医薬、化粧料或いは皮膚外用雑貨などが好適に例示できる。特に好ましいものは化粧料である。これは、化粧料は使用反復回数が多く本発明の効果がより効果的に発揮できるためである。 The external preparation for skin of the present invention can be applied without particular limitation as long as it is administered externally to the skin. As such a skin external preparation, for example, a skin external medicine, cosmetics or skin external goods can be suitably exemplified. Particularly preferred are cosmetics. This is because cosmetics have many repetitions of use and the effects of the present invention can be exhibited more effectively.
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明がかかる実施例にのみ限定されないことは言うまでもない。 Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.
以下に示す処方に従って、本発明の皮膚外用剤である化粧料１を製造した。即ち、イの成分を良く攪拌し、ロの成分と合わせ、一様に分散させ、これを８０℃に加温し、これに予め８０℃に加温しておいたハを攪拌下徐々に加え、ホモジナイザー処理をし、攪拌冷却し、本発明の皮膚外用剤である化粧料１を得た。 According to the formulation shown below, cosmetic 1 as an external preparation for skin of the present invention was produced. That is, the component (a) is stirred well, combined with the component (b), uniformly dispersed, heated to 80 ° C., and the mixture previously heated to 80 ° C. is gradually added with stirring. Then, homogenizer treatment was performed, followed by stirring and cooling to obtain a cosmetic 1 which is a skin external preparation of the present invention.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＮＬＳ−Ｋ」） ２ 質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７７ 質量％
アスコルビン酸−２−グルコシド １ 質量％
ハ）
スクワラン １５ 質量％
I)
Alginate propylene glycol ester ("Chimiloid NLS-K") 2% by mass
1,3-butanediol 5% by mass
B)
77% by mass of water
Ascorbic acid-2-glucoside 1% by mass
C)
Squalane 15% by mass
（比較例１）
化粧料１と同様に、下記処方に従って、比較例１の化粧料を製造しようとしたが、乳化が困難であった。
(Comparative Example 1)
Similar to the cosmetic 1, an attempt was made to produce the cosmetic of Comparative Example 1 according to the following formulation, but emulsification was difficult.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＮＬＳ−Ｋ」） １．５質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７７．５質量％
アスコルビン酸−２−グルコシド １ 質量％
ハ）
スクワラン １５ 質量％
I)
Alginic acid propylene glycol ester ("Chimiloid NLS-K") 1.5% by mass
1,3-butanediol 5% by mass
B)
Water 77.5% by mass
Ascorbic acid-2-glucoside 1% by mass
C)
Squalane 15% by mass
（比較例２）
化粧料１と同様に、下記処方に従って、比較例２の化粧料を製造した。
(Comparative Example 2)
Similarly to the cosmetic 1, the cosmetic of Comparative Example 2 was produced according to the following formulation.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＮＬＳ−Ｋ」） １．５質量％
アルギン酸ナトリウム ０．１質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７７．３質量％
アスコルビン酸−２−グルコシド １ 質量％
１％塩化カルシウム水溶液 ０．１質量％
ハ）
スクワラン １５ 質量％
I)
Alginic acid propylene glycol ester ("Chimiloid NLS-K") 1.5% by mass
Sodium alginate 0.1% by mass
1,3-butanediol 5% by mass
B)
Water 77.3 mass%
Ascorbic acid-2-glucoside 1% by mass
1% calcium chloride aqueous solution 0.1% by mass
C)
Squalane 15% by mass
（試験例１）
化粧料１と比較例２の化粧料とを用いて、低温保存試験を行った。即ち、これらの化粧料を５℃で３ヶ月保存した後、０．１ｇを取り、標準黒色板上に、ドクターブレードを用いて２０ミルに延展し、３ｃｍ×３ｃｍあたりのブツの発生個数を計数した。化粧料１は０であるのに対し、比較例２は１２個であった。これより、本発明の皮膚外用剤は安定性に優れることが判る。
(Test Example 1)
A low temperature storage test was conducted using the cosmetic 1 and the cosmetic of Comparative Example 2. That is, after these cosmetics were stored at 5 ° C. for 3 months, 0.1 g was taken and spread on a standard black plate to 20 mils using a doctor blade, and the number of occurrences of irregularities per 3 cm × 3 cm was counted. did. While cosmetic 1 was 0, Comparative Example 2 was 12. This shows that the external preparation for skin of the present invention is excellent in stability.
（試験例２）
化粧料１と比較例２の化粧料とを用いて、高温保存試験を行った。即ち、これらの化粧料を５０℃で３週間保存し、性状を観察した。比較例２においては、離水が明確に観察されたが、化粧料１は僅かにしか離水は見られなかった。これより、本発明の化粧料は、従来のアルギン酸塩−アルギン酸多価アルコールエステル乳化系の安定性を更に高めている製剤であると判断できる。
(Test Example 2)
A high temperature storage test was performed using the cosmetic 1 and the cosmetic of Comparative Example 2. That is, these cosmetics were stored at 50 ° C. for 3 weeks, and their properties were observed. In Comparative Example 2, water separation was clearly observed, but cosmetic 1 showed only slight water separation. From this, it can be judged that the cosmetic of the present invention is a preparation that further enhances the stability of the conventional alginate-alginate polyhydric alcohol ester emulsion system.
化粧料１と同様に、下記に示す処方に従って、本発明の皮膚外用剤である、化粧料２（水中油乳化化粧料）を作成した。このものは、試験例１と同様の保存試験でブツの出現は認めず、試験例２の保存試験では全く離水を認めなかった。 Similarly to cosmetic 1, cosmetic 2 (oil-in-water emulsified cosmetic), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. In this, no appearance of bumps was observed in the same storage test as in Test Example 1, and no water separation was observed in the storage test of Test Example 2.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＮＬＳ−Ｋ」） ３ 質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７６ 質量％
アスコルビン酸−２−グルコシド １ 質量％
ハ）
スクワラン １５ 質量％
I)
Alginic acid propylene glycol ester ("Chimiloid NLS-K") 3% by mass
1,3-butanediol 5% by mass
B)
76% by weight of water
Ascorbic acid-2-glucoside 1% by mass
C)
Squalane 15% by mass
化粧料１と同様に、下記に示す処方に従って、本発明の皮膚外用剤である、化粧料３（水中油乳化化粧料）を作成した。このものは、試験例１と同様の保存試験でブツの出現は認めず、試験例２の保存試験では全く離水を認めなかった。これより、アルギン酸の多価アルコールエステルとしては、１％水溶液の２０℃における粘度が３０ｍＰａｓｃａｌ・秒以下のものが好ましいことが判る。 Similarly to cosmetic 1, cosmetic 3 (oil-in-water emulsified cosmetic), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. In this, no appearance of bumps was observed in the same storage test as in Test Example 1, and no water separation was observed in the storage test of Test Example 2. From this, it can be seen that as the polyhydric alcohol ester of alginic acid, a 1% aqueous solution having a viscosity at 20 ° C. of 30 mPascal · second or less is preferable.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＬＬＶ」） ２ 質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７７ 質量％
アスコルビン酸−２−グルコシド １ 質量％
ハ）
スクワラン １５ 質量％
I)
Propylene glycol alginate ("Chimiloid LLV") 2% by mass
1,3-butanediol 5% by mass
B)
77% by mass of water
Ascorbic acid-2-glucoside 1% by mass
C)
Squalane 15% by mass
化粧料１と同様に、下記に示す処方に従って、本発明の皮膚外用剤である、化粧料４（水中油乳化化粧料）を作成した。このものは、試験例１と同様の保存試験でブツの出現は認めず、試験例２の保存試験では全く離水を認めなかった。これより、本発明の皮膚外用剤においては、炭化水素のみならずシリコーンのような非極性油も乳化可能であることが判る。 Similarly to cosmetic 1, cosmetic 4 (oil-in-water emulsified cosmetic), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. In this, no appearance of bumps was observed in the same storage test as in Test Example 1, and no water separation was observed in the storage test of Test Example 2. This indicates that the skin external preparation of the present invention can emulsify not only hydrocarbons but also nonpolar oils such as silicone.
イ）
アルギン酸プロピレングリコールエステル
（「キミロイドＬＬＶ」） ２ 質量％
１，３−ブタンジオール ５ 質量％
ロ）
水 ７７ 質量％
アスコルビン酸−２−グルコシド １ 質量％
ハ）
ジメチコン（１０００ｍＰａｓｃａｌ・秒） １５ 質量％
I)
Propylene glycol alginate ("Chimiloid LLV") 2% by mass
1,3-butanediol 5% by mass
B)
77% by mass of water
Ascorbic acid-2-glucoside 1% by mass
C)
Dimethicone (1000 mPascal · sec) 15% by mass
本発明は、安定な界面活性剤フリーの乳化化粧料に応用できる。 The present invention can be applied to a stable surfactant-free emulsified cosmetic.
Claims (5)
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|---|---|---|---|
| JP2004260348A JP4676730B2 (en) | 2004-09-08 | 2004-09-08 | Emulsifier type skin external preparation |
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| JP2006076898A true JP2006076898A (en) | 2006-03-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008266249A (en) * | 2007-04-24 | 2008-11-06 | Pola Chem Ind Inc | Emulsifier type external preparation for skin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62289160A (en) * | 1986-06-09 | 1987-12-16 | Kao Corp | Production of emulsified perfume |
| JPH09110638A (en) * | 1995-10-19 | 1997-04-28 | Noevir Co Ltd | Makeup removing material |
| JP2003226629A (en) * | 2002-01-30 | 2003-08-12 | Kao Corp | Body odor inhibitor |
| JP2004196728A (en) * | 2002-12-20 | 2004-07-15 | Kimica Corp | Emulsified composition of natural product origin |
-
2004
- 2004-09-08 JP JP2004260348A patent/JP4676730B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62289160A (en) * | 1986-06-09 | 1987-12-16 | Kao Corp | Production of emulsified perfume |
| JPH09110638A (en) * | 1995-10-19 | 1997-04-28 | Noevir Co Ltd | Makeup removing material |
| JP2003226629A (en) * | 2002-01-30 | 2003-08-12 | Kao Corp | Body odor inhibitor |
| JP2004196728A (en) * | 2002-12-20 | 2004-07-15 | Kimica Corp | Emulsified composition of natural product origin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008266249A (en) * | 2007-04-24 | 2008-11-06 | Pola Chem Ind Inc | Emulsifier type external preparation for skin |
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