JP2006020964A - Medical agent storage sealing body, and method for forming the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To reliably exclude the possibility of an erroneous operation that administration is performed while a medical agent bag is not opened yet concerning a multi-chemical mixture type medical agent bag. <P>SOLUTION: The medical agent bag 10 is formed of a soft film like base material. The inner cavity of the bag 10 is divided into a plurality of divided chambers 20, 22 through a soft seal part 18. A discharge port 12 is arranged to face one divided chamber 20 and is provided with a communication hole 28 at one end 12-2 facing the inner cavity of the medical agent bag 10. The communication hole 28 is normally closed by a separable peel membrane 30 so as to prevent the discharge of a medical agent from the medical agent bag 10 to the discharge port 12. The peel membrane 30 is firmly stuck onto the opposite surface of a plastic film constituting the medical agent bag, is deformed integrally with the opening deformation of the medical agent bag 10 at the moment of opening the soft seal part 18, and separated from the discharge port 12. The communication hole 28 is opened to the inner cavity of the medical agent bag so that the medical agent is discharged. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  In this invention, a plurality of medicines are stored in respective compartments of the medicine bag in a separated state, and a weak seal portion between the compartments is opened during infusion or dialysis so that the medicines are mixed and used. The present invention relates to a method for forming a stationary body and a medicine storage sealing body.

  There is a multi-liquid mixed type medical sealant for medical use for infusion or dialysis. In the multi-liquid mixed type liquid medicine sealed body, the internal cavity of the medicine bag made of a soft film is separated by a weak seal portion into a plurality of compartments each containing different liquid medicines. On the outer periphery of the drug bag, a chemical solution discharge port as a plastic molded product is provided, the chemical solution discharge port is formed in a cylindrical shape, and its internal cavity opens to one compartment on one end side, but on the other end Is provided with a rubber stopper. Prior to the administration of the drug solution to the patient, the weak seal is opened by pressurizing the drug bag from the outside, and the internal cavity of the drug bag becomes a single chamber, so the two types of drug solutions are mixed and connected to the infusion tube The rubber plug is punctured by the puncture needle of the infusion set thus made, and the drug solution can be administered from the drug bag.

In this type of medical mixed-type liquid medicine sealed body, it is indispensable to mix the two liquids by opening the weak seal part before administration of the chemical liquid, while the weak seal part is not opened. When the rubber stopper is punctured at the chemical solution outlet, there is a possibility of an erroneous operation in which only the chemical solution in the compartment on the chemical solution outlet side is administered. As a conventional technique for coping with this problem, in addition to the first weak seal portion that separates the internal cavity of the drug bag into two compartments, a second weak seal portion is provided immediately before the chemical solution outlet, By making the second second weak seal portion equal to or higher than the pressure required to open the weak seal portion, the first weak seal portion and then the second weak seal portion are opened in this order. Thus, there has been proposed a method in which discharge is performed after mixing of chemicals (see Patent Document 1).
JP 2004-661 A

  In the technique of Patent Document 1, in addition to the first weak seal portion that separates the two compartments, a second weak seal portion is provided immediately before the chemical solution discharge port, and these weak seal portions are sequentially opened so that they are not mixed. However, since the two weak seals are provided, the manufacturing process becomes complicated and the cost increases, and the user is forced to open the work by two stages of pressurization. The workability was not always good. In addition, depending on the method of pressurizing the medicine bag, the opening is not always performed in the order of the first weak seal portion → the second weak seal portion, and the second weak seal portion on the side of the chemical solution discharge port is the first. If it is opened, there is a possibility of shifting to the administration work as it is. In this case, only one solution is administered without mixing.

  The present invention has been made in view of the above-mentioned problems, and provides a novel structure of a multi-liquid mixed type drug bag that cannot be administered in an unopened state, is low in manufacturing cost, and is low on the user side. The object of the present invention is to more reliably eliminate the possibility of an erroneous operation in which administration is performed in an unmixed state despite the good workability.

  According to the first aspect of the present invention, the internal cavity of the medicine bag formed of a soft and flexible material is partitioned into a plurality of compartments by the weak seal portion, and the medicine is sealed in each compartment. A discharge port whose outer periphery is flow-tightly attached to the drug bag while facing one of the compartments, and a closing means for closing the discharge port with respect to the internal cavity of the drug bag in a normal state, The closed state of the discharge port can be released by cooperating with the expanding deformation of the drug bag when receiving a shocking fluid force induced in the drug bag at the moment of opening the weak seal part during use. There is provided a medicine container sealing body characterized in that.

  According to the second aspect of the present invention, the internal cavity of the medicine bag formed of a soft and flexible material is partitioned into a plurality of compartments by the weak seal portion, and the medicine is enclosed in each compartment. A discharge port whose outer periphery is flow-tightly attached to the drug bag while facing one of the compartments, and a detachable closing member that normally closes the discharge port with respect to the internal cavity of the drug bag, A drug storage sealing body is provided in which the closing member is integrally held on the opposing inner surface of the drug bag.

  According to the third aspect of the present invention, the internal cavity of the medicine bag formed of a soft and flexible material is divided into a plurality of compartments by the weak seal portion, and the medicine is sealed in each compartment. A discharge port whose outer periphery is flow-tightly attached to the drug bag while facing one of the compartments, the discharge port being a drug extraction part outside the drug bag, a drug inflow part and a drug inflow part inside the drug bag A detachable closing member for closing the detachable closing member, wherein the detachable closing member is integrally fixed to a facing surface of a soft and flexible material constituting the drug bag. Provided.

  According to the fourth aspect of the present invention, the internal cavity of the medicine bag formed of a soft and flexible material is divided into a plurality of compartments by the weak seal portion, and the medicine is enclosed in each compartment, A discharge port whose outer periphery is flow-tightly attached to the chemical solution bag while facing one of the compartments, and a release film that is attached so as to close the discharge port in a normal state. Provided is a drug storage sealing body characterized in that it is adhered to the opposite surface of the bag more firmly than the adhesion of the release film to the discharge port.

  According to the fifth aspect of the present invention, the internal cavity of the medicine bag formed of a soft and flexible material is partitioned into a plurality of compartments by the weak seal portion, the medicine is enclosed in each compartment, and the external force The discharge port with a built-in closure member that can be separated by the airtightly attached to the drug bag with the outer periphery facing one of the plurality of compartments, and the closure member that closes the discharge port is firmly attached to the opposite inner surface of the drug bag There is provided a medicine storage sealing body characterized in that it is fixed to the body.

  According to the sixth aspect of the present invention, the medicine bag is formed of a soft and flexible material, and the internal cavity is partitioned by a weak seal portion into a plurality of compartments, and the drainage is closed by a peelable closure member. Prepare the outlet, enclose the medicine in each compartment, and attach the outlet to the chemical bag on the outer periphery so as to face one of the plural compartments, and the peelable type provided at the outlet The closing member is fixed to the inner surface of the drug bag opposite to the closing member with a larger fixing force required to peel off the closing member.

  The operation and effect of the invention of claim 1 will be described. Normally, the closing means closes the discharge port with respect to the internal cavity of the drug bag, and the infusion from the drug bag cannot do this. The opening of the weak seal part is performed by pressing the drug bag with the entire palm, but when the weak seal part is opened, the pressing force is abruptly released, which causes a shocking flow of the drug solution in the drug bag. A large expansion deformation of the drug bag occurs at the outlet portion, and in cooperation with this expansion deformation, the closed state by the closing means is instantly released, the discharge port communicates with the internal cavity of the drug bag, and infusion starts be able to. Therefore, according to the present invention, it is possible to more reliably prevent the occurrence of erroneous work in an unmixed state before the weak seal is opened.

  The operation and effect of the invention of claim 2 will be described. The closing member normally closes the discharge port with respect to the internal cavity of the drug bag, and the infusion from the drug bag cannot perform this. The opening of the weak seal part is performed by pressing the drug bag with the entire palm, but when the weak seal part is opened, the pressing force is abruptly released, which causes a shocking flow of the drug solution in the drug bag. A large expansion deformation of the drug bag occurs at the exit portion. When this expansion deformation is received, the closure member is displaced integrally with the drug bag, so that it is separated by being displaced away from the discharge port, and the discharge port is separated from the drug bag. Communicating with the internal cavity, infusion can be initiated. Therefore, according to the present invention, it is possible to more reliably prevent the occurrence of erroneous work in an unmixed state before the weak seal is opened. In addition, the discharge port is closed by a separate type closing member. Even if the opening of the weak seal part fails to release the closing of the discharge port, the closing member is manually separated later to continue the infusion. Can be reached.

  The operation and effect of the invention of claim 3 will be described. The discharge port is provided with a medicine take-out portion on the outside of the medicine bag, and the medicine inflow portion on the inside of the medicine bag is closed by a detachable closing member. As in the case of the present invention, the discharge port can be surely opened simultaneously with the opening of the weak seal portion, and the discharge operation of the chemical solution can be easily and reliably performed from the extraction portion such as a rubber plug outside the drug bag.

  The action and effect of the invention of claim 4 will be described. The release membrane normally closes the discharge port with respect to the internal cavity of the drug bag, and the infusion from the drug bag cannot perform this. The opening of the weak seal part is performed by pressing the drug bag with the entire palm, but when the weak seal part is opened, the pressing force is abruptly released, which causes a shocking flow of the drug solution in the drug bag. A large expansion deformation of the drug bag occurs at the exit portion, and when this expansion deformation is received, the peeling film is firmly attached to the drug bag, so that it is displaced integrally with the drug bag, and on the other hand, peeling to the discharge port Since the adhesion of the membrane is weak, the release membrane is peeled off from the discharge port by integral displacement with the drug bag, and the discharge port is communicated with the internal cavity of the drug bag, so that infusion can be started. Therefore, according to the present invention, it is possible to more reliably prevent the occurrence of erroneous work in an unmixed state before the weak seal is opened. In addition, since the discharge port is closed by the release film, the drug bag and the release film can be attached simultaneously with the operation of sealing the discharge port to the drug bag, thereby forming the drug storage sealing body. The process becomes efficient.

  The operation and effect of the invention of claim 5 will be described. The closing member is built in the discharge port, and normally the discharge port is closed with respect to the internal cavity of the drug bag, and the infusion from the drug bag performs this. I can't. The opening of the weak seal part is performed by pressing the drug bag with the entire palm, but when the weak seal part is opened, the pressing force is abruptly released, which causes a shocking flow of the drug solution in the drug bag. A large expansion deformation of the drug bag occurs at the exit portion, and when this expansion deformation is received, the closing member is separated from the discharge port, and the discharge port communicates with the internal cavity of the drug bag, so that infusion can be started. . Therefore, according to the present invention, it is possible to more reliably prevent the occurrence of erroneous work in an unmixed state before the weak seal is opened. In addition, the outlet has a built-in closure member, and it is usually difficult to guarantee sterilization of the space by high-pressure steam sterilization. However, the outlet is sterilized by performing electron beam or gamma sterilization in advance. Can be attached to the drug bag after filling the inner solution, and the entire drug product can be attached to the drug bag after pre-establishing the desired sterilization condition for the outlet by autoclaving the whole drug. In addition, the sterilization guarantee essential for pharmaceuticals can be obtained easily and reliably.

  The action and effect of the invention of claim 6 will be described. The medicine bag is sealed with respect to the discharge port in a state in which the discharge port is previously closed by the closing member. Can be fixed at the same time, and the formation of the medicine container sealing body can be performed efficiently.

  In FIG. 1 and FIG. 2, the medical mixed-type liquid medicine sealing body includes a flat medicine bag 10 and a discharge port 12. The drug bag 10 is made of a soft film (soft flexible material of the present invention) such as a polypropylene film or a polyethylene film having a thickness of 200 to 400 microns. In the case of a polyethylene film, the outer periphery is sealed by a strong seal portion 14 formed by being pressed at a high temperature such as 150 ° C., which is sufficiently higher than its softening temperature, and has a rectangular bag shape. A suspension hole 16 is formed in the strong seal portion 14, and the drug bag 10 is suspended and held by the suspension hole 16 on an infusion stand or the like to perform infusion or dialysis.

  The weak seal portion 18 extends over the entire width at an intermediate portion in the length direction of the drug bag 10, and the front and back surfaces of the drug bag 10 are bonded by the weak seal portion 18, and the internal cavity of the drug bag 10 is connected to the first compartment 20. It is partitioned into a second compartment 22. The first compartment 20 is filled with the first chemical solution, and the second compartment 22 is filled with the second chemical solution. The weak seal portion 18 is formed by pressurizing the front and back surfaces of the polyethylene film forming the drug bag 10 at a low temperature such as 130 ° C., which is slightly higher than the softening temperature. Therefore, the strong seal portion 14 is left as it is by pressurizing the drug solution in the drug bag 10 from the outside in the compartments 20 and 22 with the respective drug solutions stored in the first compartment 20 and the second compartment 22. The weak seal portion 18 can be broken and opened, and the first chemical solution and the second chemical solution can be mixed.

  The discharge port 12 is made of a plastic material such as polyethylene, polypropylene, polyolefin or the like having a rigidity capable of maintaining its form (such as a plastic material similar to the drug bag 10 in order to obtain adhesion by welding with the drug bag 10). Is preferable). As shown in FIG. 2, the discharge port 12 has an enlarged diameter at one end (outer end) 12-1 (the enlarged diameter portion can be realized by a welded structure of separate parts as shown in FIG. 8). The rubber stopper 24 (the medicine extraction portion in the present invention) is fitted to the open end, and the puncture needle 26 of the infusion set can be pierced into the rubber stopper 24 at the time of infusion. The discharge port 12 has a rectangular cross section (the medicine inflow portion in the present invention) at the other end (inner end) 12-2, and the rectangular cross section 12-2 is closed at the end face 12A, A communication hole 28 is formed so as to open. The communication hole 28 is hermetically closed so as to be peelable from the outer surface side by a peeling film 30 (a closing member of the present invention). The release film 30 is made of a plastic material of the same type for the surface to be welded to the drug bag 10 and a material capable of controlling the peelable strength for the surface to be welded to the discharge port 12 (for example, the outer layer). A multilayer film containing a polyethylene inner layer olefin copolymer) is formed, and the thickness thereof is 0.1 to 0.5 mm, preferably 0.2 to 0.4 mm. The release film 30 is heat-welded to the upper and lower side surfaces 12B of the rectangular cross section 12-2 of the discharge port 12. As a result, the communication hole 28 is sealed, and the internal cavity of the discharge port 12 communicates with the internal cavity of the drug bag 10. It is blocked. As a welding temperature of the release film 30 to the side surface 12B, the through hole 28 can be kept sealed in a normal state, but is set to a strength that allows easy peeling by an external force. In the case of polyethylene, it is performed at a low temperature such as 130 ° C., which is slightly higher than the softening temperature of the plastic film constituting the drug bag 10 when the weak seal portion 18 is formed. The release film 30 is welded to the opposing surface of the plastic film 10 ′ that forms the drug bag 10 on the outer surface. Welding between the drug bag 10 and the release film 30 is strengthened so that it cannot be easily peeled off by an external force, and in the case of polyethylene, it is welded at a high temperature such as 150 ° C. when forming the strong seal portion 14. . In the normal state of the drug bag 10, the communication hole 28 of the discharge port 12 is hermetically closed with a release film 30 whose outer surface is firmly adhered to the inner surface of the drug bag 10, and is adhered to the opposite surface of the drug bag 10. The released release film 30 constitutes the closing means of the present invention. Since the release film 30 is fixed to the drug bag 10, as described later, the release film 30 is displaced in cooperation with the expansion when the drug bag 10 is expanded when the drug bag 10 is opened. It is peeled off from the outlet, the communication hole 28 is exposed, and the flow of the chemical solution is allowed.

  Next, a method for forming the drug storage sealing body of FIG. 1 will be described. A drug bag having both internal cavities separated into compartments 20 and 22 by a weak seal portion 18 is prepared. The respective compartments 20 and 22 are filled with the drug from the openings at both ends, and the openings to the respective compartments 20 and 22 are closed by the strong seal 14. At the time of filling the medicine, the sealing of the discharge port 12 with respect to the medicine bag 10 is also performed. This will be explained. It is in a state where it is detachably sealed by the film 30 (the rubber plug 24 is already mounted). Therefore, the discharge port 12 is completely sealed with respect to the outside, and the inside can be made a sealed space sterilized with an electron beam or gamma ray in advance. And the discharge port 12 which mounted | wore with the peeling film | membrane 30 in this way is mounted | worn with the opening part to the compartment 22 in a chemical | medical agent bag, and welding at high temperature is performed. At the time of this welding, the drug bag 10 and the release film 30 are also welded at the same time. That is, the welding mold integrally extends from the first welded portion, which is a half of the first welded portion that presses the plastic film 10 ′ constituting the drug bag 10 onto the cylindrical portion 12-2 of the discharge port. A drug bag for the release film 30 at the same time as the formation of the strong seal 14 by welding the plastic film 10 ′ constituting the drug bag 10 to the cylindrical part 12-2 of the discharge port 12. Ten high-temperature sticking of the opposing inner surface can be performed simultaneously.

  FIG. 2 shows a state where the weak seal portion 18 of the medicine bag 10 is not opened, and the respective chemical solutions are individually accommodated in the compartments 20 and 22, and the chemicals are contained by the amount of the chemical solution contained in the compartments 20 and 22. The bag 10 is somewhat swollen. However, since the communication hole 28 of the discharge port 12 is sealed by the release film 30, even if the puncture needle 26 of the infusion set is punctured into the rubber plug 24, the drug in the drug bag is not discharged from the discharge port 12. Can not.

  In order to open the drug bag 10, the drug bag 10 is strongly pressed from the upper surface as shown by an arrow b in FIG. 2 (in FIG. 2, the drug bag 10 is pressurized on the compartment 20 side, but the compartment 22 side is added. Pressurize or pressurize both sides). The liquid pressure is applied to the weak seal portion 18 by pressurization of the medicine bag 10, and the weak seal portion 18 is instantaneously broken and opened by a predetermined pressure. The internal pressure of the drug bag 10 is increased by the pressurization, and the increased pressure is released at once by opening the weak seal portion 18, so that a shocking flow of the drug solution is induced in the drug bag 10. . In FIG. 5, the flow of the shocking chemical liquid that is induced in the drug bag 10 is schematically indicated by an arrow f. The sudden flow f of the drug solution induced in the drug bag 10 when the weak seal portion 18 is opened causes the plastic film 10 ′ constituting the drug bag 10 to expand as shown in the figure, and is firmly attached to the drug bag 10. The attached release film 30 is peeled off from the side surface 12B of the discharge port 12 which is displaced together with the drug bag 10 but weakly attached. By peeling off the release film 30, the internal cavity of the drug bag 10 is permanently connected to the internal cavity of the discharge port 12 through the communication hole 28, and can be discharged from the infusion set punctured by the rubber plug 24. .

  In the above embodiment, the welding temperature of the release film 30 with respect to the discharge port 12 is the same as the welding temperature at the time of forming the weak seal portion 18 and the adhesive force is also equivalent, so that the chemical solution bag is expanded when the weak seal 18 is opened. In most cases, the peeling film 30 is peeled off simultaneously by opening (swelling), but even if the peeling film 30 is not completely peeled from the discharge port 12, it is possible to remove the finger from the outside of the chemical solution bag 10. It is easy to peel off the release film 30 by an operation, and the drug can be opened. That is, when the weak seal 18 is not opened, the filling rate of the chemical solution into the respective compartments 20 and 22 is relatively high, so that even if an attempt is made to peel off the plastic film constituting the drug bag 10 from the outside, the chemical solution is obstructed. Therefore, it is difficult to perform the operation, but if the weak seal 18 is opened, the proportion of the space in the drug bag increases, so that the peeling film 30 is peeled off through the plastic film without being disturbed by the liquid. It becomes easy to operate from.

  6 and 7 show a second embodiment of the present invention. A plurality of communication holes 128 of the discharge port 112 are formed in the cylindrical portion of the discharge port 112 so as to be circumferentially separated, and the release film 130 is formed by these. The communication hole 128 is wound once around the cylindrical portion of the discharge port 112 (see FIG. 7), welded at a relatively low temperature, and stuck with a weak sticking force. The upper and lower plastic films 10 constituting the chemical solution bag 10 are welded to the cylindrical portion of the discharge port 112 at a portion at the outermost end at a high temperature (forms a strong seal 14), and the chemical solution is provided at a location close to this portion 14. The plastic film 10 ′ constituting the bag 10 is welded to the outer surface of the release film 130 at a high temperature and stuck to a strong sticking force.

  Also in the second embodiment, the release film 130 normally closes the discharge port 112, prevents the drug bag 10 from communicating with the internal cavity of the drug bag 10, and opens the weak seal portion of the drug bag 10. Since the peeling film 130 is displaced integrally with the expansion deformation of the drug bag 10, the peeling film 130 is peeled and separated from the discharge port 112, and the communication hole 128 is opened, so that the discharge port 112 is an internal cavity of the drug bag 10. The medicine can be discharged. In this embodiment, since the release film 130 is wound in the circumferential direction of the discharge port 112, after the release film 130 is welded to the discharge port 112, the upper and lower plastic films 10 ′ constituting the drug bag 10 face each other. When high-temperature welding is performed, welding for strong sealing between the drug bag and the release film 130 can be performed without positioning the discharge port 112 in the circumferential direction with respect to the drug solution bag. Can be simplified accordingly.

  In the above embodiment, the peeled release films 30 and 130 are peeled from the discharge ports 12 and 112 in cooperation with the expansion deformation of the drug bag when the weak seal portion 18 is opened. Is communicated with the internal cavity of the drug bag 10, but it is also possible to use an easy peel adhesive instead of welding the release films 30 and 130, and the discharge port is partially thin. It is possible to mechanically separate (break) and form the separable part to the inner surface of the drug solution bag by high-temperature welding. Moreover, it can also manufacture so that peeling is possible with a weak seal | sticker, without using a peeling film, and such an aspect is also included in this invention. Also in this case, the integrally formed thin portion is separated or destroyed by the expansion deformation of the drug bag when the weak seal portion 18 is opened, and the internal cavity of the drug bag can be communicated with the discharge port. The effect can be achieved. Providing a plurality of communication holes 128 facilitates the manufacture and exhibits good discharge characteristics. In the figure, the number of communication holes is eight at 45 ° intervals, but it is arbitrary to change the number as necessary, such as four at 90 ° intervals. Needless to say, manufacturing using only a fragile seal without using a release film is also included in the scope of the present invention.

  FIG. 8 shows a third embodiment. In this embodiment, the discharge port 212 is formed of a rigid base material 260 that is formed of a rigid plastic material in a cylindrical shape, and extends integrally from the base portion 260 in a cylindrical shape, and is formed of a flexible plastic material. And a flexible main body 262 (a closing member of the present invention). A cap part 264 is welded to one end flange part of the main body part 262, and a rubber plug 213 is fitted to the cap part 264. The distal end 262A of the flexible main body 262 can be flattened and the opposed inner surfaces of the collapsed portion are welded at a low temperature via the release film 230. On the other hand, the upper and lower plastic films 10 ′ constituting the drug bag 10 are welded to the opposing outer surface of the flexible main body 262 at a high temperature.

  As shown in FIG. 8 (a), since the flattened tip 262A of the flexible main body 262 is usually welded at a low temperature on the opposing inner surface, the discharge port 212 is connected to the internal cavity of the drug bag 10 as shown in FIG. Even if the rubber stopper 213 is punctured by the puncture needle of the infusion set, the medicine is prevented from being discharged. As shown in FIG. 8B, when the weak seal portion is opened, since the drug bag 10 is expanded and displaced, the peeling film 230 that has been welded at low temperature is broken, and the opposing surface of the tip 262A of the flexible body 262 is peeled off. Then, the discharge port 212 is communicated with the internal cavity of the medicine bag 10 so that the medicine can be discharged.

  FIG. 9 shows another embodiment, in which one end of the soft plastic tube 362 is welded to the tip of the discharge port 312 formed of a rigid plastic material at a high temperature, and the other end 362A of the soft plastic tube 362 is flattened. It is crushed, the opposite inner surface is welded to the release film 330 at a low temperature, and the opposing surface of the plastic film 10 ′ constituting the drug bag 10 is integrated with the outer surface of the flat end 362 A of the plastic tube 362 by high-temperature welding. The operation of the embodiment of FIG. 9 is the same as that of the embodiment of FIG. 8. Normally, the flat end 362A of the plastic tube 362 is welded at a low temperature, so that the infusion from the inside of the drug bag 10 is discharged to the discharge port 312. Is prevented from flowing in, and the drug bag 10 expands and deforms at the connecting portion (flat end 362A of the plastic tube 362) with the drug discharge port 362 when the drug bag is opened when the weak seal is opened. Is broken, and the end 362A of the plastic tube 362 is expanded, so that the drug solution from the inside of the drug bag 10 can flow into the discharge port 312.

  In the above embodiment, the drug bag 10 is a type in which a drug solution and a drug solution are mixed. However, the present invention can also be implemented in a type of drug bag that is used by mixing a drug solution and a non-liquid drug such as powder. is there.

FIG. 1 is a plan view (a view taken in the direction of the arrow I in FIG. 2) of the medicine container sealing body of the present invention. 2 is a longitudinal cross-sectional view (a cross-sectional view taken along the line II-II in FIG. 1) of the medicine container sealing body in FIG. FIG. 3 is a cross-sectional view taken along the line III-III in FIG. 4 is a cross-sectional view taken along the line IV-IV in FIG. FIG. 5 is a partial view of the medicine container sealing body of FIG. 1, and shows the state of the connecting portion of the medicine bag with respect to the discharge port at the moment when the medicine bag is opened. FIG. 6 is a longitudinal cross-sectional view of a connection portion of a discharge port with respect to a medicine bag in the second embodiment. FIG. 7 is a cross-sectional view taken along the line VIII-VIII in FIG. FIG. 8 is a longitudinal cross-sectional view of the connection portion of the discharge port with respect to the drug bag in the second embodiment, where (A) shows a normal state and (B) shows when the weak seal portion is opened. FIG. 9 is a longitudinal cross-sectional view of the connection portion of the discharge port with respect to the medicine bag in the third embodiment.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Drug bag 12 ... Discharge port 14 ... Strong seal part 16 ... Suspension hole 18 ... Weak seal part 20 ... 1st compartment 22 ... 2nd compartment 24 ... Rubber stopper 28 ... Communication hole 30 ... Release film

Claims (6)

  The inner cavity of the drug bag made of a soft and flexible material is divided into a plurality of compartments by weak seals, the medicine is enclosed in each compartment, and the outer periphery faces one of the plurality of compartments. And a closing means for closing the discharge opening with respect to the internal cavity of the medicine bag in a normal state, and the closing means is used at the moment of opening the weak seal portion during use. A drug storage sealing body capable of releasing a closed state of a discharge port by cooperating with an expansion deformation of a drug bag when receiving a shocking fluid force induced in the drug bag.   The inner cavity of the drug bag made of a soft and flexible material is divided into a plurality of compartments by weak seals, the medicine is enclosed in each compartment, and the outer periphery faces one of the plurality of compartments. Is provided with a discharge port that is flow-tightly attached to the drug bag and a separable closure member that normally closes the discharge port with respect to the internal cavity of the drug bag, and the closure member is disposed on the inner surface of the drug bag. A sealed medicine container, which is held integrally.   The inner cavity of the drug bag made of a soft and flexible material is divided into a plurality of compartments by weak seals, the medicine is enclosed in each compartment, and the outer periphery faces one of the plurality of compartments. Includes a discharge port that is fluidly attached to the drug bag, and the discharge port includes a drug extraction part on the outside of the drug bag, a drug inflow part on the inside of the drug bag, and a peelable closing member that closes the drug inflow part. The peelable closure member is integrally fixed to a facing surface of a soft flexible material constituting the medicine bag.   The inner cavity of the drug bag made of a soft and flexible material is divided into a plurality of compartments by weak seals, the medicine is enclosed in each compartment, and the outer periphery faces one of the plurality of compartments. Is provided with a discharge port that is flow-tightly attached to the drug solution bag and a release film that is attached so as to close the discharge port in a normal state, and the release film is provided on the opposite surface of the drug bag to the release film with respect to the discharge port. A sealed medicine storage body characterized in that it is adhered more firmly than the pasting.   The internal cavity of the drug bag made of a soft and flexible material is divided into a plurality of compartments by a weak seal, and a built-in closure member that encloses the medicine in each compartment and can be separated by an external force is provided. The medicine container is characterized in that the discharge port faces one of a plurality of compartments and the outer periphery thereof is tightly attached to the medicine bag, and the closing member for closing the discharge port is firmly fixed to the opposite inner surface of the medicine bag. Sealed body. A medicine bag formed of a soft and flexible material and having an internal cavity divided into a plurality of compartments by weak seal portions and a discharge port closed by a detachable closing member are prepared, and a medicine is provided in each compartment. The discharge port is flow-tightly attached to the drug solution bag at the outer periphery so as to face one of the plurality of compartments, and the peelable closure member provided at the discharge port is provided on the opposite side of the drug bag. A method for forming a medicine container sealing body, wherein the inner surface is fixed to the inner surface with a larger fixing force required for peeling of the closing member.

Images