JPH0614975A - Double-chamber container - Google Patents

Double-chamber container

Info

Publication number
JPH0614975A
JPH0614975A JP6466993A JP6466993A JPH0614975A JP H0614975 A JPH0614975 A JP H0614975A JP 6466993 A JP6466993 A JP 6466993A JP 6466993 A JP6466993 A JP 6466993A JP H0614975 A JPH0614975 A JP H0614975A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
chamber
outer wall
multi
weak seal
inner wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6466993A
Other languages
Japanese (ja)
Other versions
JP3079403B2 (en )
Inventor
Fujio Inoue
Masamitsu Izumi
Shigeaki Kashiyama
冨士夫 井上
薫明 樫山
雅満 泉
Original Assignee
Otsuka Pharmaceut Factory Inc
株式会社大塚製薬工場
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093Containers having several compartments for products to be mixed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261Flexible containers having several compartments
    • B65D81/3266Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10Bag-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2024Separating means having peelable seals

Abstract

PURPOSE:To prevent moisture absorption and oxidation on only a material having the hygroscopic property and oxidation liability when the material having the hygroscopic property and oxidation liability and another material are sealed and stored in a double-chamber container, aseptically mix them easily, and facilitate the treatment of wastes after use. CONSTITUTION:A flexible double-chamber container partitioned by a communicatable partitioning means is provided with a moisture/gas-nonpermeable outer wall 12 covering the whole of one chamber and an inner wall 14 constituting the chamber covered by the outer wall 12, a material having the hygroscopic property and oxidation liability is sealed in a space section 13 in the inner wall 14, and one or two or more weak seal sections 24, 25 are provided as the partitioning means partitioning both chambers.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【産業上の利用分野】本発明は液剤、粉末剤もしくは固形剤を別個に封入する可撓性複室容器の改良に関するものである。 The present invention relates to an improvement of a flexible multi-chamber container for separately enclosing solutions, powders or solid agents.

【0002】 [0002]

【従来の技術】複室容器で易酸化性や吸湿性を有する物質を保存する場合、水分・ガスバリアー性フィルムで複室容器全体を覆うとすれば、水分・ガスバリアー性フィルムが高価でコストが高く付くので、必要とする室のみを水分・ガスバリアー性フィルムの外壁で覆うと共に、 If you want to save the Related Art materials having oxidizable or hygroscopic multiple chambers, if moisture and gas barrier film covering the entire multi-chamber container, the moisture and gas barrier films is expensive cost since costly, only chamber that require covering with the outer wall of the water-gas barrier film,
前記物質を収容するための室を構成する内壁として水分・ガス透過性フィルムを使用し、かつ外壁、内壁間の空間部に脱酸素剤や乾燥剤を収容するようにした複室容器が提案されている(特願平3ー274849号参照)。 Using the water-gas-permeable film as the inner wall constituting the chamber for containing said substance, and an outer wall, double chambered container so as to accommodate an oxygen scavenger or desiccant into the space between the inner wall have been proposed to have (see Japanese Patent Application No. 3 over 274,849).
また、内壁を外壁で覆う際、溶着により形成された各室の弱シール部(仕切部)の上に重ねて溶着することになるので、溶着強度が大きくなり、剥離しにくく、使用し難くなるおそれがあることから、これを回避するために前記弱シール部(仕切部)を少なくとも2条とし、その条間に外壁の端部を溶着するようにした複室容器が提案されている(特願平3ー274848号参照)。 Further, when covering the inner wall with the outer wall, it means that welded on top of each chamber of the weak seal portion formed by welding (partition portion), the welding strength becomes large, and not easily peeled off, it becomes difficult to use since the possibility exists, and the weak seal portion (partitioning portion) of at least two rows in order to avoid this, the multi-chamber container is proposed which is adapted to weld the end portion of the outer wall between its condition (especially Gantaira 3 - see No. 274848).

【0003】 [0003]

【発明が解決しようとする課題】ところが、このような複室容器は脱酸素剤や乾燥剤を外壁と内壁との空間部に封入するので、コストが高くなるなどの問題点があった。 [SUMMARY OF THE INVENTION However, since such a multi-chamber container enclosing the oxygen scavenger and drying agent in the space between the outer and inner walls, there is a problem of cost increases. 本願発明者らは種々研究をつづけているうちに、複室容器において脱酸素剤や乾燥剤の封入を省略した場合においても、内壁に囲まれた室内に収容された物質に対して、内壁と水分・ガスバリアー性フィルムの外壁とからなる二重構造が吸湿防止や酸化防止の一定の効果があることを見いだし、本願発明を完成した。 While the inventors have that continued various studies, in the case of omitting the inclusion of oxygen scavengers and desiccants in multiple chambers also against housed in a room surrounded by the inner wall material, the inner wall and It found that double structure consisting of an outer wall of the water-gas barrier film have a certain effect of moisture absorption prevention and antioxidation, and have completed the present invention. 本発明はこのような事情を背景としてなされたものであり、本発明の目的は吸湿性を有する液剤、粉末剤もしくは固形剤、または易酸化性を有する液剤、粉末剤もしくは固形剤を収容した室のみを外部の水分や酸素から遮断すると共に、 The present invention has been made with the above circumstances as the background, the chamber aim accommodating liquid having hygroscopic, powders or solid agents, or liquid having oxidizable, powders, or the solid preparation of the present invention while blocks only from external moisture or oxygen,
脱酸素剤や乾燥剤を封入することなく、前記物質の酸化防止や吸湿防止を図り得るようににした複室容器を提供しようとするものである。 Without encapsulating oxygen scavenger and drying agent, it is intended to provide a multi-chamber container was to obtain aim antioxidant and prevent moisture absorption of the material.

【0004】 [0004]

【課題を解決するための手段】このような目的を達成するためになされた本発明は下記のように構成される。 Means for Solving the Problems] The present invention has been made in order to achieve the above object is constructed as follows. A 液剤、粉末剤もしくは固形剤を収容するための複数の室が連通可能な仕切り手段で仕切られてなる可撓性を有する複室容器において、前記複数の室中の一部の室は室全体を覆う水分非透過性および/またはガス非透過性の外壁と、外壁に覆われた前記室を構成する内壁とを備えると共に、前記外壁に覆われない室とこの室に隣接しかつ外壁に覆われた室との仕切り手段は、室に外圧を加えることにより容易に剥離し得る弱シール部が1条もしくは2条以上配置されて構成されたことを特徴とする複室容器。 A liquid, powder or a plurality of chambers for containing the solid agent in the multi-chamber container having a flexible partitioned composed by communicable partitioning means, the portion of the chamber in a plurality of chambers entire chamber and moisture impermeable and / or gas impermeable outer wall covering the, with and an inner wall constituting the chamber covered with the outer wall, covering the adjacent and exterior walls to the chamber and chamber which are not covered with the outer wall partitioning means between Broken chamber, multi-chamber container, wherein a weak seal portion which can be easily peeled off by adding external pressure chamber is configured to be arranged Article 1 or 2 or more strips. B 前記A項記載の複室容器において、前記弱シール部は間隔を隔てて少なくとも2条配置して構成され、弱シール部同士間の中間部に外壁の端部が溶着された複室容器。 In multi-chamber container B the A claim, wherein the weak seal portion is constructed by arranging at least two rows at an interval, multiple chambers the end of the outer wall in an intermediate portion between the weak seal portions are welded. C 前記A項または前記B項記載の複室容器において、 In C the A section or multi-chamber container of the B section, wherein,
前記外壁と前記内壁との空間部には不活性ガスもしくは乾燥ガスを封入するようにした複室容器。 Wherein the space portion between the outer wall and the inner wall multi-chamber container so as to enclose the inert gas or dry gas. D 前記A項ないし前記C項のいずれかに記載の複室容器において、前記外壁で覆われた前記内壁内の室には易酸化性および/または吸湿性を有する液剤、粉末剤もしくは固形剤を収容するようにした複室容器。 In multi-chamber container according to any one of D the A section to said C section, solutions having oxidizable and / or hygroscopic the chamber within the inner wall covered with the outer wall, a powder or a solid agent double chambered container so as to accommodate.

【0005】 [0005]

【作用】上記のように構成された本発明によれば、吸湿性や易酸化性を有する液剤、粉末剤もしくは固形剤を収容する室は、水分・ガスバリアー性フィルムの外壁と内壁との二重壁を備えているので、外部の水分や酸素の影響を回避するように働く。 SUMMARY OF] According to the present invention configured as described above, the chamber accommodating liquid having hygroscopicity and easily oxidizable, the powders or solid agents, the double of the outer wall and the inner wall of the water-gas barrier film is provided with the heavy walls, it serves to avoid the influence of external moisture or oxygen.

【0006】 [0006]

【実施例】以下本発明の実施例を図面に基づいて詳細に説明する。 EXAMPLES The following examples of the present invention with reference to the drawings will be described in detail. 図1、図2において、2は吸湿性や易酸化性を有しない液剤、粉末剤もしくは固形剤の物質4を収容する室、6は吸湿性や易酸化性を有する液剤、粉末剤もしくは固形剤の物質8等を収容する側の室である。 1 and 2, 2 has no hygroscopic property and oxidizable liquid, the chamber accommodating the material 4 of powders or solid agents, the liquid having hygroscopicity and oxidizable 6, powders or solid agents a chamber on the side containing the substance 8 such as the. 室2 Room 2
には前記物質4が封入されると共に口部10が取り付けられ、一方室6は外壁12と内壁14の2重壁で構成され、内壁14の内側の空間部13(室)には前記物質8 Mouth 10 is fitted together with the material 4 is enclosed in, whereas the chamber 6 is constituted by a double wall of the outer wall 12 and inner wall 14, the the space 13 inside the inner wall 14 (chamber) material 8
が封入されている。 There has been sealed. 内壁14は図3に示すようにポリエチレン(PE)からなる外層20と、ポリエチレン(P Inner wall 14 and outer layer 20 made of polyethylene (PE) as shown in FIG. 3, polyethylene (P
E)とポリプロピレン(PP)との混合樹脂からなる内層22との多層フィルムからなり、2枚の多層フィルムが周縁で溶着されて空間部13が形成される。 A multilayer film of an inner layer 22 made of a mixed resin E) and polypropylene (PP), two multi-layer films space 13 are welded at the periphery is formed.

【0007】一方室2は、内壁14をなす2枚の前記多層フィルムが下方に伸び、溶着されて構成される。 On the other hand the chamber 2, the multilayer film of two sheets forming the inner wall 14 extends downward, and is welded. すなわち、前記多層フィルムを2枚重ね合わせ、その周縁部を溶着すると共に、その中間部において横方向に、周縁部より強度が小さくなる状態に溶着し、かつその溶着部は図2、図4に示すように間隔を隔てた2本の筋条をなすようにして、仕切り手段としての弱シール部24、2 That is, the superimposed two sheets of multilayer films, as well as welding the periphery, laterally at an intermediate portion thereof, fused to a state where the strength of the circumferential region is reduced, and the welding unit 2, FIG. 4 so as to form a two Sujijo spaced as shown, the weak seal portion serving as partition means 24,2
5を形成し、弱シール部24、25を境にして空間部1 5 is formed, the space portion 1 to the boundary of the weak seal portions 24, 25
3、室2が形成される。 3, the chamber 2 is formed.

【0008】外壁12は図5に示すように、内層26がポリエチレン(PE)で、外層28が水分非透過性、ガス非透過性のバリアフィルムからなる多層フィルムであり、バリアフィルムとして例えばアルミラミネートフィルム 、アルミ蒸着フィルム等のアルミ加工フィルムや、ポリ塩化ビニリデンとポリプロピレン(PP)の2 [0008] the outer wall 12, as shown in FIG. 5, in the inner layer 26 of polyethylene (PE), an outer layer 28 is moisture-impermeable, a multilayer film comprising a gas-impermeable barrier film, for example, aluminum laminate as a barrier film film, second and aluminum processed film such as an aluminum deposited film, polyvinylidene chloride and polypropylene (PP)
重層が使用されている。 Layer is used. そして外壁は、内壁14を覆う状態に2枚の上記多層フィルムが配置され、その左右と上部が互いに溶着されると共に、下部が弱シール部2 The outer wall, the multilayer film of two in a state of covering the inside wall 14 is disposed, with its left and right and upper are welded to each other, the lower the weak seal part 2
4、25間の中間部に溶着され、シールされた構造をなしている。 It is welded to an intermediate portion between the 4, 25, and forms a sealed structure. 従って、溶着時に弱シール部24、25上に重ねて溶着することが回避でき、弱シール部24、25 Thus, can be avoided be welded on top weakly sealed portions 24, 25 at the time of welding, the weak seal portions 24, 25
のイージーピールオープン性を保持できる。 Can of retaining the easy-peel openness. というのは、弱シール部の上に重ねて溶着した場合には、溶着強度が増す上に溶着強度にばらつきを生じ、弱シール部の剥離に要する力が、あるときには大きく、あるときにはそれ程でもない等、イージーピールオープン性が損なわれる傾向があるが、前述の方法によればイージーピールオープン性を確実に保持できる。 Because, when welded on top of the weak seal portion is caused a variation in the welding strength on the welding strength increases, the force required to peel the weak seal portion is large to a certain time, not so even when there etc., tend to easy peel open properties are impaired, it can securely hold the easy peel open properties according to the described method. 上述のように外壁は弱シール部同士間の中間部で熱溶着されるので、隣接する室とは弱シール部で隔てられていることから、溶着時にその室内に封入された物質が熱変性することを防止できる。 Since the outer wall is thermally welded at an intermediate portion between the weak seal portions, as described above, the adjacent chambers from that are separated by a weak seal portion, which is sealed in the chamber during the welding material is heat denatured it can be prevented. また、誤って外力が加えられ、一つの弱シール部が剥離しても、残余の弱シール部により両側の室間の連通が防止できる。 Furthermore, incorrectly external force is applied, even if one of the weak seal portion is peeled off, communication between both sides of the chamber by the weak seal portion of the residual can be prevented. さらに、弱シール部同士間の中間部に外壁を熱溶着するので、その熱溶着の部分が弱シール部に掛からないようにでき、熱溶着の条件設定の自由度が増し、作業を容易に行なうことができる。 Further, since the outer wall in an intermediate portion between the weak seal portions are thermally welded, can as part of the heat seal is not applied to the weak seal portion, increasing the degree of freedom in the condition setting of the thermal welding, easily perform the work be able to.

【0009】なお、各部の溶着に当たって溶着温度は、 [0009] In addition, the welding temperature hit the welding of each part,
内壁14の周縁部と室2の周縁部とが最も高く、弱シール部24、25はこれより低くする。 Periphery of the peripheral portion and the chamber 2 of the internal wall 14 and is the highest, the weak seal portions 24 and 25 is lower than this. 一方、内壁14と外壁12との溶着部の溶着温度は、弱シール部24、2 Meanwhile, the deposition temperature of the welded portion of the inner wall 14 and outer wall 12, the weak seal portion 24,2
5の中間部の内層フィルム22同士が溶着しない程度、 Extent to which the inner layer film 22 between the intermediate portion is not welded to 5,
すなわち弱シール部24、25の溶着温度より若干高い温度を限界とするよう設定される。 That is, the temperature slightly higher than the welding temperature of the weak seal portions 24 and 25 are set to the limit. その結果溶着強度は、内壁14、室2、外壁12の各周縁部と、内壁1 As a result weld strength, the inner wall 14, the chamber 2, and the peripheral portion of the outer wall 12, inner wall 1
4、外壁12間の接着部とがほぼ等しく、弱シール部2 4, approximately equal to the bonding portion between the outer wall 12, the weak seal portion 2
4、25はこれらより弱くなる。 4, 25 is weaker than these.

【0010】上記実施例の複室容器は、例えば図6の製造例に従ってつくられる。 [0010] multiple chambers of the above embodiment, for example made according to the manufacturing example of FIG. すなわち、(イ)内層がPE That is, (a) an inner layer PE
とPPとの混合樹脂で、外層がPEの多層フィルムを2 And a mixed resin of PP, a multi-layer film of the outer layer is PE 2
枚重ね合わせ、溶着温度約170〜200℃で3方の周辺シールを行なうと共に中間部を仕切るための2条のシールを溶着温度約110〜130℃で所定間隔を隔てて行ない弱シール部24、25を形成し、さらに口部10 Like overlay, the weak seal portion 24 performs at predetermined intervals the seal Article 2 at the deposition temperature of about 110-130 ° C. for partitioning an intermediate portion with performing surrounding seal three sides at the deposition temperature of about 170 to 200 ° C., forming a 25, further mouth 10
を取り付ける。 The install. (ロ)ついで、液剤4を充填し、側部(充填口)をシールして高圧蒸気滅菌または熱水滅菌等の加熱殺菌を行なう。 (B) Next, the liquid 4 filled, performing heat sterilization such as autoclaving or hot water sterilization and sealed side (filling port). (ハ)加熱殺菌後、空室部30の側部を無菌条件下でカットし、充填口を設ける。 (C) after heat sterilization, to cut the sides of the air chamber 30 under aseptic conditions, provided the fill port. な お 、必要に応じて内部を乾燥する。 Your name, to dry the inside, if necessary. (ニ)次に、空室部30の外側に内層がPEで外層がポリ塩化ビニリデンとPPの2重層をなす水分非透過性およびガス非透過性のバリアーフィルムからなる多層フィルム32を溶着して取り付ける。 (D) Next, an inner layer on the outside of the air chamber portion 30 is welded multilayer film 32 outer layer PE is made of moisture-impermeable and gas-impermeable barrier film constituting the double layer of polyvinylidene chloride and PP install. なお、弱シール部24、25に沿って溶着する部分は、弱シール部24、25の中間の位置とし、 The portion to weld along the weak seal part 24 and 25, an intermediate position of the weak seal portions 24, 25,
この弱シール部に重ならないようにして130〜135 So as not to overlap with the weak seal 130 to 135
℃で溶着される。 It is welded at ℃. (ホ)しかる後、抗生物質などの粉末薬剤8を無菌条件下で内壁内側の空間部に入れ、側部(充填口)をシールする。 (E) Thereafter, placed in a space portion of the inner wall inside the powdered medicament 8 such as an antibiotic under aseptic conditions, to seal the sides (filling port). なお、弱シール部24、25 It should be noted that the weak seal portions 24 and 25
の形成は、加熱された弱シール部形成用金型をシリンダ装置により押し当てて行なうが、この弱シール部形成用金型は所定間隔を隔てた2本の突条が電源ヒータにより温度調節可能に、かつシリンダ装置により上下動可能とされたものである。 Formation is performed a heated weak seal portion formed mold by pressing the cylinder unit, but the weak seal portion formed mold is temperature-controllable by two ridges power heater at a predetermined distance to, and is one which is vertically movable by a cylinder device.

【0011】以上のように構成された実施例においては、内壁14は外層がPE、内層がPEとPPとの混合樹脂からなる多層フィルムから構成されているので極く微量ながら水分やガスを透過する傾向があるが、外壁1 [0011] In the embodiment constructed as described above, the inner wall 14 is the outer layer is PE, transparent moisture and gas while trace amount since the inner layer is made of a multilayer film comprising a mixed resin of PE and PP there is a tendency to, but, outer wall 1
2は水分非透過性、ガス非透過性のバリアフィルムで構成されているので、外部の水分や酸素の悪影響を回避できる。 2 water-impermeable, because it is composed of a gas-impermeable barrier film can be avoided the adverse effect of external moisture or oxygen. また、内壁14、外壁12は透明であり、内部の状態を目視できる。 Further, the inner wall 14, outer wall 12 is transparent, visible internal state. そして、室2に指等で一定の圧力を加えることにより弱シール部24、25が剥離し、室2 The weak seal portions 24, 25 by applying a constant pressure with a finger or the like into the chamber 2 is separated, the chamber 2
と空間部13が連通され、物質4と物質8とが無菌状態で混合される。 The space 13 is communicated, and the material 4 and the material 8 is mixed under sterile conditions with. なお、上記実施例の物質8として例えば、抗生剤、抗癌剤、ステロイド剤ウロキナーゼまたはビタミン剤等の易酸化性、易熱変性の粉末剤等が挙げられ、物質4としてこれらの溶解液または希釈液、例えば生理食塩液あるいはブドウ糖液等の液剤が挙げられる。 Incidentally, for example, the material 8 of the above embodiment, antibiotic, anticancer, oxidizable such as steroids urokinase or vitamins, powders, and the like of the easily heat-denatured, these lysates or diluent as material 4, for example it includes solutions such as physiological saline or glucose solution.

【0012】内壁としては、上記実施例に記載された多層フィルム以外にも、ポリエチレン(PE)、ポリプロピレン(PP)およびこれらの混合樹脂から選ばれる一種以上の組合せによる単層もしくは多層フィルムを使用することも可能である。 [0012] As the inner wall, in addition to the multilayer film described in the above examples, using polyethylene (PE), polypropylene (PP) and the single-layer or multi-layer film according to one or more combinations selected from a mixed resin thereof it is also possible. 例えば、図7に示すように外層31が直鎖状低密度ポリエチレン(LLDPE)、中間層33がLLDPEと低結晶性(非晶性)のエチレン・ For example, ethylene-outer layer 31 is linear low density polyethylene, as shown in FIG. 7 (LLDPE), an intermediate layer 33 is LLDPE and low-crystalline (amorphous)
αーオレフィン系エラストマーとの混合樹脂、内層34 Mixed resins of α-olefin-based elastomer, the inner layer 34
がLLDPEとPPの混合樹脂からなる三層フィルム3 Three-layer film 3 but comprising a mixed resin of LLDPE and PP
5を挙げることができる。 5 can be mentioned. また、封入する薬剤によっては、内壁の内層に用いられるLLDPEに含まれる低分子量物質と薬剤が経時的に相互作用を起こし、患者に悪影響を及ぼす反応生成物を生ずるおそれがある。 Also, depending on the agent to be encapsulated, low molecular weight material and the drug contained in the LLDPE used in the inner layer of the inner wall undergoes over time interaction, there is a risk of causing a bad influence reaction product to the patient. そこで内層34に用いられるLLDPEを、例えばベントペレット法等により高温かつ減圧で前処理することによって炭素数約30以下の低分子量物質をある特定量以下に除去し、薬剤と内層フィルムの相互作用を好適に防止することができる。 Therefore the LLDPE used in the inner layer 34, for example by removing the specific amount or less in the low molecular weight material of from about 30 or less carbon atoms by pretreatment with a high temperature and reduced pressure by venting pellet method, etc., drug interactions and inner layer film it can be suitably prevented. さらに、フィルムの耐熱性を向上させるために上記三層フィルム35の各層に、必要に応じて適量の高密度ポリエチレン(HDPE)を配合すれば、1 Further, to each layer of the three-layer film 35 in order to improve the heat resistance of the film, it is blended with an appropriate amount of high density polyethylene (HDPE) optionally 1
21℃以上による高圧蒸気滅菌や熱水滅菌等の高温滅菌に耐える成形安定性の優れた複室容器を製造することができる。 It is possible to manufacture an excellent multi-chamber container molding stability to withstand high temperature sterilization such as high-pressure steam sterilization or hot water sterilization by 21 ° C. or higher. 外壁にはアルミ加工フィルム、ポリ塩化ビニリデン、ポリエチレンテレフタレート(PET)、ポリビニルアルコール(PVA)、エチレンビニルアルコール共重合体(EVOH)、シリカ蒸着フィルムの単層もしくは多層のシートを使用することも可能である。 Aluminum processing film on an outer wall, polyvinylidene chloride, polyethylene terephthalate (PET), polyvinyl alcohol (PVA), ethylene vinyl alcohol copolymer (EVOH), it is also possible to use a single-layer or multilayer sheet of silica-deposited film is there. 例えば、図8に示すように外層43が2軸延伸されたPE For example, PE outer layer 43 as shown in FIG. 8 is biaxially stretched
T、中間層44がシリカ蒸着PVA、内層45が低密度ポリエチレン(LDPE)であって、各層間がウレタン系接着樹脂で固定されている三層フィルム46からなる水分非透過性およびガス非透過性のバリアーフィルムを挙げることができる。 T, the intermediate layer 44 of silica deposited PVA, the inner layer 45 is a low density polyethylene (LDPE), moisture impermeable and gas non-permeability comprising a three-layer film 46 which each layer is fixed with a urethane-based adhesive resin barrier film of can be mentioned. しかし、内壁と外壁の接着を良好にするために、少なくとも外壁を多層フィルムとし、外壁の最内層の材質と内壁もしくは内壁の最外層の材質とを同一にすることが望ましい。 However, in order to improve the adhesion of the inner and outer walls, at least the outer wall is a multilayer film, it is desirable to the material of the outermost layer of the innermost layer of the material and the inner wall or the inner wall of the outer wall to the same. 前記の例では外壁で覆われた室内に封入される物質8として粉末剤を、外壁で覆われない室内に封入される物質4として液剤を使用する場合を挙げたが、物質8が液剤で、物質4が粉末剤の例としては、例えば液剤としてシステインまたはトリプトファンをそれぞれ添加したアミノ酸液等の易酸化性の物質が挙げられ、粉末剤として糖もしくは電解質、またはこれらの混合物等が挙げられる。 The powders as materials 8 to be encapsulated in a room covered with the outer wall in the example above, has been mentioned the case of using a liquid as a substance 4 to be sealed in the room which is not covered with the outer wall, material 8 is in liquid, examples of the material 4 is a powder, such as cysteine ​​or tryptophan oxidizable substances amino acid solution or the like is added respectively given as solutions, sugar or electrolyte as a powder, or a mixture thereof. 物質8が液剤で物質4 Substance 8 substance 4 in the liquid
が他の液剤の例としては、例えば前者の液剤としてシステインまたはトリプトファンをそれぞれ添加したアミノ酸液製剤あるいはビタミン剤の易酸化性または易熱変性の物質が挙げられ、後者の液剤としては糖・電解質液が挙げられる。 There Examples of other solutions, for example, the former liquid cysteine ​​or oxidizable or of an easily heat-denatured substances of amino acid solution formulation or vitamin added respectively tryptophan are mentioned as the sugar-electrolyte solution as the latter solution and the like. また他の例としては、前者の液剤として脂肪乳剤等の易酸化性の物質が、後者の液剤としては糖・ As another example, oxidizable substances, such as fat emulsion as the former solution. Examples of the latter liquid glucose and
電解質液等が挙げられる。 Electrolyte solution, and the like. さらに、物質4、8のいずれか一方が固形剤で、他方の物質が液剤であってもよい。 Furthermore, one of the materials 4 and 8 in solid formulation, other materials may be liquid.
さらにまた、上記粉末剤、液剤、固形剤の例として、経静脈または経腸(経管、経口)投与する他の種々の栄養剤や治療剤等が挙げられる。 Furthermore, the powders, solutions, examples of solid formulations, intravenous or enteral (gavage, oral), etc. Other various nutrients and therapeutic agent for administration. さらに、物質8が光劣化性を有する場合には、外壁の一部または全部にアルミ加工フィルム、着色フィルム等の遮光フィルムを使用し、内部を遮光するようにしてもよい。 Furthermore, material 8 is in the case of having a light degradation property, processed aluminum film on a part or the whole of the outer wall, using a light shielding film such as a colored film, may be to shield the interior. なお、外壁に使用されたアルミ加工フィルムは、使用時必要に応じその一部または全部が剥離可能であってもよい。 Incidentally, aluminum processing film used in the outer wall, partially or entirely necessary during use may be peelable. また、前記実施例は2種類の物質4、8を封入する2室容器の例であるが、2室以上でも適用可能である。 Further, the embodiment is an example of a two-chamber container for encapsulating two substances 4,8, it is applicable even more two chambers. 図9にその一例を示す。 Figure 9 shows an example. 外壁36内には2種の粉末剤(または粉末剤と固形剤)を封入する空間部38、40を有する内壁が配置されている。 The inner wall having a space portion 38, 40 enclosing the two powders (or powders and solid material) is arranged in the outer wall 36. 42は液剤である。 42 is a liquid. 粉末剤に限らず液剤および/または固形剤を封入する室を複数個設けることも可能である。 Providing a plurality of chambers enclosing the liquid and / or solid dosage not limited to powders are also possible.

【0013】内壁14内の空間部13に易酸化性を有する液剤、粉末剤もしくは固形剤を封入する場合は、内壁14と外壁12の空間部15には窒素ガス、炭酸ガス、 [0013] Solutions having oxidizable in the space portion 13 of the inner wall 14, when encapsulating powders or solid agents, the nitrogen gas in the space portion 15 of the inner wall 14 and outer wall 12, carbon dioxide gas,
アルゴンガス等の不活性ガスを封入することが好ましい。 It is preferable to encapsulate the inert gas such as argon gas. また内壁14内の室に吸湿性を有する液剤、粉末剤もしくは固形剤を封入する場合は、前記空間部15には乾燥空気、乾燥窒素ガス等の乾燥ガスを封入してもよい。 The liquid having hygroscopicity chamber within the inner wall 14, when encapsulating powders or solid agents, dry air into the space 15, a dry gas such as dry nitrogen gas may be sealed. 不活性ガスを封入した場合は空間部15内の空気を不活性ガスで置換するので酸化防止の効果がさらに確実であり、乾燥ガスを封入した場合は空間部15内の空気が乾燥ガスと置換されるので、防湿の効果がさらに確実である。 When encapsulating an inert gas is effective in preventing oxidation is more reliable since replacing the air in the space 15 with an inert gas, when encapsulating dry gas is air in the space 15 replaced with dry gas since the is more reliably the effect of moisture. 上記のように内壁と外壁の空間部に不活性ガスを封入したり、外壁に用いられるバリアーフィルムをよりバリアー性の高いものを用いること等により、従来内壁と外壁の空間部に封入されていた脱酸素剤および/または乾燥剤を使用しなくとも、薬剤の経時安定化を達成することができる。 Or filled with an inert gas to the space portion of the inner wall and the outer wall as described above, such as by use of a high more the barrier the barrier film used in the outer wall, has been sealed in the space of a conventional inner and outer walls without the use of oxygen scavenger and / or drying agent, it is possible to achieve a storage stability of the drug. なお、弱シール部は2条の場合に限らず2条以上としてもよい。 Incidentally, the weak seal portion may be two or more article not only in the case of Article 2. また本発明は弱シール部が1条の場合にも適用可能である。 The present invention is also applicable to the case of single-thread weak seal portion. さらに、弱シール部は必ずしも直線である必要はなく、例えば、容器中央部付近のシール形状をV字形をなすように形成してもよい。 Furthermore, the weak seal portion is not necessarily a straight line, for example, may form a seal shape around the container central portion so as to form a V-shape.
こうすれば使用時に一方の室に手で押圧を加えて弱シール部を剥離する場合、圧力がV字形の部分に一時的に集まり、剥離のきっかけを与えることができるため、比較的軽い押圧で両方の薬剤を混合することができる。 When peeling the weak seal portion by adding pressing by hand one chamber in use In this way, it is possible to pressure gathered temporarily in a portion of the V-shape, giving the cause of peeling, a relatively light pressed it is possible to mix both agents. 但し、この場合、本発明の複室容器の保存または輸送時における不慮の剥離を引き起こす危険もあるところから、 However, in this case, from where there is a risk of causing accidental delamination during storage or transport of the multi-chamber container of the present invention,
溶着条件を特に吟味することが望ましい。 It is desirable to particularly examine welding conditions.

【0014】また、前記実施例では、弱シール部の形成は内壁を構成する2枚のシートの内面同士を直接溶着する、いわゆる直接溶着方式で行なっているが、これに代えてこのシート間に多層インサートフィルムを挟んだ状態で溶着し、弱シール部を形成させる、いわゆる多層インサートフィルム挟持溶着方式で行なってもよい。 [0014] In the above embodiment, the formation of the weakly sealed portion is welded inner surfaces of the two sheets constituting the inner wall directly, but is performed by so-called direct welding method between the sheet instead of this welded in a state sandwiching the multilayer insert film to form a weak seal portion may be performed in a so-called multi-layer insert film held between the welding method. 図1 Figure 1
0は2層インサートフィルムを使用した例を示す。 0 shows an example of using a two-layer insert film. この場合48は単層フィルムからなる内壁であり、50は内壁48のシートに対して熱接着力の強いシート、52は反対側の内壁のシートに対して熱接着力の弱いシートであり、弱シール部54、56が形成されている。 In this case 48 is the inner wall consisting of a single layer film, 50 is a strong sheet thermal adhesion to a sheet of the inner wall 48, 52 a weak sheet thermal adhesion to a sheet of the inner wall of the opposite side, weak seal 54, 56 is formed. 例えば、内壁48がポリエチレン(PE)またはポリプロピレン(PP)の単層フィルムである場合には、50はこれと同じポリエチレン(PE)またはポリプロピレン(PP)のシートであり、52はポリエチレン(PE) For example, when the inner wall 48 is a single layer film of polyethylene (PE) or polypropylene (PP), the 50 is a sheet of the same polyethylene as this (PE) or polypropylene (PP), 52 polyethylene (PE)
とポリプロピレン(PP)との混合樹脂である。 A mixed resin of polypropylene (PP). インサートフィルムは各弱シール部に合わせて二分してもよい。 Insert film may be divided in accordance with each weak seal. また、外壁12の溶着は多層インサートフィルムと一緒に溶着してもよいが、内壁の内側で弱シール性を保持することが条件とされる。 Also, the welding of the outer wall 12 may be welded together with the multi-layer insert film, it is a condition for holding the weak sealing property inside the inner wall.

【0015】なお、本発明の複室容器を保存または輸送する場合には、図11に示すように弱シール部24、2 [0015] In the case of storing or transporting the multiple chambers of the present invention, the weak seal portion as shown in FIG. 11 24,2
5で二つ折りにして外装袋62に封入することが好ましい。 It is preferable to encapsulate the outer bag 62 5 in the folio. このように二つ折りにすれば、保存時の積み重ねによる重圧あるいは落下等(外圧)によって、弱シール部の剥離を未然に防止することができる。 Thus folded in two, the pressure or fall due stacking during storage (external pressure), it is possible to prevent the peeling of the weak seal portion. また、図12に示すように口部68を抗生物質等の粉末薬剤を収容する室66側に設け、溶解液等の液剤を収容する室70側を閉塞するようにしてもよい。 It is also possible to the mouth 68 as shown in FIG. 12 is provided on the chamber 66 side to accommodate the powdered medicament, such as antibiotics, it closes the chamber 70 side for accommodating a liquid preparation of the dissolution liquid, and the like. 溶解液等の液剤を収容する側の室に口部を設けている場合には、緊急の場合に誤って溶解液等の液剤だけ、先に投与してしまう危険があるが、上述のように口部68を抗生物質等の粉末薬剤を収容した室側に取り付けることによって上記のような危険を回避できる利点がある。 If you are provided a mouth on the side of the chamber for accommodating the liquid agent solution or the like, only the liquid of solution such as accidentally in case of emergency, there is a danger of administered first, as described above an advantage of avoiding the risk described above by attaching the mouth portion 68 to the chamber side containing the powdered medicament, such as antibiotics. 以上本発明のいくつかの実施例について説明したが、本発明はこのような実施例に何等限定されるものではなく、本発明の要旨を逸脱しない範囲において種々なる態様で実施し得ることはもちろんである。 Of course it has been described several embodiments of the present invention above, the present invention is not all limited to such an embodiment, which may be implemented in various embodiments without departing from the scope of the present invention it is.

【0016】 [0016]

【発明の効果】本発明は上述の通り構成されているので、次に記載する効果を奏する。 According to the present invention which is configured as described above, the effect which will be described. 水分やガスの非透過性フィルムからなる外壁と、内壁との2重壁を有する構造体での内壁によりつくられる室内に吸湿性や易酸化性を有する物質を収容することによって、その物質が保管時に外部の水分を吸収したり、酸素と化合したりすることを防止できると共に、前記2重壁を有する室が防湿や酸化防止の必要のない物質を収容する室から隔離できるので、複室容器全体を水分・ガス非透過性フィルムで覆った場合のように、乾燥させる必要のない液剤等の水分を吸収して濃縮化することが防止され、かつ外壁は吸湿性や易酸化性を有する物質を封入した室の周りにだけ配置すればよいので、外壁を構成する高価な水分・ガス非透過性フィルムが少なくてすむ利点がある。 An outer wall made of impermeable film of moisture and gases, by containing a substance having an inner wall with hygroscopic and oxidizable to a chamber made of a structure having a double wall and the inner wall, storage is the substance sometimes or absorbing external moisture, it is possible to prevent or to compounds with oxygen, since the chamber having the double wall can be isolated from the chamber accommodating the unnecessary material moisture and antioxidant, multiple chambers whole as in the case covered with moisture and gas impermeable films, can be absorbed and concentrated the moisture such as solution without the need for drying is prevented, and the outer wall has a hygroscopic and oxidizable substances since the need only disposed about the enclosed chambers, there is an advantage that an expensive water and gas impermeable film constituting the outer wall requires less. また、外壁内に脱酸素剤や乾燥剤を封入しなくてもよいので、コストを軽減できる利点がある。 Moreover, it is not necessary to encapsulate the oxygen scavenger and drying agent in the outer wall, an advantage of reducing the cost. さらに、複室間の無菌混合が可能で、可撓性のためかさばらないという利点がある。 Furthermore, can be sterile mixing of multiple chamber, there is an advantage that less bulky for flexibility.
さらにまた、ガラスや金属を使用していないので、廃棄処理が容易であるという利点がある。 Furthermore, does not use a glass or metal, there is an advantage that disposal is easy.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明の一実施例を示す断面図である。 1 is a sectional view showing an embodiment of the present invention.

【図2】同実施例の平面図である。 2 is a plan view of the embodiment.

【図3】図1のA部拡大断面図である。 3 is an A-part enlarged sectional view of FIG.

【図4】図1のB部拡大断面図である。 4 is a B-part enlarged sectional view of FIG.

【図5】図1のC部拡大断面図である。 5 is a C part enlarged sectional view of FIG.

【図6】同実施例の製造行程を示す説明図である。 6 is an explanatory view showing a manufacturing process of the embodiment.

【図7】本発明の他の実施例を示す部分拡大断面図である。 7 is a partially enlarged cross-sectional view showing another embodiment of the present invention.

【図8】本発明の別の実施例を示す部分拡大断面図である。 8 is a partially enlarged cross-sectional view showing another embodiment of the present invention.

【図9】本発明のさらに他の実施例を示す説明図である。 9 is an explanatory view showing still another embodiment of the present invention.

【図10】本発明のさらに別の実施例を示す部分拡大断面図である。 10 is a partial enlarged sectional view showing still another embodiment of the present invention.

【図11】本発明の一実施例に係る複室容器の包装状態を示す斜視図である。 11 is a perspective view showing a packaging state of the multi-chamber container according to an embodiment of the present invention.

【図12】本発明のさらに異なる実施例を示す断面図である。 12 is a sectional view showing still different embodiment of the present invention.

【符号の説明】 DESCRIPTION OF SYMBOLS

12 外壁 13 空間部 14 内壁 15 空間部 24 弱シール部 25 弱シール部 48 内壁 54 弱シール部 56 弱シール部 12 wall 13 space 14 inside wall 15 space 24 weak seal portion 25 weak seal portion 48 interior wall 54 weak seal portion 56 weak seal portion

Claims (4)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】 液剤、粉末剤もしくは固形剤を収容するための複数の室が連通可能な仕切り手段で仕切られてなる可撓性を有する複室容器において、前記複数の室中の一部の室は室全体を覆う水分非透過性および/またはガス非透過性の外壁と、外壁に覆われた前記室を構成する内壁とを備えると共に、前記外壁に覆われない室とこの室に隣接しかつ外壁に覆われた室との仕切り手段は、室に外圧を加えることにより容易に剥離し得る弱シール部が1条もしくは2条以上配置されて構成されたことを特徴とする複室容器。 1. A liquid, powder or a plurality of chambers for containing the solid agent in the multi-chamber container having a flexible partitioned composed by communicable partitioning means, a portion in said plurality of chambers the chamber together comprise a moisture impermeable and / or gas impermeable outer wall covering the entire chamber, and an inner wall constituting the chamber covered by an outer wall, adjacent to the chamber and chamber which are not covered with the outer wall and partition means in the chamber that is covered by the outer wall, multiple chambers, characterized in that the weak seal portion which can be easily peeled off by adding external pressure chamber is configured to be arranged Article 1 or 2 or more strips.
  2. 【請求項2】 請求項1記載の複室容器において、前記弱シール部は間隔を隔てて少なくとも2条配置して構成され、弱シール部同士間の中間部に外壁の端部が溶着された複室容器。 2. A multi-chamber container according to claim 1, wherein the weak seal portion is constructed by arranging at least two rows at intervals, the end of the outer wall in an intermediate portion between the weak seal portions are welded multi-chamber container.
  3. 【請求項3】 請求項1または請求項2記載の複室容器において、前記外壁と前記内壁との空間部には不活性ガスもしくは乾燥ガスを封入するようにした複室容器。 3. A multi-chamber container according to claim 1 or claim 2, wherein, in the space between the outer wall and the inner wall multi-chamber container so as to enclose the inert gas or dry gas.
  4. 【請求項4】 請求項1ないし請求項3のいずれかに記載の複室容器において、前記外壁で覆われた前記内壁内の室には易酸化性および/または吸湿性を有する液剤、 4. A liquid having the multi-chamber container according to any one of claims 1 to 3, the oxidizable and / or hygroscopic the chamber of the inner wall covered with the outer wall,
    粉末剤もしくは固形剤を収容するようにした複室容器。 Double chambered container so as to accommodate a powder or solid preparation.
JP6466993A 1992-05-03 1993-02-28 Multi-chamber container Expired - Fee Related JP3079403B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP4-140113 1992-05-03
JP14011392 1992-05-03
JP6466993A JP3079403B2 (en) 1992-05-03 1993-02-28 Multi-chamber container

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
JP6466993A JP3079403B2 (en) 1992-05-03 1993-02-28 Multi-chamber container
TW82103173A TW216768B (en) 1992-05-03 1993-04-24 Containers having plurality of chambers
EP19930911945 EP0639364B1 (en) 1992-05-03 1993-04-28 Container having a plurality of chambers
ES93911945T ES2133399T3 (en) 1992-05-03 1993-04-28 Containers having a plurality of chambers.
DK93911945T DK0639364T3 (en) 1992-05-03 1993-04-28 A container having a plurality of chambers
DE1993625801 DE69325801T2 (en) 1992-05-03 1993-04-28 Containers with a variety of chambers
KR19940070005A KR100209830B1 (en) 1992-05-03 1993-04-28 Vessel having a plurality of chambers
CA 2112661 CA2112661C (en) 1992-05-03 1993-04-28 Vessel having a plurality of chambers
HU9400012A HU216406B (en) 1992-05-03 1993-04-28 Vessel having a plurality of chambers
US08170215 US5423421A (en) 1992-05-03 1993-04-28 Containers having plurality of chambers
RU93058573A RU2103987C1 (en) 1992-05-03 1993-04-28 Multiple-chamber vessel
AU4270993A AU654442B2 (en) 1992-05-03 1993-04-28 Vessel having a plurality of chambers
AT93911945T AT182464T (en) 1992-05-03 1993-04-28 Containers with a variety of chambers
SG1996005545A SG44684A1 (en) 1992-05-03 1993-04-28 Containers having plurality of chambers
PCT/JP1993/000558 WO1993021890A1 (en) 1992-05-03 1993-04-28 Vessel having a plurality of chambers
DE1993625801 DE69325801D1 (en) 1992-05-03 1993-04-28 Containers with a variety of chambers
PL29876893A PL172973B1 (en) 1992-05-03 1993-04-30 Multicompartment container
EG25593A EG20103A (en) 1992-05-03 1993-05-02 Containers having plurality of chambers
PT10126293A PT101262B (en) 1992-05-03 1993-05-03 A container having a plurality of chambers
PH46133A PH31343A (en) 1992-05-03 1993-05-03 Containers having plurality of chambers.
CN 93106347 CN1065742C (en) 1992-05-03 1993-05-03 Containers having plurality of chambers
NO934910A NO303815B1 (en) 1992-05-03 1993-12-30 Container with several chambers
FI935972A FI107694B (en) 1992-05-03 1993-12-31 A container having a plurality of chambers in order to maintain the substance
GR990402171T GR3031088T3 (en) 1992-05-03 1999-08-26 Vessel having a plurality of chambers.

Publications (2)

Publication Number Publication Date
JPH0614975A true true JPH0614975A (en) 1994-01-25
JP3079403B2 JP3079403B2 (en) 2000-08-21

Family

ID=26405772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6466993A Expired - Fee Related JP3079403B2 (en) 1992-05-03 1993-02-28 Multi-chamber container

Country Status (10)

Country Link
EP (1) EP0639364B1 (en)
JP (1) JP3079403B2 (en)
CN (1) CN1065742C (en)
CA (1) CA2112661C (en)
DE (2) DE69325801T2 (en)
DK (1) DK0639364T3 (en)
ES (1) ES2133399T3 (en)
FI (1) FI107694B (en)
RU (1) RU2103987C1 (en)
WO (1) WO1993021890A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733353A2 (en) * 1995-03-23 1996-09-25 Nissho Corporation Dual-chambered container and method of making same
EP0737468A2 (en) 1995-04-11 1996-10-16 Nissho Corporation Flexible dual-chambered container
JPH0919482A (en) * 1995-07-04 1997-01-21 Nissho Corp Drink vessel for infant
EP0914813A2 (en) 1997-11-04 1999-05-12 Material Engineering Technology Laboratory, Inc. Container for therapeutic use
JP2000157609A (en) * 1998-11-30 2000-06-13 Ajinomoto Faruma Kk Manufacture of enclosure for liquid medical formulation and container therefor
JP2005245677A (en) * 2004-03-03 2005-09-15 Kr Business:Kk Medical multi-chamber container with unmixing-preventing mechanism
JP2006020964A (en) * 2004-07-09 2006-01-26 Ajinomoto Co Inc Medical agent storage sealing body, and method for forming the same
JP2008539208A (en) * 2005-04-28 2008-11-13 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Enclosure that contains vii factor polypeptide of activated, methods of preparation as well as methods of using the kit and the kit
JP2009022763A (en) * 2008-08-08 2009-02-05 Ajinomoto Co Inc Preliminary preparation method of chemical
JP2010094540A (en) * 2010-01-27 2010-04-30 Ajinomoto Co Inc Method of manufacturing medical solution enclosure for medical application and container for the enclosure
WO2012105524A1 (en) * 2011-01-31 2012-08-09 味の素株式会社 Multi-chambered container
WO2012121094A1 (en) * 2011-03-04 2012-09-13 学校法人久留米大学 Albumin-containing intravenous injection
JP5056754B2 (en) * 2006-05-23 2012-10-24 ニプロ株式会社 container
US8343128B2 (en) 2002-04-30 2013-01-01 Otsuka Pharmaceutical Factory, Inc. Multiple-chamber medical container and bag for enclosing same

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462526A (en) * 1993-09-15 1995-10-31 Mcgaw, Inc. Flexible, sterile container and method of making and using same
DE4447626C5 (en) 1994-03-29 2007-01-25 Fresenius Ag Medical multi-chamber bag
DE19600530C2 (en) * 1996-01-10 2000-02-17 Nutrichem Diaet & Pharma Gmbh Bag with two chambers and methods for manufacturing the bag
GB9705455D0 (en) * 1997-03-17 1997-05-07 Ucb Sa Self-rehydrating container
ES2313753T3 (en) 1997-10-27 2009-03-01 Otsuka Pharmaceutical Factory, Inc. Cleaning fluid bag and packed ophthalmic perfusion.
DE19751489A1 (en) * 1997-11-20 1999-05-27 Nutrichem Diaet & Pharma Gmbh Double pouch for administration of a fluid substance
US7678097B1 (en) 1999-11-12 2010-03-16 Baxter International Inc. Containers and methods for manufacturing same
JP4987298B2 (en) 2003-03-12 2012-07-25 藤森工業株式会社 Multi-chamber container
US7243787B2 (en) 2003-03-26 2007-07-17 Nipro Corporation Medicine bag
FR2859625B1 (en) * 2003-09-11 2006-05-05 Christiane Cinqualbre Flexible container for the extemporaneous preparation and administration of a liquid product including a solute drug use
DE10349089B3 (en) 2003-10-22 2005-06-30 Kpss-Kao Professional Salon Services Gmbh Package and method for manufacturing a package
US20050194060A1 (en) 2004-03-03 2005-09-08 Vincent Houwaert Peelable seal closure assembly
KR101211552B1 (en) 2004-08-16 2012-12-12 니프로 가부시키가이샤 Medical multi-layer container and medical multilayer compartmented container
DE102005028068B4 (en) * 2005-06-16 2016-07-14 Georg Menshen Gmbh & Co. Kg A method of filling a bag-shaped container
JP5118838B2 (en) 2006-03-31 2013-01-16 株式会社大塚製薬工場 Multi-chamber container
US9004761B2 (en) 2006-05-01 2015-04-14 Baxter International Inc. Multiple chamber container with mistake proof administration system
JP5352453B2 (en) 2006-06-15 2013-11-27 メットプロ アーベーMetpro AB Container for providing a solution, system and method
EP2266521B1 (en) 2008-03-14 2013-08-28 Otsuka Pharmaceutical Factory, Inc. Plastic ampule
CN101543461B (en) 2008-03-28 2013-07-31 丽珠集团利民制药厂 Notoginseng triterpenes medical liquor soft package
EP2674513B1 (en) * 2009-05-13 2018-11-14 SiO2 Medical Products, Inc. Vessel coating and inspection
DE102009058445B4 (en) * 2009-12-16 2016-09-15 Fresenius Medical Care Deutschland Gmbh Multi-chamber bags
FR2980180B1 (en) 2011-09-21 2015-01-16 Oreal Bag has at least two compartments
FR2981832B1 (en) * 2011-10-28 2013-12-06 Oreal Sachet OFFSET welds
EP3288851A1 (en) * 2015-04-30 2018-03-07 Cryovac, Inc. Package, packaged product, method of releasing at least one agent into chamber portion of package, and process of packaging

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1486639A1 (en) * 1963-02-23 1969-11-20 Schneider William Steven In completed Faecher packaging divided
US3749620A (en) * 1969-11-20 1973-07-31 American Cyanamid Co Package for plural reactable components with rupturable ultrasonic seal
JPH0116502B2 (en) * 1981-06-12 1989-03-24 Terumo Corp
JPH0246450B2 (en) * 1982-10-30 1990-10-16 Terumo Corp
US4496046A (en) * 1983-09-15 1985-01-29 Baxter Travenol Laboratories, Inc. Multiple chamber container with inner diaphragm and intermediate chamber
US4731053A (en) * 1986-12-23 1988-03-15 Merck & Co., Inc. Container device for separately storing and mixing two ingredients
WO1988008694A1 (en) * 1987-05-07 1988-11-17 Terumo Kabushiki Kaisha Packed transfusion
JPH01240468A (en) * 1988-03-11 1989-09-26 Mitsui Toatsu Chem Inc Packaging body of raw pineapple
JP2675049B2 (en) * 1988-03-17 1997-11-12 株式会社新素材総合研究所 The contents of the container filled
JPH03236847A (en) * 1990-02-14 1991-10-22 Material Eng Tech Lab Inc Drug-contained receptacle having plural chambers

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733353A2 (en) * 1995-03-23 1996-09-25 Nissho Corporation Dual-chambered container and method of making same
EP0733353B1 (en) * 1995-03-23 2000-01-19 Nissho Corporation Dual-chambered container and method of making same
EP0737468A2 (en) 1995-04-11 1996-10-16 Nissho Corporation Flexible dual-chambered container
EP0737468B1 (en) * 1995-04-11 2000-05-24 Nissho Corporation Flexible dual-chambered container
JPH0919482A (en) * 1995-07-04 1997-01-21 Nissho Corp Drink vessel for infant
EP0914813A2 (en) 1997-11-04 1999-05-12 Material Engineering Technology Laboratory, Inc. Container for therapeutic use
JP2000157609A (en) * 1998-11-30 2000-06-13 Ajinomoto Faruma Kk Manufacture of enclosure for liquid medical formulation and container therefor
US8343128B2 (en) 2002-04-30 2013-01-01 Otsuka Pharmaceutical Factory, Inc. Multiple-chamber medical container and bag for enclosing same
JP2005245677A (en) * 2004-03-03 2005-09-15 Kr Business:Kk Medical multi-chamber container with unmixing-preventing mechanism
JP4587096B2 (en) * 2004-03-03 2010-11-24 有限会社ケーアールビジネス Not mixing prevention mechanism with multi-chamber medical container
JP4599918B2 (en) * 2004-07-09 2010-12-15 味の素株式会社 Forming method of the medicine container sealing body and the medicine container sealing body
JP2006020964A (en) * 2004-07-09 2006-01-26 Ajinomoto Co Inc Medical agent storage sealing body, and method for forming the same
JP2008539208A (en) * 2005-04-28 2008-11-13 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Enclosure that contains vii factor polypeptide of activated, methods of preparation as well as methods of using the kit and the kit
US8703706B2 (en) 2005-04-28 2014-04-22 Novo Nordisk Healthcare Ag Closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit
JP2013151494A (en) * 2005-04-28 2013-08-08 Novo Nordisk Health Care Ag Closed container comprising activated factor vii polypeptide, process for preparation of the same, and kit and method for use of the kit
JP5056754B2 (en) * 2006-05-23 2012-10-24 ニプロ株式会社 container
JP2009022763A (en) * 2008-08-08 2009-02-05 Ajinomoto Co Inc Preliminary preparation method of chemical
JP2010094540A (en) * 2010-01-27 2010-04-30 Ajinomoto Co Inc Method of manufacturing medical solution enclosure for medical application and container for the enclosure
WO2012105524A1 (en) * 2011-01-31 2012-08-09 味の素株式会社 Multi-chambered container
JP6081799B2 (en) * 2011-01-31 2017-02-15 Eaファーマ株式会社 Multi-chamber container
WO2012121094A1 (en) * 2011-03-04 2012-09-13 学校法人久留米大学 Albumin-containing intravenous injection
JP5967622B2 (en) * 2011-03-04 2016-08-10 学校法人 久留米大学 A process for the preparation of albumin-containing intravenous agent

Also Published As

Publication number Publication date Type
FI935972A (en) 1994-02-24 application
DK639364T3 (en) grant
FI935972A0 (en) 1993-12-31 application
EP0639364A4 (en) 1994-10-24 application
CA2112661A1 (en) 1993-11-11 application
CN1082881A (en) 1994-03-02 application
CN1065742C (en) 2001-05-16 grant
ES2133399T3 (en) 1999-09-16 grant
EP0639364B1 (en) 1999-07-28 grant
EP0639364A1 (en) 1995-02-22 application
DE69325801T2 (en) 1999-11-18 grant
FI107694B1 (en) grant
DE69325801D1 (en) 1999-09-02 grant
JP3079403B2 (en) 2000-08-21 grant
RU2103987C1 (en) 1998-02-10 grant
CA2112661C (en) 2002-02-26 grant
FI107694B (en) 2001-09-28 application
DK0639364T3 (en) 1999-11-29 grant
FI935972D0 (en) grant
WO1993021890A1 (en) 1993-11-11 application

Similar Documents

Publication Publication Date Title
US4753352A (en) Impervious packaging in the form of a card having compartments and permitting gaseous exchange between the compartments
US6279736B1 (en) Barrier pack having an absorbing agent applied to the interior of the pack
US20020132359A1 (en) Dispensing unit for oxygen-sensitive drugs
US5865309A (en) Dual-chambered container and method of making same
US5129894A (en) Package units for medical purposes
US4872553A (en) Medical fluid-filled plastic container and methods of making same
US4998400A (en) Medical fluid-filled plastic container and methods of making same
US5928213A (en) Flexible multiple compartment medical container with preferentially rupturable seals
US6398771B1 (en) Containers for parenteral fluids
US5364384A (en) Flexible container with intergral protective cover
US4961495A (en) Plastic container having an easy-to-peel seal forming compartments
US5267646A (en) Containers having plurality of chambers
US5176634A (en) Flexible multiple compartment drug container
US5462526A (en) Flexible, sterile container and method of making and using same
US20070261974A1 (en) Multiple chamber container with mistake proof adminstration system
US5423421A (en) Containers having plurality of chambers
US6165161A (en) Sacrificial port for filling flexible, multiple-compartment drug container
US6113927A (en) Package and packaging method for aqueous liquid materials
US6162205A (en) Container for therapeutic use
JPH09327498A (en) Medical use container
WO2008014862A1 (en) Packaging comprising pharmaceutical forms
EP0639364A1 (en) Vessel having a plurality of chambers
JP2003062038A (en) Chemical container with inner small bag for chemical solution
JP2008018063A (en) Multilayer body for medical container and medical container
JPH11332984A (en) Medicinal liquid-containing syringe

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees