JP2005539016A - 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター - Google Patents
女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター Download PDFInfo
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- JP2005539016A JP2005539016A JP2004526857A JP2004526857A JP2005539016A JP 2005539016 A JP2005539016 A JP 2005539016A JP 2004526857 A JP2004526857 A JP 2004526857A JP 2004526857 A JP2004526857 A JP 2004526857A JP 2005539016 A JP2005539016 A JP 2005539016A
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- benzaldehyde
- oxoestradi
- dien
- oxime
- hydroxy
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40006502P | 2002-08-02 | 2002-08-02 | |
| DE10236405A DE10236405A1 (de) | 2002-08-02 | 2002-08-02 | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper Aktivität für die weibliche Fertilitätskontrolle und Hormonersatztherapie |
| PCT/EP2003/008572 WO2004014935A1 (de) | 2002-08-02 | 2003-08-01 | Progesteronrezeptormodulatoren mit erhöhter antigonadotroper aktivität für die weibliche fertilitätskontrolle und hormonersatztherapie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539016A true JP2005539016A (ja) | 2005-12-22 |
| JP2005539016A5 JP2005539016A5 (https=) | 2006-09-14 |
Family
ID=31716602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526857A Pending JP2005539016A (ja) | 2002-08-02 | 2003-08-01 | 女性用受胎調節及びホルモン置換療法のための高められた抗ゴナドトロピン活性を有するプロゲステロン受容体モジュレーター |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1525215B1 (https=) |
| JP (1) | JP2005539016A (https=) |
| AT (1) | ATE338763T1 (https=) |
| AU (1) | AU2003255355A1 (https=) |
| DE (1) | DE50304970D1 (https=) |
| DK (1) | DK1525215T3 (https=) |
| ES (1) | ES2273061T3 (https=) |
| WO (1) | WO2004014935A1 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008007507A (ja) * | 2006-06-28 | 2008-01-17 | Teva Pharmaceutical Industries Ltd | 結晶形アトルバスタチン |
| JP2013518244A (ja) * | 2010-01-21 | 2013-05-20 | エキポ アイヴィイー インヴェスティガシオン エス．エル． | 子宮内膜受容性の診断方法 |
| JP2013163683A (ja) * | 2007-08-03 | 2013-08-22 | Cosmo Spa | コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法 |
| US9211295B2 (en) | 2001-08-10 | 2015-12-15 | Cassiopea S.P.A. | 17 alpha, 21-dihydroxypregnene esters as antiandrogenic agents |
| US10081840B2 (en) | 2008-07-22 | 2018-09-25 | Igenomix S.L. | Gene expression profile as an endometrial receptivity marker |
| US10603327B2 (en) | 2015-06-22 | 2020-03-31 | Cassiopea S.P.A. | High concentration formulation |
| US11129851B2 (en) | 2014-06-17 | 2021-09-28 | Igenomix S.L. | Stem cell therapy in endometrial pathologies |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006018869A1 (de) * | 2006-04-13 | 2007-10-18 | Bayer Schering Pharma Ag | 17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung |
| WO2008109719A2 (en) * | 2007-03-07 | 2008-09-12 | Janssen Pharmaceutica N.V. | Steroids derivatives as selective progesterone receptor modulators |
| DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
| DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
| DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
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| JPH07149790A (ja) * | 1993-09-20 | 1995-06-13 | Jenapharm Gmbh | 新規な１１−ベンズアルドキシム−１７β−メトキシ−１７α−メトキシメチル−エストラジエン誘導体、その製法およびその物質を含有する医薬製剤 |
| JPH07149789A (ja) * | 1993-09-20 | 1995-06-13 | Jenapharm Gmbh | 新規な１１−ベンズアルドキシム−エストラ−ジエン誘導体とその製造方法、及びその化合物を含有する医薬製剤 |
| EP0909764A1 (de) * | 1997-10-11 | 1999-04-21 | JENAPHARM GmbH | 11 Beta-Benzaldoxim-9 Alpha, 10 Alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| WO2001015679A2 (en) * | 1999-08-31 | 2001-03-08 | Jenapharm Gmbh & Co. Kg | Mesoprogestins for the treatment and prevention of benign hormone dependent gynecological disorders |
| WO2001026603A2 (en) * | 1999-08-31 | 2001-04-19 | Jenapharm Gmbh & Co. Kg | Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives |
| WO2001034126A2 (en) * | 1999-08-31 | 2001-05-17 | Jenapharm Gmbh & Co. Kg | Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt) |
| WO2001044267A1 (de) * | 1999-12-15 | 2001-06-21 | Jenapharm Gmbh & Co. Kg | 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN |
| JP2002505335A (ja) * | 1998-03-03 | 2002-02-19 | イエナフアルム ゲーエムベーハー ウント ツェーオー． カーゲー | Ｓ−置換１１β−ベンズアルドキシム−エストラ−４，９−ジエン−炭酸チオールエステル、その製造法および該化合物を含有する製薬学的調剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3504421A1 (de) * | 1985-02-07 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 11ss-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate |
-
2003
- 2003-08-01 ES ES03784154T patent/ES2273061T3/es not_active Expired - Lifetime
- 2003-08-01 AT AT03784154T patent/ATE338763T1/de not_active IP Right Cessation
- 2003-08-01 DE DE50304970T patent/DE50304970D1/de not_active Expired - Lifetime
- 2003-08-01 DK DK03784154T patent/DK1525215T3/da active
- 2003-08-01 JP JP2004526857A patent/JP2005539016A/ja active Pending
- 2003-08-01 EP EP03784154A patent/EP1525215B1/de not_active Expired - Lifetime
- 2003-08-01 WO PCT/EP2003/008572 patent/WO2004014935A1/de not_active Ceased
- 2003-08-01 AU AU2003255355A patent/AU2003255355A1/en not_active Abandoned
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| JPH07149790A (ja) * | 1993-09-20 | 1995-06-13 | Jenapharm Gmbh | 新規な１１−ベンズアルドキシム−１７β−メトキシ−１７α−メトキシメチル−エストラジエン誘導体、その製法およびその物質を含有する医薬製剤 |
| JPH07149789A (ja) * | 1993-09-20 | 1995-06-13 | Jenapharm Gmbh | 新規な１１−ベンズアルドキシム−エストラ−ジエン誘導体とその製造方法、及びその化合物を含有する医薬製剤 |
| EP0909764A1 (de) * | 1997-10-11 | 1999-04-21 | JENAPHARM GmbH | 11 Beta-Benzaldoxim-9 Alpha, 10 Alpha-epoxy-estr-4-en-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| JP2002505335A (ja) * | 1998-03-03 | 2002-02-19 | イエナフアルム ゲーエムベーハー ウント ツェーオー． カーゲー | Ｓ−置換１１β−ベンズアルドキシム−エストラ−４，９−ジエン−炭酸チオールエステル、その製造法および該化合物を含有する製薬学的調剤 |
| WO2001015679A2 (en) * | 1999-08-31 | 2001-03-08 | Jenapharm Gmbh & Co. Kg | Mesoprogestins for the treatment and prevention of benign hormone dependent gynecological disorders |
| WO2001026603A2 (en) * | 1999-08-31 | 2001-04-19 | Jenapharm Gmbh & Co. Kg | Mesoprogestins (progesterone receptor modulators) as a component of female contraceptives |
| WO2001034126A2 (en) * | 1999-08-31 | 2001-05-17 | Jenapharm Gmbh & Co. Kg | Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt) |
| WO2001044267A1 (de) * | 1999-12-15 | 2001-06-21 | Jenapharm Gmbh & Co. Kg | 11-β-PHENYLESTRADIEN-DERIVATE MIT FLUORALKYLGRUPPEN IN DER AROMATISCHEN SEITENKETTE, DEREN HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9211295B2 (en) | 2001-08-10 | 2015-12-15 | Cassiopea S.P.A. | 17 alpha, 21-dihydroxypregnene esters as antiandrogenic agents |
| US9895379B2 (en) | 2001-08-10 | 2018-02-20 | Cassiopea S.P.A. | 17alpha, 21-dihydroxypregnene esters as antiandrogenic agents |
| JP2008007507A (ja) * | 2006-06-28 | 2008-01-17 | Teva Pharmaceutical Industries Ltd | 結晶形アトルバスタチン |
| US10166245B2 (en) | 2007-08-03 | 2019-01-01 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US11207332B2 (en) | 2007-08-03 | 2021-12-28 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 α-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US9433628B2 (en) | 2007-08-03 | 2016-09-06 | Cassiopea Spa | Enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US9486458B2 (en) | 2007-08-03 | 2016-11-08 | Cassiopea Spa | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| JP2013163683A (ja) * | 2007-08-03 | 2013-08-22 | Cosmo Spa | コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法 |
| JP2016014045A (ja) * | 2007-08-03 | 2016-01-28 | カシオペア ソシエタ ペル アチオニ | コルテキソロンの１７α−モノエステルおよび／またはその９，１１−デヒドロ誘導体を得るための酵素的方法 |
| US10159682B2 (en) | 2007-08-03 | 2018-12-25 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US12337002B2 (en) | 2007-08-03 | 2025-06-24 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US11938141B2 (en) | 2007-08-03 | 2024-03-26 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US10716796B2 (en) | 2007-08-03 | 2020-07-21 | Cassiopea S.P.A. | Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives |
| US10081840B2 (en) | 2008-07-22 | 2018-09-25 | Igenomix S.L. | Gene expression profile as an endometrial receptivity marker |
| JP2013518244A (ja) * | 2010-01-21 | 2013-05-20 | エキポ アイヴィイー インヴェスティガシオン エス．エル． | 子宮内膜受容性の診断方法 |
| US11129851B2 (en) | 2014-06-17 | 2021-09-28 | Igenomix S.L. | Stem cell therapy in endometrial pathologies |
| US10980819B2 (en) | 2015-06-22 | 2021-04-20 | Cassiopea S.P.A. | High concentration formulation |
| US11213531B2 (en) | 2015-06-22 | 2022-01-04 | Cassiopea S.P.A. | High concentration formulation |
| US11883415B2 (en) | 2015-06-22 | 2024-01-30 | Cassiopea S.P.A. | High concentration formulation |
| US10603327B2 (en) | 2015-06-22 | 2020-03-31 | Cassiopea S.P.A. | High concentration formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2273061T3 (es) | 2007-05-01 |
| EP1525215B1 (de) | 2006-09-06 |
| EP1525215A1 (de) | 2005-04-27 |
| WO2004014935A1 (de) | 2004-02-19 |
| ATE338763T1 (de) | 2006-09-15 |
| AU2003255355A1 (en) | 2004-02-25 |
| DK1525215T3 (da) | 2007-01-15 |
| DE50304970D1 (de) | 2006-10-19 |
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