JP2005539011A - ポルフィリン化合物と化学療法剤との結合体 - Google Patents

ポルフィリン化合物と化学療法剤との結合体 Download PDF

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Publication number
JP2005539011A
JP2005539011A JP2004526242A JP2004526242A JP2005539011A JP 2005539011 A JP2005539011 A JP 2005539011A JP 2004526242 A JP2004526242 A JP 2004526242A JP 2004526242 A JP2004526242 A JP 2004526242A JP 2005539011 A JP2005539011 A JP 2005539011A
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porphyrin
compound
chemotherapeutic agent
doxorubicin
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JP2004526242A
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Japanese (ja)
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JP2005539011A5 (https=
Inventor
ベンジャミン フライドマン，
アルドニア エル． バラシナス，
ジョン エー． キンク，
ローレンス ジェイ． マートン，
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セルゲイト， インコーポレイテッド
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Publication of JP2005539011A5 publication Critical patent/JP2005539011A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2004526242A 2002-08-02 2003-07-30 ポルフィリン化合物と化学療法剤との結合体 Pending JP2005539011A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40051202P 2002-08-02 2002-08-02
PCT/US2003/023898 WO2004012774A1 (en) 2002-08-02 2003-07-30 Conjugates of porphyrin compounds with chemotherapeutic agents

Publications (2)

Publication Number Publication Date
JP2005539011A true JP2005539011A (ja) 2005-12-22
JP2005539011A5 JP2005539011A5 (https=) 2006-08-31

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ID=31495832

Family Applications (1)

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JP2004526242A Pending JP2005539011A (ja) 2002-08-02 2003-07-30 ポルフィリン化合物と化学療法剤との結合体

Country Status (7)

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US (1) US20040192665A1 (https=)
EP (1) EP1525001A1 (https=)
JP (1) JP2005539011A (https=)
AU (1) AU2003257055A1 (https=)
CA (1) CA2494214A1 (https=)
MX (1) MXPA05001222A (https=)
WO (1) WO2004012774A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012502052A (ja) * 2008-09-08 2012-01-26 ホフマン／バーレット， リミテッド ライアビリティ カンパニー ポルフィラジン並びに光学的及びデュアル光学的／ｍｒコントラスト並びに治療薬
JP2019523783A (ja) * 2016-06-16 2019-08-29 オンコセレクト セラピューティクス，エルエルシー がんの治療に有用なポルフィリン化合物及び組成物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
DE60029944T2 (de) * 1999-04-30 2007-04-05 Cellgate, Inc., Redwood City Polyamine und ihre therapeutische verwendung
EP1515973A1 (en) * 2002-06-26 2005-03-23 Cellgate Inc. Porphyrin-polyamine conjugates for cancer therapy
FR2867189A1 (fr) * 2004-03-08 2005-09-09 Ludovic Bourre Nouveaux composes medicamenteux destines au traitement des pathologies dependantes de l'activite proteine kinase
CA2573927A1 (en) 2004-07-15 2006-01-19 The University Of Sydney Porphyrin linked metronidazole against gum disease: porphyromonas gingivalis
JP6807831B2 (ja) 2014-05-21 2021-01-06 エントラーダ セラピューティクス，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
WO2016033368A1 (en) 2014-08-27 2016-03-03 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
JP7372672B2 (ja) * 2017-06-16 2023-11-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 活性医薬成分の複合体
CA3078504A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation Bicyclic peptidyl inhibitors
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
WO2019148195A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of cal-pdz binding domain
WO2019165183A1 (en) 2018-02-22 2019-08-29 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
CN108409756B (zh) * 2018-03-08 2019-12-10 莎穆(上海)生物科技有限公司 一种基于喜树碱类的异二聚体多功能前药及其制备方法和应用
CN119504769B (zh) * 2024-10-21 2025-09-30 高博药业有限公司 一种靶向her2的抗体偶联金（ⅲ）卟啉药物及其合成与肿瘤治疗应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764605A1 (fr) * 1997-06-17 1998-12-18 Univ Hyderabad Molecules hybrides d'un photosensibilisateur et d'un agent chimiotherapeutique, leur procede de production et leur application collaterale en chimiotherapie et therapie photodynamique
WO2001028592A1 (en) * 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging agents and as antitumor agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435087A1 (de) * 1994-09-30 1996-04-04 Deutsches Krebsforsch Konjugat zur Behandlung von Infektions-, Autoimmun- und Hauterkrankungen
US5677350A (en) * 1995-06-07 1997-10-14 Wisconsin Alumni Research Foundation Inhibition of cancer cell growth, proliferation, and metastasis using N,N'-dα,ω-diaminoalkanes
US5889061A (en) * 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US20020155999A1 (en) * 1998-04-30 2002-10-24 Han In Suk Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer
WO1999062551A1 (en) * 1998-06-05 1999-12-09 Board Of Regents, The University Of Texas System Texaphyrin conjugates and uses thereof
DE19831217A1 (de) * 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
CA2448570A1 (en) * 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
EP1515973A1 (en) * 2002-06-26 2005-03-23 Cellgate Inc. Porphyrin-polyamine conjugates for cancer therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764605A1 (fr) * 1997-06-17 1998-12-18 Univ Hyderabad Molecules hybrides d'un photosensibilisateur et d'un agent chimiotherapeutique, leur procede de production et leur application collaterale en chimiotherapie et therapie photodynamique
WO2001028592A1 (en) * 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging agents and as antitumor agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012502052A (ja) * 2008-09-08 2012-01-26 ホフマン／バーレット， リミテッド ライアビリティ カンパニー ポルフィラジン並びに光学的及びデュアル光学的／ｍｒコントラスト並びに治療薬
JP2019523783A (ja) * 2016-06-16 2019-08-29 オンコセレクト セラピューティクス，エルエルシー がんの治療に有用なポルフィリン化合物及び組成物

Also Published As

Publication number Publication date
MXPA05001222A (es) 2005-09-12
US20040192665A1 (en) 2004-09-30
EP1525001A1 (en) 2005-04-27
WO2004012774A1 (en) 2004-02-12
CA2494214A1 (en) 2004-02-12
AU2003257055A1 (en) 2004-02-23

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