JP2005538089A5 - - Google Patents
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- Publication number
- JP2005538089A5 JP2005538089A5 JP2004522648A JP2004522648A JP2005538089A5 JP 2005538089 A5 JP2005538089 A5 JP 2005538089A5 JP 2004522648 A JP2004522648 A JP 2004522648A JP 2004522648 A JP2004522648 A JP 2004522648A JP 2005538089 A5 JP2005538089 A5 JP 2005538089A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- methyl
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000011780 sodium chloride Substances 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- -1 NR 4 R 4 Chemical group 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786902P | 2002-07-22 | 2002-07-22 | |
| US45023303P | 2003-02-25 | 2003-02-25 | |
| PCT/IB2003/003349 WO2004009086A1 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109009A Division JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005538089A JP2005538089A (ja) | 2005-12-15 |
| JP2005538089A5 true JP2005538089A5 (US06894165-20050517-C00155.png) | 2007-08-16 |
| JP4656939B2 JP4656939B2 (ja) | 2011-03-23 |
Family
ID=30773044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004522648A Expired - Fee Related JP4656939B2 (ja) | 2002-07-22 | 2003-07-16 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
| JP2010109009A Expired - Fee Related JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010109009A Expired - Fee Related JP5220800B2 (ja) | 2002-07-22 | 2010-05-11 | フェニルスルホニル基を含む選択的エストロゲン受容体モジュレーター |
Country Status (25)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2490580C (en) * | 2002-07-22 | 2012-12-11 | Eli Lilly And Company | Selective estrogen receptor modulators containing a naphthalene group |
| EA007978B1 (ru) * | 2003-02-25 | 2007-02-27 | Эли Лилли Энд Компани | Кристаллический несольватированный гидрохлорид 1-(4-(2-пиперидинилэтокси)фенокси)-2-(4-метансульфонилфенил)-6-гидроксинафталина |
| MXPA05009098A (es) * | 2003-02-25 | 2005-11-17 | Lilly Co Eli | Clorhidrato de 1- (4-(2 -piperidiniletoxifenoxi) -2-(4-metansulfonilfenil) -6-hidroxinaftaleno cristalino no solvatado. |
| CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
| US20070066595A1 (en) * | 2004-01-22 | 2007-03-22 | Dodge Jeffrey A | Selective estrogen receptor modulators |
| ATE476428T1 (de) | 2004-01-22 | 2010-08-15 | Lilly Co Eli | Selektive modulatoren des östrogenrezeptors zur behandlung von vasomotorischen symptomen |
| US20080227814A1 (en) * | 2004-01-29 | 2008-09-18 | Jeffrey Alan Dodge | Selective Estrogen Receptor Modulators |
| JP2008503588A (ja) * | 2004-06-22 | 2008-02-07 | スミスクライン ビーチャム コーポレーション | 化学化合物 |
| US20080200507A1 (en) * | 2005-07-29 | 2008-08-21 | Jeanette Tower Dunlap | Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene |
| JP5548205B2 (ja) * | 2008-09-29 | 2014-07-16 | イーライ リリー アンド カンパニー | 選択的エストロゲン受容体調節因子 |
| DE102008057230A1 (de) * | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| KR101731008B1 (ko) | 2010-06-16 | 2017-04-27 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
| JP6292744B2 (ja) * | 2012-09-19 | 2018-03-14 | 富士カプセル株式会社 | 医薬品組成物 |
| AU2014219283C1 (en) | 2013-02-19 | 2016-10-27 | Novartis Ag | Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
| CN113544125A (zh) | 2019-03-08 | 2021-10-22 | 先正达农作物保护股份公司 | 杀有害生物活性的唑-酰胺化合物 |
| BR112021018501A2 (pt) | 2019-03-20 | 2021-11-30 | Syngenta Crop Protection Ag | Compostos de azolamida ativos em termos pesticidas |
| EP3941914A1 (en) | 2019-03-22 | 2022-01-26 | Syngenta Crop Protection AG | N-[1-(5-bromo-2-pyrimidin-2-yl-1,2,4-triazol-3-yl)ethyl]-2-cyclopropyl-6-(trifluoromethyl)pyridine-4-carboxamide derivatives and related compounds as insecticides |
| UY38623A (es) | 2019-03-29 | 2020-10-30 | Syngenta Crop Protection Ag | Compuestos de diazina-amida activos como pesticidas |
| MX2021012162A (es) | 2019-04-05 | 2021-11-03 | Syngenta Crop Protection Ag | Compuestos de diazina-amida activos como pesticidas. |
| BR112022003375A2 (pt) | 2019-08-23 | 2022-05-17 | Syngenta Crop Protection Ag | Compostos de pirazina-amida pesticidamente ativos |
| CN110526881B (zh) * | 2019-08-27 | 2020-09-22 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用 |
| WO2021170881A1 (en) | 2020-02-27 | 2021-09-02 | Syngenta Crop Protection Ag | Pesticidally active diazine-bisamide compounds |
| KR20240007916A (ko) * | 2021-05-14 | 2024-01-17 | 장슈 야홍 메디텍 코퍼레이션 리미티드 | 나프탈렌 고리를 포함하는 화합물, 이를 포함하는 약학 조성물 및 이의 용도 |
| JP2024524883A (ja) | 2021-06-09 | 2024-07-09 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なジアジン－アミド化合物 |
| WO2023283315A1 (en) * | 2021-07-07 | 2023-01-12 | South Dakota Board Of Regents | Compositions and methods for treatment of cervical and ovarian cancer |
| WO2024042187A1 (en) | 2022-08-25 | 2024-02-29 | Sanofi | Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| CA2135160A1 (en) | 1992-05-08 | 1993-11-25 | Masatoshi Inai | Indole derivative |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US5484798A (en) * | 1994-09-20 | 1996-01-16 | Eli Lilly And Company | Benzothiopene compounds, compositions, and method of inhibiting restenosis |
| US7501441B1 (en) | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5998401A (en) | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| SG90193A1 (en) | 1995-02-28 | 2002-07-23 | Lilly Co Eli | Benzothiophene compounds, intermediates, compositions, and methods |
| US5599822A (en) | 1995-06-06 | 1997-02-04 | Eli Lilly And Company | Methods for minimizing bone loss |
| WO1997025033A1 (en) * | 1995-10-31 | 1997-07-17 | Eli Lilly And Company | Antithrombotic diamines |
| DE69706338T2 (de) * | 1996-02-22 | 2002-06-13 | Eli Lilly And Co., Indianapolis | Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung |
| EP0802183B1 (en) | 1996-04-19 | 2001-10-10 | American Home Products Corporation | Estrogenic agents |
| CA2213814A1 (en) | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2214070C (en) | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| JPH10204082A (ja) | 1996-10-25 | 1998-08-04 | Eli Lilly & Co | 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 |
| CA2490580C (en) * | 2002-07-22 | 2012-12-11 | Eli Lilly And Company | Selective estrogen receptor modulators containing a naphthalene group |
-
2003
- 2003-07-16 CA CA2490580A patent/CA2490580C/en not_active Expired - Fee Related
- 2003-07-16 JP JP2004522648A patent/JP4656939B2/ja not_active Expired - Fee Related
- 2003-07-16 DE DE60327931T patent/DE60327931D1/de not_active Expired - Lifetime
- 2003-07-16 EA EA200500248A patent/EA008024B1/ru not_active IP Right Cessation
- 2003-07-16 CN CN038172011A patent/CN1668303B/zh not_active Expired - Fee Related
- 2003-07-16 MX MXPA05000898A patent/MXPA05000898A/es active IP Right Grant
- 2003-07-16 US US10/521,896 patent/US7399867B2/en not_active Expired - Fee Related
- 2003-07-16 WO PCT/IB2003/003349 patent/WO2004009086A1/en active Application Filing
- 2003-07-16 ES ES03765254T patent/ES2326593T3/es not_active Expired - Lifetime
- 2003-07-16 NZ NZ537138A patent/NZ537138A/en not_active IP Right Cessation
- 2003-07-16 EP EP03765254A patent/EP1530470B9/en not_active Expired - Lifetime
- 2003-07-16 PL PL03374845A patent/PL374845A1/xx unknown
- 2003-07-16 BR BR0312675-7A patent/BR0312675A/pt not_active IP Right Cessation
- 2003-07-16 AU AU2003253129A patent/AU2003253129B2/en not_active Ceased
- 2003-07-16 AT AT03765254T patent/ATE433322T1/de not_active IP Right Cessation
- 2003-07-18 PE PE2003000717A patent/PE20040678A1/es not_active Application Discontinuation
- 2003-07-18 TW TW092119725A patent/TWI314860B/zh not_active IP Right Cessation
- 2003-07-18 MY MYPI20032711A patent/MY141879A/en unknown
-
2004
- 2004-12-13 IL IL16574504A patent/IL165745A0/xx unknown
- 2004-12-30 HR HR20041233A patent/HRP20041233A2/hr not_active Application Discontinuation
-
2005
- 2005-01-18 CR CR7657A patent/CR7657A/es unknown
- 2005-01-19 EC EC2005005549A patent/ECSP055549A/es unknown
- 2005-01-20 CO CO05004232A patent/CO5680445A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050832A patent/NO20050832L/no not_active Application Discontinuation
- 2005-10-28 HK HK05109638.4A patent/HK1078003A1/xx not_active IP Right Cessation
-
2008
- 2008-04-09 US US12/100,093 patent/US7585977B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 JP JP2010109009A patent/JP5220800B2/ja not_active Expired - Fee Related
