DE69706338T2 - Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung - Google Patents

Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung

Info

Publication number
DE69706338T2
DE69706338T2 DE69706338T DE69706338T DE69706338T2 DE 69706338 T2 DE69706338 T2 DE 69706338T2 DE 69706338 T DE69706338 T DE 69706338T DE 69706338 T DE69706338 T DE 69706338T DE 69706338 T2 DE69706338 T2 DE 69706338T2
Authority
DE
Germany
Prior art keywords
benzothiophenes
processes
preparation
same
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69706338T
Other languages
English (en)
Other versions
DE69706338D1 (de
Inventor
George Joseph Cullinan
Alan David Palkowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604912.7A external-priority patent/GB9604912D0/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69706338D1 publication Critical patent/DE69706338D1/de
Application granted granted Critical
Publication of DE69706338T2 publication Critical patent/DE69706338T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69706338T 1996-02-22 1997-02-19 Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung Expired - Fee Related DE69706338T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1204496P 1996-02-22 1996-02-22
GBGB9604912.7A GB9604912D0 (en) 1996-03-08 1996-03-08 Benzothiophenes, formulations containing same, and methods

Publications (2)

Publication Number Publication Date
DE69706338D1 DE69706338D1 (de) 2001-10-04
DE69706338T2 true DE69706338T2 (de) 2002-06-13

Family

ID=26308887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69706338T Expired - Fee Related DE69706338T2 (de) 1996-02-22 1997-02-19 Benzothiophene, selbige enthaltende Zusammensetzungen und Verfahren zu deren Herstellung

Country Status (23)

Country Link
EP (1) EP0791591B1 (de)
JP (1) JP2000505455A (de)
KR (1) KR19990087091A (de)
CN (1) CN1211921A (de)
AR (2) AR005970A1 (de)
AT (1) ATE204869T1 (de)
AU (1) AU713204B2 (de)
BR (1) BR9707657A (de)
CA (1) CA2246721A1 (de)
CO (1) CO4761064A1 (de)
CZ (1) CZ260798A3 (de)
DE (1) DE69706338T2 (de)
DK (1) DK0791591T3 (de)
EA (1) EA000767B1 (de)
ES (1) ES2162196T3 (de)
IL (1) IL125863A (de)
NO (1) NO983802D0 (de)
NZ (1) NZ331461A (de)
PL (1) PL328832A1 (de)
PT (1) PT791591E (de)
TR (1) TR199801612T2 (de)
WO (1) WO1997030709A1 (de)
YU (1) YU6797A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015521A1 (en) * 1997-09-23 1999-04-01 Eli Lilly And Company Benzothiophenes
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6060488A (en) * 1998-09-22 2000-05-09 Eli Lilly And Company Benzothiophenes for treating estrogen deficiency
BR0115963A (pt) * 2000-12-05 2003-10-28 Hoffmann La Roche Derivados de benzofurano e benzotiofeno
NZ537138A (en) * 2002-07-22 2007-11-30 Lilly Co Eli Selective estrogen receptor modulators containing a phenylsulfonyl group
EP1782810A3 (de) * 2002-07-22 2007-05-23 Eli Lilly & Company Selektive Östrogenrezeptor Modulatoren, die eine Phenylsulfonyl-Gruppe enthalten
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
PL377494A1 (pl) * 2003-02-25 2006-02-06 Eli Lilly And Company Krystaliczny, niesolwatowany chlorowodorek 1-(4-(2-pipe-rydynyloetoksy) fenoksy)-2-(4-metanosulfonylofenylo)-6- hydroksynaftalenu
EP1713770A1 (de) * 2004-01-29 2006-10-25 Eli Lilly And Company Selektive östrogen-rezeptor-modulatoren
GR1005694B (el) * 2005-06-08 2007-10-22 Αλεξης Μιχαηλ Ιστοειδικα αντιοιστρογονα ειδικα για τον αλφα υποδοχεα των οιστρογονων
CN111018770A (zh) * 2019-12-26 2020-04-17 北京鑫开元医药科技有限公司 一种巴多昔芬氧化物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65404A0 (en) * 1981-04-03 1982-07-30 Lilly Co Eli Benzothiophene compounds and process for preparing them
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents

Also Published As

Publication number Publication date
CN1211921A (zh) 1999-03-24
EP0791591B1 (de) 2001-08-29
AU2276497A (en) 1997-09-10
KR19990087091A (ko) 1999-12-15
NZ331461A (en) 1999-05-28
DE69706338D1 (de) 2001-10-04
PL328832A1 (en) 1999-02-15
EA199800753A1 (ru) 1999-02-25
AU713204B2 (en) 1999-11-25
EA000767B1 (ru) 2000-04-24
CO4761064A1 (es) 1999-04-27
EP0791591A1 (de) 1997-08-27
CZ260798A3 (cs) 1999-05-12
AR005970A1 (es) 1999-07-21
AR005969A1 (es) 1999-07-21
CA2246721A1 (en) 1997-08-28
JP2000505455A (ja) 2000-05-09
IL125863A (en) 2000-10-31
DK0791591T3 (da) 2001-10-08
PT791591E (pt) 2001-12-28
TR199801612T2 (xx) 1998-11-23
WO1997030709A1 (en) 1997-08-28
ES2162196T3 (es) 2001-12-16
IL125863A0 (en) 1999-04-11
YU6797A (sh) 1999-09-27
NO983802L (no) 1998-08-19
ATE204869T1 (de) 2001-09-15
BR9707657A (pt) 1999-07-27
NO983802D0 (no) 1998-08-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee