JP2005536448A5 - - Google Patents
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- JP2005536448A5 JP2005536448A5 JP2003545613A JP2003545613A JP2005536448A5 JP 2005536448 A5 JP2005536448 A5 JP 2005536448A5 JP 2003545613 A JP2003545613 A JP 2003545613A JP 2003545613 A JP2003545613 A JP 2003545613A JP 2005536448 A5 JP2005536448 A5 JP 2005536448A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- optionally substituted
- oxide
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 tetranylyl Chemical group 0.000 claims 486
- 125000001424 substituent group Chemical group 0.000 claims 171
- 125000000753 cycloalkyl group Chemical group 0.000 claims 79
- 229910052739 hydrogen Inorganic materials 0.000 claims 70
- 125000000217 alkyl group Chemical group 0.000 claims 57
- 229910052717 sulfur Inorganic materials 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 39
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 37
- 229910052801 chlorine Inorganic materials 0.000 claims 35
- 229910052731 fluorine Inorganic materials 0.000 claims 35
- 229910052736 halogen Inorganic materials 0.000 claims 35
- 150000002367 halogens Chemical class 0.000 claims 35
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 34
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 33
- 125000004600 benzothiopyranyl group Chemical group S1C(C=CC2=C1C=CC=C2)* 0.000 claims 32
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 32
- 229910052799 carbon Inorganic materials 0.000 claims 29
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 26
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 22
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 22
- 125000002883 imidazolyl group Chemical group 0.000 claims 22
- 125000002757 morpholinyl group Chemical group 0.000 claims 22
- 125000004193 piperazinyl group Chemical group 0.000 claims 22
- 125000003386 piperidinyl group Chemical group 0.000 claims 22
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 22
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 125000003226 pyrazolyl group Chemical group 0.000 claims 21
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 20
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 claims 20
- 125000005956 isoquinolyl group Chemical group 0.000 claims 20
- 125000001544 thienyl group Chemical group 0.000 claims 20
- 125000000168 pyrrolyl group Chemical group 0.000 claims 19
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 19
- 125000003831 tetrazolyl group Chemical group 0.000 claims 19
- 125000004429 atom Chemical group 0.000 claims 17
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 17
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 17
- 125000002971 oxazolyl group Chemical group 0.000 claims 17
- 125000004076 pyridyl group Chemical group 0.000 claims 17
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 17
- 125000000335 thiazolyl group Chemical group 0.000 claims 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 16
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 16
- 125000001041 indolyl group Chemical group 0.000 claims 16
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 16
- 125000000842 isoxazolyl group Chemical group 0.000 claims 16
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 16
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 16
- 125000003373 pyrazinyl group Chemical group 0.000 claims 16
- 125000002098 pyridazinyl group Chemical group 0.000 claims 16
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 16
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 16
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 16
- 125000001425 triazolyl group Chemical group 0.000 claims 16
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 15
- 125000005990 isobenzothienyl group Chemical group 0.000 claims 15
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 15
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 14
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 14
- 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 claims 14
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 14
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 14
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 14
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 14
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 14
- 125000001786 isothiazolyl group Chemical group 0.000 claims 14
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 claims 14
- 125000001644 phenoxazinyl group Chemical group C1(=CC=CC=2OC3=CC=CC=C3NC12)* 0.000 claims 14
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims 14
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 14
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 14
- 125000005958 tetrahydrothienyl group Chemical group 0.000 claims 14
- 125000004306 triazinyl group Chemical group 0.000 claims 14
- 125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 claims 14
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 claims 13
- 125000005992 dihydrobenzisothiazinyl group Chemical group 0.000 claims 13
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 13
- 125000003151 isocoumarinyl group Chemical group C1(=O)OC(=CC2=CC=CC=C12)* 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 13
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 12
- 125000005046 dihydronaphthyl group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000004620 quinolinyl-N-oxide group Chemical group 0.000 claims 12
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 12
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 11
- 125000002541 furyl group Chemical group 0.000 claims 11
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 10
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 10
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 10
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 10
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 10
- 125000003384 isochromanyl group Chemical group C1(OCCC2=CC=CC=C12)* 0.000 claims 10
- 125000005993 dihydrobenzisoxazinyl group Chemical group 0.000 claims 9
- 230000014509 gene expression Effects 0.000 claims 9
- 125000005995 isobenzotetrahydrothienyl group Chemical group 0.000 claims 9
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 9
- 125000001624 naphthyl group Chemical group 0.000 claims 8
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 claims 7
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 7
- 125000005051 dihydropyrazinyl group Chemical group N1(CC=NC=C1)* 0.000 claims 7
- 125000005052 dihydropyrazolyl group Chemical group N1(NCC=C1)* 0.000 claims 7
- 125000004655 dihydropyridinyl group Chemical group N1(CC=CC=C1)* 0.000 claims 7
- 125000005053 dihydropyrimidinyl group Chemical group N1(CN=CC=C1)* 0.000 claims 7
- 125000005054 dihydropyrrolyl group Chemical group [H]C1=C([H])C([H])([H])C([H])([H])N1* 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 6
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 5
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 3
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 208000027061 mild cognitive impairment Diseases 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 2
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 claims 2
- 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims 2
- 125000005466 alkylenyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 1
- NEGMMKYAVYNLCG-UHFFFAOYSA-N 5-ethyl-1-methyl-5-phenylimidazolidine-2,4-dione Chemical compound C=1C=CC=CC=1C1(CC)N(C)C(=O)NC1=O NEGMMKYAVYNLCG-UHFFFAOYSA-N 0.000 claims 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims 1
- 102100036238 Dihydropyrimidinase Human genes 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000032843 Hemorrhage Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 125000002785 azepinyl group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 108091022884 dihydropyrimidinase Proteins 0.000 claims 1
- 125000005994 isobenzotetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000005487 naphthalate group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000002739 subcortical effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 0 *CC(C(C(*)N(*)N)O)O Chemical compound *CC(C(C(*)N(*)N)O)O 0.000 description 4
- FTUQYVKZURNABV-UOCPRXARSA-N CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)C([C@@H](COC2CCCCC2)O)O)=O)c1)=O Chemical compound CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)C([C@@H](COC2CCCCC2)O)O)=O)c1)=O FTUQYVKZURNABV-UOCPRXARSA-N 0.000 description 1
- RZRMXSHIYDXONN-CONSDPRKSA-N CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)[C@H](CCOCc2ccccc2)O)=O)c1)=O Chemical compound CCCN(CCC)C(c1cc(C)cc(C(N[C@@H](Cc2cc(F)cc(F)c2)[C@H](CCOCc2ccccc2)O)=O)c1)=O RZRMXSHIYDXONN-CONSDPRKSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33308101P | 2001-11-19 | 2001-11-19 | |
| US33400001P | 2001-11-28 | 2001-11-28 | |
| US36275202P | 2002-03-08 | 2002-03-08 | |
| PCT/US2002/036999 WO2003043975A1 (en) | 2001-11-19 | 2002-11-19 | Amine 1,2- and 1,3-diol compounds and their use for treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536448A JP2005536448A (ja) | 2005-12-02 |
| JP2005536448A5 true JP2005536448A5 (enExample) | 2006-01-19 |
Family
ID=27406892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545613A Pending JP2005536448A (ja) | 2001-11-19 | 2002-11-19 | アミン１，２−及び１，３−ジオール化合物、及びアルツハイマー病を治療するためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7388118B2 (enExample) |
| EP (1) | EP1453792B1 (enExample) |
| JP (1) | JP2005536448A (enExample) |
| AT (1) | ATE359995T1 (enExample) |
| AU (1) | AU2002362008A1 (enExample) |
| BR (1) | BR0214293A (enExample) |
| CA (1) | CA2467798A1 (enExample) |
| DE (1) | DE60219680T2 (enExample) |
| ES (1) | ES2284970T3 (enExample) |
| MX (1) | MXPA04004771A (enExample) |
| WO (1) | WO2003043975A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007516207A (ja) * | 2003-06-30 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療のためのＮ−アルキルフェニルカルボキサミドβ−セクレターゼ阻害剤 |
| ITPD20040151A1 (it) * | 2004-06-15 | 2004-09-15 | Univ Degli Studi Trieste | Inibitori peptidomimetici di proteasi retrovirali e loro uso come antivirali |
| WO2010107384A1 (en) * | 2009-03-19 | 2010-09-23 | Medivir Ab | Aspartyl protease inhibitors |
| EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CA2988968A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4864017A (en) | 1986-09-05 | 1989-09-05 | The Upjohn Company | Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert |
| JP2003528071A (ja) * | 2000-03-23 | 2003-09-24 | エラン ファーマスーティカルズ インコーポレイテッド | アルツハイマー病治療用組成物および方法 |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| JP2004502665A (ja) * | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病を治療する化合物 |
| PE20020276A1 (es) * | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| WO2002100818A2 (en) * | 2001-06-13 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Aminediols as agents for the treatment of alzheimer's disease |
-
2002
- 2002-11-19 JP JP2003545613A patent/JP2005536448A/ja active Pending
- 2002-11-19 WO PCT/US2002/036999 patent/WO2003043975A1/en not_active Ceased
- 2002-11-19 DE DE60219680T patent/DE60219680T2/de not_active Expired - Fee Related
- 2002-11-19 AT AT02797133T patent/ATE359995T1/de not_active IP Right Cessation
- 2002-11-19 AU AU2002362008A patent/AU2002362008A1/en not_active Abandoned
- 2002-11-19 CA CA002467798A patent/CA2467798A1/en not_active Abandoned
- 2002-11-19 US US10/299,739 patent/US7388118B2/en not_active Expired - Fee Related
- 2002-11-19 BR BR0214293-7A patent/BR0214293A/pt not_active IP Right Cessation
- 2002-11-19 ES ES02797133T patent/ES2284970T3/es not_active Expired - Lifetime
- 2002-11-19 MX MXPA04004771A patent/MXPA04004771A/es active IP Right Grant
- 2002-11-19 EP EP02797133A patent/EP1453792B1/en not_active Expired - Lifetime
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