JP2005536220A5 - - Google Patents
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- Publication number
- JP2005536220A5 JP2005536220A5 JP2004531195A JP2004531195A JP2005536220A5 JP 2005536220 A5 JP2005536220 A5 JP 2005536220A5 JP 2004531195 A JP2004531195 A JP 2004531195A JP 2004531195 A JP2004531195 A JP 2004531195A JP 2005536220 A5 JP2005536220 A5 JP 2005536220A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonic anhydrase
- seq
- polypeptide
- antibody
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 42
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 42
- 238000000034 method Methods 0.000 claims 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 230000000694 effects Effects 0.000 claims 26
- 229920001184 polypeptide Polymers 0.000 claims 26
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 25
- 239000003795 chemical substances by application Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 21
- 108700012439 CA9 Proteins 0.000 claims 19
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 19
- 230000002401 inhibitory effect Effects 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 10
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 210000005170 neoplastic cell Anatomy 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims 4
- 108010043958 Peptoids Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 108050004689 Inhibitor of carbonic anhydrases Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40557702P | 2002-08-23 | 2002-08-23 | |
| US64693403A | 2003-08-22 | 2003-08-22 | |
| PCT/US2003/026612 WO2004017923A2 (en) | 2002-08-23 | 2003-08-25 | Compositions and methods of therapy for cancers characterized by expression of the tumor-associated antigen mn/ca ix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536220A JP2005536220A (ja) | 2005-12-02 |
| JP2005536220A5 true JP2005536220A5 (https=) | 2006-09-14 |
Family
ID=31949897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004531195A Withdrawn JP2005536220A (ja) | 2002-08-23 | 2003-08-25 | 腫瘍関連抗原ｍｎ／ｃａｉｘの発現に特徴付けられる癌のための治療組成物ならびに治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1576010A4 (https=) |
| JP (1) | JP2005536220A (https=) |
| AU (1) | AU2003268180A1 (https=) |
| CA (1) | CA2496572A1 (https=) |
| WO (1) | WO2004017923A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3031910T3 (en) | 2002-02-21 | 2017-10-23 | Inst Virology | MN / CA IX-SPECIFIC MONOCLONAL ANTIBODIES GENERATED BY MN / CA IX-DEFICIENT MOUSE AND METHODS OF USE |
| US7833734B2 (en) | 2002-11-26 | 2010-11-16 | Institute Of Virology Of The Slovak Academy Of Sciences | CA IX-specific inhibitors |
| DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| WO2008091798A2 (en) * | 2007-01-22 | 2008-07-31 | Xencor, Inc. | Optimized ca9 antibodies and methods of using the same |
| JP2011517313A (ja) * | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ，インク． | 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤 |
| WO2020226612A1 (en) * | 2019-05-06 | 2020-11-12 | Navi Bio-Therapeutics, Llc | Anti-carbonic anhydrase ix antibody |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955075A (en) * | 1992-03-11 | 1999-09-21 | Institute Of Virology, Slovak Academy Of Sciences | Method of inhibiting tumor growth using antibodies to MN protein |
| JP3910798B2 (ja) * | 1998-10-23 | 2007-04-25 | インスティトゥート オブ ヴァイロロジー | Ｍｎ遺伝子およびタンパク質 |
-
2003
- 2003-08-25 EP EP03749129A patent/EP1576010A4/en not_active Withdrawn
- 2003-08-25 AU AU2003268180A patent/AU2003268180A1/en not_active Abandoned
- 2003-08-25 JP JP2004531195A patent/JP2005536220A/ja not_active Withdrawn
- 2003-08-25 WO PCT/US2003/026612 patent/WO2004017923A2/en not_active Ceased
- 2003-08-25 CA CA002496572A patent/CA2496572A1/en not_active Abandoned
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