JP2005536220A5 - - Google Patents
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- Publication number
- JP2005536220A5 JP2005536220A5 JP2004531195A JP2004531195A JP2005536220A5 JP 2005536220 A5 JP2005536220 A5 JP 2005536220A5 JP 2004531195 A JP2004531195 A JP 2004531195A JP 2004531195 A JP2004531195 A JP 2004531195A JP 2005536220 A5 JP2005536220 A5 JP 2005536220A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonic anhydrase
- seq
- polypeptide
- antibody
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 42
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 42
- 238000000034 method Methods 0.000 claims 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 230000000694 effects Effects 0.000 claims 26
- 229920001184 polypeptide Polymers 0.000 claims 26
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 25
- 239000003795 chemical substances by application Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 21
- 108700012439 CA9 Proteins 0.000 claims 19
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 19
- 230000002401 inhibitory effect Effects 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 10
- 101000910338 Homo sapiens Carbonic anhydrase 9 Proteins 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 6
- 230000005764 inhibitory process Effects 0.000 claims 6
- 210000005170 neoplastic cell Anatomy 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims 4
- 108010043958 Peptoids Proteins 0.000 claims 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 108050004689 Inhibitor of carbonic anhydrases Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40557702P | 2002-08-23 | 2002-08-23 | |
| US64693403A | 2003-08-22 | 2003-08-22 | |
| PCT/US2003/026612 WO2004017923A2 (en) | 2002-08-23 | 2003-08-25 | Compositions and methods of therapy for cancers characterized by expression of the tumor-associated antigen mn/ca ix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536220A JP2005536220A (ja) | 2005-12-02 |
| JP2005536220A5 true JP2005536220A5 (enExample) | 2006-09-14 |
Family
ID=31949897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004531195A Withdrawn JP2005536220A (ja) | 2002-08-23 | 2003-08-25 | 腫瘍関連抗原ｍｎ／ｃａｉｘの発現に特徴付けられる癌のための治療組成物ならびに治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1576010A4 (enExample) |
| JP (1) | JP2005536220A (enExample) |
| AU (1) | AU2003268180A1 (enExample) |
| CA (1) | CA2496572A1 (enExample) |
| WO (1) | WO2004017923A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477163C (en) | 2002-02-21 | 2010-07-27 | Institute Of Virology | Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes |
| US7833734B2 (en) | 2002-11-26 | 2010-11-16 | Institute Of Virology Of The Slovak Academy Of Sciences | CA IX-specific inhibitors |
| DOP2006000277A (es) * | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| WO2008091798A2 (en) * | 2007-01-22 | 2008-07-31 | Xencor, Inc. | Optimized ca9 antibodies and methods of using the same |
| US20110015158A1 (en) * | 2007-12-11 | 2011-01-20 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
| EP3966253A4 (en) * | 2019-05-06 | 2023-02-22 | Navi Bio-Therapeutics, Inc. | ANTI-CARBONIC ANHYDRASE IX ANTIBODIES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955075A (en) * | 1992-03-11 | 1999-09-21 | Institute Of Virology, Slovak Academy Of Sciences | Method of inhibiting tumor growth using antibodies to MN protein |
| EP1123387B1 (en) * | 1998-10-23 | 2007-10-17 | Institute Of Virology | Mn gene and protein |
-
2003
- 2003-08-25 AU AU2003268180A patent/AU2003268180A1/en not_active Abandoned
- 2003-08-25 JP JP2004531195A patent/JP2005536220A/ja not_active Withdrawn
- 2003-08-25 CA CA002496572A patent/CA2496572A1/en not_active Abandoned
- 2003-08-25 EP EP03749129A patent/EP1576010A4/en not_active Withdrawn
- 2003-08-25 WO PCT/US2003/026612 patent/WO2004017923A2/en not_active Ceased
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