JP2005533075A5 - - Google Patents
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- Publication number
- JP2005533075A5 JP2005533075A5 JP2004514780A JP2004514780A JP2005533075A5 JP 2005533075 A5 JP2005533075 A5 JP 2005533075A5 JP 2004514780 A JP2004514780 A JP 2004514780A JP 2004514780 A JP2004514780 A JP 2004514780A JP 2005533075 A5 JP2005533075 A5 JP 2005533075A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- acid
- weight
- ethanimidylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 239000004067 bulking agent Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 208000003243 intestinal obstruction Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 150000004684 trihydrates Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0214147.1A GB0214147D0 (en) | 2002-06-19 | 2002-06-19 | Formulations |
| PCT/EP2003/006465 WO2004000296A1 (en) | 2002-06-19 | 2003-06-19 | (2s)-2amino-a-{[2-(ethanimidoylamino) ethyl]thio}butanoic acid, a nitric oxide synthase inhibitor, in stabilized pharmaceutical dosage forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533075A JP2005533075A (ja) | 2005-11-04 |
| JP2005533075A5 true JP2005533075A5 (enExample) | 2006-08-03 |
Family
ID=9938915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004514780A Pending JP2005533075A (ja) | 2002-06-19 | 2003-06-19 | 安定化された医薬製剤の一酸化窒素シンターゼ阻害剤（２ｓ）−２−アミノ−４−［２−（エタンイミドイルアミノ）エチル］チオブタン酸 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050222260A1 (enExample) |
| EP (1) | EP1513511A1 (enExample) |
| JP (1) | JP2005533075A (enExample) |
| AR (1) | AR039691A1 (enExample) |
| AU (1) | AU2003278958A1 (enExample) |
| GB (1) | GB0214147D0 (enExample) |
| TW (1) | TW200404766A (enExample) |
| WO (1) | WO2004000296A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004017514D1 (de) * | 2004-06-02 | 2008-12-11 | Galephar M F | Stabile orale pharmazeutische zusammensetzungen von buprenorphin und salz davon |
| WO2011052499A1 (ja) * | 2009-10-28 | 2011-05-05 | 第一三共株式会社 | 貯蔵安定性が改善された医薬組成物 |
| DE102011051304A1 (de) * | 2011-06-24 | 2012-12-27 | Hennig Arzneimittel Gmbh & Co. Kg | Wirkstoffmatrix |
| CN102908323B (zh) * | 2012-10-30 | 2015-03-04 | 天津红日药业股份有限公司 | 一种含有莫西沙星的药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957087B1 (en) * | 1994-06-15 | 2002-12-04 | The Wellcome Foundation Limited | Intermediates useful in the preparation of enzyme inhibitors |
| WO1996001128A2 (de) * | 1994-07-04 | 1996-01-18 | Schering Aktiengesellschaft | Niedrig dosierte steroidtabletten, die gallussäureester als antioxidans enthalten, verfahren zur herstellung und die verwendung |
| FR2753098B1 (fr) * | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| GB0031179D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
-
2002
- 2002-06-19 GB GBGB0214147.1A patent/GB0214147D0/en not_active Ceased
-
2003
- 2003-06-17 AR ARP030102145A patent/AR039691A1/es unknown
- 2003-06-17 TW TW092116417A patent/TW200404766A/zh unknown
- 2003-06-19 WO PCT/EP2003/006465 patent/WO2004000296A1/en not_active Ceased
- 2003-06-19 AU AU2003278958A patent/AU2003278958A1/en not_active Abandoned
- 2003-06-19 US US10/517,801 patent/US20050222260A1/en not_active Abandoned
- 2003-06-19 EP EP03740281A patent/EP1513511A1/en not_active Withdrawn
- 2003-06-19 JP JP2004514780A patent/JP2005533075A/ja active Pending
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