JP2005530732A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005530732A5 JP2005530732A5 JP2003584094A JP2003584094A JP2005530732A5 JP 2005530732 A5 JP2005530732 A5 JP 2005530732A5 JP 2003584094 A JP2003584094 A JP 2003584094A JP 2003584094 A JP2003584094 A JP 2003584094A JP 2005530732 A5 JP2005530732 A5 JP 2005530732A5
- Authority
- JP
- Japan
- Prior art keywords
- glp
- pharmaceutical composition
- composition according
- compound
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims description 12
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 11
- 101800004266 Glucagon-like peptide 1(7-37) Proteins 0.000 claims description 3
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims description 3
- 108010063245 glucagon-like peptide 1 (7-36)amide Proteins 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 11
- -1 GLP-1 compound Chemical class 0.000 claims 11
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims 3
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 claims 1
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 claims 1
- 108010011459 Exenatide Proteins 0.000 claims 1
- 102000007446 Glucagon-Like Peptide-1 Receptor Human genes 0.000 claims 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical group NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Chemical group 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 208000007542 Paresis Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229960001519 exenatide Drugs 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37165002P | 2002-04-10 | 2002-04-10 | |
| PCT/US2003/008457 WO2003087139A2 (en) | 2002-04-10 | 2003-03-27 | Treatment of gastroparesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530732A JP2005530732A (ja) | 2005-10-13 |
| JP2005530732A5 true JP2005530732A5 (OSRAM) | 2006-05-18 |
Family
ID=29250714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584094A Pending JP2005530732A (ja) | 2002-04-10 | 2003-03-27 | 胃不全麻痺の治療 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20050164925A1 (OSRAM) |
| EP (1) | EP1496924A4 (OSRAM) |
| JP (1) | JP2005530732A (OSRAM) |
| KR (1) | KR20040098063A (OSRAM) |
| CN (1) | CN1735423A (OSRAM) |
| AU (1) | AU2003220403A1 (OSRAM) |
| BR (1) | BR0308904A (OSRAM) |
| CA (1) | CA2480858A1 (OSRAM) |
| EA (1) | EA200401345A1 (OSRAM) |
| EC (1) | ECSP045345A (OSRAM) |
| HR (1) | HRP20040939A2 (OSRAM) |
| IL (1) | IL164266A0 (OSRAM) |
| MX (1) | MXPA04009929A (OSRAM) |
| NO (1) | NO20044815L (OSRAM) |
| NZ (1) | NZ535684A (OSRAM) |
| PL (1) | PL373658A1 (OSRAM) |
| WO (1) | WO2003087139A2 (OSRAM) |
| ZA (1) | ZA200408111B (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8666495B2 (en) | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
| US8792985B2 (en) | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| TW200526254A (en) * | 2003-09-19 | 2005-08-16 | Novo Nordisk As | Novel GLP-1 derivatives |
| EP1793891B1 (en) | 2004-08-18 | 2011-11-09 | Metacure Limited | Monitoring, analysis, and regulation of eating habits |
| US9339190B2 (en) | 2005-02-17 | 2016-05-17 | Metacure Limited | Charger with data transfer capabilities |
| US9821158B2 (en) | 2005-02-17 | 2017-11-21 | Metacure Limited | Non-immediate effects of therapy |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| MX2007011307A (es) | 2005-03-18 | 2007-10-08 | Novo Nordisk As | Compuestos de glp-1 extendidos. |
| US8463404B2 (en) | 2005-03-24 | 2013-06-11 | Metacure Limited | Electrode assemblies, tools, and methods for gastric wall implantation |
| US8265758B2 (en) * | 2005-03-24 | 2012-09-11 | Metacure Limited | Wireless leads for gastrointestinal tract applications |
| US8301256B2 (en) | 2005-06-02 | 2012-10-30 | Metacure Limited | GI lead implantation |
| US8442841B2 (en) * | 2005-10-20 | 2013-05-14 | Matacure N.V. | Patient selection method for assisting weight loss |
| US8295932B2 (en) | 2005-12-05 | 2012-10-23 | Metacure Limited | Ingestible capsule for appetite regulation |
| AU2012203915B9 (en) * | 2006-04-20 | 2014-10-09 | Amgen Inc. | GLP-1 compounds |
| CA2800389A1 (en) * | 2006-04-20 | 2007-11-01 | Amgen Inc. | Glp-1 compounds |
| EP2150308B1 (en) * | 2007-05-09 | 2018-08-08 | MetaCure Limited | Analysis and regulation of food intake |
| US8423130B2 (en) * | 2008-05-09 | 2013-04-16 | Metacure Limited | Optimization of thresholds for eating detection |
| US8865868B2 (en) | 2008-08-06 | 2014-10-21 | Novo Nordisk Healthcare Ag | Conjugated proteins with prolonged in vivo efficacy |
| JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| EP2461831B1 (en) | 2009-08-06 | 2018-11-21 | Novo Nordisk Health Care AG | Growth hormones with prolonged in-vivo efficacy |
| EP2482840A4 (en) * | 2009-08-07 | 2013-06-26 | Mannkind Corp | VAL (8) GLP-1 COMPOSITION AND METHOD FOR THE TREATMENT OF REAGENTS AND / OR IRRITATION SYNDROME |
| CN118767115A (zh) | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
| WO2011092710A2 (en) * | 2010-02-01 | 2011-08-04 | Metacure Limited | Gastrointestinal electrical therapy |
| JP5827218B2 (ja) | 2010-04-30 | 2015-12-02 | 株式会社三和化学研究所 | 生理活性物質等の生体内安定性向上のためのペプチド及び生体内安定性が向上した生理活性物質 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HRP20181300T1 (hr) | 2012-12-21 | 2018-10-05 | Sanofi | Derivati eksendina-4 kao dvostruki glp1/gip- ili trostruki glp1/gip/glukagon agonisti |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| JP2002510193A (ja) * | 1997-03-31 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | グルカゴン様ペプチド−１類似体 |
| IL142707A0 (en) * | 2000-04-27 | 2002-03-10 | Pfizer Prod Inc | Methods of treating obesity using a neurotensin receptor ligand |
-
2003
- 2003-03-27 NZ NZ535684A patent/NZ535684A/xx unknown
- 2003-03-27 US US10/508,762 patent/US20050164925A1/en not_active Abandoned
- 2003-03-27 IL IL16426603A patent/IL164266A0/xx unknown
- 2003-03-27 AU AU2003220403A patent/AU2003220403A1/en not_active Abandoned
- 2003-03-27 CN CNA038080079A patent/CN1735423A/zh active Pending
- 2003-03-27 BR BR0308904-5A patent/BR0308904A/pt not_active IP Right Cessation
- 2003-03-27 HR HRP20040939 patent/HRP20040939A2/hr not_active Application Discontinuation
- 2003-03-27 KR KR10-2004-7016025A patent/KR20040098063A/ko not_active Ceased
- 2003-03-27 MX MXPA04009929A patent/MXPA04009929A/es not_active Application Discontinuation
- 2003-03-27 EA EA200401345A patent/EA200401345A1/ru unknown
- 2003-03-27 CA CA002480858A patent/CA2480858A1/en not_active Abandoned
- 2003-03-27 PL PL03373658A patent/PL373658A1/xx unknown
- 2003-03-27 EP EP03716707A patent/EP1496924A4/en not_active Withdrawn
- 2003-03-27 JP JP2003584094A patent/JP2005530732A/ja active Pending
- 2003-03-27 WO PCT/US2003/008457 patent/WO2003087139A2/en not_active Ceased
-
2004
- 2004-10-07 ZA ZA200408111A patent/ZA200408111B/xx unknown
- 2004-10-08 EC EC2004005345A patent/ECSP045345A/es unknown
- 2004-11-05 NO NO20044815A patent/NO20044815L/no unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005530732A5 (OSRAM) | ||
| US20240376175A1 (en) | Novel GLP-1 Analogues | |
| JP2007001987A5 (OSRAM) | ||
| ES2444622T3 (es) | Derivado peptídico insulinotrópico en el que se ha modificado su aminoácido N-terminal | |
| CN102711804B (zh) | 包含glp-1激动剂和甲硫氨酸的药物组合物 | |
| RU2485135C2 (ru) | Соединения оксинтомодулина (варианты), фармацевтическая композиция на их основе, способы лечения и профилактики ожирения и сопутствующих заболеваний (варианты) и лекарственное средство (варианты) | |
| TW202415675A (zh) | 腸促胰島素(incretin)類似物及其用途 | |
| JP2002526454A5 (OSRAM) | ||
| JP2007523881A5 (OSRAM) | ||
| PT1143989E (pt) | Exendinas para supressão de glucagon | |
| DK0512042T3 (da) | GLP-1-analoger anvendelige ved diabetesbehandling | |
| RU2007134156A (ru) | Ацилированные glp-1 соединения | |
| CN108271356A (zh) | 肠降血糖素-胰岛素缀合物 | |
| AU2015349743B2 (en) | ELP fusion proteins for controlled and sustained release | |
| TWI353250B (en) | Glp-1 pharmaceutical compositions | |
| JP2015528795A5 (OSRAM) | ||
| US20180280480A1 (en) | Compositions and peptides having dual glp-1r and glp-2r agonist activity | |
| RU2752787C1 (ru) | Пептидный аналог ацилированного оксинтомодулина | |
| KR20230146040A (ko) | 글루카곤 유사 펩타이드-1 수용체 길항물질 | |
| WO2017200944A1 (en) | Glucagon receptor/glp-1 receptor selective analog polypeptides and methods of use thereof | |
| WO2015180634A1 (zh) | 用于治疗2型糖尿病的长效肠激素多肽类似物及应用 | |
| US20240058422A1 (en) | Glucagon-like peptide-1 receptor antagonists | |
| RU2008129731A (ru) | Новые пептиды-т-хелперные антигенные детерминанты (thd) |