JP2005530515A5 - - Google Patents
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- Publication number
- JP2005530515A5 JP2005530515A5 JP2004517874A JP2004517874A JP2005530515A5 JP 2005530515 A5 JP2005530515 A5 JP 2005530515A5 JP 2004517874 A JP2004517874 A JP 2004517874A JP 2004517874 A JP2004517874 A JP 2004517874A JP 2005530515 A5 JP2005530515 A5 JP 2005530515A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleolin
- parp
- detecting
- kit
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 35
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 20
- 102100021010 Nucleolin Human genes 0.000 claims 14
- 108091034117 Oligonucleotide Proteins 0.000 claims 14
- 108010044762 nucleolin Proteins 0.000 claims 14
- 108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 claims 11
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 claims 11
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 10
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 10
- 229940029575 guanosine Drugs 0.000 claims 10
- 238000001514 detection method Methods 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 230000006907 apoptotic process Effects 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 239000003104 tissue culture media Substances 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000037906 ischaemic injury Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39214302P | 2002-06-26 | 2002-06-26 | |
| PCT/US2003/020167 WO2004003554A1 (en) | 2002-06-26 | 2003-06-26 | A method for the detection of apoptosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530515A JP2005530515A (ja) | 2005-10-13 |
| JP2005530515A5 true JP2005530515A5 (https=) | 2006-08-10 |
Family
ID=30000819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004517874A Pending JP2005530515A (ja) | 2002-06-26 | 2003-06-26 | アポトーシスの検出方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040132049A1 (https=) |
| EP (1) | EP1516186B1 (https=) |
| JP (1) | JP2005530515A (https=) |
| AT (1) | ATE458196T1 (https=) |
| AU (2) | AU2003248724A1 (https=) |
| CA (1) | CA2489520A1 (https=) |
| DE (1) | DE60331310D1 (https=) |
| WO (1) | WO2004003554A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| EP1181304B1 (en) * | 1999-04-08 | 2007-10-10 | Antisoma Research Limited | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
| US7960540B2 (en) * | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US20110178161A1 (en) * | 1999-04-08 | 2011-07-21 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
| US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| KR20050114217A (ko) * | 2003-02-21 | 2005-12-05 | 메드벳 싸이언스 피티와이. 리미티드 | 진단 및 치료 방법 |
| EP2008102A4 (en) * | 2006-04-18 | 2009-07-08 | Wellstat Biologics Corp | DETECTION OF PROTEINS IN NEOPLASTIC CELLS IN CIRCULATION |
| US20080187894A1 (en) * | 2006-12-14 | 2008-08-07 | Cady Roger K | Method and System for Interactive Cognitive Testing |
| US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
| JP4924415B2 (ja) * | 2007-12-28 | 2012-04-25 | 株式会社日立プラントテクノロジー | アポトーシス検出方法及び装置 |
| WO2009088837A2 (en) * | 2007-12-31 | 2009-07-16 | The University Of Louisville Research Foundation, Inc. | Methods and products to target, capture and characterize stem cells |
| CN102770529B (zh) | 2009-11-17 | 2018-06-05 | Musc研究发展基金会 | 针对人核仁素的人单克隆抗体 |
| US20130052647A1 (en) * | 2010-02-10 | 2013-02-28 | Marianna Goldrick | Methods for fractionating and processing microparticles from biological samples and using them for biomarker discovery |
| ES2572915T3 (es) | 2011-06-02 | 2016-06-03 | The University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
| UA105278C2 (ru) | 2012-09-06 | 2014-04-25 | Інститут Біології Клітини Нан України | Способ получения каталитически активных антител (абзимов) с сиалидазной активностью |
| CA3020885A1 (en) | 2015-05-05 | 2016-11-10 | Mohammad Tariq MALIK | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents |
| CN111579538B (zh) * | 2020-04-22 | 2022-12-30 | 山东第一医科大学(山东省医学科学院) | 一种利用凋亡试剂盒检测循环肿瘤细胞的方法 |
| CN117054200B (zh) * | 2023-07-21 | 2024-11-26 | 伊莱瑞特(武汉)生物技术有限公司 | 用于流式细胞术分析凋亡细胞的tunel专用固定破膜剂及其制备方法与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4474892A (en) * | 1983-02-16 | 1984-10-02 | Board Of Trustees Of The Leland Stanford Junior University | Two-site immunoassays using monoclonal antibodies of different classes or subclasses and test kits for performing same |
| US5169774A (en) * | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
| US4665897A (en) * | 1984-05-25 | 1987-05-19 | Lemelson Jerome H | Composition and method for detecting and treating cancer |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5192660A (en) * | 1989-04-24 | 1993-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | ELISA methods for the determination of human platelet derived growth factor (PDGF) dimer forms present in human tissues and fluids |
| US6020145A (en) * | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| AU635008B2 (en) * | 1989-12-13 | 1993-03-11 | Genelabs Diagnostics Pte Ltd | Analytical apparatus and method for automated blot assay |
| US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5736348A (en) * | 1990-11-28 | 1998-04-07 | Fundacao Oswaldo Cruz (Fiocruz) | Method for the immunological diagnosis of Chagas' Disease using recombinant antigens |
| US5691447A (en) * | 1995-03-24 | 1997-11-25 | Tanox Biosystems, Inc. | GC1q receptor, HIV-1 gp120 region binding thereto, and related peptides and targeting antibodies |
| US6096532A (en) * | 1995-06-07 | 2000-08-01 | Aastrom Biosciences, Inc. | Processor apparatus for use in a system for maintaining and growing biological cells |
| US6048703A (en) * | 1996-11-15 | 2000-04-11 | Cephalon, Inc. | Methods for detecting cell apoptosis |
| EP1007669A1 (en) * | 1997-03-12 | 2000-06-14 | Institut Pasteur | A novel cell surface receptor for hiv retroviruses, therapeutic and diagnostic uses |
| CA2293724C (en) * | 1997-06-05 | 2010-02-02 | Xiaodong Wang | Apaf-1, the ced-4 human homolog, an activator of caspase-3 |
| EP1958962A3 (en) * | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| US6339075B1 (en) * | 1997-06-30 | 2002-01-15 | The University Of British Columbia | Use of dextran and other polysaccharides to improve mucus clearance |
| WO1999006588A1 (en) * | 1997-08-04 | 1999-02-11 | The Burnham Institute | A cell-free system of mitochondria-dependent apoptosis, and methods of use thereof |
| US6325785B1 (en) * | 1997-08-14 | 2001-12-04 | Sherwood Services Ag | Sputum trap manifold with nested caps |
| US5925334A (en) * | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| US5932475A (en) * | 1997-12-12 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human nucleolin-like protein |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6306404B1 (en) * | 1998-07-14 | 2001-10-23 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
| US6350452B1 (en) * | 1998-09-24 | 2002-02-26 | Promega Corporation | Apoptosis marker antibodies and methods of use |
| WO2000063250A1 (en) * | 1999-04-15 | 2000-10-26 | Merck Frosst Canada & Co. | Antibodies that recognize app cleaved by caspases and methods of use |
| ATE365327T1 (de) * | 1999-11-08 | 2007-07-15 | Eisai Co Ltd | Verfahren zum nachweis von zelltod mittels cytochrom c. |
| US20020028488A1 (en) * | 2000-06-19 | 2002-03-07 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
| US7541150B2 (en) * | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
| US7357928B2 (en) * | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
| US20110011002A1 (en) * | 2006-01-17 | 2011-01-20 | Christian Guillemette | Semi-removable window frame assembly |
| EP2437653B1 (en) * | 2009-10-21 | 2014-07-23 | Health Research, INC. | Paa nanoparticles for enhancement of tumor imaging |
-
2003
- 2003-06-26 JP JP2004517874A patent/JP2005530515A/ja active Pending
- 2003-06-26 EP EP03762073A patent/EP1516186B1/en not_active Expired - Lifetime
- 2003-06-26 AU AU2003248724A patent/AU2003248724A1/en not_active Abandoned
- 2003-06-26 DE DE60331310T patent/DE60331310D1/de not_active Expired - Lifetime
- 2003-06-26 US US10/607,455 patent/US20040132049A1/en not_active Abandoned
- 2003-06-26 AT AT03762073T patent/ATE458196T1/de not_active IP Right Cessation
- 2003-06-26 CA CA002489520A patent/CA2489520A1/en not_active Abandoned
- 2003-06-26 WO PCT/US2003/020167 patent/WO2004003554A1/en not_active Ceased
-
2009
- 2009-10-22 US US12/604,212 patent/US20110065121A1/en not_active Abandoned
-
2010
- 2010-05-25 AU AU2010202118A patent/AU2010202118A1/en not_active Withdrawn
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