JP2005520832A5 - - Google Patents
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- Publication number
- JP2005520832A5 JP2005520832A5 JP2003576433A JP2003576433A JP2005520832A5 JP 2005520832 A5 JP2005520832 A5 JP 2005520832A5 JP 2003576433 A JP2003576433 A JP 2003576433A JP 2003576433 A JP2003576433 A JP 2003576433A JP 2005520832 A5 JP2005520832 A5 JP 2005520832A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- general formula
- group
- methyl
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- 239000011737 fluorine Substances 0.000 claims 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- -1 hydroxy, methyl Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 3
- 150000001450 anions Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 206010040741 Sinus bradycardia Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 238000007915 intraurethral administration Methods 0.000 claims 1
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000013312 porous aromatic framework Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000021 stimulant Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims 1
- 210000001186 vagus nerve Anatomy 0.000 claims 1
- 0 CN(*)C=C1N(*)C2[C@]1*2 Chemical compound CN(*)C=C1N(*)C2[C@]1*2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10211700A DE10211700A1 (de) | 2002-03-16 | 2002-03-16 | Neue Difurylglykolsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| PCT/EP2003/002418 WO2003078428A1 (de) | 2002-03-16 | 2003-03-10 | Difurylglykolsäuretropenolester, als anticholinergika |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005520832A JP2005520832A (ja) | 2005-07-14 |
| JP2005520832A5 true JP2005520832A5 (https=) | 2006-04-27 |
Family
ID=27771378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003576433A Pending JP2005520832A (ja) | 2002-03-16 | 2003-03-10 | 抗コリンエステラーゼ薬として使用するジフリルグリコール酸トロペノールエステル |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1487831B1 (https=) |
| JP (1) | JP2005520832A (https=) |
| AT (1) | ATE341547T1 (https=) |
| AU (1) | AU2003208703A1 (https=) |
| CA (1) | CA2476746A1 (https=) |
| DE (2) | DE10211700A1 (https=) |
| ES (1) | ES2272947T3 (https=) |
| WO (1) | WO2003078428A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005037280A1 (en) * | 2003-10-14 | 2005-04-28 | Glaxo Group Limited | Muscarinic acetycholine receptor antagonists |
| US20080027094A1 (en) * | 2004-08-30 | 2008-01-31 | Ono Pharmaceutical Co., Ltd. | Tropane Compounds and Pharmaceutical Compositions Comprising the Same as an Active Ingredient |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
-
2002
- 2002-03-16 DE DE10211700A patent/DE10211700A1/de not_active Withdrawn
-
2003
- 2003-03-10 ES ES03706609T patent/ES2272947T3/es not_active Expired - Lifetime
- 2003-03-10 DE DE50305263T patent/DE50305263D1/de not_active Expired - Lifetime
- 2003-03-10 CA CA002476746A patent/CA2476746A1/en not_active Abandoned
- 2003-03-10 WO PCT/EP2003/002418 patent/WO2003078428A1/de not_active Ceased
- 2003-03-10 AT AT03706609T patent/ATE341547T1/de active
- 2003-03-10 AU AU2003208703A patent/AU2003208703A1/en not_active Abandoned
- 2003-03-10 JP JP2003576433A patent/JP2005520832A/ja active Pending
- 2003-03-10 EP EP03706609A patent/EP1487831B1/de not_active Expired - Lifetime
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