JP2005518379A5 - - Google Patents
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- Publication number
- JP2005518379A5 JP2005518379A5 JP2003552769A JP2003552769A JP2005518379A5 JP 2005518379 A5 JP2005518379 A5 JP 2005518379A5 JP 2003552769 A JP2003552769 A JP 2003552769A JP 2003552769 A JP2003552769 A JP 2003552769A JP 2005518379 A5 JP2005518379 A5 JP 2005518379A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- heteroaryl
- lower alkyl
- group
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 10
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 150000002466 imines Chemical class 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 239000003909 protein kinase inhibitor Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10161940A DE10161940A1 (de) | 2001-12-17 | 2001-12-17 | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
| PCT/EP2002/013753 WO2003051887A1 (en) | 2001-12-17 | 2002-12-04 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005518379A JP2005518379A (ja) | 2005-06-23 |
| JP2005518379A5 true JP2005518379A5 (cg-RX-API-DMAC10.html) | 2006-01-26 |
Family
ID=7709523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552769A Pending JP2005518379A (ja) | 2001-12-17 | 2002-12-04 | プロテインキナーゼ阻害剤としてのｎ−炭素環式単置換インドロカルバゾール |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7262215B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1456211A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2005518379A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2002356625A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2467780A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE10161940A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2003051887A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122526B2 (en) * | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
| CL2007003693A1 (es) | 2006-12-22 | 2008-06-27 | Actelion Pharmaceuticals Ltd | Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas. |
| US20100273769A1 (en) * | 2009-01-26 | 2010-10-28 | Hanno Roder | Composition and method for the treatment of parkinson's disease |
| CN102557967A (zh) * | 2011-12-28 | 2012-07-11 | 合肥科尚医药科技有限公司 | 一种盐酸氨溴索的制备方法 |
| CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
| CN117886799B (zh) * | 2024-01-11 | 2025-07-29 | 浙江工业大学 | 一类靶向降解GSK-3β的蛋白降解靶向嵌合体化合物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
| ATE175873T1 (de) * | 1992-03-20 | 1999-02-15 | Wellcome Found | Weitere indolderivate mit antiviraler wirkung |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
| GB9416467D0 (en) * | 1994-08-13 | 1994-10-05 | Wellcome Found | Compounds for use in medicine |
| CN1285836A (zh) * | 1997-12-31 | 2001-02-28 | 赛福伦公司 | 3′－差向异构的K－252a衍生物 |
| US6013646A (en) * | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US7122526B2 (en) * | 2000-10-31 | 2006-10-17 | Nanosphere, Inc. | Indolocarbazole anticancer agents and methods of using same |
| WO2003022861A1 (en) * | 2001-09-13 | 2003-03-20 | Bristol-Myers Squibb Company | Process for the preparation of rebeccamycin and analogs thereof |
-
2001
- 2001-12-17 DE DE10161940A patent/DE10161940A1/de not_active Withdrawn
-
2002
- 2002-12-04 CA CA002467780A patent/CA2467780A1/en not_active Abandoned
- 2002-12-04 JP JP2003552769A patent/JP2005518379A/ja active Pending
- 2002-12-04 AU AU2002356625A patent/AU2002356625A1/en not_active Abandoned
- 2002-12-04 WO PCT/EP2002/013753 patent/WO2003051887A1/en not_active Ceased
- 2002-12-04 EP EP02804874A patent/EP1456211A1/en not_active Withdrawn
- 2002-12-04 US US10/496,505 patent/US7262215B2/en not_active Expired - Fee Related
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