JP2005518344A5 - - Google Patents
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- Publication number
- JP2005518344A5 JP2005518344A5 JP2003536383A JP2003536383A JP2005518344A5 JP 2005518344 A5 JP2005518344 A5 JP 2005518344A5 JP 2003536383 A JP2003536383 A JP 2003536383A JP 2003536383 A JP2003536383 A JP 2003536383A JP 2005518344 A5 JP2005518344 A5 JP 2005518344A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- binding protein
- polypeptide
- residues
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32883501P | 2001-10-15 | 2001-10-15 | |
| US34188101P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/032717 WO2003033653A2 (en) | 2001-10-15 | 2002-10-15 | Affinity enhancement agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518344A JP2005518344A (ja) | 2005-06-23 |
| JP2005518344A5 true JP2005518344A5 (cg-RX-API-DMAC10.html) | 2006-01-05 |
| JP4443923B2 JP4443923B2 (ja) | 2010-03-31 |
Family
ID=26986533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003536383A Expired - Fee Related JP4443923B2 (ja) | 2001-10-15 | 2002-10-15 | 親和性向上剤 |
Country Status (13)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US6346454B1 (en) * | 1999-01-12 | 2002-02-12 | Agere Systems Guardian Corp. | Method of making dual damascene interconnect structure and metal electrode capacitor |
| US20040018557A1 (en) * | 2002-03-01 | 2004-01-29 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| US20050003403A1 (en) * | 2003-04-22 | 2005-01-06 | Rossi Edmund A. | Polyvalent protein complex |
| CA2531118C (en) * | 2003-07-01 | 2013-01-08 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
| CN101171034B (zh) | 2005-03-03 | 2014-06-18 | 免疫医疗公司 | 人源化l243抗体 |
| AU2009239491B2 (en) | 2008-04-21 | 2014-07-17 | Lawrence Livermore National Security, Llc | Selective high-affinity polydentate ligands and methods of making such |
| US9050375B2 (en) * | 2009-07-06 | 2015-06-09 | Hoffmann-La Roche, Inc. | Bi-specific digoxigenin binding antibodies |
| US9264453B2 (en) | 2013-11-08 | 2016-02-16 | At&T Mobility Ii Llc | Front end processor for short message service centers |
| AU2024233139A1 (en) * | 2023-03-03 | 2025-08-28 | Oncoone Research & Development Gmbh | Improved bispecific anti-tumor antigen/anti-hsg antibodies for pre-targeting of hyperproliferative disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6027725A (en) * | 1991-11-25 | 2000-02-22 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US6096289A (en) * | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
| CA2145278C (en) * | 1992-09-25 | 2009-03-10 | Commonwealth Scientific And Industrial Research Organisation | Target binding polypeptide |
| ATE199392T1 (de) * | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5874540A (en) * | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
| US5989830A (en) * | 1995-10-16 | 1999-11-23 | Unilever Patent Holdings Bv | Bifunctional or bivalent antibody fragment analogue |
| US6254868B1 (en) * | 1996-03-20 | 2001-07-03 | Immunomedics, Inc. | Glycosylated humanized B-cell specific antibodies |
| WO1997038102A1 (en) * | 1996-04-04 | 1997-10-16 | Unilever Plc | Multivalent and multispecific antigen-binding protein |
| US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| US7074405B1 (en) * | 1998-06-22 | 2006-07-11 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
| PL372144A1 (en) * | 2001-12-26 | 2005-07-11 | Immunomedics, Inc. | Methods of generating multispecific, multivalent agents from v sb h /sb and v sb l /sb domains |
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2002
- 2002-10-15 IL IL16141702A patent/IL161417A0/xx unknown
- 2002-10-15 BR BRPI0213284-2A patent/BR0213284A/pt not_active IP Right Cessation
- 2002-10-15 KR KR1020047005675A patent/KR101027889B1/ko not_active Expired - Fee Related
- 2002-10-15 PL PL02374426A patent/PL374426A1/xx unknown
- 2002-10-15 EP EP02770573.0A patent/EP1444267B1/en not_active Expired - Lifetime
- 2002-10-15 JP JP2003536383A patent/JP4443923B2/ja not_active Expired - Fee Related
- 2002-10-15 US US10/270,071 patent/US20030113333A1/en not_active Abandoned
- 2002-10-15 RU RU2004114878/13A patent/RU2004114878A/ru not_active Application Discontinuation
- 2002-10-15 CA CA2463616A patent/CA2463616C/en not_active Expired - Fee Related
- 2002-10-15 CN CNA028250710A patent/CN1604910A/zh active Pending
- 2002-10-15 AU AU2002335808A patent/AU2002335808B2/en not_active Ceased
- 2002-10-15 WO PCT/US2002/032717 patent/WO2003033653A2/en not_active Ceased
- 2002-10-15 MX MXPA04003533A patent/MXPA04003533A/es not_active Application Discontinuation