JP2005516916A5 - - Google Patents
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- Publication number
- JP2005516916A5 JP2005516916A5 JP2003551144A JP2003551144A JP2005516916A5 JP 2005516916 A5 JP2005516916 A5 JP 2005516916A5 JP 2003551144 A JP2003551144 A JP 2003551144A JP 2003551144 A JP2003551144 A JP 2003551144A JP 2005516916 A5 JP2005516916 A5 JP 2005516916A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazolo
- pyridin
- amine
- pyrimidinyl
- cyclopentylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- AKXTWEMSABOQTE-UHFFFAOYSA-N 2-(2-fluoropyridin-4-yl)-3-(2-methylsulfanylpyrimidin-4-yl)pyrazolo[1,5-a]pyridine Chemical compound CSC1=NC=CC(C2=C3C=CC=CN3N=C2C=2C=C(F)N=CC=2)=N1 AKXTWEMSABOQTE-UHFFFAOYSA-N 0.000 claims 1
- MQWBATCDLYQGBX-UHFFFAOYSA-N 2-(5-bromofuran-2-yl)-n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound O1C(Br)=CC=C1C1=NN(C(NC2CCCC2)=CC=C2)C2=C1C1=CC=NC(NC2CCCC2)=N1 MQWBATCDLYQGBX-UHFFFAOYSA-N 0.000 claims 1
- MMMXYXKMCKKTND-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-n-cyclopropyl-2-(furan-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CC1NC1=CC=CC2=C(C=3N=C(NC4CCCC4)N=CC=3)C(C=3OC=CC=3)=NN12 MMMXYXKMCKKTND-UHFFFAOYSA-N 0.000 claims 1
- DSMHQEKKIDNHKB-UHFFFAOYSA-N 3-[2-(cyclopentylamino)pyrimidin-4-yl]-n-propan-2-yl-2-[2-(propan-2-ylamino)pyridin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=NC(NC(C)C)=CC(C=2C(=C3C=CC=C(NC(C)C)N3N=2)C=2N=C(NC3CCCC3)N=CC=2)=C1 DSMHQEKKIDNHKB-UHFFFAOYSA-N 0.000 claims 1
- UBGAVHWBSINZFN-UHFFFAOYSA-N 3-[2-(cyclopropylamino)pyrimidin-4-yl]-n-propan-2-yl-2-[2-(propan-2-ylamino)pyridin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=NC(NC(C)C)=CC(C=2C(=C3C=CC=C(NC(C)C)N3N=2)C=2N=C(NC3CC3)N=CC=2)=C1 UBGAVHWBSINZFN-UHFFFAOYSA-N 0.000 claims 1
- RABJHBBVBNPXDI-UHFFFAOYSA-N 4-[2,3-bis(2-morpholin-4-ylpyrimidin-4-yl)pyrazolo[1,5-a]pyridin-7-yl]morpholine Chemical compound C1COCCN1C1=NC=CC(C=2C(=C3C=CC=C(N3N=2)N2CCOCC2)C=2N=C(N=CC=2)N2CCOCC2)=N1 RABJHBBVBNPXDI-UHFFFAOYSA-N 0.000 claims 1
- TZDWWUAWVKFTQT-UHFFFAOYSA-N 4-[2-(2-fluoropyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]-n-propan-2-ylpyrimidin-2-amine Chemical compound CC(C)NC1=NC=CC(C2=C3C=CC=CN3N=C2C=2C=C(F)N=CC=2)=N1 TZDWWUAWVKFTQT-UHFFFAOYSA-N 0.000 claims 1
- BXWYBXLKSLNBEJ-UHFFFAOYSA-N 4-[7-chloro-2-[2-(cyclopentylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-3-yl]-n-cyclopentylpyrimidin-2-amine Chemical compound N=1N2C(Cl)=CC=CC2=C(C=2N=C(NC3CCCC3)N=CC=2)C=1C(N=1)=CC=NC=1NC1CCCC1 BXWYBXLKSLNBEJ-UHFFFAOYSA-N 0.000 claims 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- KEEGPCXSSGYVIT-UHFFFAOYSA-N n-(2-methoxyethyl)-2,3-bis[2-(2-methoxyethylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound COCCNC1=NC=CC(C=2C(=C3C=CC=C(NCCOC)N3N=2)C=2N=C(NCCOC)N=CC=2)=N1 KEEGPCXSSGYVIT-UHFFFAOYSA-N 0.000 claims 1
- LOBTWFNOIAQZSJ-UHFFFAOYSA-N n-(2-methylpropyl)-2,3-bis[2-(2-methylpropylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound CC(C)CNC1=NC=CC(C=2C(=C3C=CC=C(NCC(C)C)N3N=2)C=2N=C(NCC(C)C)N=CC=2)=N1 LOBTWFNOIAQZSJ-UHFFFAOYSA-N 0.000 claims 1
- FDRVWGCQSKBAMK-UHFFFAOYSA-N n-benzyl-2,3-bis[2-(benzylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C=1C=CC=CC=1CNC(N=1)=NC=CC=1C(C(=C1C=CC=2)C=3N=C(NCC=4C=CC=CC=4)N=CC=3)=NN1C=2NCC1=CC=CC=C1 FDRVWGCQSKBAMK-UHFFFAOYSA-N 0.000 claims 1
- YMCWZHBUCKQQJU-UHFFFAOYSA-N n-butyl-2,3-bis[2-(butylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound CCCCNC1=NC=CC(C=2C(=C3C=CC=C(NCCCC)N3N=2)C=2N=C(NCCCC)N=CC=2)=N1 YMCWZHBUCKQQJU-UHFFFAOYSA-N 0.000 claims 1
- UEYZILPHQWTLPO-UHFFFAOYSA-N n-cyclopentyl-2,3-bis[2-(cyclopentylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CCCC1NC1=NC=CC(C=2C(=C3C=CC=C(NC4CCCC4)N3N=2)C=2N=C(NC3CCCC3)N=CC=2)=N1 UEYZILPHQWTLPO-UHFFFAOYSA-N 0.000 claims 1
- GRCKZNQHTWIEOG-UHFFFAOYSA-N n-cyclopentyl-2-[2-(cyclopentylamino)pyridin-4-yl]-3-[2-(propan-2-ylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound CC(C)NC1=NC=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2C=C(NC3CCCC3)N=CC=2)=N1 GRCKZNQHTWIEOG-UHFFFAOYSA-N 0.000 claims 1
- WNNCISRUMZUUQA-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyridin-4-yl]-2-(2-methyl-1,3-thiazol-4-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound S1C(C)=NC(C=2C(=C3C=CC=C(NC4CCCC4)N3N=2)C=2C=C(NC3CCCC3)N=CC=2)=C1 WNNCISRUMZUUQA-UHFFFAOYSA-N 0.000 claims 1
- COJKEPNDFKGQKK-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyridin-4-yl]-2-(furan-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CCCC1NC1=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2OC=CC=2)=CC=N1 COJKEPNDFKGQKK-UHFFFAOYSA-N 0.000 claims 1
- RGMDUCGAKACWBL-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(3-methylfuran-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=COC(C=2C(=C3C=CC=C(NC4CCCC4)N3N=2)C=2N=C(NC3CCCC3)N=CC=2)=C1C RGMDUCGAKACWBL-UHFFFAOYSA-N 0.000 claims 1
- ZBKWLCBHFXICLN-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(furan-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CCCC1NC1=NC=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2OC=CC=2)=N1 ZBKWLCBHFXICLN-UHFFFAOYSA-N 0.000 claims 1
- SUIZTJZJNBYQTJ-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-[2-(propan-2-ylamino)pyridin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=NC(NC(C)C)=CC(C=2C(=C3C=CC=C(NC4CCCC4)N3N=2)C=2N=C(NC3CCCC3)N=CC=2)=C1 SUIZTJZJNBYQTJ-UHFFFAOYSA-N 0.000 claims 1
- DWHPPRIWPJWOHS-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-pyridin-3-ylpyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CCCC1NC1=NC=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2C=NC=CC=2)=N1 DWHPPRIWPJWOHS-UHFFFAOYSA-N 0.000 claims 1
- KPPYWNZPUFNSMK-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-pyridin-4-ylpyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CCCC1NC1=NC=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2C=CN=CC=2)=N1 KPPYWNZPUFNSMK-UHFFFAOYSA-N 0.000 claims 1
- XQUMSZAZNJEUCF-UHFFFAOYSA-N n-cyclopentyl-3-[2-(cyclopropylamino)pyrimidin-4-yl]-2-(3-methylfuran-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=COC(C=2C(=C3C=CC=C(NC4CCCC4)N3N=2)C=2N=C(NC3CC3)N=CC=2)=C1C XQUMSZAZNJEUCF-UHFFFAOYSA-N 0.000 claims 1
- WRPLLFUBPBDTKZ-UHFFFAOYSA-N n-cyclopentyl-3-[2-(methylamino)pyrimidin-4-yl]-2-pyridin-4-ylpyrazolo[1,5-a]pyridin-7-amine Chemical compound CNC1=NC=CC(C2=C3C=CC=C(NC4CCCC4)N3N=C2C=2C=CN=CC=2)=N1 WRPLLFUBPBDTKZ-UHFFFAOYSA-N 0.000 claims 1
- BOZVJZQAIHJKQF-UHFFFAOYSA-N n-cyclopentyl-4-[2-[2-(cyclopentylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-amine Chemical compound C1CCCC1NC1=NC=CC(C=2C(=C3C=CC=CN3N=2)C=2N=C(NC3CCCC3)N=CC=2)=N1 BOZVJZQAIHJKQF-UHFFFAOYSA-N 0.000 claims 1
- PUKUDMGHWIXSQG-UHFFFAOYSA-N n-cyclopropyl-2,3-bis[2-(cyclopropylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1CC1NC1=NC=CC(C=2C(=C3C=CC=C(NC4CC4)N3N=2)C=2N=C(NC3CC3)N=CC=2)=N1 PUKUDMGHWIXSQG-UHFFFAOYSA-N 0.000 claims 1
- VVXYBAMCSWAHMV-UHFFFAOYSA-N n-cyclopropyl-3-[2-(cyclopropylamino)pyrimidin-4-yl]-2-(3-methylfuran-2-yl)pyrazolo[1,5-a]pyridin-7-amine Chemical compound C1=COC(C=2C(=C3C=CC=C(NC4CC4)N3N=2)C=2N=C(NC3CC3)N=CC=2)=C1C VVXYBAMCSWAHMV-UHFFFAOYSA-N 0.000 claims 1
- CYZVBAZTJNJPCM-UHFFFAOYSA-N n-propan-2-yl-2,3-bis[2-(propan-2-ylamino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-7-amine Chemical compound CC(C)NC1=NC=CC(C=2C(=C3C=CC=C(NC(C)C)N3N=2)C=2N=C(NC(C)C)N=CC=2)=N1 CYZVBAZTJNJPCM-UHFFFAOYSA-N 0.000 claims 1
- PXQQVWLAWNRFRZ-UHFFFAOYSA-N n-propan-2-yl-4-[2-[2-(propan-2-ylamino)pyridin-4-yl]pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-amine Chemical compound C1=NC(NC(C)C)=CC(C=2C(=C3C=CC=CN3N=2)C=2N=C(NC(C)C)N=CC=2)=C1 PXQQVWLAWNRFRZ-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33958501P | 2001-12-11 | 2001-12-11 | |
| PCT/US2002/037052 WO2003050120A1 (en) | 2001-12-11 | 2002-11-20 | Pyrazolo-pyridine derivatives as antiherpes agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005516916A JP2005516916A (ja) | 2005-06-09 |
| JP2005516916A5 true JP2005516916A5 (enExample) | 2005-12-22 |
Family
ID=23329708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003551144A Pending JP2005516916A (ja) | 2001-12-11 | 2002-11-20 | 抗ヘルペス薬としてのピラゾロ−ピリジン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7199120B2 (enExample) |
| EP (1) | EP1453830B1 (enExample) |
| JP (1) | JP2005516916A (enExample) |
| AT (1) | ATE373000T1 (enExample) |
| AU (1) | AU2002357740A1 (enExample) |
| DE (1) | DE60222465T2 (enExample) |
| ES (1) | ES2292839T3 (enExample) |
| WO (1) | WO2003050120A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1485385B1 (en) | 2002-03-07 | 2005-08-17 | SmithKline Beecham Corporation | Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| WO2010011816A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
| EP2402335A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazolopyridine compounds |
| TW201221518A (en) * | 2010-11-18 | 2012-06-01 | Glaxo Group Ltd | Compounds |
| EP2757884B1 (en) * | 2011-09-22 | 2022-07-27 | Merck Sharp & Dohme LLC | Pyrazolopyridyl compounds as aldosterone synthase inhibitors |
| WO2013050434A1 (en) * | 2011-10-06 | 2013-04-11 | Bayer Intellectual Property Gmbh | Heterocyclylpyri(mi)dinylpyrazole |
| WO2020224568A1 (en) | 2019-05-05 | 2020-11-12 | Qilu Regor Therapeutics Inc. | Cdk inhibitors |
| WO2025202955A1 (en) | 2024-03-28 | 2025-10-02 | Pi Industries Ltd. | Fused bicyclic compounds and their use as pest control agents |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0151962A3 (en) * | 1984-01-25 | 1985-10-02 | Beecham Group Plc | Pyrazolopyridine derivatives |
| GB8404586D0 (en) * | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| GB8404584D0 (en) * | 1984-02-22 | 1984-03-28 | Beecham Group Plc | Compounds |
| US5002941A (en) | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
| US4925849A (en) * | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
| US5155114A (en) * | 1989-01-23 | 1992-10-13 | Fujisawa Pharmaceutical Company, Ltd. | Method of treatment using pyrazolopyridine compound |
| GB8901423D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| JPH05503919A (ja) | 1989-06-13 | 1993-06-24 | スミスクライン・ビーチャム・コーポレイション | 単球および／またはマクロファージによるインターロイキン―１または腫瘍壊死因子生成の抑制 |
| AU622330B2 (en) | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| KR930700104A (ko) | 1990-06-12 | 1993-03-13 | 원본미기재 | 5-리프옥시게나제 및 사이클로옥시게나제 경로 개재된 질병의 억제 |
| GB9015764D0 (en) * | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| CA2060138A1 (en) | 1991-01-29 | 1992-07-30 | Youichi Shiokawa | New use of the adenosine antagonist |
| GB9107513D0 (en) * | 1991-04-10 | 1991-05-29 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| US5300478A (en) * | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
| US5552422A (en) * | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
| EP0819127A1 (en) | 1995-04-04 | 1998-01-21 | Glaxo Group Limited | IMIDAZO [1,2-a]PYRIDINE DERIVATIVES |
| JPH11505524A (ja) | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
| US5700816A (en) | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
| ATE301457T1 (de) * | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| EP0833664A1 (en) | 1995-06-12 | 1998-04-08 | G.D. SEARLE & CO. | Combination of a cyclooxygenase-2 inhibitor and a leukotriene b 4? receptor antagonist for the treatment of inflammations |
| FR2757166B1 (fr) * | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757059B1 (fr) | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouvelle application therapeutique des derives du pyrrole |
| EP1023066A4 (en) | 1997-06-13 | 2001-05-23 | Smithkline Beecham Corp | NEW PYRAZOLE AND PYRAZOLINE SUBSTITUTED COMPOUND |
| CA2303152A1 (en) | 1997-09-05 | 1999-03-18 | Glaxo Group Limited | 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) inhibitors |
| EP1077971A1 (en) | 1998-05-14 | 2001-02-28 | G.D. SEARLE & CO. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| US6245789B1 (en) * | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| FR2779724B1 (fr) | 1998-06-10 | 2001-04-20 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| CN1263755C (zh) | 1998-11-03 | 2006-07-12 | 葛兰素集团有限公司 | 作为选择性cox－2抑制剂的吡唑并吡啶衍生物 |
| DE69915519T2 (de) | 1999-02-27 | 2005-02-03 | Glaxo Group Ltd., Greenford | Pyrazolopyridine |
| CZ20014573A3 (cs) | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| AUPQ969800A0 (en) | 2000-08-28 | 2000-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| US7163940B2 (en) | 2000-12-15 | 2007-01-16 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyrimidine therapeutic compounds |
| DE60112609T2 (de) * | 2000-12-15 | 2006-01-19 | Glaxo Group Ltd., Greenford | Pyrazolopyridine |
| GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| JP4237497B2 (ja) * | 2001-03-30 | 2009-03-11 | スミスクライン ビーチャム コーポレーション | ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用 |
| EP1385847B1 (en) * | 2001-04-27 | 2005-06-01 | SmithKline Beecham Corporation | Pyrazolo[1,5-a]pyridine derivatives |
| SK287857B6 (sk) * | 2001-05-24 | 2012-01-04 | Eli Lilly And Company | Novel pyrrole derivatives as pharmaceutical agents |
| US7196095B2 (en) | 2001-06-25 | 2007-03-27 | Merck & Co., Inc. | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds |
-
2002
- 2002-11-20 US US10/496,358 patent/US7199120B2/en not_active Expired - Fee Related
- 2002-11-20 JP JP2003551144A patent/JP2005516916A/ja active Pending
- 2002-11-20 AU AU2002357740A patent/AU2002357740A1/en not_active Abandoned
- 2002-11-20 AT AT02792278T patent/ATE373000T1/de not_active IP Right Cessation
- 2002-11-20 DE DE60222465T patent/DE60222465T2/de not_active Expired - Fee Related
- 2002-11-20 EP EP02792278A patent/EP1453830B1/en not_active Expired - Lifetime
- 2002-11-20 WO PCT/US2002/037052 patent/WO2003050120A1/en not_active Ceased
- 2002-11-20 ES ES02792278T patent/ES2292839T3/es not_active Expired - Lifetime
-
2006
- 2006-11-09 US US11/558,005 patent/US20070161653A1/en not_active Abandoned
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