JP2005515964A5 - - Google Patents
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- Publication number
- JP2005515964A5 JP2005515964A5 JP2003508362A JP2003508362A JP2005515964A5 JP 2005515964 A5 JP2005515964 A5 JP 2005515964A5 JP 2003508362 A JP2003508362 A JP 2003508362A JP 2003508362 A JP2003508362 A JP 2003508362A JP 2005515964 A5 JP2005515964 A5 JP 2005515964A5
- Authority
- JP
- Japan
- Prior art keywords
- enantiomer
- prodrug
- isomer
- salt
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000651 prodrug Substances 0.000 claims 12
- 229940002612 prodrug Drugs 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 8
- 229960005309 estradiol Drugs 0.000 claims 8
- 229930182833 estradiol Natural products 0.000 claims 8
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 claims 6
- 229960001566 methyltestosterone Drugs 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009245 menopause Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/892,981 US20030027804A1 (en) | 2001-06-27 | 2001-06-27 | Therapeutic combinations for the treatment of hormone deficiencies |
| PCT/US2002/020141 WO2003002123A2 (en) | 2001-06-27 | 2002-06-26 | Therapeutic combinations for the treatment of hormone deficiencies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005515964A JP2005515964A (ja) | 2005-06-02 |
| JP2005515964A5 true JP2005515964A5 (https=) | 2006-01-05 |
Family
ID=25400826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508362A Pending JP2005515964A (ja) | 2001-06-27 | 2002-06-26 | ホルモン欠乏症を治療するための治療用組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20030027804A1 (https=) |
| EP (1) | EP1404343A4 (https=) |
| JP (1) | JP2005515964A (https=) |
| CA (1) | CA2451725C (https=) |
| WO (1) | WO2003002123A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040072810A1 (en) * | 2001-11-07 | 2004-04-15 | Besins International Belgique | Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof |
| IL163981A0 (en) * | 2002-03-15 | 2005-12-18 | Unimed Pharmaceuticals Inc | Androgen pharmaceutical composition and method fortreating depression |
| MY139721A (en) * | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| US8883769B2 (en) * | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) * | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| US20050037040A1 (en) * | 2003-08-13 | 2005-02-17 | Moshe Arkin | Topical compositions of urea and ammonium lactate |
| US20050036953A1 (en) * | 2003-08-13 | 2005-02-17 | Moshe Arkin | Topical compositions of ammonium lactate |
| US20050042182A1 (en) * | 2003-08-13 | 2005-02-24 | Moshe Arkin | Topical compositions of urea |
| US20050025833A1 (en) * | 2003-07-16 | 2005-02-03 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20050020552A1 (en) * | 2003-07-16 | 2005-01-27 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20050042268A1 (en) * | 2003-07-16 | 2005-02-24 | Chaim Aschkenasy | Pharmaceutical composition and method for transdermal drug delivery |
| US20050222106A1 (en) * | 2004-04-01 | 2005-10-06 | Stefan Bracht | Drospirenone-containing preparations for transdermal use |
| EP1750766B1 (en) * | 2004-05-11 | 2013-07-03 | Emotional Brain B.V. | Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
| AU2005301035A1 (en) * | 2004-11-01 | 2006-05-11 | Endorecherche, Inc. | Use of androgens to reduce the likelihood of acquiring or to treat skin aging |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| EP1868590A4 (en) * | 2005-04-13 | 2012-08-29 | Unimed Pharmaceuticals Inc | PROCESS FOR INCREASING TESTOSTERONE AND CORRESPONDING STEROID CONCENTRATIONS IN WOMEN |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| GEP20125432B (en) | 2005-10-12 | 2012-03-26 | Unimed Pharmaceuticals Llc | Improved testosterone gel and use thereof |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US20070254036A1 (en) * | 2006-04-13 | 2007-11-01 | Besins Healthcare Sa | Treatment of menopause associated symptoms |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| EP2044943A1 (en) * | 2007-10-04 | 2009-04-08 | Solvay Pharmaceuticals, Inc. | Pharmaceutical compositions comprising esterified estrogens and methyltestosterone and method of using the same |
| WO2009142699A1 (en) * | 2008-05-19 | 2009-11-26 | The Procter & Gamble Company | Treatment of heart failure in women |
| GB2482868A (en) * | 2010-08-16 | 2012-02-22 | Franciscus Wilhelmus Henricus Maria Merkus | A testosterone liquid spray formulation for oromucosal administration |
| EP2640398A4 (en) | 2010-11-18 | 2014-05-14 | White Mountain Pharma Inc | METHOD FOR TREATING CHRONIC OR BZW. NON-RELIABLE PAIN AND / OR INCREASE OF PATIENT PAIN THRESHOLD AND PHARMACEUTICAL COMPOSITION FOR USE THEREOF |
| SG10201606751XA (en) | 2011-05-13 | 2016-10-28 | Eb Ip Hybritabs B V | Drug Delivery System |
| WO2015077407A1 (en) * | 2013-11-20 | 2015-05-28 | Derivlan Bioscience, Llc | Libido-enhancing therapeutic and use |
| US11439668B2 (en) | 2014-05-23 | 2022-09-13 | JangoBio, LLC | Methods to differentiate stem cells into hormone-producing cells |
| US11253549B2 (en) * | 2014-05-23 | 2022-02-22 | JangoBio, LLC | Methods to rebalance the hypothalamic-pituitary-gonadal axis |
| US20180207264A1 (en) * | 2017-01-23 | 2018-07-26 | Government Of The United States As Represented By The Secretary Of The Air Force | Porcine immune modulation model |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8301550A (nl) * | 1983-05-03 | 1984-12-03 | Gist Brocades Nv | Imidazolethanol esters. |
| US5059603A (en) * | 1989-06-12 | 1991-10-22 | Centuries Laboratories, Inc. | Method and composition for treating impotence |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| US5639743A (en) * | 1992-11-13 | 1997-06-17 | University Of Georgia Research Foundation | Compositions and methods for treating exocrine gland atrophy |
| DE19619045C1 (de) * | 1996-05-02 | 1997-11-13 | Jenapharm Gmbh | Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen |
| IT1283102B1 (it) * | 1996-06-06 | 1998-04-07 | Permatec Nv | Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele |
| US6117446A (en) * | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
| AU2001285367B2 (en) * | 2000-08-30 | 2006-05-18 | Besins Healthcare Luxembourg Sarl | Method of increasing testosterone and related steroid concentrations in women |
-
2001
- 2001-06-27 US US09/892,981 patent/US20030027804A1/en not_active Abandoned
-
2002
- 2002-06-26 JP JP2003508362A patent/JP2005515964A/ja active Pending
- 2002-06-26 CA CA002451725A patent/CA2451725C/en not_active Expired - Lifetime
- 2002-06-26 EP EP02746682A patent/EP1404343A4/en not_active Withdrawn
- 2002-06-26 WO PCT/US2002/020141 patent/WO2003002123A2/en not_active Ceased
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