JP2005514718A5 - - Google Patents
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- Publication number
- JP2005514718A5 JP2005514718A5 JP2003517550A JP2003517550A JP2005514718A5 JP 2005514718 A5 JP2005514718 A5 JP 2005514718A5 JP 2003517550 A JP2003517550 A JP 2003517550A JP 2003517550 A JP2003517550 A JP 2003517550A JP 2005514718 A5 JP2005514718 A5 JP 2005514718A5
- Authority
- JP
- Japan
- Prior art keywords
- microfluidic
- processing device
- zone
- sample
- microfluidic processing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012530 fluid Substances 0.000 claims description 145
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- 230000003834 intracellular Effects 0.000 claims description 48
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- 238000003752 polymerase chain reaction Methods 0.000 claims description 14
- 239000012468 concentrated sample Substances 0.000 claims description 8
- 238000009736 wetting Methods 0.000 claims description 8
- 229920000023 polynucleotide Polymers 0.000 claims description 7
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- 230000005012 migration Effects 0.000 claims 1
- 210000004027 cells Anatomy 0.000 description 77
- 238000002360 preparation method Methods 0.000 description 31
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- 229920003013 deoxyribonucleic acid Polymers 0.000 description 17
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- 238000003199 nucleic acid amplification method Methods 0.000 description 10
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-M lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
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- 238000001816 cooling Methods 0.000 description 2
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- 239000011800 void material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 210000000170 Cell Membrane Anatomy 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
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- 238000001746 injection moulding Methods 0.000 description 1
- 229940079866 intestinal antibiotics Drugs 0.000 description 1
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- 238000000465 moulding Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
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- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
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- 230000001717 pathogenic Effects 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
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- 239000004094 surface-active agent Substances 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30763801P | 2001-07-26 | 2001-07-26 | |
| US10/014,519 US7192557B2 (en) | 2001-03-28 | 2001-12-14 | Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids |
| US10/014,520 US7270786B2 (en) | 2001-03-28 | 2001-12-14 | Methods and systems for processing microfluidic samples of particle containing fluids |
| US10/075,371 US7323140B2 (en) | 2001-03-28 | 2002-02-15 | Moving microdroplets in a microfluidic device |
| PCT/US2002/009440 WO2003012406A1 (fr) | 2001-07-26 | 2002-03-27 | Procedes et systemes de traitement microfluidique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514718A JP2005514718A (ja) | 2005-05-19 |
| JP2005514718A5 true JP2005514718A5 (fr) | 2006-02-09 |
| JP4596776B2 JP4596776B2 (ja) | 2010-12-15 |
Family
ID=27486401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003517550A Expired - Lifetime JP4596776B2 (ja) | 2001-07-26 | 2002-03-27 | 微細流体処理方法及びシステム |
Country Status (4)
| Country | Link |
|---|---|
| EP (2) | EP1438567B1 (fr) |
| JP (1) | JP4596776B2 (fr) |
| ES (1) | ES2683698T3 (fr) |
| WO (1) | WO2003012406A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9028773B2 (en) | 2001-09-12 | 2015-05-12 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| WO2005011867A2 (fr) | 2003-07-31 | 2005-02-10 | Handylab, Inc. | Traitement d'echantillons contenant des particules |
| US7665303B2 (en) | 2004-03-31 | 2010-02-23 | Lifescan Scotland, Ltd. | Method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit |
| US7059352B2 (en) | 2004-03-31 | 2006-06-13 | Lifescan Scotland | Triggerable passive valve for use in controlling the flow of fluid |
| US7156117B2 (en) | 2004-03-31 | 2007-01-02 | Lifescan Scotland Limited | Method of controlling the movement of fluid through a microfluidic circuit using an array of triggerable passive valves |
| CA2994321C (fr) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | Un dispositif microfluidique et ses methodes pour le traitement d'echantillons contenant des polynucleotides |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| DK3088083T3 (en) | 2006-03-24 | 2018-11-26 | Handylab Inc | Method of carrying out PCR down a multi-track cartridge |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| EP2091647A2 (fr) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Système microfluidique utilisé pour amplifier et détecter des polynucléotides en parallèle |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8324372B2 (en) | 2007-07-13 | 2012-12-04 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| BR112013026451B1 (pt) | 2011-04-15 | 2021-02-09 | Becton, Dickinson And Company | sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| JP6117217B2 (ja) | 2011-09-30 | 2017-04-19 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | ユニット化された試薬ストリップ |
| EP2773892B1 (fr) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Dispositif de préparation d'échantillons de polynucléotides |
| US10822644B2 (en) | 2012-02-03 | 2020-11-03 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
| US11666910B2 (en) | 2018-11-26 | 2023-06-06 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
| CN112023990B (zh) * | 2019-06-03 | 2023-06-23 | 利多(香港)有限公司 | 一种微流控检测芯片及制造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304487A (en) * | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5639423A (en) * | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
| US6168948B1 (en) * | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
| US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
| JPH10108666A (ja) * | 1996-10-04 | 1998-04-28 | Asahi Medical Co Ltd | 中空糸型培養器 |
| WO1998022625A1 (fr) * | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Dispositifs microfabriques et procedes d'amplification isotherme d'acides nucleiques |
| EP0941766B1 (fr) * | 1998-03-12 | 2006-12-20 | Miltenyi Biotec GmbH | Système à colonne micro pour séparation magnétique |
| JP4074713B2 (ja) * | 1998-07-29 | 2008-04-09 | 財団法人川村理化学研究所 | 送液デバイス及びその製造方法 |
| JP2000166535A (ja) * | 1998-12-10 | 2000-06-20 | Nippon Laser Denshi Kk | 微量分注針体 |
| DE19948473A1 (de) * | 1999-10-08 | 2001-04-12 | Nmi Univ Tuebingen | Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen |
| US6272939B1 (en) * | 1999-10-15 | 2001-08-14 | Applera Corporation | System and method for filling a substrate with a liquid sample |
-
2002
- 2002-03-27 EP EP02715213.1A patent/EP1438567B1/fr not_active Expired - Lifetime
- 2002-03-27 EP EP18185265.8A patent/EP3427834A1/fr not_active Withdrawn
- 2002-03-27 WO PCT/US2002/009440 patent/WO2003012406A1/fr active Application Filing
- 2002-03-27 JP JP2003517550A patent/JP4596776B2/ja not_active Expired - Lifetime
- 2002-03-27 ES ES02715213.1T patent/ES2683698T3/es not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9028773B2 (en) | 2001-09-12 | 2015-05-12 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
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