JP2005514327A5 - - Google Patents
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- Publication number
- JP2005514327A5 JP2005514327A5 JP2003513557A JP2003513557A JP2005514327A5 JP 2005514327 A5 JP2005514327 A5 JP 2005514327A5 JP 2003513557 A JP2003513557 A JP 2003513557A JP 2003513557 A JP2003513557 A JP 2003513557A JP 2005514327 A5 JP2005514327 A5 JP 2005514327A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- independently
- represented
- following structural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 heteroalkenyl Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 102000034527 Retinoid X Receptors Human genes 0.000 claims 6
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000000833 heterodimer Substances 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims 2
- BIXMBBKKPTYJEK-UHFFFAOYSA-N 1,3-benzoxazin-2-one Chemical class C1=CC=C2OC(=O)N=CC2=C1 BIXMBBKKPTYJEK-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 102000000536 PPAR gamma Human genes 0.000 claims 2
- 108010016731 PPAR gamma Proteins 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 claims 2
- NKLCNNUWBJBICK-UHFFFAOYSA-N dess–martin periodinane Chemical compound C1=CC=C2I(OC(=O)C)(OC(C)=O)(OC(C)=O)OC(=O)C2=C1 NKLCNNUWBJBICK-UHFFFAOYSA-N 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 101150014691 PPARA gene Proteins 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims 1
- 229910000024 caesium carbonate Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30695101P | 2001-07-20 | 2001-07-20 | |
| PCT/US2002/023017 WO2003007950A1 (en) | 2001-07-20 | 2002-07-18 | (pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514327A JP2005514327A (ja) | 2005-05-19 |
| JP2005514327A5 true JP2005514327A5 (cg-RX-API-DMAC10.html) | 2005-12-22 |
Family
ID=23187597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513557A Pending JP2005514327A (ja) | 2001-07-20 | 2002-07-18 | レチノイドｘレセプターモジュレータとしての（ピリジニルおよびピミジル）トリエン酸誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040248913A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1414450A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2005514327A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2002319583B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2452541A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MXPA04000613A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2003007950A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1368296A1 (en) * | 2001-03-14 | 2003-12-10 | Eli Lilly And Company | Fluorinated trienes and their use as rxr modulators |
| ES2687177T3 (es) * | 2010-02-19 | 2018-10-24 | Arizona Board Of Regents, A body corporate of the State of Arizona acting, For and on behalf of Arizona State University | Inhibidores de radicales multifuncionales y su uso |
| CA2976937C (en) | 2015-02-17 | 2023-04-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Therapeutic compounds |
| CA2976776C (en) | 2015-02-17 | 2023-06-20 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
| US11390605B2 (en) | 2016-08-25 | 2022-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted pyrimidine compounds as multifunctional radical quenchers and their uses |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
| US5977125A (en) * | 1994-10-31 | 1999-11-02 | Eisai Co., Ltd. | Mono-or polyenic carboxylic acid derivatives |
| AU726450B2 (en) * | 1995-10-06 | 2000-11-09 | Ligand Pharmaceuticals Incorporated | Dimer-selective RXR modulators and methods for their use |
| US6593493B1 (en) * | 1999-09-14 | 2003-07-15 | Ligand Pharmaceuticals, Inc. | RXR modulators with improved pharmacologic profile |
| EP1368296A1 (en) * | 2001-03-14 | 2003-12-10 | Eli Lilly And Company | Fluorinated trienes and their use as rxr modulators |
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2002
- 2002-07-18 CA CA002452541A patent/CA2452541A1/en not_active Abandoned
- 2002-07-18 WO PCT/US2002/023017 patent/WO2003007950A1/en not_active Ceased
- 2002-07-18 US US10/483,160 patent/US20040248913A1/en not_active Abandoned
- 2002-07-18 JP JP2003513557A patent/JP2005514327A/ja active Pending
- 2002-07-18 EP EP02750182A patent/EP1414450A1/en not_active Withdrawn
- 2002-07-18 MX MXPA04000613A patent/MXPA04000613A/es not_active Application Discontinuation
- 2002-07-18 AU AU2002319583A patent/AU2002319583B2/en not_active Ceased