JP2005513506A - プロテオミクスにおける分子−分子間相互作用決定法 - Google Patents

プロテオミクスにおける分子−分子間相互作用決定法 Download PDF

Info

Publication number
JP2005513506A
JP2005513506A JP2003556814A JP2003556814A JP2005513506A JP 2005513506 A JP2005513506 A JP 2005513506A JP 2003556814 A JP2003556814 A JP 2003556814A JP 2003556814 A JP2003556814 A JP 2003556814A JP 2005513506 A JP2005513506 A JP 2005513506A
Authority
JP
Japan
Prior art keywords
biomolecule
moiety
target
specific
linker molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003556814A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005513506A5 (https=
Inventor
ピーター・ジェイムズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2005513506A publication Critical patent/JP2005513506A/ja
Publication of JP2005513506A5 publication Critical patent/JP2005513506A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/824Immunological separation techniques
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/905Photochemical activation of reactions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2003556814A 2001-12-28 2002-12-16 プロテオミクスにおける分子−分子間相互作用決定法 Pending JP2005513506A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0131014.3A GB0131014D0 (en) 2001-12-28 2001-12-28 Method for molecule-mlecule analysis
PCT/EP2002/014315 WO2003056342A2 (en) 2001-12-28 2002-12-16 Method for determining molecule-molecule interaction in proteomics

Publications (2)

Publication Number Publication Date
JP2005513506A true JP2005513506A (ja) 2005-05-12
JP2005513506A5 JP2005513506A5 (https=) 2006-02-09

Family

ID=9928438

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003556814A Pending JP2005513506A (ja) 2001-12-28 2002-12-16 プロテオミクスにおける分子−分子間相互作用決定法

Country Status (9)

Country Link
US (1) US7022491B2 (https=)
EP (1) EP1459073B1 (https=)
JP (1) JP2005513506A (https=)
AT (1) ATE386270T1 (https=)
AU (1) AU2002358143A1 (https=)
CA (1) CA2465300A1 (https=)
DE (1) DE60225059D1 (https=)
GB (1) GB0131014D0 (https=)
WO (1) WO2003056342A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014137307A (ja) * 2013-01-17 2014-07-28 Toyama Univ 蛍光性質量標識プローブ
JP2021512300A (ja) * 2018-02-02 2021-05-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質二量体化を特徴解析するためのシステムおよび方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005140755A (ja) * 2003-11-10 2005-06-02 Japan Science & Technology Agency 質量分析用プローブ及びそれを用いた質量分析方法
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
CN110853712B (zh) * 2018-08-01 2022-06-07 清华大学 鉴定多对生物分子间相互作用调控因子的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487838A (en) * 1982-01-12 1984-12-11 Massachusetts Institute Of Technology Radio-labelled cross-linking reagents
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
GB9815166D0 (en) * 1998-07-13 1998-09-09 Brax Genomics Ltd Compounds for mass spectrometry

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014137307A (ja) * 2013-01-17 2014-07-28 Toyama Univ 蛍光性質量標識プローブ
JP2021512300A (ja) * 2018-02-02 2021-05-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質二量体化を特徴解析するためのシステムおよび方法
JP7171746B2 (ja) 2018-02-02 2022-11-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質二量体化を特徴解析するためのシステムおよび方法
JP2023022021A (ja) * 2018-02-02 2023-02-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質二量体化を特徴解析するためのシステムおよび方法
JP7449351B2 (ja) 2018-02-02 2024-03-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質二量体化を特徴解析するためのシステムおよび方法
US12174173B2 (en) 2018-02-02 2024-12-24 Regeneron Pharmaceuticals, Inc. System and method for characterizing protein dimerization

Also Published As

Publication number Publication date
AU2002358143A8 (en) 2003-07-15
DE60225059D1 (de) 2008-03-27
US20050095654A1 (en) 2005-05-05
GB0131014D0 (en) 2002-02-13
CA2465300A1 (en) 2003-07-10
US7022491B2 (en) 2006-04-04
ATE386270T1 (de) 2008-03-15
WO2003056342A3 (en) 2003-11-06
EP1459073B1 (en) 2008-02-13
EP1459073A2 (en) 2004-09-22
AU2002358143A1 (en) 2003-07-15
WO2003056342A2 (en) 2003-07-10

Similar Documents

Publication Publication Date Title
JP5374363B2 (ja) ペプチド混合物を評価する方法
Hamdan et al. Modern strategies for protein quantification in proteome analysis: advantages and limitations
AU2008213716B2 (en) Affinity selected signature peptides for protein identification and quantification
JP4290003B2 (ja) 質量標識体
AU2002303760B2 (en) Methods for isolating and labeling sample molecules
US20100068819A1 (en) Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
US7163803B2 (en) Method for characterizing polypeptides
JP2004505248A (ja) ポリペプチドの配列決定のための新しい方法及びキット
Soderblom et al. Tandem mass spectrometry acquisition approaches to enhance identification of protein‐protein interactions using low‐energy collision‐induced dissociative chemical crosslinking reagents
JP2004516486A (ja) マーカー/標的タンパク質を迅速に同定するための逆標識方法
US7244411B2 (en) Method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixtures
JP2005513507A (ja) タンパク質発現分析方法
EP1459073B1 (en) Method for determining molecule-molecule interaction in proteomics
US7371514B2 (en) Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry
JP2010503852A (ja) C末端のペプチドの識別に基づいたタンパク質の試料を分析するための方法
Hansen et al. Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-ICAT and multi-dimensional chromatography
EP1916526A1 (en) Method for diagnostic and therapeutic target discovery by combining isotopic and isobaric labels
Nokihara et al. High throughput sequencing of cyclic peptide immobilized on a gel-type single bead
Delahunty et al. Protein–Protein Interactions
WO2003031982A1 (en) Method for analysing protein/peptide expression
Zhou Comprehensive LC-MS and MS/MS studies of N-glycans derived from biological samples
Borchers et al. CH 12 Application of Proteomics in Basic Biological Sciences and Cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051209

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051209

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20081224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090210

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090630