JP2005510201A5 - - Google Patents

Info

Publication number

JP2005510201A5

JP2005510201A5 JP2002559456A JP2002559456A JP2005510201A5 JP 2005510201 A5 JP2005510201 A5 JP 2005510201A5 JP 2002559456 A JP2002559456 A JP 2002559456A JP 2002559456 A JP2002559456 A JP 2002559456A JP 2005510201 A5 JP2005510201 A5 JP 2005510201A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

binding portion

atcc accession

hiv

Prior art date

2002-01-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims 54
• 108091007433 antigens Proteins 0.000 claims 54
• 102000036639 antigens Human genes 0.000 claims 54
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 35
• 210000004027 cell Anatomy 0.000 claims 33
• 210000004408 hybridoma Anatomy 0.000 claims 23
• 230000003472 neutralizing effect Effects 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 8
• 229940124597 therapeutic agent Drugs 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• 239000002955 immunomodulating agent Substances 0.000 claims 6
• 229940121354 immunomodulator Drugs 0.000 claims 6
• 230000002401 inhibitory effect Effects 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 241000725303 Human immunodeficiency virus Species 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 239000003443 antiviral agent Substances 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 229960001438 immunostimulant agent Drugs 0.000 claims 3
• 239000003022 immunostimulating agent Substances 0.000 claims 3
• 230000003308 immunostimulating effect Effects 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 208000031886 HIV Infections Diseases 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 229940027941 immunoglobulin g Drugs 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 1
• 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 1
• 101100450244 Dictyostelium discoideum hbx2 gene Proteins 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 229940033332 HIV-1 vaccine Drugs 0.000 claims 1
• 101000946926 Homo sapiens C-C chemokine receptor type 5 Proteins 0.000 claims 1
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 125000000837 carbohydrate group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 102000048160 human CCR5 Human genes 0.000 claims 1
• 102000053523 human CXCR4 Human genes 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 230000003389 potentiating effect Effects 0.000 claims 1
• 230000002685 pulmonary effect Effects 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1