JP2005508663A5 - - Google Patents
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- JP2005508663A5 JP2005508663A5 JP2003503270A JP2003503270A JP2005508663A5 JP 2005508663 A5 JP2005508663 A5 JP 2005508663A5 JP 2003503270 A JP2003503270 A JP 2003503270A JP 2003503270 A JP2003503270 A JP 2003503270A JP 2005508663 A5 JP2005508663 A5 JP 2005508663A5
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- JP
- Japan
- Prior art keywords
- group
- groups
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- macromer system
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001519 tissue Anatomy 0.000 claims 28
- 238000000034 method Methods 0.000 claims 26
- 229920000642 polymer Polymers 0.000 claims 24
- 239000007943 implant Substances 0.000 claims 18
- 239000003999 initiator Substances 0.000 claims 13
- 239000011159 matrix material Substances 0.000 claims 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
- 102000008186 Collagen Human genes 0.000 claims 6
- 108010035532 Collagen Proteins 0.000 claims 6
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 6
- 230000003213 activating effect Effects 0.000 claims 6
- 229920001436 collagen Polymers 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920002674 hyaluronan Polymers 0.000 claims 6
- 229960003160 hyaluronic acid Drugs 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 5
- 238000006116 polymerization reaction Methods 0.000 claims 5
- 239000003505 polymerization initiator Substances 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 claims 3
- WROUWQQRXUBECT-UHFFFAOYSA-N 2-ethylacrylic acid Chemical group CCC(=C)C(O)=O WROUWQQRXUBECT-UHFFFAOYSA-N 0.000 claims 3
- NLGDWWCZQDIASO-UHFFFAOYSA-N 2-hydroxy-1-(7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-yl)-2-phenylethanone Chemical compound OC(C(=O)c1cccc2Oc12)c1ccccc1 NLGDWWCZQDIASO-UHFFFAOYSA-N 0.000 claims 3
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- 239000004342 Benzoyl peroxide Substances 0.000 claims 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 229920000045 Dermatan sulfate Polymers 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 102000016942 Elastin Human genes 0.000 claims 3
- 108010014258 Elastin Proteins 0.000 claims 3
- 102000016359 Fibronectins Human genes 0.000 claims 3
- 108010067306 Fibronectins Proteins 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- 229920002971 Heparan sulfate Polymers 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- 229920000288 Keratan sulfate Polymers 0.000 claims 3
- 102000007547 Laminin Human genes 0.000 claims 3
- 108010085895 Laminin Proteins 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 3
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 claims 3
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 3
- 229930006711 bornane-2,3-dione Natural products 0.000 claims 3
- 229940045110 chitosan Drugs 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229940051593 dermatan sulfate Drugs 0.000 claims 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- 229960000633 dextran sulfate Drugs 0.000 claims 3
- 229920002549 elastin Polymers 0.000 claims 3
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims 3
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims 3
- 229940011411 erythrosine Drugs 0.000 claims 3
- 235000012732 erythrosine Nutrition 0.000 claims 3
- 239000004174 erythrosine Substances 0.000 claims 3
- UKZQEOHHLOYJLY-UHFFFAOYSA-M ethyl eosin Chemical compound [K+].CCOC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 UKZQEOHHLOYJLY-UHFFFAOYSA-M 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical group OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 3
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 3
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 3
- 229940043138 pentosan polysulfate Drugs 0.000 claims 3
- 239000003495 polar organic solvent Substances 0.000 claims 3
- 229920001308 poly(aminoacid) Polymers 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000010526 radical polymerization reaction Methods 0.000 claims 3
- 229930187593 rose bengal Natural products 0.000 claims 3
- 229940081623 rose bengal Drugs 0.000 claims 3
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 229940032147 starch Drugs 0.000 claims 3
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 claims 3
- BPAZNZINLQSFMN-UHFFFAOYSA-N 2-propan-2-yl-4,5-dihydro-1h-imidazole;dihydrochloride Chemical compound Cl.Cl.CC(C)C1=NCCN1 BPAZNZINLQSFMN-UHFFFAOYSA-N 0.000 claims 2
- VFXXTYGQYWRHJP-UHFFFAOYSA-N 4,4'-azobis(4-cyanopentanoic acid) Chemical compound OC(=O)CCC(C)(C#N)N=NC(C)(CCC(O)=O)C#N VFXXTYGQYWRHJP-UHFFFAOYSA-N 0.000 claims 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims 2
- 239000012965 benzophenone Substances 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 230000008467 tissue growth Effects 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- XRUKRHLZDVJJSX-UHFFFAOYSA-N 4-cyanopentanoic acid Chemical compound N#CC(C)CCC(O)=O XRUKRHLZDVJJSX-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- LBSPZZSGTIBOFG-UHFFFAOYSA-N bis[2-(4,5-dihydro-1h-imidazol-2-yl)propan-2-yl]diazene;dihydrochloride Chemical compound Cl.Cl.N=1CCNC=1C(C)(C)N=NC(C)(C)C1=NCCN1 LBSPZZSGTIBOFG-UHFFFAOYSA-N 0.000 claims 1
- 230000001680 brushing effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000003127 knee Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229920002994 synthetic fiber Polymers 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/018345 WO2002100453A1 (en) | 2001-06-07 | 2001-06-07 | Crosslinkable macromers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508663A JP2005508663A (ja) | 2005-04-07 |
| JP2005508663A5 true JP2005508663A5 (enExample) | 2008-08-07 |
Family
ID=21742629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503270A Pending JP2005508663A (ja) | 2001-06-07 | 2001-06-07 | 架橋性マクロマー |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1395301A1 (enExample) |
| JP (1) | JP2005508663A (enExample) |
| CA (1) | CA2449964A1 (enExample) |
| MX (1) | MXPA03011263A (enExample) |
| WO (1) | WO2002100453A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518256A (ja) * | 2003-01-31 | 2006-08-10 | ジンマー オーソバイオロジクス，インコーポレイティド | 髄核組織（ｎｕｃｌｅｕｓｐｕｌｐｏｓｕｓｔｉｓｓｕｅ）を含むヒドロゲル組成物 |
| WO2004076511A2 (en) * | 2003-02-21 | 2004-09-10 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel surface coatings |
| US7169404B2 (en) * | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
| US8202833B2 (en) * | 2003-11-26 | 2012-06-19 | Surmodics, Inc. | Composition containing biocompatible polymerization accelerator and polymerizable material |
| DE102004011497B4 (de) | 2004-03-09 | 2008-05-21 | Ivoclar Vivadent Ag | Dentalwerkstoffe mit verbesserter Verträglichkeit |
| EP1807133B1 (en) * | 2004-10-28 | 2013-12-11 | SurModics, Inc. | Pro-fibrotic coatings |
| CA2611693A1 (en) * | 2005-06-15 | 2006-12-28 | Surmodics, Inc. | Macromer composition including light activated initiator |
| US20070065483A1 (en) * | 2005-09-21 | 2007-03-22 | Chudzik Stephen J | In vivo formed matrices including natural biodegradable polysaccharides and uses thereof |
| WO2009038783A1 (en) * | 2007-09-19 | 2009-03-26 | Surmodics, Inc. | Biocompatible foams, systems, and methods |
| US8283384B2 (en) * | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| CN101978040A (zh) | 2008-01-24 | 2011-02-16 | 犹他卅大学研究基金会 | 胶粘复合凝聚物及其制备和使用方法 |
| US8916188B2 (en) | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
| WO2010047799A1 (en) * | 2008-10-22 | 2010-04-29 | Surmodics, Inc. | Swellable biodegradable polymeric matrices and methods |
| CN103025360A (zh) | 2010-05-24 | 2013-04-03 | 犹他大学研究基金会 | 增强的粘合剂复合物凝聚层和其制备和使用方法 |
| US9173971B2 (en) | 2010-11-12 | 2015-11-03 | University Of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| US10077324B2 (en) | 2013-02-06 | 2018-09-18 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| EP2958947B1 (en) | 2013-02-20 | 2019-08-14 | The University of Queensland | Conjugate compound and uses of same |
| CA2955048C (en) | 2014-07-14 | 2020-11-03 | University Of Utah Research Foundation | In situ solidifying compositions and methods of making and using therof |
| WO2019147922A2 (en) | 2018-01-26 | 2019-08-01 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
| BR112020025527B1 (pt) * | 2018-06-11 | 2023-10-03 | Universidade De Coimbra | Formulações de copolímero biodegradável fotopolimerizado para aplicações biomédicas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169001A3 (en) * | 1984-07-17 | 1987-11-25 | Collagen Corporation | Collagen coated bone implants |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| AU4743696A (en) * | 1995-12-29 | 1997-07-28 | Minnesota Mining And Manufacturing Company | Use of pendant photoreactive moieties on polymer precursors to prepare hydrophilic pressure sensitive adhesives |
| US6007833A (en) * | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
-
2001
- 2001-06-07 WO PCT/US2001/018345 patent/WO2002100453A1/en not_active Ceased
- 2001-06-07 CA CA002449964A patent/CA2449964A1/en not_active Abandoned
- 2001-06-07 EP EP01942016A patent/EP1395301A1/en not_active Withdrawn
- 2001-06-07 MX MXPA03011263A patent/MXPA03011263A/es not_active Application Discontinuation
- 2001-06-07 JP JP2003503270A patent/JP2005508663A/ja active Pending
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