JP2005508663A5 - - Google Patents
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- JP2005508663A5 JP2005508663A5 JP2003503270A JP2003503270A JP2005508663A5 JP 2005508663 A5 JP2005508663 A5 JP 2005508663A5 JP 2003503270 A JP2003503270 A JP 2003503270A JP 2003503270 A JP2003503270 A JP 2003503270A JP 2005508663 A5 JP2005508663 A5 JP 2005508663A5
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- JP
- Japan
- Prior art keywords
- group
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- macromer system
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001519 tissue Anatomy 0.000 claims 28
- 238000000034 method Methods 0.000 claims 26
- 229920000642 polymer Polymers 0.000 claims 24
- 239000007943 implant Substances 0.000 claims 18
- 239000003999 initiator Substances 0.000 claims 13
- 239000011159 matrix material Substances 0.000 claims 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
- 102000008186 Collagen Human genes 0.000 claims 6
- 108010035532 Collagen Proteins 0.000 claims 6
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 6
- 230000003213 activating effect Effects 0.000 claims 6
- 229920001436 collagen Polymers 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920002674 hyaluronan Polymers 0.000 claims 6
- 229960003160 hyaluronic acid Drugs 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 5
- 238000006116 polymerization reaction Methods 0.000 claims 5
- 239000003505 polymerization initiator Substances 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 claims 3
- WROUWQQRXUBECT-UHFFFAOYSA-N 2-ethylacrylic acid Chemical group CCC(=C)C(O)=O WROUWQQRXUBECT-UHFFFAOYSA-N 0.000 claims 3
- NLGDWWCZQDIASO-UHFFFAOYSA-N 2-hydroxy-1-(7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-yl)-2-phenylethanone Chemical compound OC(C(=O)c1cccc2Oc12)c1ccccc1 NLGDWWCZQDIASO-UHFFFAOYSA-N 0.000 claims 3
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- 239000004342 Benzoyl peroxide Substances 0.000 claims 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 3
- 229920001661 Chitosan Polymers 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 229920000045 Dermatan sulfate Polymers 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 102000016942 Elastin Human genes 0.000 claims 3
- 108010014258 Elastin Proteins 0.000 claims 3
- 102000016359 Fibronectins Human genes 0.000 claims 3
- 108010067306 Fibronectins Proteins 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 3
- 229920002971 Heparan sulfate Polymers 0.000 claims 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 3
- 229920000288 Keratan sulfate Polymers 0.000 claims 3
- 102000007547 Laminin Human genes 0.000 claims 3
- 108010085895 Laminin Proteins 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 3
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 claims 3
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 3
- 229930006711 bornane-2,3-dione Natural products 0.000 claims 3
- 229940045110 chitosan Drugs 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229940051593 dermatan sulfate Drugs 0.000 claims 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- 229960000633 dextran sulfate Drugs 0.000 claims 3
- 229920002549 elastin Polymers 0.000 claims 3
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims 3
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 claims 3
- 229940011411 erythrosine Drugs 0.000 claims 3
- 235000012732 erythrosine Nutrition 0.000 claims 3
- 239000004174 erythrosine Substances 0.000 claims 3
- UKZQEOHHLOYJLY-UHFFFAOYSA-M ethyl eosin Chemical compound [K+].CCOC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 UKZQEOHHLOYJLY-UHFFFAOYSA-M 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical group OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 3
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 3
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 3
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 3
- 229940043138 pentosan polysulfate Drugs 0.000 claims 3
- 239000003495 polar organic solvent Substances 0.000 claims 3
- 229920001308 poly(aminoacid) Polymers 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 238000010526 radical polymerization reaction Methods 0.000 claims 3
- 229930187593 rose bengal Natural products 0.000 claims 3
- 229940081623 rose bengal Drugs 0.000 claims 3
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 229940032147 starch Drugs 0.000 claims 3
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- YRHRIQCWCFGUEQ-UHFFFAOYSA-N thioxanthen-9-one Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 YRHRIQCWCFGUEQ-UHFFFAOYSA-N 0.000 claims 3
- BPAZNZINLQSFMN-UHFFFAOYSA-N 2-propan-2-yl-4,5-dihydro-1h-imidazole;dihydrochloride Chemical compound Cl.Cl.CC(C)C1=NCCN1 BPAZNZINLQSFMN-UHFFFAOYSA-N 0.000 claims 2
- VFXXTYGQYWRHJP-UHFFFAOYSA-N 4,4'-azobis(4-cyanopentanoic acid) Chemical compound OC(=O)CCC(C)(C#N)N=NC(C)(CCC(O)=O)C#N VFXXTYGQYWRHJP-UHFFFAOYSA-N 0.000 claims 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims 2
- 239000012965 benzophenone Substances 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 230000008467 tissue growth Effects 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- XRUKRHLZDVJJSX-UHFFFAOYSA-N 4-cyanopentanoic acid Chemical compound N#CC(C)CCC(O)=O XRUKRHLZDVJJSX-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- LBSPZZSGTIBOFG-UHFFFAOYSA-N bis[2-(4,5-dihydro-1h-imidazol-2-yl)propan-2-yl]diazene;dihydrochloride Chemical compound Cl.Cl.N=1CCNC=1C(C)(C)N=NC(C)(C)C1=NCCN1 LBSPZZSGTIBOFG-UHFFFAOYSA-N 0.000 claims 1
- 230000001680 brushing effect Effects 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000003127 knee Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229920002994 synthetic fiber Polymers 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/018345 WO2002100453A1 (en) | 2001-06-07 | 2001-06-07 | Crosslinkable macromers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508663A JP2005508663A (ja) | 2005-04-07 |
| JP2005508663A5 true JP2005508663A5 (enExample) | 2008-08-07 |
Family
ID=21742629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503270A Pending JP2005508663A (ja) | 2001-06-07 | 2001-06-07 | 架橋性マクロマー |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1395301A1 (enExample) |
| JP (1) | JP2005508663A (enExample) |
| CA (1) | CA2449964A1 (enExample) |
| MX (1) | MXPA03011263A (enExample) |
| WO (1) | WO2002100453A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004208821B2 (en) * | 2003-01-31 | 2009-01-15 | Zimmer Orthobiologics Inc. | Hydrogel compositions comprising nucleus pulposus tissue |
| WO2004076511A2 (en) * | 2003-02-21 | 2004-09-10 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel surface coatings |
| US7169404B2 (en) | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
| US8202833B2 (en) * | 2003-11-26 | 2012-06-19 | Surmodics, Inc. | Composition containing biocompatible polymerization accelerator and polymerizable material |
| DE102004011497B4 (de) * | 2004-03-09 | 2008-05-21 | Ivoclar Vivadent Ag | Dentalwerkstoffe mit verbesserter Verträglichkeit |
| EP1807133B1 (en) | 2004-10-28 | 2013-12-11 | SurModics, Inc. | Pro-fibrotic coatings |
| WO2006138542A2 (en) * | 2005-06-15 | 2006-12-28 | Surmodics, Inc. | Macromer composition including light activated initiator |
| WO2007040557A1 (en) * | 2005-09-21 | 2007-04-12 | Surmodics, Inc. | Coatings and articles including natural biodegradable polysaccharides |
| US8999377B2 (en) * | 2007-09-19 | 2015-04-07 | Surmodics, Inc. | System for forming a biocompatible foam using polymerizable alpha(1-4)glucopyranose polymers and gas-producing component |
| US8283384B2 (en) * | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| BRPI0822229A2 (pt) | 2008-01-24 | 2015-06-23 | Univ Utah Res Foudation | Coacervados de complexos adesivo e métodos de fabricação e uso dos mesmos |
| US8916188B2 (en) | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
| JP2012506478A (ja) * | 2008-10-22 | 2012-03-15 | サーモディクス，インコーポレイティド | 膨潤性および生分解性を有するポリマーマトリクス並びにその製造方法 |
| CN103025360A (zh) | 2010-05-24 | 2013-04-03 | 犹他大学研究基金会 | 增强的粘合剂复合物凝聚层和其制备和使用方法 |
| WO2012065148A2 (en) | 2010-11-12 | 2012-05-18 | University Of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| EP2958947B1 (en) * | 2013-02-20 | 2019-08-14 | The University of Queensland | Conjugate compound and uses of same |
| JP6742297B2 (ja) | 2014-07-14 | 2020-08-19 | ユニヴァーシティ オブ ユタ リサーチ ファンデーション | その場凝固複合コアセルベートならびにその製造および使用方法 |
| AU2019212513B2 (en) | 2018-01-26 | 2024-10-31 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
| BR112020025527B1 (pt) * | 2018-06-11 | 2023-10-03 | Universidade De Coimbra | Formulações de copolímero biodegradável fotopolimerizado para aplicações biomédicas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0169001A3 (en) * | 1984-07-17 | 1987-11-25 | Collagen Corporation | Collagen coated bone implants |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| JP2000503053A (ja) * | 1995-12-29 | 2000-03-14 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ポリマー先駆物質の光反応性側鎖部分を使用して親水性感圧接着剤配合物を製造する方法 |
| US6007833A (en) * | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
-
2001
- 2001-06-07 CA CA002449964A patent/CA2449964A1/en not_active Abandoned
- 2001-06-07 EP EP01942016A patent/EP1395301A1/en not_active Withdrawn
- 2001-06-07 JP JP2003503270A patent/JP2005508663A/ja active Pending
- 2001-06-07 MX MXPA03011263A patent/MXPA03011263A/es not_active Application Discontinuation
- 2001-06-07 WO PCT/US2001/018345 patent/WO2002100453A1/en not_active Ceased
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