JP2005508337A5 - - Google Patents
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- Publication number
- JP2005508337A5 JP2005508337A5 JP2003530699A JP2003530699A JP2005508337A5 JP 2005508337 A5 JP2005508337 A5 JP 2005508337A5 JP 2003530699 A JP2003530699 A JP 2003530699A JP 2003530699 A JP2003530699 A JP 2003530699A JP 2005508337 A5 JP2005508337 A5 JP 2005508337A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkyl
- compound
- halogen
- physiologically functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052736 halogen Chemical group 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 101700043017 NTRK1 Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32601201P | 2001-09-27 | 2001-09-27 | |
| PCT/US2002/030150 WO2003027111A1 (en) | 2001-09-27 | 2002-09-24 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508337A JP2005508337A (ja) | 2005-03-31 |
| JP2005508337A5 true JP2005508337A5 (de) | 2005-12-22 |
Family
ID=23270442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530699A Pending JP2005508337A (ja) | 2001-09-27 | 2002-09-24 | 化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7015231B2 (de) |
| EP (1) | EP1430053B1 (de) |
| JP (1) | JP2005508337A (de) |
| AT (1) | ATE343575T1 (de) |
| DE (1) | DE60215682T2 (de) |
| ES (1) | ES2275021T3 (de) |
| WO (1) | WO2003027111A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002020513A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Oxindole derivatives |
| WO2002020479A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
| PT2383268E (pt) | 2005-02-04 | 2015-12-21 | Astrazeneca Ab | Derivados de pirazolilaminopiridina úteis como inibidores de quinase |
| MX2007009842A (es) * | 2005-02-16 | 2007-08-23 | Astrazeneca Ab | Compuestos quimicos. |
| PT1853588E (pt) | 2005-02-16 | 2008-08-25 | Astrazeneca Ab | Compostos químicos |
| EP1945631B8 (de) | 2005-10-28 | 2013-01-02 | AstraZeneca AB | 4-(3-aminopyrazol)pyrimidinderivate zur verwendung als tyrosinkinaseinhibitoren bei der behandlung von krebs |
| US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| KR20090004976A (ko) | 2006-04-19 | 2009-01-12 | 아스테라스 세이야쿠 가부시키가이샤 | 아졸카르복사미드 유도체 |
| WO2009054468A1 (ja) | 2007-10-24 | 2009-04-30 | Astellas Pharma Inc. | アゾールカルボキサミド化合物又はその塩 |
| CA2711865A1 (en) | 2008-01-11 | 2009-07-16 | Astellas Pharma Inc. | A pathological animal model simultaneously developing testicular pain or discomfort behaviors and urinary frequency |
| BRPI0922224A2 (pt) | 2008-12-08 | 2016-08-02 | Vm Pharma Llc | composições de inibidores de proteína tirosina quiinase receptora. |
| JP5778755B2 (ja) * | 2010-04-15 | 2015-09-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ヒドロキノンの製造方法 |
| US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
| CN103804273B (zh) * | 2014-01-27 | 2016-06-15 | 贵州大学 | 氧化吲哚与茚三酮双季碳拼接衍生物及其制备方法 |
| TWI672141B (zh) | 2014-02-20 | 2019-09-21 | 美商醫科泰生技 | 投予ｒｏｓ１突變癌細胞之分子 |
| US10301271B2 (en) | 2014-09-17 | 2019-05-28 | Purdue Pharma L.P. | Crystalline forms of tyrosine kinase inhibitors and their salts |
| AU2015355220B2 (en) | 2014-12-02 | 2020-02-27 | Ignyta, Inc. | Combinations for the treatment of neuroblastoma |
| WO2017106492A1 (en) | 2015-12-18 | 2017-06-22 | Ignyta, Inc. | Combinations for the treatment of cancer |
| AU2018302170B2 (en) | 2017-07-19 | 2024-02-29 | Ignyta, Inc. | Pharmaceutical compositions comprising entrectinib |
| EP3697390A1 (de) | 2017-10-17 | 2020-08-26 | Ignyta, Inc. | Pharmazeutische zusammensetzungen und darreichungsformen |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423997D0 (en) * | 1994-11-28 | 1995-01-11 | Erba Carlo Spa | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| CA2383623A1 (en) | 1998-08-04 | 2000-02-17 | Sugen, Inc. | 3-methylidenyl-2-indolinone modulators of protein kinase |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
-
2002
- 2002-09-24 JP JP2003530699A patent/JP2005508337A/ja active Pending
- 2002-09-24 US US10/490,831 patent/US7015231B2/en not_active Expired - Fee Related
- 2002-09-24 EP EP02799606A patent/EP1430053B1/de not_active Expired - Lifetime
- 2002-09-24 ES ES02799606T patent/ES2275021T3/es not_active Expired - Lifetime
- 2002-09-24 AT AT02799606T patent/ATE343575T1/de not_active IP Right Cessation
- 2002-09-24 WO PCT/US2002/030150 patent/WO2003027111A1/en active IP Right Grant
- 2002-09-24 DE DE60215682T patent/DE60215682T2/de not_active Expired - Fee Related
-
2006
- 2006-01-20 US US11/336,010 patent/US20060128745A1/en not_active Abandoned
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