JP2005507245A5 - - Google Patents
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- Publication number
- JP2005507245A5 JP2005507245A5 JP2003519098A JP2003519098A JP2005507245A5 JP 2005507245 A5 JP2005507245 A5 JP 2005507245A5 JP 2003519098 A JP2003519098 A JP 2003519098A JP 2003519098 A JP2003519098 A JP 2003519098A JP 2005507245 A5 JP2005507245 A5 JP 2005507245A5
- Authority
- JP
- Japan
- Prior art keywords
- subunits
- genetically modified
- camp
- subunit
- cng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101000771077 Drosophila melanogaster Cyclic nucleotide-gated cation channel subunit A Proteins 0.000 claims description 6
- 241000283690 Bos taurus Species 0.000 claims description 3
- 108010036281 Cyclic Nucleotide-Gated Cation Channels Proteins 0.000 claims description 2
- 102000012003 Cyclic Nucleotide-Gated Cation Channels Human genes 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 125000004122 cyclic group Chemical class 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 description 3
- 102000030782 GTP binding Human genes 0.000 description 3
- 108091000058 GTP-Binding Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical group CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000008713 feedback mechanism Effects 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000004474 valine Chemical group 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10138876A DE10138876B4 (de) | 2001-08-08 | 2001-08-08 | Genetisch modifizierte zyklisch-Nukleotid-gesteuerte lonenkanäle und deren Verwendung |
| PCT/EP2002/008756 WO2003014149A2 (de) | 2001-08-08 | 2002-08-06 | Genetisch modifizierte zyklisch-nukleotid-gesteuerte ionenkanäle und deren verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507245A JP2005507245A (ja) | 2005-03-17 |
| JP2005507245A5 true JP2005507245A5 (https=) | 2008-10-30 |
| JP4304064B2 JP4304064B2 (ja) | 2009-07-29 |
Family
ID=7694756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519098A Expired - Fee Related JP4304064B2 (ja) | 2001-08-08 | 2002-08-06 | 遺伝子修飾された環状ヌクレオチド作動性イオンチャンネル及びその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7417117B2 (https=) |
| EP (1) | EP1414850B1 (https=) |
| JP (1) | JP4304064B2 (https=) |
| CA (1) | CA2456882A1 (https=) |
| DE (1) | DE10138876B4 (https=) |
| WO (1) | WO2003014149A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002311919B8 (en) | 2001-05-11 | 2007-03-22 | Ludwig Institute For Cancer Research Ltd | Specific binding proteins and uses thereof |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| DE10138876B4 (de) * | 2001-08-08 | 2008-11-06 | Forschungszentrum Jülich GmbH | Genetisch modifizierte zyklisch-Nukleotid-gesteuerte lonenkanäle und deren Verwendung |
| DE10311769A1 (de) * | 2003-03-18 | 2004-09-30 | Bayer Healthcare Ag | Testmethoden zur Bestimmung der intrazellulären Konzentration zyklischer Nukleotide |
| WO2011001885A1 (ja) * | 2009-06-30 | 2011-01-06 | 大塚製薬株式会社 | 甲状腺刺激ホルモンレセプターに対する抗体のバイオアッセイ法及び測定キットとこれらに用いる新規の遺伝子組み換え細胞 |
| US9316588B2 (en) | 2010-12-24 | 2016-04-19 | Otsuka Pharmaceutical Co., Ltd. | Bioassay method for detecting physiologically active substance |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001581A (en) | 1993-06-04 | 1999-12-14 | Sibia Neurosciences, Inc. | Cation-based bioassay using human metabotropic glutamate receptors |
| EP0988395A2 (en) | 1997-06-13 | 2000-03-29 | Allelix Biopharmaceuticals Inc. | Assay methods and compositions useful for measuring receptor ligand binding |
| DE19806581A1 (de) * | 1998-02-17 | 1999-10-21 | Forschungszentrum Juelich Gmbh | Sequenzen eines Ih-Ionenkanals und deren Verwendung |
| DE10138876B4 (de) * | 2001-08-08 | 2008-11-06 | Forschungszentrum Jülich GmbH | Genetisch modifizierte zyklisch-Nukleotid-gesteuerte lonenkanäle und deren Verwendung |
-
2001
- 2001-08-08 DE DE10138876A patent/DE10138876B4/de not_active Expired - Fee Related
-
2002
- 2002-08-06 WO PCT/EP2002/008756 patent/WO2003014149A2/de not_active Ceased
- 2002-08-06 JP JP2003519098A patent/JP4304064B2/ja not_active Expired - Fee Related
- 2002-08-06 EP EP02767329.2A patent/EP1414850B1/de not_active Expired - Lifetime
- 2002-08-06 US US10/486,316 patent/US7417117B2/en not_active Expired - Fee Related
- 2002-08-06 CA CA002456882A patent/CA2456882A1/en not_active Withdrawn
-
2008
- 2008-07-30 US US12/182,395 patent/US7951914B2/en not_active Expired - Fee Related
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