JP2005504770A5 - - Google Patents

Info

Publication number

JP2005504770A5

JP2005504770A5 JP2003521232A JP2003521232A JP2005504770A5 JP 2005504770 A5 JP2005504770 A5 JP 2005504770A5 JP 2003521232 A JP2003521232 A JP 2003521232A JP 2003521232 A JP2003521232 A JP 2003521232A JP 2005504770 A5 JP2005504770 A5 JP 2005504770A5

Authority

JP

Japan

Prior art keywords

compound

alkyl

following formula

haloalkyl

independently

Prior art date

2002-08-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 claims 50
• 125000000217 alkyl group Chemical group 0.000 claims 41
• 229910052736 halogen Inorganic materials 0.000 claims 14
• 150000002367 halogens Chemical class 0.000 claims 14
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 12
• 238000000034 method Methods 0.000 claims 12
• 125000001424 substituent group Chemical group 0.000 claims 12
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 11
• 229910052802 copper Inorganic materials 0.000 claims 11
• 239000010949 copper Substances 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 9
• 125000001475 halogen functional group Chemical group 0.000 claims 7
• 239000012351 deprotecting agent Substances 0.000 claims 6
• 239000002904 solvent Substances 0.000 claims 6
• 239000002738 chelating agent Substances 0.000 claims 5
• 230000008878 coupling Effects 0.000 claims 4
• 238000010168 coupling process Methods 0.000 claims 4
• 238000005859 coupling reaction Methods 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 150000001412 amines Chemical class 0.000 claims 3
• 229940124530 sulfonamide Drugs 0.000 claims 3
• 150000003456 sulfonamides Chemical class 0.000 claims 3
• GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 2
• -1 -OH Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
• 229940125758 compound 15 Drugs 0.000 claims 2
• KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
• 125000001033 ether group Chemical group 0.000 claims 2
• 150000003459 sulfonic acid esters Chemical class 0.000 claims 2
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
• FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical group N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims 1
• 125000003342 alkenyl group Chemical group 0.000 claims 1
• 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
• 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 229940125773 compound 10 Drugs 0.000 claims 1
• 230000005494 condensation Effects 0.000 claims 1
• 238000009833 condensation Methods 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 125000001188 haloalkyl group Chemical group 0.000 claims 1
• ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 239000001301 oxygen Substances 0.000 claims 1
• 125000005561 phenanthryl group Chemical group 0.000 claims 1
• 239000003223 protective agent Substances 0.000 claims 1
• 239000000376 reactant Substances 0.000 claims 1
• 229920006395 saturated elastomer Polymers 0.000 claims 1
• 0 *NCc1ccccc1 Chemical compound *NCc1ccccc1 0.000 description 2
• DIDKWCOCQJWMDJ-UHFFFAOYSA-N Oc(c1ncccc11)c(C(NCc(cc2)ccc2F)=O)nc1N(CCCC1)S1(=O)=O Chemical compound Oc(c1ncccc11)c(C(NCc(cc2)ccc2F)=O)nc1N(CCCC1)S1(=O)=O DIDKWCOCQJWMDJ-UHFFFAOYSA-N 0.000 description 1