JP2005504731A - ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造 - Google Patents

ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造 Download PDF

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JP2005504731A
JP2005504731A JP2002585380A JP2002585380A JP2005504731A JP 2005504731 A JP2005504731 A JP 2005504731A JP 2002585380 A JP2002585380 A JP 2002585380A JP 2002585380 A JP2002585380 A JP 2002585380A JP 2005504731 A JP2005504731 A JP 2005504731A
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compound
phenyl
gsk
pyrazolo
pyridazin
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JP2005504731A5 (https=
Inventor
ハー， エルンスト テア
ロボルカ スウェンソン，
ジェレミー グリーン，
マイケル ジェイ． アーノスト，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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JP2002585380A 2001-04-30 2002-04-29 ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造 Withdrawn JP2005504731A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28736601P 2001-04-30 2001-04-30
US29709401P 2001-06-08 2001-06-08
US36189902P 2002-02-27 2002-02-27
PCT/US2002/013511 WO2002088078A2 (en) 2001-04-30 2002-04-29 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3β PROTEIN AND PROTEIN COMPLEXES

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JP2009229078A Division JP2010059162A (ja) 2001-04-30 2009-09-30 ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造

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JP2005504731A true JP2005504731A (ja) 2005-02-17
JP2005504731A5 JP2005504731A5 (https=) 2005-07-21

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JP2002585380A Withdrawn JP2005504731A (ja) 2001-04-30 2002-04-29 ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造
JP2009229078A Pending JP2010059162A (ja) 2001-04-30 2009-09-30 ＧＳＫ−３のインヒビター、およびＧＳＫ−３βタンパク質およびタンパク質複合体の結晶構造

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US (4) US7390808B2 (https=)
EP (3) EP2295550A3 (https=)
JP (2) JP2005504731A (https=)
AT (1) ATE433751T1 (https=)
AU (1) AU2002259071A1 (https=)
CA (1) CA2444882A1 (https=)
DE (1) DE60232669D1 (https=)
MX (1) MXPA03009957A (https=)
WO (1) WO2002088078A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019502674A (ja) * 2015-08-25 2019-01-31 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用

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