JP2005503318A5 - - Google Patents
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- Publication number
- JP2005503318A5 JP2005503318A5 JP2001559423A JP2001559423A JP2005503318A5 JP 2005503318 A5 JP2005503318 A5 JP 2005503318A5 JP 2001559423 A JP2001559423 A JP 2001559423A JP 2001559423 A JP2001559423 A JP 2001559423A JP 2005503318 A5 JP2005503318 A5 JP 2005503318A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- agent
- solvent
- weight
- antifungal agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 23
- 229940121375 antifungal agent Drugs 0.000 description 13
- 239000003429 antifungal agent Substances 0.000 description 13
- 239000002904 solvent Substances 0.000 description 12
- 239000012745 toughening agent Substances 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 239000012528 membrane Substances 0.000 description 6
- 239000003961 penetration enhancing agent Substances 0.000 description 5
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- FKUPPRZPSYCDRS-UHFFFAOYSA-N Cyclopentadecanolide Chemical group O=C1CCCCCCCCCCCCCCO1 FKUPPRZPSYCDRS-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 150000007514 bases Chemical class 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000002998 adhesive polymer Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical group ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- YZWRNSARCRTXDS-UHFFFAOYSA-N tripropionin Chemical compound CCC(=O)OCC(OC(=O)CC)COC(=O)CC YZWRNSARCRTXDS-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18292400P | 2000-02-16 | 2000-02-16 | |
| PCT/US2001/005302 WO2001060325A1 (en) | 2000-02-16 | 2001-02-16 | Pharmaceutical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503318A JP2005503318A (ja) | 2005-02-03 |
| JP2005503318A5 true JP2005503318A5 (enExample) | 2008-04-03 |
Family
ID=22670647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001559423A Pending JP2005503318A (ja) | 2000-02-16 | 2001-02-16 | 医薬組成物 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1257248B1 (enExample) |
| JP (1) | JP2005503318A (enExample) |
| KR (2) | KR20030016227A (enExample) |
| CN (1) | CN1422142A (enExample) |
| AT (1) | ATE526917T1 (enExample) |
| AU (2) | AU4318901A (enExample) |
| BR (1) | BR0108438A (enExample) |
| CA (1) | CA2400178A1 (enExample) |
| HU (1) | HUP0204555A3 (enExample) |
| MA (1) | MA26883A1 (enExample) |
| MX (1) | MXPA02008072A (enExample) |
| NO (1) | NO20023866L (enExample) |
| NZ (1) | NZ520749A (enExample) |
| PL (1) | PL357111A1 (enExample) |
| TW (1) | TWI232756B (enExample) |
| WO (1) | WO2001060325A1 (enExample) |
| ZA (1) | ZA200206553B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6585963B1 (en) * | 2001-02-15 | 2003-07-01 | Watson Pharmaceuticals, Inc. | Nail compositions and methods of administering same |
| GB0203276D0 (en) * | 2002-02-12 | 2002-03-27 | Novartis Ag | Organic compounds |
| DE60318867T2 (de) | 2002-09-05 | 2009-01-15 | Galderma S.A. | Lösung für die anwendung an nägeln |
| AU2004224326B2 (en) * | 2003-03-21 | 2010-04-22 | Nexmed Holdings, Inc. | Antifungal nail coat and method of use |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| JP5010125B2 (ja) * | 2005-09-02 | 2012-08-29 | 有限会社日本健康科学研究センター | 水虫治療用フィルム製剤 |
| WO2007056068A2 (en) * | 2005-11-02 | 2007-05-18 | Bentley Pharmaceuticals, Inc. | Macrocyclic formulations for transmembrane drug delivery |
| EP1959929A4 (en) * | 2005-12-14 | 2012-08-15 | Zars Pharma Inc | COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL SUFFERING |
| WO2007077806A1 (ja) * | 2005-12-28 | 2007-07-12 | Teikoku Seiyaku Co., Ltd. | 爪用医薬組成物 |
| WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| JP5654497B2 (ja) * | 2009-02-13 | 2015-01-14 | トピカ ファーマシューティカルズ，インコーポレイテッド | 抗真菌製剤 |
| PL2408299T3 (pl) * | 2009-03-20 | 2014-03-31 | Stiefel Laboratories | Kompozycje monoglicerydu kwasu tłuszczowego |
| GB201021386D0 (en) * | 2010-12-16 | 2011-01-26 | Burke Michael H | A process for the manufacture of an antifungal nail lacquer |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| AR100562A1 (es) | 2014-05-22 | 2016-10-12 | Therapeuticsmd Inc | Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal |
| KR101580077B1 (ko) * | 2015-03-28 | 2015-12-24 | 한국콜마주식회사 | 시크로피록스 함유 네일락카 조성물 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| RU2018133932A (ru) | 2016-04-01 | 2020-05-12 | Терапьютиксмд, Инк. | Фармацевтическая композиция стероидного гормона |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299826A (en) * | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5731303A (en) * | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
| DE3720147A1 (de) * | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
| DE69216446T2 (de) * | 1991-03-13 | 1997-06-26 | Firmenich & Cie | Verfahren zur Herstellung von 15-Pentadecanolid oder von an diesem Makrolid reichen Gemischen |
| CA2211004A1 (en) * | 1994-10-20 | 1996-05-02 | The Procter & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| US5693828A (en) * | 1996-05-09 | 1997-12-02 | International Flavors & Fragrances Inc. | Process for preparing lactones and intermediates therefor |
| CA2278328C (en) * | 1998-02-09 | 2008-07-22 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| US6231875B1 (en) * | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
| US6495124B1 (en) * | 2000-02-14 | 2002-12-17 | Macrochem Corporation | Antifungal nail lacquer and method using same |
-
2001
- 2001-02-16 KR KR1020027010571A patent/KR20030016227A/ko not_active Ceased
- 2001-02-16 PL PL01357111A patent/PL357111A1/xx not_active Application Discontinuation
- 2001-02-16 NZ NZ520749A patent/NZ520749A/en unknown
- 2001-02-16 CA CA002400178A patent/CA2400178A1/en not_active Abandoned
- 2001-02-16 AT AT01916128T patent/ATE526917T1/de not_active IP Right Cessation
- 2001-02-16 JP JP2001559423A patent/JP2005503318A/ja active Pending
- 2001-02-16 MX MXPA02008072A patent/MXPA02008072A/es not_active Application Discontinuation
- 2001-02-16 KR KR1020087011722A patent/KR20080049148A/ko not_active Withdrawn
- 2001-02-16 AU AU4318901A patent/AU4318901A/xx active Pending
- 2001-02-16 CN CN01807713A patent/CN1422142A/zh active Pending
- 2001-02-16 WO PCT/US2001/005302 patent/WO2001060325A1/en not_active Ceased
- 2001-02-16 EP EP01916128A patent/EP1257248B1/en not_active Expired - Lifetime
- 2001-02-16 AU AU2001243189A patent/AU2001243189B2/en not_active Ceased
- 2001-02-16 HU HU0204555A patent/HUP0204555A3/hu unknown
- 2001-02-16 TW TW090103582A patent/TWI232756B/zh not_active IP Right Cessation
- 2001-02-16 BR BR0108438-0A patent/BR0108438A/pt not_active IP Right Cessation
-
2002
- 2002-08-15 NO NO20023866A patent/NO20023866L/no not_active Application Discontinuation
- 2002-08-15 ZA ZA200206553A patent/ZA200206553B/en unknown
- 2002-09-11 MA MA26811A patent/MA26883A1/fr unknown
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