JP2005501874A5 - - Google Patents
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- Publication number
- JP2005501874A5 JP2005501874A5 JP2003524354A JP2003524354A JP2005501874A5 JP 2005501874 A5 JP2005501874 A5 JP 2005501874A5 JP 2003524354 A JP2003524354 A JP 2003524354A JP 2003524354 A JP2003524354 A JP 2003524354A JP 2005501874 A5 JP2005501874 A5 JP 2005501874A5
- Authority
- JP
- Japan
- Prior art keywords
- cross
- collagenous tissue
- linking reagent
- linking
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003431 cross linking reagent Substances 0.000 claims 55
- 210000001519 tissue Anatomy 0.000 claims 34
- 238000000034 method Methods 0.000 claims 22
- 239000002612 dispersion medium Substances 0.000 claims 13
- 230000015556 catabolic process Effects 0.000 claims 11
- 238000006731 degradation reaction Methods 0.000 claims 11
- 238000013268 sustained release Methods 0.000 claims 10
- 239000012730 sustained-release form Substances 0.000 claims 10
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims 7
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims 7
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000007975 buffered saline Substances 0.000 claims 2
- 229920002770 condensed tannin Polymers 0.000 claims 2
- 238000007654 immersion Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 231100000065 noncytotoxic Toxicity 0.000 claims 2
- 230000002020 noncytotoxic effect Effects 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 241001272720 Medialuna californiensis Species 0.000 claims 1
- 210000001188 articular cartilage Anatomy 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31628701P | 2001-08-31 | 2001-08-31 | |
| PCT/US2002/027677 WO2003020031A1 (en) | 2001-08-31 | 2002-08-29 | Use of non-toxic crosslinking reagents to improve fatigue resistance and reduce mechanical degradation of intervertebral disc and other collagenous tissues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501874A JP2005501874A (ja) | 2005-01-20 |
| JP2005501874A5 true JP2005501874A5 (https=) | 2005-12-22 |
Family
ID=23228386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524354A Pending JP2005501874A (ja) | 2001-08-31 | 2002-08-29 | 椎間板及び他のコラーゲン性組織の耐疲労性を向上させ、且つ機械的劣化を低下させるための無毒性架橋試薬の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9084772B2 (https=) |
| EP (1) | EP1432312B1 (https=) |
| JP (1) | JP2005501874A (https=) |
| CN (1) | CN1578624A (https=) |
| AU (1) | AU2002335683B2 (https=) |
| CA (1) | CA2458821C (https=) |
| WO (1) | WO2003020031A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436143B1 (en) * | 1999-02-22 | 2002-08-20 | Anthony C. Ross | Method and apparatus for treating intervertebral disks |
| US6723335B1 (en) | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
| WO2012006095A1 (en) | 2010-06-28 | 2012-01-12 | Hedman Thomas P | Tissue crosslinking for treatment of snoring and obstructive sleep apnea |
| US7435722B2 (en) * | 2001-08-31 | 2008-10-14 | University Of Southern California | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability |
| US8022101B2 (en) * | 2001-08-31 | 2011-09-20 | Orthopeutics, L.P. | Method of treating a knee meniscus with a cross-linking reagent to increase resistance to tearing or rupturing |
| US20070202143A1 (en) * | 2001-08-31 | 2007-08-30 | Hedman Thomas P | Direct application of non-toxic crosslinking reagents to restabilize surgically destabilized intervertebral joints |
| US8119599B2 (en) * | 2001-08-31 | 2012-02-21 | Orthopeutics, L.P. | Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity |
| CA2536415C (en) * | 2001-08-31 | 2013-07-23 | University Of Southern California | Crosslinking reagent for treating intervertebral disc disorders |
| US20050209699A1 (en) * | 2002-03-19 | 2005-09-22 | Slivka Michael A | Method for nonsurgical treatment of the nucleus pulposus of the intervertebral disc using genipin or proanthrocyanidin, and kit therefor |
| US6812211B2 (en) | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
| JP2009525327A (ja) * | 2006-02-02 | 2009-07-09 | ヘドマン，トム | 進行性の脊髄の奇形に抵抗する非毒性架橋試薬の直接的なアプリケーション |
| US20090123581A1 (en) * | 2006-06-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Collagen cross-linking agents on dental restorative treatment and preventive dentistry |
| US20080065218A1 (en) * | 2006-09-13 | 2008-03-13 | O'neil Michael J | Annulus fibrosus repair devices and techniques |
| US20080172126A1 (en) * | 2006-10-03 | 2008-07-17 | Reynolds Martin A | Nucleus pulposus injection devices and methods |
| KR20230146124A (ko) | 2006-10-06 | 2023-10-18 | 셀룰래리티 인코포레이티드 | 천연(텔로펩티드) 태반 콜라겐 조성물 |
| US10278947B2 (en) | 2007-02-28 | 2019-05-07 | Orthopeutics, L.P. | Crosslinker enhanced repair of connective tissues |
| US8557319B2 (en) | 2008-03-28 | 2013-10-15 | Wild Flavors, Inc. | Stable natural color process, products and use thereof |
| US20130085569A1 (en) | 2010-05-27 | 2013-04-04 | Orthopeutics, L.P. | Crosslinker enhanced repair of knee meniscus |
| US9339478B2 (en) * | 2011-02-04 | 2016-05-17 | Reckitt Benckiser Llc | Pharmaceutical formulation |
| EA028521B1 (ru) | 2011-11-07 | 2017-11-30 | Уайлд Флэйворс, Инк. | Богатый генипином материал и его применение |
| EP3838280A1 (en) | 2012-12-07 | 2021-06-23 | Celularity Inc. | Treating oral lesions using placental extracellular matrix |
| WO2014165023A1 (en) | 2013-03-12 | 2014-10-09 | Carnegie Mellon University | Coated vaso-occclusive device for treatment of aneurysms |
| NO2975611T3 (https=) | 2013-03-15 | 2018-06-09 | ||
| JP2016526387A (ja) | 2013-06-24 | 2016-09-05 | アントフロゲネシス コーポレーション | 細胞培養のための細胞外マトリクス組成物ビーズ |
| ES2667821B1 (es) * | 2016-10-14 | 2019-02-22 | Univ Granada | Membranas bioartificiales de rigidez y viscoelasticidad controlada para su utilizacion en ingenieria tisular |
| JP6994147B2 (ja) * | 2016-10-31 | 2022-02-15 | 地方独立行政法人東京都立産業技術研究センター | 高分子多糖類又はタンパク質架橋用架橋剤及びその製造方法、架橋高分子多糖類又は架橋タンパク質形成用ゾル及びその製造方法 |
| US12186199B2 (en) | 2022-11-15 | 2025-01-07 | Spinal Simplicity, Llc | Shield for spinal defect |
| CN120733129B (zh) * | 2025-08-28 | 2025-11-14 | 浙江珂瑞康生物医疗科技有限公司 | 一种胶原双相体系交联材料及其制备方法和植入支架 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5270446A (en) * | 1989-04-04 | 1993-12-14 | Suntory Limited | Decolorized crosslinked products and method for decolorization of crosslinked products |
| JPH02263833A (ja) | 1989-04-04 | 1990-10-26 | Suntory Ltd | イリドイド化合物により架橋された形成物の脱色方法及び脱色された架橋形成物 |
| KR920702383A (ko) * | 1989-08-28 | 1992-09-03 | 원본미기재 | 치료제의 방출을 조절하는데 유용한 생부식성 중합체 |
| KR100218052B1 (ko) * | 1992-07-15 | 1999-09-01 | 이병언 | B형 간염 바이러스의 복제를 억제하는 약학적 제제 |
| FI955691L (fi) * | 1994-11-28 | 1996-05-29 | Suntory Ltd | Lipoproteiini(a):ta alentava aine, kolesterolia alentava aine ja näitä aineita sisältävät lääkkeet |
| WO1998019718A1 (en) * | 1996-11-05 | 1998-05-14 | Challenge Bioproducts Co., Ltd. | Chemical modification of biomedical materials with genipin |
| AU7781498A (en) * | 1997-06-04 | 1998-12-21 | Biocompatibles Limited | Zwitterionic compounds and their use to cross-link collagenous materials |
| US6375672B1 (en) * | 1999-03-22 | 2002-04-23 | Board Of Trustees Of Michigan State University | Method for controlling the chemical and heat induced responses of collagenous materials |
| AU6918700A (en) * | 1999-08-20 | 2001-03-19 | Howard Murad | Pharmaceutical compositions and methods for reducing the appearance of cellulite |
| US6812211B2 (en) * | 2002-03-19 | 2004-11-02 | Michael Andrew Slivka | Method for nonsurgical treatment of the intervertebral disc and kit therefor |
| JP2004214443A (ja) | 2003-01-06 | 2004-07-29 | Nec Corp | 折り畳み式電子装置 |
-
2002
- 2002-08-29 JP JP2003524354A patent/JP2005501874A/ja active Pending
- 2002-08-29 US US10/230,671 patent/US9084772B2/en active Active
- 2002-08-29 CN CNA028216849A patent/CN1578624A/zh active Pending
- 2002-08-29 EP EP02770446.9A patent/EP1432312B1/en not_active Expired - Lifetime
- 2002-08-29 AU AU2002335683A patent/AU2002335683B2/en not_active Expired
- 2002-08-29 WO PCT/US2002/027677 patent/WO2003020031A1/en not_active Ceased
- 2002-08-29 CA CA 2458821 patent/CA2458821C/en not_active Expired - Lifetime
-
2010
- 2010-12-13 US US12/966,812 patent/US9101602B2/en not_active Expired - Lifetime
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