JP2005501251A - 電場を使用する分析物の操作 - Google Patents
電場を使用する分析物の操作 Download PDFInfo
- Publication number
- JP2005501251A JP2005501251A JP2003523982A JP2003523982A JP2005501251A JP 2005501251 A JP2005501251 A JP 2005501251A JP 2003523982 A JP2003523982 A JP 2003523982A JP 2003523982 A JP2003523982 A JP 2003523982A JP 2005501251 A JP2005501251 A JP 2005501251A
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- analyte
- region
- power source
- manipulation device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- B03C5/022—Non-uniform field separators
- B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N2001/4038—Concentrating samples electric methods, e.g. electromigration, electrophoresis, ionisation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Electrochemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Engineering & Computer Science (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/938,894 US7014744B2 (en) | 2001-08-24 | 2001-08-24 | Method of purification and concentration using AC fields with a transfer tip |
PCT/US2002/026827 WO2003019164A1 (en) | 2001-08-24 | 2002-08-23 | Manipulation of analytes using electric fields |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007034138A Division JP2007178437A (ja) | 2001-08-24 | 2007-02-14 | 電場を使用する分析物の操作 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005501251A true JP2005501251A (ja) | 2005-01-13 |
Family
ID=25472154
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003523982A Pending JP2005501251A (ja) | 2001-08-24 | 2002-08-23 | 電場を使用する分析物の操作 |
JP2007034138A Pending JP2007178437A (ja) | 2001-08-24 | 2007-02-14 | 電場を使用する分析物の操作 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007034138A Pending JP2007178437A (ja) | 2001-08-24 | 2007-02-14 | 電場を使用する分析物の操作 |
Country Status (7)
Country | Link |
---|---|
US (3) | US7014744B2 (de) |
EP (4) | EP1419376B1 (de) |
JP (2) | JP2005501251A (de) |
AT (1) | ATE483967T1 (de) |
CA (1) | CA2456684A1 (de) |
DE (1) | DE60237900D1 (de) |
WO (1) | WO2003019164A1 (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017512483A (ja) * | 2014-04-08 | 2017-05-25 | バイオロジカル ダイナミクス,インク. | 生体物質の単離のための改良された装置 |
JP2019508686A (ja) * | 2016-03-02 | 2019-03-28 | ジェイ・ピィ・サイエンティフィック・リミテッドJp S | サンプルから成分を抽出するための方法および装置 |
US11534756B2 (en) | 2016-03-24 | 2022-12-27 | Biological Dynamics, Inc. | Compact device for detection of nanoscale analytes |
US11731132B2 (en) | 2017-12-19 | 2023-08-22 | Biological Dynamics, Inc. | Methods and devices for detection of multiple analytes from a biological sample |
US11883833B2 (en) | 2018-04-02 | 2024-01-30 | Biological Dynamics, Inc. | Dielectric materials |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7014744B2 (en) * | 2001-08-24 | 2006-03-21 | Applera Corporation | Method of purification and concentration using AC fields with a transfer tip |
US7188731B2 (en) | 2002-08-26 | 2007-03-13 | The Regents Of The University Of California | Variable flexure-based fluid filter |
US7147764B2 (en) | 2003-03-28 | 2006-12-12 | Applera Corporation | Dual electrode injection of analyte into a capillary electrophoretic device |
WO2006087890A1 (ja) * | 2005-02-15 | 2006-08-24 | Kochi University Of Technology | 電極対式非接触型マニピュレーション装置並びにマニピュレーション方法 |
KR100773542B1 (ko) | 2005-07-19 | 2007-11-07 | 삼성전자주식회사 | 유체의 pH를 전기화학적으로 조절하기 위한 미세유동장치및 그를 이용하여 pH를 조절하는 방법 |
US20070059213A1 (en) * | 2005-09-15 | 2007-03-15 | Lucent Technologies Inc. | Heat-induced transitions on a structured surface |
US8734003B2 (en) * | 2005-09-15 | 2014-05-27 | Alcatel Lucent | Micro-chemical mixing |
US8721161B2 (en) | 2005-09-15 | 2014-05-13 | Alcatel Lucent | Fluid oscillations on structured surfaces |
IL203741A (en) * | 2010-02-04 | 2016-07-31 | Ben Gurion Univ Of The Negev Res And Dev Authority | Neutralizing harmful powders by mail |
US9618431B2 (en) * | 2010-11-30 | 2017-04-11 | Inspirotec, Inc. | Electrokinetic device for capturing assayable agents in a dielectric fluid |
WO2013018414A1 (ja) * | 2011-07-29 | 2013-02-07 | 東京エレクトロン株式会社 | 処理液供給装置、処理液供給方法及びコンピュータ記憶媒体 |
US9852560B2 (en) | 2013-03-08 | 2017-12-26 | Lear Corporation | Vehicle remote function system and method for effectuating vehicle operations based on vehicle FOB movement |
US10206663B2 (en) | 2015-01-14 | 2019-02-19 | Roc8Sci Co. | Apparatus for drawing of a bodily fluid and method therefor |
JP6355857B2 (ja) | 2015-03-09 | 2018-07-11 | カリフォルニア・インスティテュート・オブ・テクノロジーCalifornia Institute Of Technology | 中赤外ハイパースペクトル分光システム及び方法 |
EP3112869A1 (de) * | 2015-06-30 | 2017-01-04 | IMEC vzw | Sensorvorrichtung |
JP6714924B2 (ja) * | 2015-11-30 | 2020-07-01 | 国立大学法人大阪大学 | サンプル検出用デバイス、サンプル検出装置及びイオン電流の検出方法 |
WO2020079220A1 (en) * | 2018-10-18 | 2020-04-23 | Danmarks Tekniske Universitet | Methods for extraction of molecules |
EP3921612A4 (de) | 2019-02-06 | 2022-11-02 | California Institute of Technology | Kompaktes hyperspektrales mittelinfrarot-spektrometer |
US11313722B2 (en) | 2019-11-08 | 2022-04-26 | California Institute Of Technology | Infrared spectrometer having dielectric-polymer-based spectral filter |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59216583A (ja) * | 1983-05-13 | 1984-12-06 | ケルンフオルシユングスアンラ−ゲ・ユ−リツヒ・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング | 電気的な場において細胞を処理するための装置 |
JPS61285984A (ja) * | 1985-06-12 | 1986-12-16 | フォルシュングスツエントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 電気的な場において細胞を処理するための装置 |
US4911806A (en) * | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
JPH03502043A (ja) * | 1987-10-09 | 1991-05-16 | ベイラー カレッジ オブ メディシン | 高周波電気パルスによる細胞ポレーションと細胞融合用の方法及び装置 |
JPH04250332A (ja) * | 1991-01-28 | 1992-09-07 | Res Dev Corp Of Japan | 生体関連物質の捕捉装置とそれを用いた生体関連物質の観察方法 |
JPH09271379A (ja) * | 1996-04-05 | 1997-10-21 | Moritex Corp | マイクロマニピュレータ及びこれに用いるセル |
US6203683B1 (en) * | 1998-11-09 | 2001-03-20 | Princeton University | Electrodynamically focused thermal cycling device |
JP2001165905A (ja) * | 1999-09-30 | 2001-06-22 | Wako Pure Chem Ind Ltd | 誘電泳動力を用いた物質の分離方法 |
JP2003527601A (ja) * | 2000-03-10 | 2003-09-16 | アプレラ コーポレイション | 交流電場を用いた極性分析物を配置および濃縮するための方法および装置 |
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US4326934A (en) * | 1979-12-31 | 1982-04-27 | Pohl Herbert A | Continuous dielectrophoretic cell classification method |
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US4643814A (en) * | 1985-02-20 | 1987-02-17 | Ionics, Incorporated | Structure selective fibrous sorbents and method and apparatus for using the same |
DE3522610A1 (de) | 1985-06-12 | 1986-12-18 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Kammer fuer die behandlung von zellen im elektrischen feld |
US4767514A (en) * | 1987-03-31 | 1988-08-30 | Candor James T | Apparatus and method for removing liquid from liquid bearing material |
US4970154A (en) * | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
USRE35102E (en) | 1989-06-01 | 1995-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Capillary electrophoretic device employing structure permitting electrical contact through ionic movement |
US5164055A (en) | 1990-01-29 | 1992-11-17 | Applied Biosystems, Inc. | High-viscosity polymer matrix and methods |
WO1992008517A1 (en) | 1990-11-16 | 1992-05-29 | Steven Kaali | Alternating current supplied electrically conductive method and system for treatment of blood and/or other body fluids and/or synthetic fluids with electric forces |
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US5422272A (en) * | 1993-07-14 | 1995-06-06 | Andrew A. Papp | Improvements to apparatus and method for electroporation |
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US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5985119A (en) | 1994-11-10 | 1999-11-16 | Sarnoff Corporation | Electrokinetic pumping |
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US5989402A (en) | 1997-08-29 | 1999-11-23 | Caliper Technologies Corp. | Controller/detector interfaces for microfluidic systems |
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US6132582A (en) | 1998-09-14 | 2000-10-17 | The Perkin-Elmer Corporation | Sample handling system for a multi-channel capillary electrophoresis device |
US6149787A (en) * | 1998-10-14 | 2000-11-21 | Caliper Technologies Corp. | External material accession systems and methods |
US6159368A (en) | 1998-10-29 | 2000-12-12 | The Perkin-Elmer Corporation | Multi-well microfiltration apparatus |
CA2371880A1 (en) * | 1999-02-15 | 2000-08-24 | Frank Vitzthum | Method and sample support system for separating and processing substances in situ |
HUP9900603A1 (hu) * | 1999-03-12 | 2000-12-28 | MTA Mezőgazdasági Kutatóintézete | Eljárás és berendezés magasabbrendű növények polarizálható sejtjeinek immobilizálására nagy frekvenciájú váltóáram alkalmazásával |
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US7014744B2 (en) * | 2001-08-24 | 2006-03-21 | Applera Corporation | Method of purification and concentration using AC fields with a transfer tip |
-
2001
- 2001-08-24 US US09/938,894 patent/US7014744B2/en not_active Expired - Lifetime
-
2002
- 2002-08-23 JP JP2003523982A patent/JP2005501251A/ja active Pending
- 2002-08-23 EP EP02766066A patent/EP1419376B1/de not_active Expired - Lifetime
- 2002-08-23 DE DE60237900T patent/DE60237900D1/de not_active Expired - Lifetime
- 2002-08-23 CA CA002456684A patent/CA2456684A1/en not_active Abandoned
- 2002-08-23 WO PCT/US2002/026827 patent/WO2003019164A1/en active Application Filing
- 2002-08-23 EP EP10013119A patent/EP2295956A3/de not_active Withdrawn
- 2002-08-23 EP EP10000182A patent/EP2187200A3/de not_active Withdrawn
- 2002-08-23 EP EP06003605A patent/EP1674159A1/de not_active Withdrawn
- 2002-08-23 AT AT02766066T patent/ATE483967T1/de not_active IP Right Cessation
-
2006
- 2006-01-24 US US11/338,255 patent/US7611614B2/en not_active Expired - Lifetime
-
2007
- 2007-02-14 JP JP2007034138A patent/JP2007178437A/ja active Pending
-
2009
- 2009-10-15 US US12/580,220 patent/US20100032298A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59216583A (ja) * | 1983-05-13 | 1984-12-06 | ケルンフオルシユングスアンラ−ゲ・ユ−リツヒ・ゲゼルシヤフト・ミト・ベシユレンクテル・ハフツング | 電気的な場において細胞を処理するための装置 |
JPS61285984A (ja) * | 1985-06-12 | 1986-12-16 | フォルシュングスツエントルム・ユーリッヒ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 電気的な場において細胞を処理するための装置 |
US4911806A (en) * | 1987-02-27 | 1990-03-27 | Biotronics | Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields |
JPH03502043A (ja) * | 1987-10-09 | 1991-05-16 | ベイラー カレッジ オブ メディシン | 高周波電気パルスによる細胞ポレーションと細胞融合用の方法及び装置 |
JPH04250332A (ja) * | 1991-01-28 | 1992-09-07 | Res Dev Corp Of Japan | 生体関連物質の捕捉装置とそれを用いた生体関連物質の観察方法 |
JPH09271379A (ja) * | 1996-04-05 | 1997-10-21 | Moritex Corp | マイクロマニピュレータ及びこれに用いるセル |
US6203683B1 (en) * | 1998-11-09 | 2001-03-20 | Princeton University | Electrodynamically focused thermal cycling device |
JP2001165905A (ja) * | 1999-09-30 | 2001-06-22 | Wako Pure Chem Ind Ltd | 誘電泳動力を用いた物質の分離方法 |
JP2003527601A (ja) * | 2000-03-10 | 2003-09-16 | アプレラ コーポレイション | 交流電場を用いた極性分析物を配置および濃縮するための方法および装置 |
Non-Patent Citations (3)
Title |
---|
CHARLES L. ASBURY AND GER VAN DEN ENGH: "Trapping of DNA in Nonuniform Oscillating Electric Fields", BIOPHYSICAL JOURNAL, vol. 74, no. 2, JPNX006053042, February 1998 (1998-02-01), US, pages 1024 - 1030, XP003009260, ISSN: 0000788881 * |
M. WASHIZU AND O. KUROSAWA: "Electrostatic Manipulation of DNA in Microfabricated Structures", IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, vol. 26, no. 6, JPN4007012542, 1990, US, pages 1165 - 1172, XP000177513, ISSN: 0000867417 * |
WASHIZU, M. KUROSAWA, O. ARAI, I. SUZUKI, S. SHIMAMOTO, N.: "Applications of electrostatic stretch-and-positioning of DNA", IEEE TRANSACTIONS OF INDUSTRY APPLICATIONS, vol. 31, no. 3, JPN4006021450, June 1995 (1995-06-01), US, pages 447 - 456, ISSN: 0000788880 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017512483A (ja) * | 2014-04-08 | 2017-05-25 | バイオロジカル ダイナミクス,インク. | 生体物質の単離のための改良された装置 |
JP2019508686A (ja) * | 2016-03-02 | 2019-03-28 | ジェイ・ピィ・サイエンティフィック・リミテッドJp S | サンプルから成分を抽出するための方法および装置 |
US11534756B2 (en) | 2016-03-24 | 2022-12-27 | Biological Dynamics, Inc. | Compact device for detection of nanoscale analytes |
US11731132B2 (en) | 2017-12-19 | 2023-08-22 | Biological Dynamics, Inc. | Methods and devices for detection of multiple analytes from a biological sample |
US11883833B2 (en) | 2018-04-02 | 2024-01-30 | Biological Dynamics, Inc. | Dielectric materials |
Also Published As
Publication number | Publication date |
---|---|
EP1674159A1 (de) | 2006-06-28 |
EP2187200A2 (de) | 2010-05-19 |
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EP1419376A1 (de) | 2004-05-19 |
US7611614B2 (en) | 2009-11-03 |
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EP2295956A2 (de) | 2011-03-16 |
ATE483967T1 (de) | 2010-10-15 |
JP2007178437A (ja) | 2007-07-12 |
US20100032298A1 (en) | 2010-02-11 |
DE60237900D1 (de) | 2010-11-18 |
US20030038032A1 (en) | 2003-02-27 |
EP1419376A4 (de) | 2005-06-01 |
WO2003019164A1 (en) | 2003-03-06 |
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