JP2005501031A5 - - Google Patents
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- Publication number
- JP2005501031A5 JP2005501031A5 JP2003510106A JP2003510106A JP2005501031A5 JP 2005501031 A5 JP2005501031 A5 JP 2005501031A5 JP 2003510106 A JP2003510106 A JP 2003510106A JP 2003510106 A JP2003510106 A JP 2003510106A JP 2005501031 A5 JP2005501031 A5 JP 2005501031A5
- Authority
- JP
- Japan
- Prior art keywords
- agonism
- sildenafil
- concentration
- frequency
- increase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 2
- 230000008484 agonism Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QGNBTYAQAPLTMX-UHFFFAOYSA-L calcium dobesilate Chemical compound [Ca+2].OC1=CC=C(O)C(S([O-])(=O)=O)=C1.OC1=CC=C(O)C(S([O-])(=O)=O)=C1 QGNBTYAQAPLTMX-UHFFFAOYSA-L 0.000 description 1
- 229960005438 calcium dobesilate Drugs 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 229960003310 sildenafil Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101535A ES2180446B1 (es) | 2001-07-02 | 2001-07-02 | Empleo de derivados de acidos 2,5-dihidroxibencenosulfonicos en la elaboracion de un medicamento para potenciar el efecto de otros farmacos en el tratamiento de la disfuncion erectil. |
| PCT/ES2002/000325 WO2003004097A1 (es) | 2001-07-02 | 2002-07-01 | Empleo de derivados de ácidos 2,5-dihidroxibencenosulfónicos en la elaboración de un medicamento para potenciar el efecto de otros fármacos en el tratamiento de la disfunción eréctil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501031A JP2005501031A (ja) | 2005-01-13 |
| JP2005501031A5 true JP2005501031A5 (https=) | 2006-01-05 |
Family
ID=8498259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510106A Pending JP2005501031A (ja) | 2001-07-02 | 2002-07-01 | 勃起障害の治療における他の薬物の効果を増強するために用いる医薬の生産における２，５−ジヒドロキシベンゼンスルホン酸誘導体の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040143010A1 (https=) |
| EP (1) | EP1413332B1 (https=) |
| JP (1) | JP2005501031A (https=) |
| AR (1) | AR036124A1 (https=) |
| AT (1) | ATE419012T1 (https=) |
| BR (1) | BR0211315A (https=) |
| CA (1) | CA2453572A1 (https=) |
| DE (1) | DE60230629D1 (https=) |
| ES (2) | ES2180446B1 (https=) |
| HU (1) | HUP0400924A3 (https=) |
| MX (1) | MXPA04000007A (https=) |
| NO (1) | NO20040007L (https=) |
| PL (1) | PL367766A1 (https=) |
| WO (1) | WO2003004097A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2208123A1 (es) * | 2002-11-29 | 2004-06-01 | Laboratorios Del Dr. Esteve, S.A. | Uso de los compuestos 2,5-dihidroxibencenosulfonicos para la fabricacion de un medicamento. |
| ES2222831B2 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
| RU2281101C2 (ru) * | 2004-10-01 | 2006-08-10 | Юрий Михайлович Есилевский | Способ лечения больных хроническим простатитом |
| EP1676573A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Phamaceutical composition comprising a 2,5-dihydroxybenzenesulfonic-compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| CN109678764A (zh) * | 2018-12-05 | 2019-04-26 | 湖北广辰药业有限公司 | 一种羟苯双磺酸及其钙盐和制备方法 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681503A (en) * | 1970-04-17 | 1972-08-01 | Om Lab Sa | Method for combating disturbances of the lipid content of the blood |
| US4252821A (en) * | 1979-12-07 | 1981-02-24 | Laboratoires Om Societe Anonyme | Method for treating ulcers |
| US4511557A (en) * | 1981-08-24 | 1985-04-16 | Gauri Kailash Kumar | Pharmaceutical composition |
| US4513007A (en) * | 1983-05-03 | 1985-04-23 | Laboratoires Om Sa | Method for treating heart disease |
| RU1776408C (ru) * | 1990-08-13 | 1992-11-23 | Одесский Медицинский Институт Им.Н.И.Пирогова | Способ лечени гломерулонефрита |
| JP2000508308A (ja) * | 1996-04-03 | 2000-07-04 | ラボラトリオス デル ドクトール エステベ，エス．アー． | 内皮機能の正常化、性的機能障害、糖尿病の血管合併症及び内皮起源の血管障害の治療用の医薬の製造のための２，５―ジヒドロキシベンゼンスルホン酸誘導体の使用 |
| HU225149B1 (en) * | 1996-12-30 | 2006-07-28 | Teva Gyogyszergyar Zrt | Use of dobesilate salts for the manufacture of medicaments for the treatment or prevention of embryonic retardation or discordance |
| US6403643B1 (en) * | 1997-04-03 | 2002-06-11 | Laboratories Del Dr. Esteve, S.A. | Use of 2,5-dihydroxybenzenesulfonic derivatives for the normalization of endothelial function |
| US5994363A (en) * | 1998-08-24 | 1999-11-30 | Pentech Pharmaceuticals, Inc. | Amelioration of apomorphine adverse effects |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
-
2001
- 2001-07-02 ES ES200101535A patent/ES2180446B1/es not_active Expired - Fee Related
-
2002
- 2002-07-01 PL PL02367766A patent/PL367766A1/xx not_active Application Discontinuation
- 2002-07-01 AR ARP020102472A patent/AR036124A1/es not_active Application Discontinuation
- 2002-07-01 BR BR0211315-5A patent/BR0211315A/pt not_active IP Right Cessation
- 2002-07-01 WO PCT/ES2002/000325 patent/WO2003004097A1/es not_active Ceased
- 2002-07-01 HU HU0400924A patent/HUP0400924A3/hu unknown
- 2002-07-01 ES ES02745439T patent/ES2318023T3/es not_active Expired - Lifetime
- 2002-07-01 MX MXPA04000007A patent/MXPA04000007A/es not_active Application Discontinuation
- 2002-07-01 DE DE60230629T patent/DE60230629D1/de not_active Expired - Fee Related
- 2002-07-01 EP EP02745439A patent/EP1413332B1/en not_active Expired - Lifetime
- 2002-07-01 CA CA002453572A patent/CA2453572A1/en not_active Abandoned
- 2002-07-01 US US10/482,457 patent/US20040143010A1/en not_active Abandoned
- 2002-07-01 AT AT02745439T patent/ATE419012T1/de not_active IP Right Cessation
- 2002-07-01 JP JP2003510106A patent/JP2005501031A/ja active Pending
-
2004
- 2004-01-02 NO NO20040007A patent/NO20040007L/no not_active Application Discontinuation
-
2006
- 2006-12-19 US US11/641,269 patent/US20070197543A1/en not_active Abandoned
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