BR0211315A - Uso de derivados de ácido 2,5-diidroxibenzeno-sulfÈnicos na elaboração de um produto medicinal para aumentar o efeito de outros medicamentos utilizados no tratamento de disfunção erétil - Google Patents
Uso de derivados de ácido 2,5-diidroxibenzeno-sulfÈnicos na elaboração de um produto medicinal para aumentar o efeito de outros medicamentos utilizados no tratamento de disfunção erétilInfo
- Publication number
- BR0211315A BR0211315A BR0211315-5A BR0211315A BR0211315A BR 0211315 A BR0211315 A BR 0211315A BR 0211315 A BR0211315 A BR 0211315A BR 0211315 A BR0211315 A BR 0211315A
- Authority
- BR
- Brazil
- Prior art keywords
- increase
- acid derivatives
- effect
- medicinal product
- manufacture
- Prior art date
Links
- 229940126601 medicinal product Drugs 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 3
- IKQCSJBQLWJEPU-UHFFFAOYSA-N 2,5-dihydroxybenzenesulfonic acid Chemical class OC1=CC=C(O)C(S(O)(=O)=O)=C1 IKQCSJBQLWJEPU-UHFFFAOYSA-N 0.000 title abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 201000001881 impotence Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- HSNWZBCBUUSSQD-UHFFFAOYSA-N amyl nitrate Chemical compound CCCCCO[N+]([O-])=O HSNWZBCBUUSSQD-UHFFFAOYSA-N 0.000 abstract 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 abstract 1
- 229960004046 apomorphine Drugs 0.000 abstract 1
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 abstract 1
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 abstract 1
- 230000001856 erectile effect Effects 0.000 abstract 1
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 1
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960002497 nicorandil Drugs 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 229960002460 nitroprusside Drugs 0.000 abstract 1
- 230000018052 penile erection Effects 0.000 abstract 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 abstract 1
- 229960003310 sildenafil Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960002381 vardenafil Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200101535A ES2180446B1 (es) | 2001-07-02 | 2001-07-02 | Empleo de derivados de acidos 2,5-dihidroxibencenosulfonicos en la elaboracion de un medicamento para potenciar el efecto de otros farmacos en el tratamiento de la disfuncion erectil. |
| PCT/ES2002/000325 WO2003004097A1 (es) | 2001-07-02 | 2002-07-01 | Empleo de derivados de ácidos 2,5-dihidroxibencenosulfónicos en la elaboración de un medicamento para potenciar el efecto de otros fármacos en el tratamiento de la disfunción eréctil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0211315A true BR0211315A (pt) | 2004-09-28 |
Family
ID=8498259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0211315-5A BR0211315A (pt) | 2001-07-02 | 2002-07-01 | Uso de derivados de ácido 2,5-diidroxibenzeno-sulfÈnicos na elaboração de um produto medicinal para aumentar o efeito de outros medicamentos utilizados no tratamento de disfunção erétil |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040143010A1 (https=) |
| EP (1) | EP1413332B1 (https=) |
| JP (1) | JP2005501031A (https=) |
| AR (1) | AR036124A1 (https=) |
| AT (1) | ATE419012T1 (https=) |
| BR (1) | BR0211315A (https=) |
| CA (1) | CA2453572A1 (https=) |
| DE (1) | DE60230629D1 (https=) |
| ES (2) | ES2180446B1 (https=) |
| HU (1) | HUP0400924A3 (https=) |
| MX (1) | MXPA04000007A (https=) |
| NO (1) | NO20040007L (https=) |
| PL (1) | PL367766A1 (https=) |
| WO (1) | WO2003004097A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2208123A1 (es) * | 2002-11-29 | 2004-06-01 | Laboratorios Del Dr. Esteve, S.A. | Uso de los compuestos 2,5-dihidroxibencenosulfonicos para la fabricacion de un medicamento. |
| ES2222831B2 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
| RU2281101C2 (ru) * | 2004-10-01 | 2006-08-10 | Юрий Михайлович Есилевский | Способ лечения больных хроническим простатитом |
| EP1676573A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Phamaceutical composition comprising a 2,5-dihydroxybenzenesulfonic-compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| CN109678764A (zh) * | 2018-12-05 | 2019-04-26 | 湖北广辰药业有限公司 | 一种羟苯双磺酸及其钙盐和制备方法 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681503A (en) * | 1970-04-17 | 1972-08-01 | Om Lab Sa | Method for combating disturbances of the lipid content of the blood |
| US4252821A (en) * | 1979-12-07 | 1981-02-24 | Laboratoires Om Societe Anonyme | Method for treating ulcers |
| US4511557A (en) * | 1981-08-24 | 1985-04-16 | Gauri Kailash Kumar | Pharmaceutical composition |
| US4513007A (en) * | 1983-05-03 | 1985-04-23 | Laboratoires Om Sa | Method for treating heart disease |
| RU1776408C (ru) * | 1990-08-13 | 1992-11-23 | Одесский Медицинский Институт Им.Н.И.Пирогова | Способ лечени гломерулонефрита |
| JP2000508308A (ja) * | 1996-04-03 | 2000-07-04 | ラボラトリオス デル ドクトール エステベ，エス．アー． | 内皮機能の正常化、性的機能障害、糖尿病の血管合併症及び内皮起源の血管障害の治療用の医薬の製造のための２，５―ジヒドロキシベンゼンスルホン酸誘導体の使用 |
| HU225149B1 (en) * | 1996-12-30 | 2006-07-28 | Teva Gyogyszergyar Zrt | Use of dobesilate salts for the manufacture of medicaments for the treatment or prevention of embryonic retardation or discordance |
| US6403643B1 (en) * | 1997-04-03 | 2002-06-11 | Laboratories Del Dr. Esteve, S.A. | Use of 2,5-dihydroxybenzenesulfonic derivatives for the normalization of endothelial function |
| US5994363A (en) * | 1998-08-24 | 1999-11-30 | Pentech Pharmaceuticals, Inc. | Amelioration of apomorphine adverse effects |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
-
2001
- 2001-07-02 ES ES200101535A patent/ES2180446B1/es not_active Expired - Fee Related
-
2002
- 2002-07-01 PL PL02367766A patent/PL367766A1/xx not_active Application Discontinuation
- 2002-07-01 AR ARP020102472A patent/AR036124A1/es not_active Application Discontinuation
- 2002-07-01 BR BR0211315-5A patent/BR0211315A/pt not_active IP Right Cessation
- 2002-07-01 WO PCT/ES2002/000325 patent/WO2003004097A1/es not_active Ceased
- 2002-07-01 HU HU0400924A patent/HUP0400924A3/hu unknown
- 2002-07-01 ES ES02745439T patent/ES2318023T3/es not_active Expired - Lifetime
- 2002-07-01 MX MXPA04000007A patent/MXPA04000007A/es not_active Application Discontinuation
- 2002-07-01 DE DE60230629T patent/DE60230629D1/de not_active Expired - Fee Related
- 2002-07-01 EP EP02745439A patent/EP1413332B1/en not_active Expired - Lifetime
- 2002-07-01 CA CA002453572A patent/CA2453572A1/en not_active Abandoned
- 2002-07-01 US US10/482,457 patent/US20040143010A1/en not_active Abandoned
- 2002-07-01 AT AT02745439T patent/ATE419012T1/de not_active IP Right Cessation
- 2002-07-01 JP JP2003510106A patent/JP2005501031A/ja active Pending
-
2004
- 2004-01-02 NO NO20040007A patent/NO20040007L/no not_active Application Discontinuation
-
2006
- 2006-12-19 US US11/641,269 patent/US20070197543A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070197543A1 (en) | 2007-08-23 |
| HUP0400924A2 (hu) | 2004-07-28 |
| CA2453572A1 (en) | 2003-01-16 |
| WO2003004097A1 (es) | 2003-01-16 |
| NO20040007L (no) | 2004-02-23 |
| EP1413332A1 (en) | 2004-04-28 |
| ES2318023T3 (es) | 2009-05-01 |
| JP2005501031A (ja) | 2005-01-13 |
| ES2180446B1 (es) | 2004-01-16 |
| EP1413332B1 (en) | 2008-12-31 |
| DE60230629D1 (de) | 2009-02-12 |
| MXPA04000007A (es) | 2004-05-21 |
| US20040143010A1 (en) | 2004-07-22 |
| ATE419012T1 (de) | 2009-01-15 |
| PL367766A1 (en) | 2005-03-07 |
| HUP0400924A3 (en) | 2007-11-28 |
| ES2180446A1 (es) | 2003-02-01 |
| AR036124A1 (es) | 2004-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2060 DE 29/06/2010. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/185 (2006.01), A61P 15/10 (2006.01) |