JP2005500820A5 - - Google Patents

Info

Publication number

JP2005500820A5

JP2005500820A5 JP2002569881A JP2002569881A JP2005500820A5 JP 2005500820 A5 JP2005500820 A5 JP 2005500820A5 JP 2002569881 A JP2002569881 A JP 2002569881A JP 2002569881 A JP2002569881 A JP 2002569881A JP 2005500820 A5 JP2005500820 A5 JP 2005500820A5

Authority

JP

Japan

Prior art keywords

polypeptide

nucleic acid

acid molecule

disease

binding domain

Prior art date

2002-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims 33
• 229920001184 polypeptide Polymers 0.000 claims 32
• 102000004196 processed proteins & peptides Human genes 0.000 claims 32
• 150000007523 nucleic acids Chemical class 0.000 claims 20
• 108020004707 nucleic acids Proteins 0.000 claims 19
• 102000039446 nucleic acids Human genes 0.000 claims 19
• 150000001875 compounds Chemical class 0.000 claims 13
• 102000007399 Nuclear hormone receptor Human genes 0.000 claims 11
• 108020005497 Nuclear hormone receptor Proteins 0.000 claims 11
• 108020001756 ligand binding domains Proteins 0.000 claims 11
• 230000000694 effects Effects 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 239000003446 ligand Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 238000003745 diagnosis Methods 0.000 claims 4
• 206010020772 Hypertension Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 230000000890 antigenic effect Effects 0.000 claims 2
• 238000009739 binding Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 208000017520 skin disease Diseases 0.000 claims 2
• 230000009261 transgenic effect Effects 0.000 claims 2
• 208000002874 Acne Vulgaris Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000019901 Anxiety disease Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 208000019399 Colonic disease Diseases 0.000 claims 1
• 201000004624 Dermatitis Diseases 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 206010014561 Emphysema Diseases 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 206010018364 Glomerulonephritis Diseases 0.000 claims 1
• 208000037147 Hypercalcaemia Diseases 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
• 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
• 206010020850 Hyperthyroidism Diseases 0.000 claims 1
• 206010061598 Immunodeficiency Diseases 0.000 claims 1
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 208000002193 Pain Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 206010000496 acne Diseases 0.000 claims 1
• 230000032683 aging Effects 0.000 claims 1
• 208000037883 airway inflammation Diseases 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 230000003321 amplification Effects 0.000 claims 1
• 230000033115 angiogenesis Effects 0.000 claims 1
• 230000036506 anxiety Effects 0.000 claims 1
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• 208000010668 atopic eczema Diseases 0.000 claims 1
• 230000031018 biological processes and functions Effects 0.000 claims 1
• 230000006931 brain damage Effects 0.000 claims 1
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• 208000029028 brain injury Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000003197 catalytic effect Effects 0.000 claims 1
• 230000017455 cell-cell adhesion Effects 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 230000000148 hypercalcaemia Effects 0.000 claims 1
• 208000030915 hypercalcemia disease Diseases 0.000 claims 1
• 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
• 201000008980 hyperinsulinism Diseases 0.000 claims 1
• 230000007813 immunodeficiency Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000011159 matrix material Substances 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000002071 myeloproliferative effect Effects 0.000 claims 1
• 230000009826 neoplastic cell growth Effects 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 208000015122 neurodegenerative disease Diseases 0.000 claims 1
• 238000003199 nucleic acid amplification method Methods 0.000 claims 1
• 239000002853 nucleic acid probe Substances 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
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• 208000011580 syndromic disease Diseases 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1
• 230000029663 wound healing Effects 0.000 claims 1