JP2005330200A - Leg motor function-improving medicine, leg muscle-building medicine, tissue- atrophic pain-reducing medicine and anti- metastatic bone tumor agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new Japanese and Chinese medicine which not only mitigates tissue-atrophic pain but also improves leg motor function lesion and leg muscle attenuation by a mitigation action. <P>SOLUTION: The leg motor function-improving medicine contains Psoralea corylifolia L., Myristica fragrans Houttuyn, and Saussureae lappa Clarke as active ingredients. The ingredients are processed into a powder or a pill together with a binder such as rice paste, except decoction. The Psoralea corylifolia L., the Myristica fragrans Houttuyn, and the Saussureae lappa Clarke are preferably mixed in amounts of 50 pts.wt., 50 pts.wt. and 2.5 to 5 pts.wt., respectively. The leg motor function-improving medicine is administered at a dose of 2 to 8 g twice or three times a day. It is preferable that the Psoralea corylifolia L. is roasted with Sake (rice wine). <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a lower limb motor function improving agent, a lower limb muscle strengthening agent, an organic atrophic pain reducing agent, and an anti-metastatic bone tumor agent. Specifically, it relates to a new effect of the Mikamimaru prescription consisting of osteoblastic fat, nutmeg, and incense.

  Currently, drugs used for treatment are roughly classified into so-called Western medicines, so-called Chinese medicines, and Japanese medicines. Most of the former western medicines are synthetic drugs or single animal and plant extract components, and are almost chemically single compounds except for extracts whose composition is unknown. In most cases, these drugs are administered aiming at a specific pharmacological action, and the action is strong and sometimes causes serious side effects on the human body. It is also a well-known fact that even if administered in the hope of improving specific symptoms, it may not be fully effective.

  On the other hand, the latter Kampo and Japanese-Chinese medicines are based on oriental medicine, which has a different concept from modern medicine (Western medicine), and may be able to cure or relieve symptoms that could not be cured by Western medicine. There are many. It is also well known that its action is very mild compared to Western medicine and there are few side effects.

  By the way, pain is associated with bone disorders accompanied by bone damage such as fractures and bone tumors. This pain subsides with the recovery of the bone disorder, but in rare cases, even if no abnormalities are seen surgically, only the pain may remain. In addition, these bone disorders may cause muscle weakness and weakness of the lower limbs, and may cause motor dysfunction such as difficulty walking and sitting.

  In such a case, administration of an analgesic in terms of Western medicine is effective for pain, but administration of the analgesic is only a symptomatic treatment to make the pain not feel. In addition, motor dysfunctions in the lower limbs such as difficulty walking and inflexion of joints may be caused by pain, but it is rarely improved by removing the pain alone. Treatment is often necessary. Nevertheless, it cannot be said that a fundamental treatment has been established for muscle strengthening and strength strengthening. On the other hand, when relying on Japanese and Chinese medicines, Hoyakuto for the treatment of low back pain and severed rounds that are said to be effective in lowering and lowering the lower limbs are selected. It was not effective for weakness, bone damage, pain associated with bone disorders, and lower limb motor dysfunction.

  In addition, when it comes to prosthetic fat used in Hoyodo, it is not used in herbal medicines. For example, Kampo medicines such as Mikamimaru or Hoyodo made of osteokic fat, nutmeg, and wood incense. It is only used as an agent. Further, for example, JP-A-7-109225 (Patent Document 1) discloses a bone strength enhancing and bone mineralization agent obtained from the extract, and JP-A-10-158177 (Patent Document 2). Is disclosed that the extract is used as a pain suppressant, but these are only focused on specific components in prosthetic fat, and are not focused on as a traditional Chinese medicine. The effect on it is also unknown.

The basic structure of Mikami Maru, according to “Honso Tuname”, is complement bone fat, nutmoku, and wood incense = 8: 4: 2; By adding incense, it is said that the effect of Nikagamimaru can be easily applied to the whole body and the medicinal effect of Ni-ni is strengthened. In addition, the utility of Futagami Maru and Mikami Maru in the classics was merely to treat diarrhea due to cold of the splenic stomach (chilly diarrhea).
Japanese Patent Application Laid-Open No. 07-109225 JP-A-10-158177

  The present invention has been made in view of the above-described conventional technology, and relieves organic atrophy pain by a relaxed action, and improves motor dysfunction of the lower limbs caused by muscle weakness and bone disorders of the lower limbs. The purpose is to provide Japanese and Chinese medicines. Therefore, the present inventors conducted research on Kampo prescriptions centering on prosthetic fats commonly used in the above-mentioned Toyoto and Sugimaru. As a result, the present invention has been found to be effective as an inhibitor of metastatic bone tumors, and the present invention has been completed.

  In order to achieve the above object, in the present invention, a mixture of prosthetic fat, nutmeg, and incense is used as a lowering limb motor function improving agent, and a mixture of prosthetic oil, nutmeg, and incense is used as a muscle strengthening agent for lower limbs. It is used as a drug for reducing organic atrophic pain and an anti-metastatic bone tumor drug.

  The present invention provides a new effect of Mikamimaru, so to speak, according to the drug of the present invention, there are few side effects and organic atrophic pain that has been difficult to recover by conventional treatment methods, motor function of the lower limbs Insufficiency, weakness and weakness of lower limb muscles are improved. In addition, expansion and metastasis of metastatic bone tumor are suppressed.

  The lower limb motor function improving agent, lower limb muscle strengthening agent, organic atrophy pain reducing agent and anti-metastatic bone tumor agent according to the present invention comprise a mixture of prosthetic fat, nutmeg, and incense. Prosthetic fat is the dried fruit of Psoralea corylifolia L., also called Dutch view, also known as broken paper. Nutzuku is a seed of seed seed coat of Myristica fragrans Houttuyn. The incense is the root of Saussureae lappa Clarke.

  In the present invention, the blending ratio of the osteoblastic fat, nutmeg, and incense is different from the so-called conventionally used Mikamimaru formula, preferably 40-60 parts by weight of the osteoclast fat, and the nutmeg 40. -60 parts by weight, 2 to 6 parts by weight of incense, and usually about 10: 10: 0.5 to 1 part of 50 parts by weight of bone substitute fat, 50 parts by weight of nutmeg, 2.5 to 5 parts by weight of incense It is. Mika is formulated for the purpose of making the whole effect of the two effects of osteoblastic fat and nutmeg. Both the incense and the nutmeg are too strong when the ratio of the amount to the prosthetic fat is higher than this, and if it is lower than this, sufficient effects cannot be obtained.

  The lower limb motor function improving drug or the like of the present invention is provided and taken as a powder or pill. In order to form a powder, it is only necessary to simply mix the bone repellent fat, nutmeg, and woody incense powders, or a mixture of herbal medicines. Further, in order to obtain a pill, a binder such as peanut pulp or rice paste is mixed evenly with these mixed powders and formed into a spherical shape. In the present invention, a hot water agent or an extractant (one obtained by concentrating the hot water agent into an extract or powder) is not preferred. Mikamimaru is not able to obtain the expected effect because the action of Japanese and Chinese medicines is weakened.

  In addition, the osteoblastic fat may be only dried, but it is preferable to use the one further fried in liquor. In this case, after adding liquor to the extent that the osteoclast is soaked, fry until dry. Moreover, sake should just be drinkable, and it is preferable to use sake or shochu.

  The patients to be administered according to the present invention are those with lower limb motor function, those with lower limb muscle weakness, and those with organic atrophic pain. Lower limb motor function refers to, for example, difficulty in walking due to bone disorders, inability to sit down, or inability to bend and stretch knees. Pain when sitting and bending and stretching. Regardless of the presence or absence of pain, the lower limbs are weakened (muscular qualities) or weakened (quantitative muscles), that is, the lower limbs are dying and impairing the lower limbs. In some cases, the prescription of the present invention can be applied. In addition, although pain and lower limb atrophy are not observed, cases where motor dysfunction of unknown cause develops after recovery from bone disorders are also included in the administration subject of the present invention. In this way, all persons (including animals) whose motor function is reduced due to lowering of the lower limbs or bone disorders are targeted. Among these, those who are currently suffering from or have recovered from some kind of bone disorder, those who have chronic diseases such as the elderly, diabetes, renal failure, and liver disorder are particularly preferred subjects. Here, the bone disorder means not only fractures, sprains and cracks but also cases where some abnormality appears in bones or joints such as intervertebral disc herniation, osteoporosis, rheumatism, and bone tumor. That is, the lower limb motor dysfunction improving agent of the present invention effectively acts on difficulty in walking or sitting due to numbness of the lower limbs remaining after bone disorders or after recovery, muscle atrophy of the lower limbs, and the like. The drug of the present invention is intended to improve muscle wilting and weakening that cause motor dysfunction and to recover to a healthy state. For example, a steroid hormone such as a steroid hormone is It's not something to enhance.

  The organic atrophic pain referred to in the present invention is pain accompanied by muscle weakness or contracture of the lower limbs, or present or past bone damage. Often, the site complaining of pain is the lower extremity or the whole body bone or joint proximal. Specifically, it is pain associated with the aforementioned back pain, knee joint pain, and bone disorders such as aftereffects of fracture, herniated disc, osteoporosis, and rheumatism. In addition, for example, (1) aging phenomenon, (2) chronic diseases such as diabetes, renal failure, and liver disorder exist as constitutional predisposing factors for causing such pain. (1) is a phenomenon in which the biological organs (various organ muscles, etc.) gradually fail to perform their functions as they age. (2) is due to the fact that chronic diseases over a long period of time are thought to cause systemic damage to the body. Organic atrophic pain is pain in which the deterioration of the growth and maintenance function of the organs associated with aging and chronic diseases is a constitutional predisposition and is deeply involved in the cause. For example, it may be assumed that a constitutional predisposition such as aging or chronic illness is causing pain even if no bone abnormality or physical disorder due to X-ray findings is observed. As described above, the organic atrophy pain alleviating agent of the present invention has an aging phenomenon or a chronic disease as a constitutional element, and effectively improves pain associated with muscle weakness / muscle lowering of the lower limbs or bone disorders. Therefore, pain that is completely unrelated to these factors, such as a headache due to a cold, is excluded from administration.

  The drug of the present invention has not only the above-mentioned effects but also effects on metastatic bone tumors. The anti-metastatic bone tumor agent of the present invention is intended for metastatic bone tumors, ie, symptoms in which cancer of other organs or sarcomas of other sites have metastasized to bone, but is not intended for radical healing, It suppresses the enlargement of the region and further prevents metastasis to other organs. In the case of metastatic bone tumors, many of them are accompanied by severe pain, and the drug according to the present invention also alleviates the pain associated with such metastatic bone tumors.

  Although the dose in the present invention varies depending on the symptoms, it is 2 to 8 g per day as a traditional Chinese medicine, and it is preferable to take it in 2 to 3 divided doses. The dose is preferably adjusted appropriately depending on body weight and symptoms. For example, in the case of animals (dogs weighing 20 kg), it is about 1/3 to 1/4 of that for adults (weight 65 kg). In addition, the dosage is taken continuously for at least 1 to 7 days, and is taken until pain disappears or the motor function of the lower limbs, preferably the muscle weakness of the lower limbs recovers. Although the symptoms may be alleviated by administration for only about 1 day, the period of continuous administration is usually about 3 to 14 days. And after the symptoms have been relieved, it is preferable to take it once, for example, about once to several times when pain, muscle weakness, contracture, or movement disorder occurs. In this case, taking a dose is not to say that it is taken every time when there is pain, such as an analgesic for Western medicine. 1 to 2 days). As described above, the therapeutic agent of the present invention is continuously taken until the symptoms are alleviated, and thereafter, the dysfunction of the lower limbs, the lowering of the lower limbs, and the physical atrophy pain are rapidly suppressed due to inadequate use. Can do. In addition, the daily dose is the same for continuous and non-regular doses.

  Hereinafter, the present invention will be described more specifically with reference to actual cases.

[Alleviation of pain and recovery of motor function due to aftereffects of fracture]
It was administered to a female patient (49 years old) who had difficulty in sitting and back pain due to severe pain in the affected area as a sequelae of tail fracture. Four weeks after the fracture, the bones were completely joined together by X-ray findings. However, even after 2 months of fracture, symptoms of difficult sitting were observed, and severe pain was felt near the fracture site. After that, the pain gradually healed, but after 8 months from the recovery of the fracture, the pain recurred again in the vicinity of the back pain and the fracture site, and it became difficult to stand. At this time, the meat fell from the buttocks to the foot, accompanied by pain in the varicose veins of the left foot. Therefore, in accordance with a conventional method, continuous rounding (decoction) was administered for 30 days, and then Yodoto was administered for 10 days, but there was almost no effect.

  To this patient, the drug of the present invention was administered. After soaking 50g of osteoclast in sake, thoroughly fry the sake over low heat and stir well until smoke comes out, mix with 50g of nutmeg in a cold place, add 3g of incense, and use this as a rice paste It was adjusted to pills (1030 pills) in an appropriate amount. Patients were given 20 rounds 3 times a day.

  As a result, surprisingly, the day after the start of administration, the pain from the waist to the proximal tail bone was halved, and the mood was relieved. After that, by continuing daily administration for 7 days, muscular improvement was seen from the buttocks to the foot, and pain in the varicose veins of the foot almost disappeared as well as pain from the waist to the proximal base of the tail base, making walking difficult Is almost eliminated.

[Alleviation of severe pain associated with secondary bone tumor, ambulatory recovery, and prevention of tumor metastasis]
It was administered to a female patient (75 years old) who had severe pain due to a bone tumor that had metastasized to the lumbar region and had difficulty walking. The patient was treated with an anticancer drug after total right mastectomy for breast cancer, but administration of the anticancer drug was discontinued due to side effects. Later, Shinbu-to and Tsuku-kanzo-to were administered, but although they recovered, they did not relieve pain.

  Therefore, powdered powder of 25 g of osteoclast oil, 25 g of nutmeg, and 2 g of wood incense was taken as powder for 3 days a day, divided into 2 to 3 times a day, while using kankanzoto and mabuto. However, my back pain went away in a few days, and as a result I was able to walk in the hospital. After that, if you feel back pain, take the drug for 1 to 2 or 3 days and stop taking it, and if you feel back pain, take the same prescription, Each time, the pain in the lower limbs subsided, and walking did not become difficult. In addition, after the start of administration of this drug, no other treatment has been given, but no cancer has occurred in a new site for about 3 years. In addition, the osteoclast fat fried in liquor like Example 1 was used for the prescription.

[Alleviation of severe pain associated with disc herniation and walking recovery]
Surgery was attempted by surgery with an intervertebral disk hernia, but it was administered to a female patient (43 years old) who still had pain and paralysis in the lower limbs and was unable to walk without a cane. The patient complained that the lower limbs were cold and convulsed, and that the convulsions made pain hate, so in order to suppress the lower limbs and convulsions, 5g of glaze licorice extract (Tsumura) and processed bush (Sanwa) 6 tablets (produced by Seiko Co., Ltd.) and 20 g of prosthetic fat, 20 g of nutmeg, and 2 g of wood incense were mixed and divided into 4 g twice a day. As a result, 3 days after the start of administration, coldness and convulsions were halved and pain was slightly reduced. Subsequent administration for 6 days (same amount as above) resulted in hospitalization due to sudden melena of unknown cause, but pain and convulsion completely subsided after the melena ceased and can be walked like a normal person It became so. This sudden melena is considered to be a meditation in Chinese medicine.

[Alleviation of severe pain associated with knee joint pain in the elderly]
It was administered to a female patient (80 years old) who suffered from diabetes and knee pain. The patient had severe senile dementia for the past year, and every time she went to orthopedics to receive an analgesic, she worsened her neuropsychiatric symptoms such as anxiety, confusion, and memory impairment. For the pain in the lower limbs, Hogi Kosaido-to, Ushizura Rengan-maru, and Kosakenkenchuto were administered for 1 month each, but were ineffective. Therefore, administration of the drug of the present invention (powder consisting of 50 g of prosthetic fat, 50 g of nutmeg, and 3 g of incense) once a day for 2 days per day for 14 days was markedly effective for pain and was withdrawn. Twenty days later, a slight pain began to appear, and the pain decreased drastically when taken alternately with Akanzoyu every other day. In the same manner as in Example 1, prosthetic fat fried in sake was used.

[Improvement of sciatica and walking recovery]
It was administered to a female patient (79 years old) who had sciatica and complained of difficulty walking and stiff shoulders. When the patient visited an orthopedic surgeon, it was pointed out that “the bone density is low and there is a tendency for osteoporosis”. She was prescribed and taking analgesics, but she did not improve her symptoms. For this reason, when taking the medicine of the present invention (powder consisting of 50 g of prosthetic fat, 50 g of nutmeg, and 3 g of incense) once a day for 1 day twice a day for 7 days, the lower limbs became painful and walking became possible. Continuing to administer this drug for 14 days, the patient stopped taking as well as the difficulty in walking improved.

[Alleviation of severe rheumatic pain and walking recovery in old dogs]
The drug of the present invention was administered to a dog (11 years old, female small improved collie, body weight of about 18 kg) that developed a hindlimb motor dysfunction due to an aging disorder and became unable to walk or urinate. The dog was diagnosed with senile rheumatism with no abnormal bones as revealed by X-rays. For this reason, it was diagnosed that recovery was impossible, and the only treatment before administration of this drug was administration of an analgesic. Therefore, when a mixture of 20 g of osteoblastic fat, 20 g of nutmeg, and 1 g of incense was put into a food dish once a day and allowed to ingest freely, the painful cry that conveys pain halved immediately after administration, about 10 days. The painful squeal was completely subsided by the administration of, and when I took it for a walk, I started to run well and I was able to walk freely and urinate smoothly. In the same manner as in Example 1, prosthetic fat fried in sake was used.

[Walking recovery of hip fracture in old dogs]
This drug was administered to a dog (13 years old, female Siberian Husky) who developed a phenomenon of hind paw wilt and hip breakage due to an aging disorder and began to fall many times. This dog was painless and there was no abnormality in urination / defecation, but he stopped taking it for a walk because he repeatedly fell when he tried to walk. One week after the first seizure, a mixture of 20 g of osteoclast oil, 20 g of nutmeg, and 1 g of woody incense was administered three times a day for 1 g each for 3 days. On the next day, the foot was improved and the patient did not fall, so the administration was stopped. However, when the administration was stopped, it fell again, and when this drug was re-administered for 7 consecutive days, it recovered until it did not fall unless it was run. The body weight, which had fallen from 32 kg to 27 kg in 3 months as a progenitor of the hip fracture phenomenon, recovered to 29 kg or more in 3 months after the start of administration.

  As described above, according to the drug of the present invention, not only the organic atrophic pain can be dramatically improved, but also the lowering of the lower limbs and the lowering of the muscles of the lower limbs can be promptly improved.

  In oriental medicine, health is a state of balance between “disgust” and “cheerful”, and when some symptoms appear, the balance between “disgust” and “cheerful” is biased to either one And evaluate. “Insanity” and “cheerfulness” are the concepts that divide all the functions of the living body into two, and “cheerfulness” is a concept of total tightening to control the activities of the living body.・ It is regarded as a concept of total tightening to control organic functions such as retention. A syndrome generally called an aging phenomenon and a disease state that has suffered from chronic diseases over a long period of time is a state in which this “disgust” has become insufficient. Older people and patients with chronic diseases such as diabetes, renal failure, and hepatic disorder are imbalanced in the body's “gloomy” and “cheerful”. There is a foundation that tends to fall short. If the bone's “coldness” does not flow normally, the function of the whole body's “cold” that causes the growth and maintenance of the organs will occur, and the organs, bone tissue and muscles and other organs will gradually decline. It is thought to go. In other words, if the bone's “coldness” becomes inadequate, all organs possessed by the living body will be poor, organ atrophy, bone damage, muscle weakness of the lower limbs, motor dysfunction, organic atrophy Causes pain. The drug of the present invention is administered to those who have lower leg movement function, those who have lower leg muscle weakness, and those who have organic atrophic pain due to such incomplete distribution of bone “coldness” Then, the balance between so-called “disquiet” and “cheerful” is restored, and the systemic constitution and maintenance, which are the main effects of “disappear”, are achieved. As a result, these symptoms are alleviated.

In any of the above examples, the symptoms changed drastically at the start of taking this prescription, even though they were all taken for a short period of 1 to 14 days. Maintained for a long time. In addition, even after the symptoms relapsed, the patient's condition improved again by taking a dose for a short period. In other words, after the start of administration, a wide range of symptom changes have been observed, including improvement of pain, improvement of lower limb motor function, lower limb muscle strengthening, improvement of wrinkles, and suppression of metastatic bone tumors. It is considered that the effect of is not only the analgesic effect and the bone strength enhancing action by the osteoclast.

Claims (11)

  A lower limb motor function improving drug comprising a mixture of osteoclast, nutmeg, and incense.   The agent for improving the lower limbs' motor function according to claim 1, wherein 40 to 60 parts by weight of prosthetic fat, 40 to 60 parts by weight of nutmeg, and 2 to 6 parts by weight of incense.   A muscle strengthening agent for the lower limbs that contains a mixture of osteoclast, nutmeg, and incense.   4. The lower limb muscle strengthening agent according to claim 3, wherein 40-60 parts by weight of osteoclasts, 40-60 parts by weight of nutmeg, and 2-6 parts by weight of incense.   An agent for reducing organic atrophic pain comprising a mixture of prosthetic fat, nutmeg, and incense.   The agent for reducing organic atrophic pain according to claim 5, wherein 40-60 parts by weight of osteoblastic fat, 40-60 parts by weight of nutmeg, and 2-6 parts by weight of incense.   An anti-metastatic bone tumor drug containing as an active ingredient a mixture of prosthetic fat, nutmeg, and woody incense.   The anti-metastatic bone tumor drug according to claim 7, wherein 40-60 parts by weight of prosthetic fat, 40-60 parts by weight of nutmeg, and 2-6 parts by weight of incense.   Use of a mixture of prosthetic fat, nutmeg, and incense for the purpose of improving the motor function of the lower limbs, strengthening the muscles of the lower limbs, reducing organic atrophy pain, or suppressing metastatic bone tumors .   The method according to claim 9, wherein 40 to 60 parts by weight of prosthetic fat, 40 to 60 parts by weight of nutmeg, and 2 to 6 parts by weight of incense. The use according to any one of claims 9 and 10, wherein a continuous dose is taken until the motor function of the lower limbs, organic atrophic pain, and the recovery of muscles of the lower limbs, and after the recovery of the symptoms, the dose is taken when the symptoms appear.