JP2005320278A - Composition having autonomic nerve-adjusting activity and use of the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition acting on autonomic nerve, having an autonomic nerve-adjusting activity for maintaining homeostasis of a living body or recovering collapsed homeostasis and obtained from a naturally derived substance existing in the natural world by a simple process. <P>SOLUTION: The composition is a sea water mineral components-containing composition containing sea water minerals obtained by treating the sea water and has the autonomic nerve-adjusting activity. The sea water mineral components-containing composition preferably contains ≥70 mg/L magnesium concentration and ≤3 mg/L sodium concentration. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

TECHNICAL FIELD OF THE INVENTION

  The present invention relates to a seawater mineral component-containing composition and food and drink containing the same.

  In order to maintain the homeostasis of the living body, the living body is equipped with an autonomic nervous system, an endocrine system, and an immune system. Among them, the autonomic nervous system is relatively independent from cerebral control, especially because it works automatically regardless of will, and this name is given mainly to regulate the function of the internal organs. There are two autonomic nervous systems, the sympathetic nervous system and the parasympathetic nervous system, which are controlled by the balance between the two. That is, when the body is active, sympathetic nerve activity is dominant, and the whole body is in tension. Conversely, when parasympathetic activity predominates, the body becomes tense and relaxed.

  Increased systemic sympathetic activity results in hormone secretion from the adrenal medulla, resulting in increased heart rate and blood pressure, dilatation of bronchioles, suppression of intestinal motility and secretion, increased glucose metabolism, pupillary scatter Large, napped, skin and visceral blood vessel contraction, and skeletal muscle vasodilation occurs (Iwanami Lecture, “Basics of Modern Medicine”, Volume 4, Toshio Sugawara, Seiichiro Tarui, Biological Regulation System, 1999). Therefore, when sympathetic nerve activity is enhanced, health problems such as hypertension, hyperglycemia, skin blood flow reduction, and immune function decline occur. On the other hand, when the parasympathetic nerve is increased, chronic diarrhea occurs. Moreover, decreased parasympathetic nerve activity and relative increased sympathetic nerve activity have been reported to be important risk factors for ischemic heart disease and sudden death (Akselrod et al., Science 213: 220-22 ( 1981), Billman GE et al., Circulation 80: 874-80 (1989)). Autonomic nerve imbalance is caused by stress, and many people complain of poor physical condition.

From this point of view, there is a demand for pharmaceuticals or health foods that control autonomic nervous activity, and many pharmaceuticals are already on the market.
The water obtained by processing seawater is rich in minerals, and products using mineral components derived from seawater have been developed and are attracting attention. Also, many disclosures have been made regarding its application (JP 2000-295974, JP 2001-136942, JP 2001-211864, JP 2001-87762, etc.). However, despite the fact that various effects of seawater have been reported, the health-related effects of ingesting the beverages, especially the effects on autonomic nervous activity and their regulation have been investigated. There is no report.

  Conventionally, in the case of pharmaceuticals, it has been difficult to achieve both autonomic nerve control and low side effects. In addition, the synthesis of a pharmaceutical product requires a process of another stage, and it is necessary to process it into a form such as a tablet so that it can be ingested more easily, resulting in a high cost. Therefore, there is a strong demand for an active substance obtained by a simple process from a naturally occurring substance existing in nature. An object of the present invention is to provide a composition that acts on the autonomic nerve and has an action of regulating autonomic nerve activity in order to maintain the homeostasis of the living body or restore the collapsed homeostasis.

  The present inventors have intensively studied to solve the above problems, and have found that the seawater mineral component-containing composition has an action of maintaining the homeostasis of this living body. That is, the composition of the present invention is a seawater mineral component-containing composition characterized by containing seawater minerals obtained by treating seawater and having an autonomic nerve regulating action. The seawater mineral component-containing composition of the present invention preferably has a magnesium concentration of 70 mg / L or more and a sodium concentration of 6 mg / L or less, particularly 3 mg / L or less.

Although the seawater mineral component containing composition in this invention is not specifically limited, For example, it can obtain by the method described in Unexamined-Japanese-Patent No. 2004-065196.
Examples of seawater that can be used as a raw material for producing a seawater mineral component-containing composition include surface water, middle water, and deep water. Among these, deep seawater, especially seawater with a depth of 200 m or more, is highly clean because it is not easily affected by environmental pollution, and is also rich in minerals because it is rarely used by marine organisms. Is preferable.

  As the mineral component amount of the seawater mineral component-containing composition, it is preferable that the ratio of mineral components having health effects such as magnesium and calcium is high and the sodium concentration is low. The magnesium concentration is preferably 70 mg / L or more, and the sodium concentration is preferably 6 mg / L or less, particularly preferably 3 mg / L or less.

  In order to obtain such a composition, a method of electrodialyzing seawater by electrodialysis using a monovalent cation selective dialysis membrane is preferable. As the monovalent cation selective dialysis membrane, AC120 (manufactured by Asahi Kasei Co., Ltd.) or the like can be used. Electrodialysis can be performed by using a normal electrodialysis machine, and the sodium concentration is reduced by dialysis so that the electrical conductivity at the end of electrodialysis is low, for example, less than 10 mS / cm. And increasing the magnesium concentration to obtain a seawater mineral component-containing composition having a stable mineral composition. The low conductivity is preferably 8 mS / cm or less, particularly 6 mS / cm at the end of electrodialysis in consideration of the cost of water used and power used. If the electrical conductivity at the end of electrodialysis is low conductivity, for example 6mS / cm, when adjusted to an aqueous solution of hardness 100 (EDTA method), the sodium concentration is 4mg / L or less, the magnesium concentration is 20mg / L or more, A seawater mineral component-containing composition having a weight ratio of magnesium and calcium of 4 or more can be obtained. The advantage of having a magnesium to calcium weight ratio of 4 or more is that it can efficiently consume the magnesium that is lacking in modern people.

  When it is desired to produce a seawater mineral component-containing composition having a magnesium concentration of 70 mg / L or more and a sodium concentration of 3 mg / L or less in order to sufficiently exert the autonomic nerve regulating action of the seawater mineral component-containing composition of the present invention. For example, the following multi-stage electrodialysis method can be used. That is, as primary electrodialysis, seawater is electrodialyzed using a monovalent cation selective dialysis membrane to the electrical conductivity (12mS / cm) used in normal salt production or below. . At this time, the magnesium concentration is about 1300 mg / L, and the sodium concentration is about 640 mg / L. The mineral water from this primary electrodialysis is again secondary electrodialyzed using a monovalent cation selective dialysis membrane until the electrical conductivity is 6 mS / cm or less. The mineral water after secondary electrodialysis has a magnesium concentration of about 740 mg / L and a sodium concentration of about 2 mg / L. Therefore, if this is appropriately diluted with water having a reduced sodium content, for example, RO (reverse osmosis) treated water to obtain a mineral water having a hardness of about 330 (EDTA method), the preferred magnesium and sodium concentrations of the present invention are obtained. A seawater mineral component-containing composition can be obtained.

  Alternatively, the seawater mineral component-containing composition of the present invention having a preferable magnesium and sodium concentration can be stably prevented by suppressing the back diffusion of sodium by suppressing the sodium concentration on the concentration chamber side in the electrodialyzer. It is possible to remove monovalent ions such as sodium and potassium as much as possible. In that case, it is desirable to perform electrodialysis while maintaining the concentration of sodium in the concentration chamber at 20 mg / L or less, preferably 2 mg / L or less.

  Since the seawater mineral component-containing composition of the present invention is excellent in flavor and has a very low sodium concentration, it can be used for a wide variety of products in the above-mentioned food and drink. It becomes possible to adjust the amount of mineral components such as magnesium and calcium. The amount of the seawater mineral component-containing composition of the present invention can be set according to the shape of the food or drink provided, and for example, a product can be designed using the intake of magnesium as an index. In this case, it can be prepared to contain 1 mg to 700 mg of a single intake of magnesium. The daily intake of magnesium by the seawater mineral component-containing composition of the present invention is preferably 100 mg or more. Since the seawater mineral component-containing composition of the present invention contains 70 mg / L or more of magnesium, it can be efficiently ingested.

  In addition, since the seawater mineral component of the present invention is extremely stable as a composition, it is heated, cooled, frozen in the seawater mineral component-containing composition itself or in the application of the seawater mineral component-containing composition to food and drink. Such processing may be performed. As a form, you may use it as a form as it is mineral water, and it is good also as forms, such as a dried product, a concentrate, and a dilution. For example, the form of supplements such as drinking water, capsules, tablets, powders, jelly, and the like can be mentioned. Specifically, fruit juice beverages, soft drinks, lactic acid beverages, carbonated beverages, coffee beverages, tea beverages, vegetable beverages, liqueurs, candy High, shochu, wine, beer, tablet, candy, gummy, cookie, jelly and the like. Furthermore, you may use as a form which added additives, such as vitamins, polyphenols, an amino acid, a peptide, protein, saccharides, and an organic acid, to these.

  Autonomic nerve activity can be adjusted by ingesting the seawater mineral component-containing composition of the present invention. For example, by ingesting a seawater mineral component-containing composition that has been subjected to a specific treatment, autonomic nerve activity evaluation using a heart rate variability power spectrum analysis method shows suppression of sympathetic nerve activity, enhancement of parasympathetic nerve activity, An analysis of the electrocardiogram can provide a result indicating a reduction in cardiac depolarization / repolarization time (Recovery Time: RT). That is, the seawater mineral component-containing composition of the present invention has an action of regulating autonomic nerve activity.

  As a method for evaluating the autonomic nervous activity of the seawater mineral component-containing composition in the present invention, biophysical measurement methods such as an electrocardiograph, blood pressure monitor, skin electrical reflex, and pupil diameter measurement, and live catecholamine concentration measurement and the like Examples include chemical measurement methods.

  Among them, since heart rate variability is caused by the action of the autonomic nerve on the heart, a method of evaluating the activity state of the autonomic nerve by looking at the heart rate variability is preferable. For example, the improvement effect on the disturbance of autonomic nerve activity can be evaluated using heart rate variability power spectrum analysis and RT as indices. Specifically, the electrocardiogram RR interval (the rhythm of the heart beat, that is, the interval between heart beats (RR interval) is constantly changing, and the fluctuation of the RR interval is called heart rate fluctuation) Is obtained as a power spectrum using fast Fourier transform, and the power (LOW) of the low frequency component having a frequency of 0.03 to 0.15 Hz, the power (HIGH) of a high frequency component having a frequency of 0.15 to 0.4 Hz, and the sum ( TOTAL) is obtained, and autonomic nerve activity can be evaluated using LOW / HIGH as a sympathetic nerve activity index and HIGH / TOTAL as a parasympathetic nerve activity index. That is, when cardiac sympathetic nerve activity is suppressed, the value of LOW / HIGH decreases, and when parasympathetic nerve activity is increased, the value of HIGH / TOTAL increases.

The RT obtained from the analysis of the electrocardiogram reflects the repolarization of the ventricular muscle, that is, the duration of the intracellular action potential, and is also an important index reflecting the refractory period of the ventricular muscle. The repolarization phase of the myocardium is sensitive to various pathological factors in daily life, such as heart rate, autonomic nerve activity, serum electrolytes, ischemia, and drug administration.
[Example]

  EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example, this invention is not limited to these.

<Example 1 of preparation of seawater mineral component-containing composition>
Conduct electrodialysis treatment of seawater at a depth of 330m (off Mizaki Peninsula Mizaki) using the Asahi Kasei Electrodialyzer (SV1 / 2 type) until the electroconductivity at the end of electrodialysis is 12mS / cm. Obtained.

  The primary mineral water was subjected to electrodialysis using an Asahi Kasei electrodialyzer (S3 type) until the electrical conductivity reached 6 mS / cm, thereby producing secondary mineral water. As the electrodialysis membrane, Asahi Kasei AC120 type was used for both the production of primary mineral water and the production of secondary mineral water. Electrodialysis was performed at a constant temperature of 15 ° C. at the start, a concentration chamber side conductivity of 1.5 mS / cm, a circulating flow rate of 1.4 L / min, and a voltage of 12.5 V.

  Demineralized water obtained by treating the obtained secondary mineral water with seawater at a depth of 330 m in two stages by Dow Chemical's reverse osmosis membrane SW30HR-380 (high pressure) SWLE-440 (low pressure) (sodium concentration = A composition containing seawater mineral components having a hardness of 330 (EDTA method) was prepared by dilution at 1.8 mg / L. The ingredients are shown in Table 1.

[Table 1]
Table 1: Seawater mineral component-containing composition (per liter) (hardness 330 (EDTA method))

Energy, protein 0
Fat, carbohydrate 0
Sodium 2.6mg
Magnesium 75.2mg
Calcium 11.0mg
Potassium 58.6μg
Iodine 0.84μg
Phosphorus 5.26 μg
Copper 0.18μg
Selenium 1.40μg
Zinc 0.54μg
Molybdenum 0.08μg

Modulatory effect on autonomic nervous activity The study was conducted on 21 adult men. That is, the seawater mineral component-containing composition (hardness 330 mg / L) obtained in Example 1 was ingested 1.5 L per day for 5 weeks, and electrocardiograms at rest were measured at the start and end of the intake, and Ue, H. In accordance with their method (Ue, H. et al., Ann. Noninvasive Electrocardiol., 5: 336-345 (2000)) The effect on myocardial depolarization / repolarization time (RT) was examined.

The ECG was sampled at 1024 Hz using 14-bit A / D conversion. The heart rate variability obtained from the electrocardiogram was processed by fast Fourier transform and frequency analysis was performed to obtain a heart rate variability power spectrum. In order to separate and quantify the heart rate variability spectrum, the low frequency component power (LOW) with a frequency of 0.03 to 0.15 Hz, the high frequency component power (HIGH) with a frequency of 0.15 to 0.4 Hz, and the sum (TOTAL) ) Was determined, and LOW / HIGH was used as a sympathetic nerve activity index, and HIGH / TOTAL was used as a parasympathetic nerve activity index. The obtained results are shown in FIGS. Furthermore, cardiac depolarization / repolarization time was examined by RT. The obtained results are shown in FIG.
[The invention's effect]

  By ingesting the seawater mineral component-containing composition, it is possible to suppress an increase in sympathetic nerve activity and increase a decrease in parasympathetic nerve activity. Such an autonomic nerve regulating action is not only extremely useful in terms of preventing and mitigating the imbalance of the autonomic nervous system, but is also extremely useful for various diseases caused by sympathetic nerve activity predominance. .

FIG. 1 is a diagram showing the inhibitory effect of a sympathetic nerve activity index due to intake of a seawater mineral component-containing composition. FIG. 2 is a diagram showing the effect of enhancing parasympathetic nerve activity by ingesting a seawater mineral component-containing composition. FIG. 3 is a diagram showing the effect of suppressing the extension of RT by ingesting a seawater mineral component-containing composition.

Claims (9)

  A seawater mineral component-containing composition having seawater minerals obtained by processing seawater, and having an autonomic nerve regulating action.   The seawater mineral component-containing composition according to claim 1, wherein the magnesium concentration is 70 mg / L or more and the sodium concentration is 6 mg / L or less.   The seawater mineral component-containing composition according to claim 1, wherein the seawater is deep seawater and has an electrical conductivity of less than 10 mS / cm obtained by treatment with a monovalent cation selective dialysis membrane.   The seawater mineral component-containing composition according to any one of claims 1 to 3, which has an autonomic nerve regulating action for preventing, ameliorating, and alleviating turbulence of autonomic nerves and symptoms caused thereby.   The composition according to claim 4, wherein an increase in sympathetic nerve activity is suppressed by ingesting a seawater mineral component-containing composition.   The composition according to claim 4, wherein parasympathetic nerve activity is enhanced by ingesting a seawater mineral component-containing composition.   The composition according to claim 4, wherein the heart depolarization / repolarization time is shortened by ingesting the seawater mineral component-containing composition.   The composition according to any one of claims 4 to 7, which is suitable for ingesting 100 mg or more of magnesium per day.   The composition according to claim 1, which is a food or drink or a component thereof.

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