JP2003063969A - Functional goods using concentrated mineral solution obtained from deep sea water by separation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide functional goods making use of functions which a concentrated mineral solution separated from cool water peculiar to the Sea of Japan has. SOLUTION: The functional goods using the concentrated mineral solution separated from cool water peculiar to the Sea of Japan particularly make use of a function for stabilizing the blood pressure, a function for improving allergic physical conditions and a function for improving lifestyle-related diseases, respectively or in combination, among the functions the concentrated mineral solution has.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a product utilizing the functionality of a mineral concentrate separated from deep sea water, and specifically, functional drinks, functional foods, functional cosmetics, functional baths. Regarding agents, etc.

[0002]

2. Description of the Related Art Deep sea water is under 300 m below sea level and is subject to high water pressure. Therefore, all elements are dissolved for a long period of time, rich in inorganic nutrients necessary for living body support, organic substances and bacteria. It is known to have few kinds and cleanliness and to be stable at low temperatures throughout the year. It is also known that the mineral content of deep water is higher than that of surface water. In particular, various studies have been conducted on the deep sea water of Toyama Bay (hereinafter referred to as "cool water peculiar to the Sea of Japan"), which is under unique location conditions on the Sea of Japan side. In addition to the above, an invention utilizing the feature has been filed.

On the other hand, the reverse osmosis membrane method and the ion exchange membrane method are used as means for obtaining salt from seawater. The ion exchange membrane method has been established as a method of obtaining sodium hydroxide and chlorine gas from electrolysis of saline solution by using a cation exchange membrane (a membrane that allows only cations to pass through). When the saline solution is electrolyzed in a multi-tank electrolytic cell in which the and anion exchange membranes are alternately arranged, electrodialysis occurs in the intermediate tank, and a salt solution thicker than the stock solution and a thin saline solution are obtained in the alternate tanks. According to this method, the salt solution can be thinned, and thus it is used as a desalination plant for obtaining drinking water from seawater.

[0004]

DISCLOSURE OF THE INVENTION In a desalination means using a reverse osmosis membrane, chlorine (Cl) having an overwhelmingly large component ratio is used.
And sodium (Na) are separated and removed, other useful minerals are also removed at about the same rate as the separation of chlorine and sodium, so there is little change in the content of minerals in seawater and fresh water after separation. There is a problem that useful minerals in fresh water are scarcely left. ,

The useful mineral content of deep water is higher than that of surface water, but it still contains less than 1% of Na and Cl. Therefore, the filtration of deep water does not change the Na and Cl and mineral content. Therefore, since the mineral content of fresh water separated by filtration or the reverse osmosis membrane is inevitably equal, there is a problem that the mineral content cannot be replenished even if these are used for the purpose of nutritional supplementation.

Therefore, the present invention advances the research on the technology for selectively separating useful mineral components from cold water peculiar to the Sea of Japan, and pursues the functionality of the separated mineral concentrated liquid, and finds that it has unique functionality, We have succeeded in providing functional products that make use of their usefulness.

[0007]

In order to achieve the above-mentioned object, a functional product using a mineral concentrate separated from cold water peculiar to the Sea of Japan of the present invention is Functionality that contributes to stability of blood pressure, improvement functionality of allergic constitution, functionality that contributes to improvement of lifestyle-related diseases, etc., or those functions can be used in combination Is.

[0008] Here, the cold water peculiar to the Sea of Japan means Toyama Bay (area 2120 km2, the depth near the center of the bay reaches 1,000 m or more, and is 3000, which is the largest open sea inland bay of the Sea of Japan.
Melting water flows from the m-class mountains throughout the year, the shore is deep and the slope is steep, the continental shelf is poorly developed, and there are many sea valleys called "Obore Valley" on the seabed, which live in the deep sea. Famous as a habitat for firefly squid, white shrimp, and shellfish, and has a unique feature that mirages occur.) It refers to the deep water, and the coastal surface layer with low salinity that is affected by inland water such as river water. Water, Tsushima warm current water with a thickness of 200-300m below it, and deeper than 300m.

The cold water peculiar to the Sea of Japan is about 65 times the volume of Toyama Bay.
%, And as described in JP 2000-290168 A, JP 2000-290161 A, etc., is slightly different from the deep sea water of Kochi prefecture, and as a property thereof, the water temperature changes at a low temperature of 2 ° C. or less throughout the year. Almost no salt (3
It is also stable at 4.0 to 34.1 psu), has a remarkably rich amount of nutrient salts compared to surface water, and has very few organic substances and bacteria.

(1) The cold water peculiar to the Sea of Japan has a large amount of dissolved oxygen as compared with the deep water in the North Pacific Ocean at Cape Muroto in Kochi Prefecture, indicating that it is young as deep water. (2) Comparing both deep water and surface water, cold water peculiar to the Sea of Japan contained more inorganic nutrients such as phosphate phosphorus and nitrate nitrogen, and the number of general viable bacteria was smaller. This seems to be because the temperature of the cold water peculiar to the Sea of Japan is about 5 ° C lower than the deep water in the North Pacific Ocean at Cape Muroto, Kochi Prefecture. (3) The number of viable bacteria and fungi in the cold water peculiar to the Sea of Japan was considerably smaller than that in surface water.

Here, the mineral concentrate is obtained by separating the cold water characteristic of the Sea of Japan with a primary electrodialyzer and removing concentrated fresh water from the cold water characteristic of the Sea of Japan to further separate the concentrated deep water with a secondary electrodialyzer. , Concentrated salt water is removed from concentrated deep water, and useful minerals are selected and concentrated. Especially, it means that biocompatible components are mixed, and it is in liquid or powder form and can be used as it is. , That can be used after diluting to a free concentration. Here, the term "functionality" refers to, for example, a compound that can be expected to have a specific effect, a compound that exhibits a specific effect, or the like with respect to stability of blood pressure, improvement of allergic constitution, improvement of lifestyle-related diseases and the like.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION A functional product using a mineral concentrate separated from cold water peculiar to the sea of the present invention will be described. Among the functions of the mineral concentrate, the functionality that contributes particularly to the stabilization of blood pressure. , A function that contributes to the improvement of allergic constitution, a function that contributes to the improvement of lifestyle-related diseases, and the like, and those that can be used in combination.

As shown in FIG. 1, the mineral concentrate is separated by a multi-stage electrodialysis system consisting of a primary electrodialysis device 1 and a secondary electrodialysis device 2.
Is equipped with an ion-exchange membrane 11, and the cold water A unique to the Sea of Japan
(The salt is removed) and the concentrated deep-water C (water is removed) are separated, and the secondary electrodialysis device 2 is provided with the ion exchange membrane 12 having excellent monovalent ion selectivity. It is obtained by further separating the concentrated deep-layer water C separated as described above, and removing the concentrated salt water E containing monovalent elements as a main component from the concentrated deep-layer water C.

The primary electrodialysis device 1 is a cold water A unique to the Sea of Japan.
Is separated into fresh water B and concentrated deep water C, and the secondary electrodialyzer 2 separates concentrated deep water C into mineral concentrated liquid D and concentrated salt water E, and a monovalent plus element and a minus used for the product of the present invention. A mineral concentrate D from which elements and are removed is obtained. In the separation of the mineral concentrate D, a method of separating excess components by the ion-exchange membranes 11 and 12 (dialysis that enables the collection of minerals that are considered to be useful to the human body and the removal of trace amounts of components that are considered to be harmful to the human body) Membrane). That is, the cold water A specific to the Sea of Japan was treated using several kinds of ion exchange membranes 11 and 12, and the appropriate ion exchange membranes 11 and 12 were selected by analyzing the components of the treated liquid.

The functional product of the present invention is a product in which the mineral concentrate D is added to various products. As typical applications, as shown in FIG. 2, a product group for which blood pressure is stabilized and an allergic constitution is desired to be improved. The product group and the product group wishing to improve lifestyle-related diseases are listed. In FIG. 2, deep sea water represents the unique cold water A of the Sea of Japan, and minerals represent the mineral concentrate D.
The column of reduced water is derived from the fact that the properties of deep water and reduced water are said to be equivalent.

Specific applications of the functional product according to the present invention include mineral water, soft drinks, fruit drinks, sports drinks, whey drinks, bath salts, pharmaceuticals, as shown in FIG.
In addition to quasi-drugs, mouthwash, nasal cavity wash, cosmetics, hair products, processed foods, nutritional supplements, special-purpose foods, confectionery, bread, seasonings, food additives, etc., liquors (eg beer, sake) , Western liquor, fruit liquor, Chinese liquor, condiment liquor).

[0017]

[Experimental Example 1] The effect of a mineral concentrate on L-NAME-induced hypertensive rats was tested using the test method shown in FIG. The blood pressure elevation mechanism of L-NAME, an NO synthesis inhibitor used in this experiment, is as shown in FIG. In the above test, when the effect on the body weight transition in L-NAME-induced hypertensive rats was measured, the results shown in FIG. 6 were obtained,
This is illustrated in FIG. When the effect on blood pressure in L-NAME-induced hypertensive rats was measured, the results shown in FIG. 8 were obtained, and the results are shown in FIG. L-NAME
When the effect on the heart rate in induced hypertensive rats was measured, the results were obtained as shown in FIG. The deep water in FIGS. 4 to 10 indicates the mineral concentrate D separated from the cold water A peculiar to the Sea of Japan.

Effect on blood flow in L-NAME-induced hypertensive rats Method: Male SD rats were anesthetized with pentoparbital.nettrium (30-40 mg / kg, intraperitoneal administration) and fixed in the dorsal position, then the neck was fixed. Make an incision along the midline. The left common carotid artery is detached from the surrounding connective tissue, a flow probe (Primetech, HDP20.20R: φ20 mm) is attached, and blood flow is measured using a pulse Doppler blood flow needle (Crystal Biotech, PD-20). , LINEAC
Record on ORDER (Graphtech, WR3101). The measurement is recorded on the chart for several minutes, and then the relatively stable place is read and used as the blood flow rate. The results are shown in FIG. 11 (mean value ± standard error), and statistical analysis is performed by one-way analysis.

[0019]

[Experimental Example 2] The effect of a mineral concentrate on mouse IgE antibody production was tested using the test method shown in FIG. The characteristics of mouse IgE (immunoglobulin E) antibody production used in this experiment are shown in FIG. I in the above test
The gE antibody titer measurement was as shown in FIG. 14, and the influence of the mineral concentrate on mouse IgE antibody production was as shown in FIG. a. Transition of body weight When the transition of body weight in mouse IgE antibody production of the concentrated mineral solution was measured, the results were obtained as shown in FIG. 16, which is shown in FIG. The changes in body weight in the control group and the tap water-administered group increased with time in both groups. on the other hand,
The change in body weight of the mineral concentrate administration group was lower than those of the control group and the tap water administration group, but no significant difference was observed between the nuclear groups. b, Effect on IgE antibody production IgE antibody in the control group was 9.0 ± 00.55 (log
2: 512). 8.83 ± 0 in the tap water administration group
-An antibody titer of 79 was shown. On the other hand, the IgE antibody of the mineral concentrate administration group showed 8.33 ± 0.61, which was
And showed a tendency to suppress IgE antibody production as compared with that of the tap water administration group. In the non-sensitized group (normal group), production of IgE antibody against ovalbumin was not detected. The deep water in FIGS. 13 to 17 indicates the mineral concentrate D separated from the cold water A peculiar to the Sea of Japan.

[0020]

[Experimental Example 3] The effect of the mineral concentrate on the experimental lifestyle-related disease model was tested using the test method shown in FIG.
The experimental lifestyle-related disease model used in this experiment is as shown in FIG. In the above test, the effect of the mineral concentrate on the body weight was measured in the lifestyle-related disease model, the results were obtained as shown in FIG. 20, and the effect of the mineral concentrate on the blood glucose in the lifestyle-related disease model was measured. The results were obtained as shown in FIG. In addition, when the effect on total cholesterol in the lifestyle-related disease model was measured, the results were obtained as shown in FIG. 22, and when the effect on triglyceride in the lifestyle-related disease model was measured, the results were obtained as shown in FIG. It was Further, when the influence on the platelet aggregation ability in the lifestyle-related disease model was measured, the results were obtained as shown in FIG. The deep water in FIGS.
A mineral concentrate separated from the cold water A peculiar to the Sea of Japan.

[0021]

EXAMPLE The components of the cold water A peculiar to the Sea of Japan, the fresh water B separated from the cold water A peculiar to the Sea of Japan, the mineral concentrated liquid D, and the concentrated salt water E were as shown in FIG. The ion contents of the fresh water B and concentrated deep water C separated from the cold water A unique to the Sea of Japan, and the mineral concentrated liquid D and concentrated salt water E separated from the concentrated deep water C are as shown in FIG. Therefore, the fresh water B can be used for diluting the mineral concentrated liquid D or the concentrated salt water E, for example, or the concentrated salt water E can be used as a sterilizing means or a sterilizing means of the filling material. The raw water in FIG. 25 indicates the cold water A peculiar to the Sea of Japan, and the concentrated salt water is the concentrated salt water E.
Refers to.

As the mineral concentrate D, chlorine ions, nitrogen ions, iodine ions, sodium, magnesium, potassium, calcium, strontium, lithium, rubidium, cadmium, barium, vanadium, aluminum, germanium, molybdenum which are biocompatible components close to body fluids. , Boron, soluble silicon, total phosphorus, zinc, arsenic, copper,
It is desirable to leave lead, iron, nickel, chromium, manganese, selenium, cobalt, etc. The fresh water B is demineralized water from which sodium chloride, chlorine, etc. have been removed, and the concentrated deep-layer water C is one in which water has been removed and concentrated, and one in which water has been completely removed and powdered is also included.

The components of the mineral concentrate D can be separated into finer particles by combining the ion-exchange membranes 11 and 12 having different properties, so that the functionalities other than those obtained in the experiment of the present invention can be obtained. Can be expected. The content range of the mineral concentrate D in the product varies depending on the type of the product, but is generally 50% or less, the desirable range is 25% or less, and the optimum range is 10% or less. Mineral concentrate D
As a result of comparing the element concentrations of the concentrated salt water E and the concentrated salt water E, it was confirmed that the monovalent ions were efficiently removed and that the trace metal elements were concentrated. Although the taste and the mineral content are contradictory factors, it is possible to select the mineral content and taste suitable for each person's constitution.

[0024]

The functional products using the mineral concentrate of the present invention are as described above, and therefore have the following effects. It is possible to provide high-value-added deep sea water products or nutritionally balanced deep sea water products. Since it contains other kinds of minerals, when it is used in beverages and foods, the nutritional balance is improved, the content rate of inorganic nutrient salts is increased, and the addition of minerals in that amount can be omitted.

By selecting the ion-exchange membrane, it is possible to collect all the minerals that are considered to be useful to the human body without leakage, and to remove the trace amount of harmful components, that is, to leave only the mineral components close to body fluid. As it has a low salt content,
It is possible to provide sea products that are mild to the constitution by reducing the irritation caused by salt. By mixing electrolyzed fresh water (demineralized water) with the mineral concentrate, it is possible to provide a beverage having a high mineral content, which is produced from 100 natural deep sea water.

To summarize the effects on L-NAME-induced hypertensive rats, as shown in FIG. 27 (deep water in the figure indicates a mineral concentrate), there is a tendency to suppress weight gain with respect to the change in body weight, and to blood pressure. Shows a tendency to suppress an increase of about 30 mmHg due to L-NAME loading, and a decrease in L-NAME loading due to L-NAME loading (5th week; 7
0 beats / min) was slightly enhanced, and the blood flow showed a tendency to increase the decrease due to L-NAME loading.

To summarize the effect on mouse IgE antibody production, it shows a tendency to suppress IgE antibody production against ovalbumin against mouse IgE antibody production.
It is inferred that there is a relationship as shown in FIG. 28, and the effects on the lifestyle-related disease model rat are summarized as shown in FIG. 29. The test results are summarized in FIG. 30 when L-NAME-induced hypertensive rats and mouse IgE antibody production and model rats for lifestyle-related diseases are summarized. Figure 2
Deep water in 7 to 30 refers to a mineral concentrate separated from the cold water A peculiar to the Sea of Japan.

It can be presumed that the mineral concentrate of the cold water unique to the Sea of Japan is useful for improving cerebral infarction, myocardial infarction, stiff shoulder and constipation, and as reducing water, it is useful for improving diabetes, arteriosclerosis and allergies. By using a dense ion exchange membrane, it contains appropriate mineral components, which contributes to the production of products with increased added value.

Examining the functionality (predominance) of cosmetics, for example, if the sodium chloride content is reduced from the mineral balance of seawater to make it a component close to human body fluid or amniotic fluid, immunity will be increased during the skin formation process. No fetal skin formation,
It is possible to provide products that are deeply involved in protection and products that form barrier properties for the skin. In other words, it is possible to manufacture products that are suitable for the properties of hair, cosmetics that are effective in recovering the functions of the skin, and products that are highly value-added as skin-friendly cosmetic raw materials.

Examining the functionality (dominance) as a bath agent, it is possible to commercialize a skin-friendly bath agent having high moisturizing properties and low irritation, which is useful for general skin diseases. By using the mineral concentrate, it is possible to reproduce amniotic fluid and to develop a bath salt useful for children with weak skin (atopic dermatitis, etc.).

When used in beverages, the taste and the mineral content are contradictory factors, but a product having a wide range of choices of the mineral content and taste suitable for each person's constitution becomes possible. In addition, as the difference in mineral content between body fluid and seawater, the order of Ca and Mg content is reversed, but by matching the mineral water components of the ground to fill this difference, a balanced match can be achieved. If the hardness is too high, diarrhea is often caused, and the taste is heavy and bitter. Therefore, it is preferable to set the hardness to 200 to 250 as a hardness that balances deliciousness and tenderness to the stomach. Also, compared to other products of the same hardness,
Chlorine ion, sodium ion, and potassium ion are properly removed, making it a product that is very easy to drink and is gentle on the body. The concentrated deep water was separated by an electrodialysis device using an ion exchange membrane having excellent monovalent ion selectivity to obtain a mineral component from which monovalent elements were removed.

[Brief description of drawings]

FIG. 1 is a schematic block diagram showing an example of separation of deep sea water (cool water unique to the Sea of Japan).

FIG. 2 is a schematic classification diagram of a functional product group according to the present invention.

FIG. 3 is a specific classification diagram of functional products.

FIG. 4 is an explanatory view showing a test method for the effect of deep water on L-NAME-induced hypertensive rats.

FIG. 5 is an explanatory diagram showing the blood pressure elevation mechanism of NO synthesis inhibitor, L-NAME.

FIG. 6 is a measurement diagram showing the influence of deep water on the body weight transition in L-NAME-induced hypertensive rats.

FIG. 7 is a chart of FIG.

FIG. 8 is a measurement diagram showing the effect on blood pressure in L-NAME-induced hypertensive rats.

9 is a chart of FIG. 8. FIG.

FIG. 10 is a measurement diagram showing the influence on the heart rate in L-NAME-induced hypertensive rats.

FIG. 11 is an explanatory diagram showing the effect on blood flow in L-NAME-induced hypertensive rats.

FIG. 12 is an explanatory view showing a method for testing the influence of deep layer water on mouse IgE antibody production.

FIG. 13 is an explanatory diagram showing the properties of mouse IgE (immunoglobulin E) antibody production.

FIG. 14 is an explanatory diagram showing mouse IgE antibody titers in a test group.

FIG. 15 is an explanatory diagram showing the influence of deep layer water on mouse IgE antibody production.

FIG. 16 is a measurement diagram showing changes in body weight during production of deep-water mouse IgE antibody.

FIG. 17 is a chart of FIG. 16.

FIG. 18 is an explanatory diagram showing a test method for the effect of deep water on an experimental lifestyle-related disease model.

FIG. 19 is an explanatory diagram showing an experimental lifestyle-related disease model.

FIG. 20 is an explanatory diagram showing the effect of deep water on the body weight in a lifestyle-related disease model.

FIG. 21 is an explanatory diagram showing the effect of deep water on blood glucose in a lifestyle-related disease model.

FIG. 22 is an explanatory diagram showing the effect on total cholesterol in a lifestyle-related disease model.

FIG. 23 is an explanatory diagram showing effects on triglycerides in a lifestyle-related disease model.

FIG. 24 is an explanatory diagram showing the effect on platelet aggregation in a lifestyle-related disease model.

FIG. 25 is an elemental analysis diagram showing the cold water peculiar to the Sea of Japan (Toyama Bay deep water) and the element-containing state after the separation.

FIG. 26 is an ion content diagram of fresh water, concentrated deep water, concentrated mineral liquid, and concentrated salt water separated from cold water peculiar to the Sea of Japan.

FIG. 27 is an explanatory diagram showing the effect on L-NAME-induced hypertensive rats.

FIG. 28 is an explanatory diagram showing the effect on mouse IgE antibody production.

FIG. 29 is an explanatory diagram showing the effect on a lifestyle-related disease model rat.

FIG. 30 is a summary diagram supporting the efficacy of deep water.

[Explanation of symbols]

1 Primary electrodialysis device 2 Secondary electrodialysis equipment 12,13 Ion exchange membrane A Deep sea water (Cold water unique to the Sea of Japan) B Fresh water (demineralized water) C concentrated deep water D concentrated mineral liquid E concentrated salt water

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[Procedure amendment]

[Submission date] October 17, 2001 (2001.10.
17)

[Procedure Amendment 1]

[Document name to be corrected] Drawing

[Name of item to be corrected] Fig. 17

[Correction method] Change

[Correction content]

FIG. 17

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 33/00 A61P 3/00 A61P 3/00 9/00 9/00 9/12 9/12 37/08 37/08 A23L 2/00 FF term (reference) 4B017 LC03 LK02 LP02 LP18 4B018 LB08 LE05 MD01 ME04 ME07 MF01 MF06 4C083 AA021 AA022 AB00 CC01 CC25 DD27 EE11 EE42 4C086 AA01 AA02 HA00 MA01 A04 A10 A02 A01 A04 ZB17A02 MA17 NA14 ZA42 ZB13 ZC21

Claims (4)

[Claims] 1. A functional product characterized by utilizing the functionality of a mineral concentrated liquid separated from deep sea water. 2. The functional product according to claim 1, wherein among the functional properties of the mineral concentrate, the functional properties mainly contributing to the stabilization of blood pressure are utilized. 3. The functional product according to claim 1, wherein among the functional properties of the concentrated mineral liquid, the functional properties mainly contributing to improvement of allergic constitution are utilized. 4. The functional product according to claim 1, wherein among the functional properties of the concentrated mineral liquid, the functional properties mainly contributing to the improvement of lifestyle-related diseases are utilized.