JP2005306851A - Antidermopathic agent and skin lotion containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antidermopathic agent effective for suppressing or ameliorating one or more skin lesions such as pachyderma caused by UV exposure, sclerema, abnormal accumulation of extradermatocytic materix component and formation of collagen crosslink and provide a skin lotion containing the agent as an active component. <P>SOLUTION: The antidermopathic agent contains the extract of the leaf of a plant of the genus Psidium, family Myrtaceae, and the skin lotion contains the agent as an active component. Preferably, the plant of the genus Psidium, family Myrtaceae is one or more plants selected from Psidium guajava, Psidium guineense and Psidium cattleianum. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an anti-dermatological agent that suppresses or ameliorates skin damage caused by exposure to ultraviolet rays, and a skin external preparation containing the same. More specifically, it contains an anti-dermatological agent of a leaf extract of Psidium, which is an abnormal accumulation of skin extracellular matrix components caused by UV exposure, collagen cross-linking, skin thickening, and skin hardening. The present invention relates to a topical skin preparation useful as a cosmetic or pharmaceutical agent that suppresses or improves one or more.

Continuous long-term exposure to ultraviolet light (for example, sunlight) causes skin to become irritated by chemical mediators, cytokines, etc., resulting in skin disorders such as wrinkles, tarmi, skin thickening, skin hardening, and solar elastic fibrosis ( Non-patent document 1). In particular, the thickening of the epidermis and dermis results in a decrease in skin elasticity and moisture retention, which is considered to be one of the factors of skin aging. Therefore, in order to prevent these obstacles conventionally, an external preparation containing an ultraviolet absorber (see Patent Document 1 and Non-Patent Document 2) and an ultraviolet scattering agent (see Non-Patent Document 3), that is, an emulsion, cream, lotion, Cosmetic liquids, foundations, ointments, cataplasms, patches, etc. are used.
In addition, retinoic acid (see Non-Patent Document 4), anti-inflammatory drug (see Non-Patent Document 5) to prevent or ameliorate skin wrinkles, talmi, elasticity and reduction in elasticity caused by aging, UV exposure, etc. ), Buckwheat extract, birch extract, sage extract, roman chamomile extract, etc. (see Patent Document 2), Melissa extract (see Patent Document 3), and also active in inhibiting abnormal accumulation of extracellular matrix components, skin thickening, wrinkles, etc. Formulation of type vitamin D ₃ (see Non-Patent Document 6) has been reported.

However, for example, a topical skin preparation containing retinoic acid has an effect of improving the skin damage caused by ultraviolet rays including wrinkles by proliferating collagen in the upper layer of the dermis. is there. The active vitamin D ₃ have a side effect problems such as calcium metabolism. Even in the topical skin preparations containing other UV absorbers, UV scattering agents, anti-inflammatory agents, plant extracts, etc., these are not effective in suppressing or improving wrinkle formation, skin thickening, etc. When these additives are blended at a high concentration, the usability of the preparation may be impaired, and problems such as deterioration at high temperatures and over time may occur.

JP 09-268194 A Japanese Patent Application Laid-Open No. 08-109122 JP 09-241148 A Tsutomu Sugawara and Keiichi Nozu, “Solar UV and Health,” Yukabo (1998) p. 2-100 Nicholas J. Rowe / Nadim A. Germ, “Sunscreens and Dermatology”, Fragrance Journal, published May 20, 1993, p. 195-262 “Fragrance Journal”, Fragrance Journal, July 2002 16-27, 33-38 Lorraine H. Kligman, “Effects of all-trans-retinoic acid on the dermis of hairless rice,” Journal of the American Academy of Dermatology, 1988. 15, no. 4, Part. 2, October, P.M. 779-785 Bissett DL, et al. Author, “Photoprotective effect of topical anti-inflammatory agents against ultraradiation radiation-induced chronic skin damage in the hair 90.” 7, p. 153-158 Koshiishi I, et al. “1,25-dihydroxyvitamin D3 presents the conversion of adipose tissue into fibrosstic in skin and exposed to chronic UV irradiation.”, Toxico. 173, P.I. 99-104

  Therefore, it has an adverse effect on anti-skin disorder agents that effectively suppress or improve skin disorders such as abnormal accumulation of extracellular matrix components, collagen cross-linking formation, skin thickening, and skin hardening caused by UV exposure, and the feeling of use and dosage form. There has been a demand for the development of an external preparation for skin containing the same without affecting it.

  In order to achieve the above object, the present inventors have focused on plants already used in pharmaceuticals, cosmetic raw materials, folk medicine and the like that have been confirmed to be safe, and as a result of earnest research, Psidium leaf extract suppresses or ameliorates the development of at least one skin disorder such as abnormal accumulation of skin extracellular matrix components, collagen cross-linking, skin thickening, skin hardening, etc. caused by UV exposure The present invention was completed by obtaining new knowledge that the effect is excellent.

  That is, the present invention relates to an anti-dermatological agent that suppresses and improves a skin disorder caused by exposure to ultraviolet rays, which contains a leaf extract of the genus Psidium as an active ingredient, and preferably, Psidium guajava), Psidium guineense, and Psidium cattleianum (hereinafter referred to as the scientific name Latin notation) are at least one kind of anti-disorder agent selected from the group It is. Moreover, the skin disorder | damage | failure resulting from an ultraviolet-ray exposure is related with the anti-dermatological disorder agent which is at least 1 or more of abnormal accumulation | storage of a skin extracellular matrix component, collagen cross-linking formation, skin thickening, and skin hardening. Still further, the present invention relates to an external preparation for skin containing the anti-dermatological agent as an active ingredient and suppressing or improving the above-mentioned skin damage, particularly to an external preparation for preventing aging.

  The leaf extract of the Myrtaceae Psidium plant according to the present invention suppresses at least one skin disorder of abnormal accumulation of skin extracellular matrix components and collagen cross-linking formation, skin thickening, and skin hardening caused by exposure to ultraviolet rays. It is an anti-dermatological agent that is highly effective for improvement. The topical skin preparation containing the anti-dermatological agent as an active ingredient effectively suppresses or ameliorates the skin disorder caused by exposure to ultraviolet rays. Therefore, a cosmetic or quasi-drug that prevents skin aging. Etc., which can be advantageously used.

Hereinafter, the present invention will be described in detail.
The leaf extract of the genus Psidium plant used in the present invention is an abnormal accumulation of extracellular matrix components caused by UV exposure, in particular, abnormal production of collagen, cross-linking formation of collagen, further skin thickening, skin hardening, etc. It suppresses or improves at least one skin disorder. There are no particular limitations on the leaf extract of the Myrtaceae Psidium genus used in the present invention, but guava, Psidium guineense, and Psidium katuleaneum are preferred from the standpoint of effects.

  The leaf extract used in the present invention is not particularly limited in terms of its preparation method, and the leaves are dried or subjected to appropriate treatments such as fermentation, and then at a low temperature or from room temperature to warming. The method of extracting with a solvent can be mentioned below.

  Examples of the extraction solvent include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, 1, 3 -Butylene glycol, etc.), lower alkyl esters (ethyl acetate, etc.), hydrocarbons (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether, etc.), acetonitrile 1 type, or 2 or more types can be used. Particularly preferred extraction solvents include water, water-ethyl alcohol mixed solvent, ethyl alcohol, 2-propanol and the like.

  Further, the extract may be any of a molecular weight fraction, a solvent fraction, a product purified by various purification treatments (ion exchange resin, adsorbent), and a freeze-dried product.

  As a specific production method, for example, a dried product of a plant leaf is pulverized and extracted with hydrous ethyl alcohol or 1,3-butylene glycol having a concentration of about 10 times mass and 0 to 100% by volume at room temperature for 1 to 5 days. After 2 hours of reflux extraction or 1 hour of hot water extraction, the mixture is filtered, and the extract is further purified by molecular weight fractionation, solvent fractionation, various purification treatments (ion exchange resin, adsorbent), etc. There is a method of obtaining an extract (solid matter) by lyophilization. In the case of ethyl alcohol or 2-propanol solvent, the solvent is distilled off, and then an extract (solid content) is obtained by lyophilization or the like.

  The form of the anti-dermatological agent of the present invention is not particularly limited as long as it contains a leaf extract of the genus Psidium, and can be used in any form such as liquid, paste, cream or gel. Further, it can be dried by spray drying or the like and used as a powder.

  The external preparation for skin of the present invention is characterized by containing an anti-dermatological agent of a leaf extract of the genus Psidium plant. The content of the anti-dermatological agent in the external preparation for skin of the present invention is not particularly limited, but is 0.0001 to 10% by mass (hereinafter simply referred to as “%”) as the dry solid content in the external preparation for skin. And preferably 0.001 to 5%. Within this range, abnormal accumulation of extracellular components of the skin due to UV exposure, especially abnormal production of collagen and collagen cross-linking, as well as manifestation of at least one skin disorder such as skin thickening and skin hardening. It is excellent in the effect of suppressing or improving the symptom, and good in terms of stability over time can be obtained.

  In addition to the above essential components, the external preparation for skin containing the anti-dermatological agent of the present invention includes various components usually used in cosmetics, quasi-drugs, external medicines, that is, water, alcohols, oils, interfaces. Active agents, thickeners, powders, chelating agents, pH adjusters, whitening agents, anti-inflammatory agents, antioxidants, moisturizers, bactericides, blood circulation promoters and other medicinal agents, extracts derived from animals, plants and microorganisms In addition, an ultraviolet absorber, an ultraviolet scattering agent, a fragrance and the like can be appropriately added depending on the purpose within a range not impairing the effects of the present invention.

  Examples of the external preparation for skin containing the anti-dermatological agent of the present invention include cosmetics, quasi-drugs, pharmaceuticals, etc., and the dosage form is an aqueous dosage form, an oil-based dosage form, an emulsifier type, a powder dosage form, It can mix | blend with any dosage forms, such as a solid dosage form. For example, cosmetics can be used in lotions, emulsions, creams, cosmetics, packs, bath salts, ointments, gels, foundations, powders, lip balms, lipsticks, sunscreen products, and the like.

  Next, although the manufacture example of a plant extract and an Example are given and this invention is demonstrated further in detail, this invention is not restrict | limited at all.

  Production examples of leaf extract of Psidium spp. In production examples 1 to 4 and comparative samples already have anti-wrinkle effect on skin, anti-aging effect (promoting proliferation and differentiation of epidermal cells, promoting keratin turnover The production example of birch bark extract in which keratin improvement, skin beautifying effect, etc.) have been reported is shown in Comparative Production Example 5.

[Production Example 1]
1,000 mL of 25 vol% ethyl alcohol aqueous solution was added to 100 g of dried guava leaf, and reflux extraction was performed for 2 hours. Centrifugation, pressure filtration, and membrane separation were used to collect a sample having a molecular weight of 5,000 or less, and 750 mL of an extract was obtained and concentrated under reduced pressure using an evaporator. After distilling off ethanol, this solution was freeze-dried. 8.5 g were obtained as a solid.

[Production Example 2]
To 100 g of dried Psidium guineense leaf, 1,000 mL of purified water was added, and hot water extraction was performed for 1 hour. Centrifugation, pressure filtration, and membrane separation were used to collect a product having a molecular weight of 5,000 or less to obtain 650 mL of an extract. After concentration under reduced pressure with an evaporator, this solution was freeze-dried to obtain 10. 4 g was obtained.

[Production Example 3]
1,000 mL of a 25 vol% ethyl alcohol aqueous solution was added to 100 g of the dried leaf of Psidium katreiranum, and reflux extraction was performed for 2 hours. Centrifugation, pressure filtration, and membrane separation were used to collect a material having a molecular weight of 5,000 or less, and 780 mL of an extract was obtained, concentrated under reduced pressure using an evaporator, ethanol was distilled off, and this solution was freeze-dried. 9.3 g was obtained as a solid.

[Production Example 4]
Purified water (1,000 mL) was added to 100 g of dried guava leaf, and hot water extraction was performed for 1 hour. Centrifugation, pressure filtration, and membrane separation were used to collect one having a molecular weight of 5,000 or less to obtain 750 mL of an extract, which was concentrated under reduced pressure using an evaporator. 5 g was obtained.

[Comparative Production Example 5]
1,000 mL of 25 vol% ethyl alcohol aqueous solution was added to 100 g of a crushed dried birch bark, and reflux extraction was performed for 2 hours. Centrifugation, pressure filtration, and membrane separation were used to collect a sample having a molecular weight of 5,000 or less, and 660 mL of an extract was obtained and concentrated under reduced pressure using an evaporator. After distilling off ethanol, this solution was freeze-dried. 7.4 g was obtained as a solid.

Example 1: Skin damage test by hairless mouse UV irradiation Anti-skin damage preparation was prepared by the following preparation method, skin thickening by UV irradiation, skin hardening, abnormal accumulation of skin extracellular matrix components (total hydroxyproline amount, dermatan sulfate amount ) And collagen crosslink formation (pepsin resistant hydroxyproline).

[Preparation of sample (anti-dermatological preparation)]
The extracts of Production Examples 1 to 4 and Comparative Production Example 5 were dissolved in a base (polyethylene glycol 1000: ethyl alcohol = 1: 1) so as to have a solid content concentration of 5%, and used as a sample, and hairless massus UV irradiation was performed. Used for skin evaluation test.

[Sample application method and UV irradiation method]
One group consists of 8 animals, and 0.1 g of the above sample is applied to the back of hairless mice (10 weeks old) 90 minutes before UV irradiation, and a certain amount of UV light (Toshiba FL20S / BLB lamp) is applied for 2 hours a day (5 times). / Week) Irradiation was performed for 20 weeks (total irradiation amount: 750 J / cm ² ), and skin thickening and skin hardening, abnormal accumulation of skin extracellular matrix components, and inhibition of collagen cross-linking formation were examined.
In addition, the ultraviolet absorption spectrum of these samples was measured, and it was confirmed that these did not affect the evaluation test.

[Evaluation method]
(Skin thickening suppression effect)
The skin thickness before and 20 weeks after UV irradiation was measured using a dial thickness gauge (OZAK.MFG.CO.LTD.). The results were evaluated by the average value of the skin thickness of 8 animals and the rate of increase after 20 weeks.

(Skin hardening inhibitory effect)
The skin at the center of the back of the hairless mouse was picked with a finger, and the skin that required 5 seconds or more for restoration was regarded as skin hardening, and the expression rate in 8 mice was evaluated.

[Abnormal accumulation of skin extracellular matrix components; total hydroxyproline content, dermatan sulfate content]
(Total hydroxyproline; collagen determination method)
Hydroxyproline in the skin was measured, and the abnormal accumulation amount of skin extracellular matrix components (abnormal accumulation amount of collagen) was evaluated.
For the determination of hydroxyproline, first, a frozen section (20 microns) of hairless mouse dorsal skin was prepared, the skin section was heated on a slide glass, and then 0.05% alkaline protease (actinase E; manufactured by Kaken Pharmaceutical) (500 tyrosinase). (Unit / mL) was enzymatically decomposed (40 ° C.-2 hours) and solubilized. Then, after vacuum-sealing and hydrolyzing with 6N hydrochloric acid (145 ° C. for 4 hours), the hydroxyproline was colored by the Woessner method and measured.

(Dermatan sulfate determination method)
Like collagen, abnormal accumulation of dermatan sulfate, a skin extracellular matrix component, is one of the indicators of skin aging caused by ultraviolet irradiation, and the degree of skin aging was evaluated by measuring this component. After formalin fixation of the hairless mouse dorsal skin, a 6-micron skin section was prepared, and the skin section was enzyme-enzymed with chondroitinase ABC (0.5 units / mL) and collagenase (500 mandel units / mL) on a slide glass. After decomposition (37 ° C-2 hours) and solubilization, the sample is separated using an HPLC apparatus by the post-column method under the following conditions, mixed with reaction reagent 1 and reaction reagent 2, and then at 110 ° C-2 minutes The reaction was carried out in the interior to obtain a fluorescent derivative, which was measured with a fluorescence detector.

(HPLC conditions)
HPLC column: DOCOSIL (4.6id × 150mm: manufactured by Senshu Scientific Co., Ltd.)
Fluorescence detection: Ex. 346 nm, Em. 410nm
Mobile phase: 8.5% acetonitrile-1 mM tetra n-butylammonium hydrogensulfate Flow rate: 1.5 mL / min Column temperature: 60 ° C.
Reaction reagent 1: 0.3 M NaOH (0.25 mL / min)
Reaction reagent 2: 0.25% 2-cyanoacetamide

(Collagen cross-linking: Pepsin resistant hydroxyproline quantitative method)
The degree of collagen cross-linking in the skin was evaluated based on the difficulty of degradation by acid protease (pepsin; manufactured by Nacalai Tesque).
First, a frozen section (20 microns) of the hairless mouse dorsal skin prepared by the above-described collagen quantification method was enzymatically degraded with 0.01% pepsin (366 units / mL) on a slide glass (5 ° C.-64 hours) to allow pepsin. The dissolved collagen was washed with water and removed. Thereafter, pepsin-resistant collagen was heated by the same method as described above, and then enzymatically decomposed using actinase E and solubilized. Next, the solution was sealed in a vacuum, hydrolyzed with 6N hydrochloric acid (145 ° C. for 4 hours), and then developed with hydroxyproline by Woessener method to measure pepsin resistant hydroxyproline.

(Pepsin resistant hydroxyproline (%) calculation method)
The content of pepsin resistant hydroxyproline relative to total hydroxyproline in the skin was calculated and used as an index for collagen cross-linking formation.
Pepsin resistant hydroxyproline content (%) = (pepsin resistant hydroxyproline / total hydroxyproline) × 100

Tables 1 and 2 show the evaluation results of skin thickening, sclerosis, abnormal accumulation of skin extracellular matrix components (total hydroxyproline amount, dermatan sulfate amount), and collagen crosslinking (pepsin-resistant hydroxyproline amount, content), respectively. .

As is clear from Tables 1 and 2, all of the extracts of Production Examples 1 to 4 of the present invention were extremely excellent in the effects of suppressing remarkable skin thickening, skin hardening, abnormal accumulation of skin extracellular matrix components, and collagen crosslinking. It was a thing.

Example 2 Cream (ingredient) (%)
(1) Polyethylene glycol monostearate (40 EO) 2.0
(2) Self-emulsifying glyceryl monostearate 5.0
(3) Stearic acid 5.0
(4) Behenyl alcohol 1.0
(5) Liquid paraffin 10.0
(6) Glyceryl trioctanoate 10.0
(7) Guava leaf extract * 1 1.0
(8) Psidium guineense leaf extract * 2 2.0
(9) Glycerin 5.0
(10) Preservative appropriate amount (11) perfume appropriate amount (12) remaining amount of purified water * 1 Production Example 1
* 2 Production Example 2

(Manufacturing method)
A. Ingredients (1)-(6) are mixed and heated to keep at 70 ° C.
B. Ingredients (9), (10) and (12) are mixed and heated to keep at 70 ° C.
C. B is added to A and emulsified.
D. Components (7), (8) and (11) were added to C, and then cooled to obtain a cream.

  Example 2 is stable without discoloration and odor, has a smooth emollient effect when applied to the skin, is excellent in suppressing or improving skin disorders such as skin thickening and skin hardening, and has an anti-aging effect Met.

Example 3 lotion (ingredient) (%)
(1) Glycerin 10.0
(2) 1,3-butylene glycol 6.0
(3) Citric acid 0.1
(4) Sodium citrate 0.3
(5) Psidium cutlet anum leaf extract * 1 0.5
(6) Guava leaf extract * 2 0.5
(7) Purified water remaining amount (8) polyoxyethylene (60E.O.) hydrogenated castor oil 0.5
(9) Ethyl alcohol 8.0
(10) Preservative appropriate amount (11) Fragrance appropriate amount * 1 Production Example 3
* 2 Production Example 4

(Manufacturing method)
A. Components (1) to (7) are mixed and dissolved.
B. Components (8) to (11) are mixed and dissolved.
C. A and B were mixed and made uniform to obtain a skin lotion.

  Example 3 is stable without discoloration, odor, precipitation, etc. When applied to the skin, it has a fresh moisturizing feeling, is excellent in suppressing or improving skin disorders such as skin thickening and skin hardening, and has an anti-aging effect. There was something.

Example 4 Latex (component) (%)
(1) Sorbitan monostearate 0.3
(2) Polyoxyethylene monooleate (20E.O.)
Sorbitan 0.1
(3) Lipophilic glyceryl monostearate 0.2
(4) Stearic acid 0.5
(5) Cetanol 0.5
(6) Squalane 3.0
(7) Liquid paraffin 4.0
(8) Glyceryl tri-2-ethylhexanoate 2.0
(9) Dimethylpolysiloxane 1.0
(10) Hydrogenated soybean phospholipid 0.1
(11) Carboxyvinyl polymer aqueous solution (1.0%) 10.0
(12) Sodium hydroxide 0.05
(13) Glycerin 5.0
(14) 1,3-butylene glycol 7.0
(15) Purified water remaining amount (16) Guava leaf extract * 1 0.2
(17) Ethyl alcohol 5.0
(18) Silicic anhydride 1.0
(19) Preservative appropriate amount (20) Fragrance appropriate amount * 1 Production Example 1

(Manufacturing method)
A. Ingredients (1) to (10) are heated and mixed and maintained at 70 ° C.
B. Ingredients (11) to (15) are heated and mixed and maintained at 70 ° C.
C. Add B to A, mix and uniformly emulsify.
D. After cooling C, (16) and (17) to (20) were added and mixed uniformly to obtain an emulsion.

  Example 4 is stable without discoloration, odor and separation, has a smooth moisturizing feeling when applied to the skin, has an excellent effect of suppressing or improving skin disorders such as skin thickening and skin hardening, and has an anti-aging effect. There was something.

Example 5 Pack (ingredient) (%)
(1) Polyvinyl alcohol 15.0
(2) Silicic anhydride 0.5
(3) Polyethylene glycol 0.5
(4) Polyoxypropylene methyl glucoside 5.0
(5) Glycerin 5.0
(6) Purified water remaining amount (7) Ethyl alcohol 10.0
(8) Preservative Appropriate amount (9) Psidium cuttleinum leaf extract * 1 0.05
(10) Perfume appropriate amount * 1 Production Example 3

(Manufacturing method)
A. Components (1) to (6) are mixed and heated to 70 ° C. to dissolve.
B. Components (7) to (8) are mixed and dissolved.
C. B was added to the previous A, mixed, and then cooled to uniformly disperse (9) and (10) to obtain a pack.

  Example 5 is stable without discoloration, odor, separation, etc. When applied to the skin, there is a moderate tension, the skin after peeling the pack has a high moist feeling, skin thickening, skin hardening and other skin disorders It was excellent in the effect which suppresses or reduces.

Example 6 Liquid foundation (component) (%)
(1) Dipentaerythritol tetra-12-hydroxy stearic acid sesquistearic acid hemirosin ester 2.0
(2) Liquid paraffin 5.0
(3) Stearic acid 2.0
(4) Cetanol 1.0
(5) Self-emulsifying glyceryl monostearate 1.0
(6) Paramethoxycinnamic acid-2-ethylhexyl 8.0
(7) Guava leaf extract * 1 0.01
(8) Psidium guineense leaf extract * 2 0.01
(9) Preservative appropriate amount (10) Glycerin 5.0
(11) Triethanolamine 1.0
(12) Carboxymethylcellulose 0.2
(13) Bentonite 0.5
(14) Purified water remaining amount (15) Titanium oxide 6.0
(16) Fine particle titanium oxide 2.0
(17) Fine zinc oxide 5.0
(18) Mica 2.0
(19) Talc 4.0
(20) Color pigment 4.0
(21) Perfume appropriate amount * 1 Production Example 1
* 2 Production Example 2

(Manufacturing method)
A. Components (1) to (6) are heated and mixed and dissolved.
B. Ingredients (15) to (20) are added to A, mixed uniformly, and kept at 70 ° C.
C. Ingredients (9) to (14) are uniformly dissolved and kept at 70 ° C.
D. B is added to C and emulsified uniformly.
E. After cooling D, components (7), (8) and (21) were added to obtain a liquid foundation.

  Example 6 is stable with no odor, separation, etc., and when applied to the skin, it excels in a moisturizing makeup effect, protects the skin from ultraviolet rays during the day, and suppresses skin disorders such as skin thickening and skin hardening. Or it was excellent in the effect to reduce and had the antiaging effect.

Example 7 Sunscreen Latex (Component) (%)
(1) Polyoxyalkylene-modified organopolysiloxane 1.0
(2) Dimethylpolysiloxane 5.0
(3) Octamethylcyclotetrasiloxane 20.0
(4) Isotridecyl isononanoate 5.0
(5) Paramethoxycinnamic acid-2-ethylhexyl 5.0
(6) Fine particle titanium oxide 10.0
(7) Fine zinc oxide 10.0
(8) Zirconium oxide 5.0
(9) Polystyrene powder 3.0
(10) Trimethylsiloxysilicate 0.5
(11) Preservative appropriate amount (12) Dipropylene glycol 3.0
(13) Ethyl alcohol 10.0
(14) Purified water remaining amount (15) Salt 0.2
(16) Guava leaf extract * 1 0.2
(17) Perfume appropriate amount * 1 Production Example 4

(Manufacturing method)
A. Components (1) to (10) are mixed and dispersed.
B. Components (11) to (15) are mixed and dissolved.
C. Add B to A and emulsify uniformly.
D. Components (16) and (17) were added to C to obtain a sunscreen emulsion.

  Example 7 is stable without odor and separation, has an emollient effect when applied to the skin, protects the skin from ultraviolet rays during the day, and suppresses or reduces skin damage such as skin thickening and skin hardening. It was excellent.

Claims (5)

An anti-dermatological agent characterized by suppressing or ameliorating skin damage caused by exposure to ultraviolet rays, comprising a leaf extract of Pseudium spp. As an active ingredient. The plant belonging to the genus Psidium, which is a myrtaceae, is at least one selected from the group consisting of guava (Psidiumu guajava), Psidium guineense, and Psidium cattleianum. Skin disorder agent. 3. The anti-dermatological agent according to claim 1 or 2, wherein the skin damage caused by exposure to ultraviolet rays is at least one of abnormal accumulation of skin extracellular matrix components, collagen cross-linking formation, skin thickening, and skin hardening. . A skin external preparation comprising the anti-dermatological agent according to any one of claims 1 to 3 as an active ingredient. The external preparation for skin according to claim 4, wherein the external preparation for skin is used for preventing aging.