JP2005278442A - Method for increasing vitamin e in cow milk - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for increasing vitamin E in cow milk comprising increasing content of vitamin E in cow milk. <P>SOLUTION: The method for increasing vitamin E in cow milk comprises administering vitamin E coated with oil and fat so as to make the vitamin E pass through the rumen of a cow. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a method for increasing vitamin E in milk, and more particularly to a method for increasing vitamin E in milk by administering fat-coated vitamin E to cows.

  Vitamin E has the function of preventing the formation of lipid peroxides, which is an oxide of unsaturated fatty acids and is said to be a causative agent of aging, and has the function of strengthening blood vessels and increasing blood flow, As an effective vitamin, it is one of the vital nutrients for humans and other animals.

  In the livestock sector, recovery and prevention of reproductive disorders and mastitis in cows, treatment and prevention of diseases such as diarrhea in young livestock, and further prevention of aging in animals, treatment and prevention of diseases, reduction of stress, increase in hatching rate Attempts have been made to administer vitamin E or derivatives thereof for the purpose of improving egg quality, treating or preventing reproductive disorders (Japanese Patent Laid-Open Nos. 6-98687 and 10-155429).

  On the other hand, milk is roughly classified into component-free milk (so-called raw milk) and processed milk according to the standards of the Ministry of Agriculture, Forestry and Fisheries. From the recent health orientation, unadjusted milk tends to be preferred over processed milk. Usually, the content of vitamin E in raw milk is less than 0.1 mg / 100 ml, which is very small. In general, the method of adding vitamin E to milk is the simplest method for increasing vitamin E in milk. In this case, processed milk is used. In this situation, it is conceivable to add vitamin E to the feed of dairy cows to improve the content of vitamin E in the milk. It is degraded by microorganisms in the stomach and the purpose cannot be achieved. At present, no effective method has been reported to improve vitamin E content in milk.

JP-A-6-98687 Japanese Patent Laid-Open No. 10-155429

  An object of the present invention is to provide a method for increasing the content of vitamin E in milk.

  As a result of diligent investigations to solve the above-mentioned problems, the present inventors have administered vitamin E coated with fats and oils so as not to be affected by microorganisms in the rumen of dairy cows. It was found that the vitamin E concentration in the blood can be improved by passing the solution to the intestine and absorbed in the intestine, thereby improving the concentration of vitamin E in the raw milk. The present invention has been completed based on this finding.

That is, according to the present invention, there is provided a method for increasing vitamin E in milk, which comprises administering to a cow vitamin E coated with fats and oils so that it can pass through the rumen of the cow.
Preferably, the cow is orally administered with vitamin E coated with oil so that it can pass through the rumen of the cow.
Preferably, vitamin E coated with fats and oils so as to pass through the rumen of the cow is administered in an amount of 0.1 to 100 g as the amount of vitamin E per day.
Preferably, 10 to 50 parts by weight of vitamin E coated with 50 to 90 parts by weight of fat is administered to the cow.

According to another aspect of the present invention, milk having a high vitamin E content is produced, including collecting milk from a cow administered with vitamin E coated with fats and oils so that it can pass through the rumen of the cow. A method is provided.
According to yet another aspect of the present invention, there is provided a feed for increasing vitamin E in milk, comprising vitamin E coated with fats and oils to allow passage through the rumen of the cow.

  Vitamin E is an unsaturated fatty acid oxide that prevents the formation of lipid peroxides, which are said to be the causative agent of aging, functions to strengthen blood vessels and increase blood flow, and has anti-stress effects. The protective effect against the disease is also known. By increasing the content of vitamin E in milk, the value of milk as a health drink increases. According to the method of the present invention, the vitamin E content in raw milk can be increased compared to before administration by administering to the cow vitamin E coated with vegetable oil so that it can pass through the rumen of the cow. . That is, according to the method of the present invention, milk having a high commercial value can be produced as a health drink.

Embodiments of the present invention will be described below.
In order to increase the vitamin E content of raw milk, it is first necessary to improve the vitamin E concentration in the blood. In order for the administered vitamin E to move into the blood, the attack by the microorganisms in the rumen must be suppressed and transferred to the rumen. As a method for suppressing the attack of microorganisms in the rumen, in the present invention, vitamin E coated with fats and oils is administered to cattle.

  Vitamin E is a general term for a series of fat-soluble compounds called tocopherols and tocotrienols. The form of vitamin E with high biological activity is α-tocophenol, and α-tocophenol can also be used as vitamin E in the present invention. In addition, α-tocopherol has eight stereoisomers, and the isomer having the highest biological activity is RRR-α-tocopherol. In the present invention, any stereoisomer of α-tocopherol can be used.

  The fat or oil for coating vitamin E used in the present invention may be either animal fat or vegetable fat. The fats and oils are preferably fats and oils having a high melting point, that is, hardened fats and oils, for example, vegetable hardened oils can be used.

  Although the ratio of vitamin E and fats and oils is not particularly limited, it is preferable to coat 50 to 90 parts by weight of vegetable oil with respect to 10 to 50 parts by weight of vitamin E in consideration of the production method and administration efficiency to cattle. It is more preferable to coat with 70 to 90 parts by weight of vegetable oil to -30 parts by weight of vitamin E. If the content of Vitamin E is less than 10 parts by weight, the administration efficiency will be lowered, which is not preferable. If the content of Vitamin E is more than 50 parts by weight, the tendency for vitamin E to be decomposed in the rumen becomes stronger. It is not preferable.

  Specific examples of vitamin E coated with fats and oils that can be used in the present invention include Biopath E20 (manufactured by Zeris, France). Biopass E20 is a granular vitamin E formulation consisting of 20% α-tocopherol and 80% hardened vegetable oil.

  There are no particular limitations on the method of administration of fat and oil-coated vitamin E to cattle, and any method of administration can be used. For example, a method of orally administering vitamin E coated with fats and oils as it is, a method of orally administering it after adding it to feed, other vitamins or other pharmaceuticals, and the like can be mentioned.

  The dosage of vitamin E coated with fats and oils is not particularly limited as long as the vitamin E content in milk can be improved, but is generally administered in an amount of 0.1 g to 100 g as the amount of vitamin E per day. Preferably, it can be administered in an amount of 1.0 g to 20 g as the amount of vitamin E per day. Also, the administration period is not particularly limited as long as the vitamin E content in the milk can be improved, but it can generally be continuously administered over about 2 to 20 days, preferably 5 to 20 days. It can be administered over about a day, particularly preferably over about 7 to 20 days.

  By administering vitamin E coated with fats and oils to cows as described above, milk having a high vitamin E content can be produced. The content of vitamin E in the milk obtained by the method of the present invention is preferably 0.1 mg / 100 ml or more, particularly preferably 0.2 mg / 100 ml or more. Raw milk obtained by the production method of the present invention and having a vitamin E content of 0.1 mg / 100 ml or more (particularly preferably 0.2 mg / 100 ml or more) is also included in the scope of the present invention.

  The feed component used for raising cattle to which vitamin E coated with fats and oils is administered may be any as long as it is commonly used as feed for dairy cattle. Such feeds are usually corn, bran, rice, wheat, cottonseed meal, milo, soybean meal, raw fish, frozen fish, refrigerated fish, fish meal, defatted rice meal, fats, alfalfa, calcium carbonate, calcium phosphate, sodium chloride, Choline chloride, various vitamins (vitamin A, vitamin D, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, calcium pantothenate, nicotinamide, folic acid), inorganic salts (magnesium sulfate, iron sulfate, copper sulfate) , Zinc sulfate, potassium iodide, cobalt sulfate) or the like.

As main ingredient in feed,
Cereals or processed cereal by-products such as corn, ground corn, corn flour, corn germ meal, mylo, millet, wheat, flour, wheat germ, barley, rice, rye, oats;
Rice bran such as rice bran, bran and wheat bran, pea seeds, peanut flour, beans such as soybean flour, potatoes such as potato flour;
Vegetable oil meal such as soybean meal, defatted soybean, cottonseed meal, rapeseed meal, sesame meal, peanut meal, sunflower meal, safflower meal, coconut meal, etc .;
Manufactured products such as barley malt, beer lees, sake lees, glutamic acid fermented lees, corn fermented lees, corn gluten feed, corn germ meal, and konjac flying powder;
Animal materials such as raw fish, frozen fish, refrigerated fish, fish meal, meat meal, meat and bone meal, meat meal, meat bone meal, blood meal, feather meal, skim milk powder, dried whey, krill meal, casein, gelatin;
Yeasts such as beer yeast;
Sugars such as corn starch and dextrin;
Vegetable proteins such as alfalfa, dried alfalfa, grass, various leaf meals, soy protein, wheat gluten, corn twein;
Fine powders of inorganic substances such as crystalline cellulose, talc, silica, muscovite, zeolite;
Inorganic calcium compounds such as calcium carbonate; and inorganic phosphates such as calcium phosphate;
And so on. If necessary, the feed may be blended with other additives that are permitted in the livestock field (for example, other antibiotics, fungicides, anthelmintics, antioxidants, etc.). it can.
The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to the examples.

(1) Test method Four dairy cows were used for the test. As feed, timothy hay (free feeding) and concentrated feed (10.6 kg dry matter / day, restricted feed) were used. As Vitamin E, Biopath E20 (manufactured by Zeris Co., Ltd., granular vitamin E preparation comprising 20% α-tocopherol and 80% hardened plant oil) was orally administered in an amount of 10 g / day (as the dosage of vitamin E, 2 g / day).

  Blood was collected on the first day and 7 days after oral administration of vitamin E (Biopath E20), and the vitamin E content in plasma was measured. In addition, milk was collected on the first day, the fifth day, and the seventh day of oral administration of vitamin E, and the vitamin E content in the milk was measured.

(2) Results The measurement results are shown in Table 3 and Table 4 below. As can be seen from the results of Table 3 and Table 4, administration of Biopath E20 (vitamin E preparation) increased the vitamin content in plasma and at the same time increased the vitamin E content in milk to a detectable level.

Claims (6)

A method for increasing vitamin E in milk, comprising administering to a cow a vitamin E coated with an oil so that it can pass through the rumen of the cow. The method for increasing vitamin E in milk according to claim 1, wherein vitamin E coated with fats and oils so that it can pass through the rumen of the cow is orally administered to the cow. Vitamin E in milk according to claim 1 or 2, wherein vitamin E coated with fats and oils so that it can pass through the rumen of cows is administered in an amount of 0.1 to 100 g as vitamin E amount per day. Way to increase. The method for increasing vitamin E in milk according to any one of claims 1 to 3, wherein 10 to 50 parts by weight of vitamin E coated with 50 to 90 parts by weight of fats and oils is administered to cows. A method for producing milk having a high vitamin E content, comprising collecting milk from a cow administered with vitamin E coated with fats and oils so as to pass through the rumen of the cow. A feed for increasing vitamin E in milk, comprising vitamin E coated with fats and oils so that it can pass through the rumen of cattle.