JP2000281575A - Reinforcement of immune activity of domestic animal by oral feeding of oil and fat-coated vitamin c, and protection of stress and prevention of wastage - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent the wastage of a domestic animal by reinforcing immune activity, preventing infections disease such as a cold and also protecting stress by feeding an oil and fat-coated vitamin C to the domestic animal. SOLUTION: This method for protecting the wastage of a domestic animal is provided by feeding (A) 5-50 (g/day head) oil and-fat-coated vitamin C, and preferably (B) 1-20 (g/day head) chromium yeast and (C) 10-500 (g/day head) theriac for reinforcing immune activity, preventing infectious disease such as a cold, protecting stress and improving the amount of eating of a feed. The oil and fat of the component A is a hardened oil and fat and especially a hardened soybean oil and fat is preferable. The heardened oil and fat preferably has <=5 acid value, <=3 iodine value and 60-65 deg.C melting point. The component B is a beer yeast and contains 1,000-1,600 ppm non-toxic trivalent chromium. Also it is preferable to use 10-100 pt.wt. coating oil and fat based on 100 pts.wt. vitamin C.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to a method for immunity reduction when feed intake is reduced due to transport stress of domestic animals (cows, horses, sheep, pigs, and chickens), breeding stress and disease stress such as cold caused by infectious diseases. And a method for relieving stress.

[0002]

2. Description of the Related Art Vitamin C has been conventionally used to enhance the functions of leukocytes, promote the absorption of iron, inhibit the production of nitrosamines, form connective tissue, reduce the symptoms of colds, and suppress the production of active oxygen. It is said that it has the effect of enhancing functions. Also, chromium yeast has diabetes,
It has been reported to reduce the risk of cardiovascular disease and hypertension, enhance glucose tolerance and insulin resistance, and reduce serum insulin, cholesterol, and total triglyceride.

On the other hand, livestock, especially cattle, lose their bite at the time of introduction, decrease their bite due to various stresses occurring during the breeding period, exhibit the symptoms of colds due to infectious diseases, etc., and eat food. The phenomenon of falling is frequent, and as a result, the weight gain is reduced, causing illness, and in the worst case, death.

As a countermeasure against these problems, a method of adding an additive to livestock feed has been conventionally performed.
Antibiotics (JP-A-46-4380, JP-B-51-219)
97, JP-A-52-130925, JP-A-54-702
89, JP-A-55-160767), lactic acid bacteria (JP-A No. 0-160767).
7-126178), yeast (JP-A-08-28317).
5) and chitosan (JP-A-11-9196) are known. These methods are problematic in that they are expensive and cannot always be satisfactory in terms of cost-effectiveness, and that satisfactory methods cannot be obtained in terms of effect.

[0005] It is widely recognized that the key to the success of fattening of livestock lies in the feeding management during the early fattening period. In other words, in the case of fattening cattle, cattle that have eaten well immediately after the introduction
It is the one that demonstrates its full potential. However, fattening cattle are significantly stressed by transportation, etc., and immediately after introduction, they are heavily worn and poorly eaten, and their survival is poor. ing. Cows that have experienced some troubles during this time often have difficulty in managing them and cannot expect good quality meat. Therefore, it is an effective solution to reduce stress and increase immunity.

[0006] Under such circumstances, a method of adding vitamin C to the feed to activate biting has been considered.
In the case of ruminants such as cattle and sheep, even if they are fed as they are, they are decomposed by microorganisms in the rumen (rumen), and the purpose cannot be achieved. It is said that ruminants such as cows synthesize vitamin C in their bodies,
Very few reports have given vitamin C.

[0007]

DISCLOSURE OF THE INVENTION The present invention is to provide an oil- and fat-coated vitamin C which is devised so as not to be affected by microorganisms in the rumen (orum) by orally supplying the vitamin C to the abomasum and to intestine. Increase the concentration of vitamin C in the blood, control livestock stress, and / or
Alternatively, they have found that the immunity can be enhanced, and have completed the present invention.

[0008]

In order to achieve the effects of vitamin C, it is necessary to first increase the concentration of vitamin C in the blood. In order for the supplied vitamin C to enter the blood, the attack of microorganisms in the rumen must be controlled and transferred to the abomasum. As a method for suppressing the attack of microorganisms in the rumen, vitamin C coated with oil and fat should be 10 to 5%.
Give 0 (g / day / head) orally.

Further, in order to improve the effect, one chromium yeast is used.
Pay between 20 and 20 (g / day / head). The chromium yeast is a brewer's yeast, and a non-toxic trivalent chromium is prepared in a quantity of 1,000 to 1,6.
It contains 00 ppm. As molasses for the purpose of improving palatability, powdered molasses is used in an amount of 10 to 500 (g / day / head).

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. The present invention increases the immunity by preventing the infectious diseases by orally feeding vitamin C coated with fats and oils to livestock, and improves the eating when the eating of food due to stress, cold, etc. is reduced. This is a method to prevent livestock wear. Attrition refers to the cessation or delay of growth and, in the worst case, death. The type of infectious disease referred to in the present invention varies depending on livestock, but refers to all diseases in which microorganisms invade the main host, colonize and multiply.

The livestock referred to in the present invention includes, for example, cows, horses, and chickens, but is not particularly limited. The immunity-enhancing effect and the stress control effect of fat-coated vitamin C are reduced in immunity among mature livestock, or livestock in which the amount eaten by stress is reduced, and immunity is weak,
It is more pronounced in larvae whose eating volume is reduced by stress.

The vitamin C of the present invention,
In order to exhibit the in vivo effect, it is necessary to first increase the concentration of vitamin C in the blood. In order for the supplied vitamin C to enter the blood, the attack of microorganisms in the rumen must be suppressed and the vitamin C must be transferred to the abomasum. As a method for suppressing the attack of microorganisms in the rumen, vitamin C coated with fat is fed daily. By supplying fat-coated vitamin C which is devised so as not to be affected by the action of microorganisms in the rumen (lumen), the concentration of vitamin C in the blood is increased and the effect of enhancing the immunity of vitamin C is obtained. The purpose is to:

To further enhance the effect, chromium yeast is added. Chromium yeast is brewer's yeast and contains 1,000 to 1600 ppm of non-toxic trivalent chromium.
As molasses for the purpose of improving palatability, powdered molasses (trade name: Hard Morath, manufactured by Fuji Development Co., Ltd.) is used.

The vitamin C coating fat used in the present invention is:
Any fats and oils of animals and plants can be used, but fats and oils having a high melting point, that is, hardened fats and oils are preferable.
Vegetable oils and fats such as rice bran wax and seed hardened oil, and animal oils and fats such as tallow hardened oil are mentioned, and soybean hardened oil and fat are most preferable in view of taste and odor. The hardened oil has an acid value of 5 or less, an iodine value of 3 or less and a melting point of 60 to 65.
C is preferred.

The ratio of the coated fat to the vitamin C is preferably as low as possible. However, in consideration of the production method and the feeding efficiency to the dairy cow, about 10 to 100 parts by weight based on 100 parts by weight of the vitamin C is considered. Is preferred. If the amount is more than 100 parts by weight, the same amount of fat or oil as vitamin C, which is an active ingredient, will be given, and not only will the efficiency be poor, but also the microorganisms in the rumen will be adversely affected and the digestibility of the feed will decrease, Feed efficiency decreases. On the other hand, if the amount is less than 10 parts by weight, a stable coating cannot be formed in production, and the rate of separation of vitamin C in the stomach tends to be extremely high.

The apparatus for producing fat / oil-coated vitamin C suitable for the present invention is not particularly limited. For example, rolling granulation, extrusion granulation, compression granulation, fluidized granulation, pulverized granulation, and the like. An ordinary coating method such as a mixing method, a stirring granulation method, and a melt mixing method can be appropriately used, but a fluidized granulation apparatus is preferable.

The beef animals to which the present invention can be applied include Japanese beef,
Beef cattle, such as Holstein steers and jazz steers,
There are no particular restrictions on livestock such as pigs and sheep, and poultry such as broilers, but the so-called rumen-bypass type is more preferable when used on ruminant animals such as cattle, as it is more effective.

EXAMPLES The present invention will be described in more detail with reference to the following examples to clarify the effects of the present invention. However, these are merely examples, and the scope of the present invention is limited by these examples. Instead, the present invention includes any modifications and / or modifications made without departing from the spirit of the present invention.

Example 1 (Production of Vitamin C Coated with Oils and Fats) 8.0 kg of L-ascorbic acid crystals (45 to 60 mesh) can be placed in a fluidized granulator (Seishin Co., Ltd. Best Vulzer BK type). Put in the product, set the temperature to 50 ° C, and rotate slowly (15 rpm
m). Then 1.9K of soy hardened oil (melting point 63 ° C)
g and 100 kg of glycerin fatty acid ester were dissolved in a can at 160 ° C., and rotated for about 2 hours while cooling naturally (40 ° C.). This was cut into aggregates with an 18 mesh sieve. The properties of the obtained fat-coated vitamin C were as follows. Content: 70% by weight Appearance: White to faint yellow powder with no odor or slight peculiar odor. Content: 700 mg of L-ascorbic acid in 1 g (HPLC method) Water: 2% by weight or less (measured under reduced pressure at 70 ° C. for 5 hours) Granularity: 20 mesh pass, 98% by weight or more (Sieve test method) Dissolution rate: 20 minutes, 25% by weight (pregnancy method)

Similarly, in order to produce a product having a different vitamin C content, it is only necessary to change the mixing ratio. Actually, in the case of 70% by weight, L-ascorbic acid was added to 7.0% by weight.
Kg, 3.85 Kg of soybean hardened oil, fatty acid ester 0.1
To obtain 50% by weight of 5 kg, L-ascorbic acid 5.0 kg, soybean hardened oil 4.75 kg, and fatty acid ester 0.25 kg were used.

[Example 2] (Preparation of oral preparation) 25 parts by weight of fat-coated vitamin C, 2 parts by weight of chromium yeast, molasses mixed feed (composition: 45 parts by weight of molasses, 30 parts by weight of coconut oil cake, 13 grated rice bran) Parts by weight, rice bran oil cake 8
36.5 parts by weight, defatted bran 3
6.5 parts by weight were mixed and subjected to the following feeding test 2.

(Feeding test 1) The fat-coated vitamin C prepared in Example 1 was introduced into Japanese black cattle (7 months old) for 2, 5, 10, 25, 50 and 100 g / day for about one month.・
Feeding the head, combined feed (concentrated feed) 5-6K
g, and then 3.5 kg of roughage (rice straw, etc.) was given to investigate the change in the situation. Test cows each prepared 10 steers. With the introduction of the winter season, it is generally cold, and it is customary to burn hands for training after the introduction. The test cows had a cold again, but the cows fed 5 to 50 g / day of fat-coated vitamin C were light and did not take much labor. The bait was good and the belly was deep enough. In order to verify the effect, a predetermined amount of blood was collected from test cows and subjected to a blood test. The test items were blood urea nitrogen (BUN), glucose (GLU), total cholesterol (T-CHO), glutamic acid-oxaloacetate transaminase (GOT), and vitamin C (Vit).
C) and six items of vitamin A (VitA). still,
Table 1 shows the results of the blood test.

[0023]

[Table 1]

The amount of the fat-coated vitamin C is 100 g /
When it is about day / head, the appetite of the test cow decreases, the amount of the supply is too large, and the cattle do not eat fat-coated vitamin C. When calves (introduced cows) suffer from stress and colds and eat less food, BUN and GOT in the blood rise, but this is caused by poor nutritional metabolism. BUN reflects the feeding status of protein (nitrogen) in feed, and an increase in BUN suggests feeding of insufficient protein due to excess protein, high feed of concentrated feed, kidney damage, dehydration, and the like. Fattening: 8 to 12 mg / dL, higher values suggest abnormal ruminal fermentation. This indicates that cows whose rumen was abnormally fermented at the time of introduction were improved by feeding fat-coated vitamin C. GOT indicates the status of liver function, and the value increases when a cold is caught or there is a disease. From this fact, cattle that had a cold at the time of introduction were improved by feeding fat-coated vitamin C.
From these results, it was suggested that nutritional supplementation was performed efficiently. In the cows in the test group, the BUN and GOT values in the blood returned to normal values, indicating that the nutritional metabolism was well. In addition, the bait was good for eating, and the body developed into an ideal shape with a deep belly and a wide width.

(Feeding Test 2) The oral preparation prepared in Example 2 was administered to Japanese black cattle (7 months of age) for about 1 month.
25, 50, 100, 250, 500, 1000 g / day / head, and a mixed feed (concentrated feed) 5 to 6
Kg, 3.5 kg of roughage (rice straw, etc.)
The situation change was investigated. Test cows each prepared 10 steers. The test cows had a cold this time, but the cows fed 25 to 500 g / day of the sunscreen were light and did not take much labor. The food was good and the belly was deep enough. In order to verify the effect, a predetermined amount of blood was collected from test cows and subjected to a blood test. still,
Table 2 shows the results of the blood test.

[0026]

[Table 2]

When the amount of the oral preparation is about 1000 g / day / head, the appetite is reduced, the supply is too large, and the daily preparation is not eaten. When calves (introduced cows) suffer from stress and colds and eat less food, BUN and GOT in the blood rise, but this is caused by poor nutritional metabolism. In the cows in the test group, the BUN and GOT values in the blood returned to normal values, indicating that the nutritional metabolism was well. Also, because of this, the bait was good, and the body developed into an ideal shape with a deep belly and a wide width.

[0028]

According to the present invention, the fat and oil-coated vitamin C, which is devised so as not to be affected by microorganisms in the rumen (rumen), is orally supplied, so that it can pass through the abomasum and be absorbed in the intestine. In addition, the concentration of vitamin C in blood can be increased, the stress of livestock can be controlled, and the immunity can be enhanced. Furthermore, the effect is enhanced because the oral preparation was prepared by preparing oil-coated vitamin C and chromium yeast. In addition, by adding molasses to the oral preparation for the purpose of improving palatability, the amount of supply can be increased, and the effect becomes more remarkable. In addition, in the present invention, vitamin C is orally supplied by mixing it in feed or feeding fat- and oil-coated vitamin C itself, so that not only does the livestock not be stressed at the time of feeding, Has the advantage of being simple.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 43/00 A61K 31/00 643Q

Claims (4)

[Claims] Claims 1. An animal coated with 5 to 5 fats and oils coated vitamin C.
By feeding 0 (g / day / head), immunity is enhanced, infectious diseases such as colds are prevented, and stress is controlled.
A method of improving feed intake and preventing livestock wear. 2. Livestock is provided with 5 to 5 fat-coated vitamin C.
By feeding 0 (g / day / head) and 1 to 20 (g / day / head) of chromium yeast, immunity is enhanced, infectious diseases such as colds are prevented, stress is controlled, and feed A method of improving digging and preventing livestock wastage. 3. Livestock is provided with 5 to 5 fat-coated vitamin C.
0 (g / day / head) and 1 to 20 (g / day / chromium yeast)
10) to 500 (g / day / head) to enhance immunity, prevent infectious diseases such as colds, control stress, improve feed intake and improve livestock feeding. How to prevent wear. 4. The method according to claim 1, wherein the fat or oil of the fat-coated vitamin C is a hardened fat or oil, preferably a soybean hardened fat or oil.