JP2005206597A - Sedative or sleeping composition, sedative or sleeping material, and odorizing product given by using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an aromatherapeutic composition capable of inhibiting sympathetic activity or stimulating parasympathetic activity, by stimulating olfactory perception, and therefore capable of being used for improving undesirable body condition, and in detail, capable of being suitably used in a field in which a sedative or sleeping effect is required by inhibiting the sympathetic activity, and to provide an odorizing product containing the aromatherapeutic composition, having the sedative or sleeping effect, and capable of being used in the field in which the effect is utilized. <P>SOLUTION: This aromatherapeutic composition contains linalol as an active ingredient. An odorizing product contains the aromatherapeutic composition. A sedative or seeping material is preferably formed by encapsulating (+)-linalol or (±)-linalol in shells made of a resin, so as to form microcapsules, and using the microcapsules. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an aroma therapy composition used to improve a physical condition based on parasympathetic excitation or sympathetic nerve inhibitory action by odor stimulation, specifically to relieve mental tension and bring sedation or sleep. This invention relates to a composition (a composition for sedation / sleeping) used for the purpose. In addition, the present invention relates to a lumber having such a sedative / sleeping composition that has a sustained release property and durability that are easy to use. The present invention further relates to a scented product used to provide sedation or sleep, in particular textile products such as bedding.

  Since ancient times, it has been empirically known that fragrance has various psychological and physiological effects. "Aromatherapy" means aroma therapy that uses aromatic oils (essences, essential oils) collected from plants to improve the state of mind and body, but the current aromatherapy is the French scientist René Morris in 1928・ It is said that Gatfosse was disseminated as a result of the publication of “Aroma Therapy”, and in 1964, Dr. Jean Volnet published “Plant = Aroma Therapy”.

In recent years, aromatherapy has been widely used mainly as aroma therapy for mental stability, stress relief, and insomnia. Regarding the neuropsychophysiological effects of plant essences (fragrances), Rovesti and Colombo reported in 1973 that the psychotropic effects of fragrances were divided into sedation and activation, and the potential application of fragrances to psychiatric disorders was reported. As a starting point (see Non-Patent Document 1), many research reports have been made (for example, see Non-Patent Documents 2 to 5). For example, it is known that essential oil extracts such as lavender and chamomile have sedative and hypnotic effects (see, for example, Non-Patent Document 6, Patent Document 1, etc.). The sedative action of lavender is known to be effective for attacks of asthma caused by extreme mental tension such as respiratory diseases, particularly anxiety (see, for example, Non-patent Document 7). ) In addition to the above-mentioned neuropsychophysiological effects, lavender essential oil has an effect of promoting wound healing (scar formation) and an anti-inflammatory effect, and various skin problems (dermatitis, burns, pruritus, ulcers) It has an anticoagulant effect and can be used to treat blood circulation diseases (phlebitis, coronary arteritis, arteritis, poor capillary circulation, edema). It is known (see, for example, Non-Patent Document 7).

However, there are still many unclear points about why the essence (fragrance) of plants is effective in treating diseases, and the vitality of plants restores a healthy state by harmonizing the imbalance that occurs in human mind and body. It is also true that there is only a vague explanation that it has an effect. This is in common with the treatment with Kampo medicines that emphasizes the balance between Yin and Yang. Whether the above essence (fragrance) treatment is based on a pharmacological action such as antibiotics or analgesics or a psychological effect like perfume is currently available. The situation is not clearly understood.
Rovesti, P. And Colombo, E. (1973) Aromatherapy and aerosol.Soap, Perfumery and Cosmetics, 46: 475-477 Takashi Yagyu “Psychiatric Clinical Application of Fragrances and its Problems: Neuropsychophysiological Study” FOOD & FOOD INGREDIENTS JOURNAL No.156, 1993, p.50-57 Yoshihiko Koga “Stress and Aromatherapy” Fragrance Journal No.86 (1987) p.25-28 Teruhisa Komori et al. “Attempts to Treat Depression with Scents—Scientific Verification and Clinical Application—” Journal of Japanese Neuropsychopharmacology (Jpn. J. Psychopharmacol.) 15: 39-42 (1995) Yoshihiko Koga “Effects of Aromatherapy from the Viewpoint of Brain Function” Fragrance Journal No.86 (1987) p.47-51 Monthly Food Chemical, Vol.10, No.12 Nihon Ester website http://www.esters.co.jp/index.html Japanese Utility Model Publication No. 06-50570

  Sleep, which accounts for one third of life, is an instinctive behavior that is essential for people to live a healthy life. However, in an environment where strict time management, complex human relationships, and the use of advanced equipment are forced, modern people are constantly exposed to stress and are becoming urban lifestyles. There is a report that 1 out of 5 Japanese adults have some problems with sleep due to changes in the situation (Ministry of Health, Labor and Welfare: 2000 Health and Welfare Trend Survey, etc.). In order to ensure good quality sleep, it is necessary to relax the mind and body before going to bed, or to create an appropriate sleeping environment during bedtime.

  An object of the present invention is to provide a fragrance therapeutic composition (a fragrance composition for body improvement) used for improving an undesirable body condition. More specifically, the present invention relates to an aroma therapy composition used to excite the parasympathetic nerve by smelling or to suppress the sympathetic nerve to improve the physical condition, specifically at awakening or The purpose of the present invention is to provide a composition for aroma therapy that relaxes mental and physical tension before going to bed, and has a sedative effect (relaxation) and a sleep improvement effect such as smoothing sleep and reducing awakening frequency during sleep. And

  Furthermore, the present invention provides a fragrance product, particularly a textile product including bedding, which has the above-mentioned effect by containing the above-mentioned aroma therapy composition as an odor component, and is used exclusively for applications utilizing the effect. For the purpose.

  The inventors of the present invention have been diligently investigating the odor components of various plant essential oils. As a result, linalool's odor stimulation to olfaction suppresses lipolysis and promotes fat accumulation (decreases energy consumption). In addition, we found that appetite increased and weight gained, and from this finding, linalool's odor stimulation changed the body's nutritional state to an anabolic state, resulting in increased appetite, reduced energy consumption or energy It was confirmed that it can be effectively used to promote accumulation, improve malnutrition (improvement of leprosy), and promote tissue damage healing. In addition, the present inventors have found that blood pressure can be lowered by scent stimulation of linalool with respect to olfaction, and confirmed that scent of linalool can be effectively used for blood pressure reduction with respect to hypertension. Further, the present inventors have found that linalool's odor stimulation to olfaction can improve hyperglycemic symptoms in diabetic model animals, and linalool's odor can be effectively used to improve diabetes symptoms and prevent diabetic complications. I confirmed that I can do it.

  By the way, in higher animals such as humans, olfactory information is processed mainly in the limbic system in the cerebral cortex. In the limbic system, in addition to the processing of such olfactory information, instincts such as appetite and sexual desire, emotions, and autonomic nerve functions are controlled. Blood pressure regulation and regulation of visceral functions such as the heart, lungs, stomach, and intestinal tract are performed in the subcortical region centering on the hypothalamus, but the limbic system also plays a role as a superior center that governs it. ing. For this reason, it is considered that olfactory stimulation has a considerable influence on various functions of these limbic systems.

  Based on this idea, the present inventors conducted further research and found that all of the above physiological phenomena were suppressed by the scent stimulation of linalool and the activity of the sympathetic nerve was increased, resulting in increased parasympathetic activity. I found out that it was caused by the predominance of the nerve activity of the nerve. Specifically, the above-mentioned anabolic action by the scent stimulation of linalool is caused by suppression of the activity of the sympathetic nerve governing the white adipose tissue, brown adipose tissue and adrenal gland, and by the increase of the activity of the parasympathetic nerve governing the intestine. The above-mentioned blood pressure lowering action by the scent stimulation of linalool is caused by the suppression of the activity of the sympathetic nerve governing the adrenal gland and the suppression of the activity of the sympathetic nerve governing the kidney; It was found that the anti-diabetic action is caused by suppression of adrenaline secretion accompanying suppression of sympathetic nerve activity that governs the adrenal glands. And from this, by using the scent of linalool, based on its parasympathetic excitement or sympathetic inhibitory action, debilitating diseases such as chronic infection and cachexia, leanness, malnutrition, It was confirmed that it is possible to lead to unfavorable physical conditions including improvement in healing of tissue damage, diabetes, hypertension and the like.

  Based on the support of these studies, the present inventors have conducted further studies, and the olfactory stimulation of linalool (scent stimulation) increases the activity of the vagus nerve (parasympathetic nerve) that controls the thymus and the spleen. It was confirmed that the activity of the sympathetic nerve that controls the sympathetic nerve was suppressed, and from this finding, it was convinced that the scent of linalool had the effect of improving the immune activity of the living body. Furthermore, the present inventors confirmed that the sympathetic nerve activity related to the vascular contraction of the skin is suppressed by the stimulation to the olfactory sense of linalool (scent stimulation). I was convinced that there was an effect of increasing the flow rate and promoting the metabolism (turnover) of the skin.

  By the way, the sympathetic nerve activity of the adrenal gland is suppressed by the scent stimulation of linalool, which means that the scent stimulation of linalool reduces the secretion of adrenaline, relaxes the state of mind and body tension, and provides a sedative and restful sleep effect. I mean. Therefore, the inventors examined the influence of linalool odor on the rhythm behavior of rats, and confirmed that the exercise amount of rats decreased by applying linalool odor stimulation, especially in sleep time. It was convinced that the effect of sedation and sleep improvement was obtained by the odor stimulation of linalool.

The present invention has been completed based on such findings:
Item 1. A composition for sedation / sedation (sleep improvement) based on parasympathetic nerve excitation or sympathetic nerve inhibitory action by odor stimulation, comprising (+)-linalool or (±) -linalool as an active ingredient.
Item 2. Sedation / sleep (improves sleep) based on parasympathetic excitation or sympathetic inhibitory action by odor stimulation, which is formed by encapsulating (+)-linalool or (±) -linalool in a resin shell. Wood.
Item 3. A sedative / somnia (sleep improvement) scented product containing the sedation / slumber (sleep improvement) composition described in item 1 or the sedation / sleep (sleep improvement) material described in item 2. Such a scented product contains a sedative / somnia (sleep improvement) composition described in item 1 or a sedative / somnia (sleep improvement) material described in item 2, thereby sedating or sleeping (sleep improvement). And a scented product that is labeled for use for sedation or sleep (improve sleep).
Item 4. Item 3. The scented product according to item 3, which is a textile product.
Item 5. Item 5. The scented product according to item 4, wherein the textile product is a bedding product.

The present invention is described in detail below.
I. Aroma therapy composition (sedation / sleep composition)
The present invention relates to a fragrance composition used to improve an unfavorable state of mind and body using odor stimulation. More specifically, the present invention relates to a fragrance composition used for improving a mind-body unfavorable state caused by stress or stress by using odor stimulation. In this sense, in the present invention, it is referred to as a “fragrance therapeutic composition” in order to distinguish it from a simple fragrance composition. Among them, the “fragrance therapy composition” of the present invention is a composition for the purpose of sedation or sleep (improves sleep), and in this sense is referred to as “sedation / sleep (improves sleep) composition”. .

  The aroma therapy composition of the present invention comprises linalool (linalool, 3,7-dimethyl-1,6-octadien-3-ol; 2,6-dimethyl-2,7-octadien-6-ol) as an active ingredient. It is characterized by containing. In addition, linalool is an l-form [R (−) type, referred to as “(−)-linalool” in the present invention], d-form [S (+) type, referred to as “(+)-linalool” in the present invention]. And dl form (racemic form, referred to as (±) -linalool in the present invention)), and linalool targeted by the present invention includes any of these. Preferred is (+)-linalool or (±) -linalool, and more preferred is (+)-linalool. The origin of these linalools is not particularly limited, and any of those derived from natural extracts extracted from plant essential oils or those derived from synthesis may be used. However, as can be seen from the results of the experimental examples described later, since the effect of the present invention is recognized for linalool even for synthetic products, synthetic products are selected from the viewpoint of economics, etc. You can also Synthetic and naturally derived linalool can be obtained commercially from any of (+)-linalool, (±) -linalool, and (−)-linalool.

  The aroma therapy composition of the present invention preferably contains substantially only linalool as an aroma component that brings about the effect of sedation or sleep (improves sleep), but uses linalool sedation or sleep (improves sleep). As long as it has an effect of sedation or sleep (improves sleep) as a whole, it may have linalool in combination with other aroma components (except for naturally derived essential oils). Examples of such combinations include linalool (synthetic linalool or linalool separated from linalool-containing plant essential oils such as coriander and lavender essential oil) and other artificially or naturally derived aroma components. can do.

  The essential oils containing linalool are derived from rosewood, thyme linalool, coriander, nerolia busolute, ylang ylang, lavender, basil sweet, neroli, oregano, marjoram, primgren, basil, clarisage, bergamot, camomile blue, myrtle, etc. Plant essential oils. These essential oils can be prepared by, for example, steam distillation of specific parts of various plants, but can also be easily obtained commercially.

  The composition for aroma therapy according to the present invention is composed only of a fragrance component based on linalool, or contains components other than the fragrance component based on linalool within the range where the effects of the present invention are exhibited. It may be. Examples of components other than the aroma component include bases and additives that are usually used in the preparation of a fragrance composition.

  When the composition for aroma therapy of the present invention contains a component other than the aroma component, the content ratio of linalool contained in the composition is, for example, 0.0001 to the limit of achieving the effect of the present invention. It can select suitably from the range of 99% (w / w).

  The shape of the composition for aroma therapy of the present invention is not particularly limited as long as the effects of the present invention are exhibited. For example, a solution dissolved in a lower alcohol having 1 to 6 carbon atoms such as ethanol, propyl alcohol or isopropyl alcohol, and a polyhydric alcohol such as propylene glycol or glycerin, which is used as a solvent for ordinary fragrances; gum arabic, tragacanth gum, etc. Natural gums or emulsions emulsified with glycerin fatty acid ester, sucrose fatty acid ester, etc .; natural gums such as gum arabic, coated with known materials as flavoring excipients such as gelatin and dextrin Powder form; Solubilized form (dispersed form) solubilized (dispersed) using a surfactant, etc .; Select any shape according to the purpose, such as microcapsules obtained by processing with a known encapsulating agent. Can be prepared according to conventional methods. Moreover, it can also be included by well-known excipient | fillers, such as a cyclodextrin, and sustained release property can also be given.

II. Fragrance therapy material (sedation / sleep material)
The aroma therapy composition (sedation / sleeping composition) preferably has a microencapsulated form encapsulated in a resin shell. By having such a microcapsule form, the evaporation rate of linalool, which is the active ingredient of the aroma therapy composition (sedation / sleeping composition) of the present invention, is controlled (sustained release), and the effects of the present invention are maintained. Can be made. Further, alteration due to direct exposure to heat and light can be suppressed. Furthermore, by making it into the form of a microcapsule, processing into a textile product etc. becomes easy, and loss | disappearance of the fragrance by washing can be suppressed. Accordingly, the present invention provides an aroma therapy material (sedation / sleeping material) obtained by encapsulating the above-mentioned aroma therapy composition (sedation / sleeping composition) in a resin shell and microencapsulating it.

  The shell material encapsulating the aroma therapy composition of the present invention (sedation / sleeping composition) is usually used for microencapsulation of perfume, preferably non-aqueous and excellent in heat resistance during processing. There is no particular limitation as long as it is a new one. Preferably, an acrylic resin, a urethane resin, a silicone resin, a melamine resin, or a urea-formaldehyde resin can be preferably used. From the viewpoint of versatility, urethane resin or melamine resin is more preferable. Methods known in the art can be widely used for the production of microcapsules using these resins as shell materials (wall film materials). Although not limited, specifically, a phase separation method, a polymerization method, an air suspension method, an in situ polymerization method or a coacervation method can be exemplified.

  The size (average particle diameter) and film thickness of the microcapsules are not particularly limited. Examples of the average particle diameter of the microcapsules are usually in the range of 0.5 to 50 μm, preferably in the range of 1 to 10 μm. Moreover, as a film thickness of a microcapsule, it can illustrate normally in the range of 0.1-20 micrometers, Preferably it exists in the range of 0.2-5 micrometers.

  The aroma therapy material (sedation / sleeping material) having such a microcapsule form is the above-mentioned aroma therapy composition (sedation / sleeping composition) in a proportion of 5 to 90% by weight, preferably 20 to 80% by weight. It is preferable to include.

III. Scented products The aroma therapy composition (sedation / slumber composition) or aroma therapy material (sedation / slumber) described above is used in various products for the purpose of sedation / slumber (sleep improvement). Can be blended as Therefore, the present invention uses the sedation / somnia (sleep improvement) containing the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention as an application. Provide incense products.

  The scented product targeted by the present invention is a product that emits an odor caused by the above linalool, and has an action of improving an undesirable body condition based on the odor. More specifically, the scented product of the present invention has the effect of sedating the body and mind (sedation), or smoothing the body and body, leading to sleep smoothly and reducing the arousal frequency during sleep. It is a product having an action that brings about a good night's sleep (sleeping effect, sleep-improving action), and is used for that purpose and application.

  The scented product of the present invention is not particularly limited as long as it has the above-mentioned action, purpose, and use. Examples of the scented product include fragrances, cosmetics, inhalation administration agents, and textile products. Detergents, textile products, building materials, foods, pharmaceuticals, quasi drugs or daily necessities (miscellaneous goods). Preferred are fragrances, cosmetics, inhalation administration agents, textile products, building materials, foods, quasi drugs or daily necessities (miscellaneous goods), and more preferred are textile products and foods. These perfumed products include sedation (relaxation) or sleep based on containing the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention. It may be a product with a display indicating the effect or use.

  As the fragrance, the fragrance therapy composition (sedation / sleeping composition) or the fragrance therapy material (sedation / sleeping material) of the present invention has the above-mentioned sedation or sleep (sleep improvement) action, and sedation Or the thing used for the use of a sleep can be mentioned. Among these, fragrances for indoor use, toilets, automobiles, entrances, bathrooms, closets, textiles such as clothes, and chiffon are included. In addition, what has a deodorizing effect is also contained in this fragrance | flavor. Various forms such as solid, semi-solid (jelly, gel, etc.), liquid, aerosol and the like are used as the fragrance.

  The cosmetic contains the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention, thereby having the sedation or sleeping (sleep improvement) action described above. Or cosmetics used for the purpose of sleeping, biological cleaners and bathing agents such as soaps, fragrances such as perfumes, toothpastes, liquid toothpastes, mouthwashes, mouth pets, and mouth fresheners. Specific examples of cosmetics include creams, emulsions, cosmetic powders, body lotions, hair styling agents, hair shampoos, soaps, body soaps, antiperspirants, shampoos, rinses, perfumes, lotions, lipsticks, lip balms, sun creams. Examples include screens, massage oils, massage creams, and skin care oils.

  The inhalation administration agent has the above-mentioned sedation or sleep (sleep improvement) action by containing the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention, It is used for the purpose of sedation or sleep, and includes those that generate fragrance near the nose by spraying or volatilization of fragrance components, and intentionally inhale the fragrance. Specifically, nasal sprays, sprays, inhalation liquids and the like can be exemplified.

  As a food, by containing the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention, the food has the sedation or sleep (sleep improvement) action, Examples thereof include those ingested for the purpose of action-based effects (sedation, restful sleep / sleep improvement). In order to efficiently obtain the effect of the odor component (linalool) of the fragrance therapy composition of the present invention, the fragrance stays in the mouth for a relatively long time and is inhaled via the nasal cavity, or the scent before entering the mouth Those in which the components are inhaled through the nasal cavity are preferred. Specific examples include confectionery such as gum, candy, gummi, and troche; frozen desserts and desserts such as yogurt and ice cream; soft drinks such as tea: fresheners in the mouth; supplements and the like.

  As a detergent for textile products, it has the above-mentioned sedation or sleep (improve sleep) action by containing the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention. And those used to add sedation or sleep (improve sleep) to the fiber. Specific examples include anionic, cationic, nonionic or zwitterionic detergents, textile softeners, textile softener products, dryer textile softener products, and the like.

  As a textile product, the fragrance therapy composition (sedation / sleeping composition) or the fragrance therapy material (sedation / sleeping material) of the present invention has the above-mentioned sedation or sleep (sleep improvement) action, and the sedation Or what is used for the purpose of a good sleep can be mentioned widely. Specifically, clothing such as underwear (including socks, tights and stockings) and outerwear; handkerchiefs and towels; hygiene items such as masks and sweat-absorbing pads; comforters, mattresses, mats, blankets, towels, Examples include pillows, bed mats, sofas, cushions, cushions, and beddings such as these covers; carpets and other rugs; bags and bags; curtains and accessories.

  There are no particular restrictions on the type (material) of the fiber constituting the fiber product and the shape of the fiber product. For example, the types (materials) of the fibers include polyester fibers, polyamide fibers, polyacrylonitrile fibers, vinylon fibers, polyvinyl chloride fibers, polyethylene fibers, polypropylene fibers, polyurethane fibers, and the like. Examples thereof include semi-synthetic fibers such as acetate and triacetate, regenerated fibers such as rayon, cupra and tencel, and natural fibers such as cotton, hemp, wool and silk. A fiber product in which two or more of these are mixed at an arbitrary ratio may be used. Examples of the shape of the textile product include fabric forms such as woven fabrics, knitted fabrics, nonwoven fabrics, and felts; cotton-like products; rope-like products; and thread-like products.

  The method for containing the aroma therapy composition of the present invention (sedation / sleeping composition) in such a textile product is not particularly limited, but the above-mentioned aroma therapy material (sedation / sleeping material) usually prepared in the form of microcapsules is used. It can be performed by fixing to the fiber via a binder resin. Such a binder resin is preferably one that is fixed in the form of a film on the surface of a single fiber. Specifically, an acrylic resin, a urethane resin, a silicone resin, a polyester resin, or the like can be used alone or in combination. . In addition, as a method for fixing the microcapsule to the fiber through the binder resin, a known method generally used in the industry can be used. For example, the microcapsule and the binder resin are used as an aqueous dispersion. Thereafter, a method of applying the moisture liquid to the fiber by a padding method, a spray method, a coating method, etc., and heating and solidifying in a dryer can be exemplified. Among them, the adhering method by the padding method is preferable from the viewpoint of production efficiency. Although not limited, it is preferable that the microcapsule and the binder resin are fixed to the fiber in a weight ratio of 1:10 to 10: 1.

  In addition, as a quasi-drug, the sedation or sleep (improvement of sleep) action can be achieved by containing the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention. And those used for the purpose of sedation or sleep. Specifically, toothpaste, liquid toothpaste, mouthwash, mouth pet, mouth freshener, poultice and the like are included.

  As a building material, the composition has the sedation or sleep (sleep improvement) action by containing the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention. The thing used for the purpose of sleep can be mentioned. Specifically, wallpaper, shoji paper, bran paper, board, coating material, and the like are included.

  The content of the aroma therapy composition of the present invention (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) in the scented product is not particularly limited, but is usually 0 in terms of the content of linalool. It can be suitably selected from the range of 0.0001 to 99.9% (w / w). However, since the effect of the aroma therapy composition of the present invention is affected by individual differences such as age, sex, psychological state, and physical condition, the fragrance composition is less than 0.0001% (w / w). Perfumed products that contain

  In addition to the composition for fragrance therapy (sedation / sleeping composition) or the fragrance therapy material (sedation / sleeping material) of the present invention, the fragrances include bases and additives that have been conventionally used in fragrances. Ingredients can be included. As a base for a fragrance, those in the form of solid, liquid, semi-solid (jelly, gel, etc.), aerosol, etc. are common. Examples include water, ethanol, solid or liquid anionic, cationic, nonionic active agents, polymer agents, fats and oils, guar gum, xanthan gum, gum arabic, gellan gum, carrageenan, gelatin, agar and the like. Furthermore, it can be used in the form of a product impregnated with a carrier for holding such as a solid polymer (eg, polystyrene, polypropylene), calcium silicate or the like.

  For cosmetics, in addition to the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention, the bases, additives, etc. that have been used in conventional cosmetics Ingredients can be included. Although it does not restrict | limit especially as a base, For example, water, ethanol, talc, gelatin, etc. are mentioned. Although it does not restrict | limit especially as an additive, For example, a moisturizer, a skin softener, an antiseptic | preservative, a solubilizer, etc. are mentioned.

  When the cosmetic product is a perfume, the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) according to the present invention can be used as it is without adding anything, or alcohol ( For example, it can be used in a state where the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention is dissolved in ethyl alcohol) or aqueous alcohol. In the perfume, the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention is converted to a linalool content of 0.0001 to 99.9 (w / It can mix | blend in the ratio of w)%. The compounding ratio of water and alcohol can be in the range of 50:50 to 0: 100 (volume ratio). The colon can contain solubilizers, softeners, humectans, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using a conventional perfume means, the composition of the aroma therapy of the present invention (sedation / sleeping composition) or a fragrance ingredient that harmonizes with the aroma therapy material (sedation / sleeping material) is further added to modulate, and the retention property It can be finished by adding a body or the like, or a top note, a middle note, and a base note can be appropriately combined to prepare a composition that emits an attractive fragrance over time.

  For inhalation administration, in addition to the composition for fragrance therapy (sedation / sleeping composition) or the fragrance therapy material (sedation / sleeping material) of the present invention, the bases and additives conventionally used for inhalation administration agents Etc. can be contained. Moreover, when using the gas for inhalation, the gas which has been used for the conventional inhalation administration agent can be used.

  In addition to the aroma therapy composition (sedation / sleeping composition) or aroma therapy material (sedation / sleeping material) of the present invention, other detergents conventionally used in textile detergents Ingredients can be used.

  In addition to the aroma therapy composition (sedation / sleeping composition) or the aroma therapy material (sedation / sleeping material) of the present invention, the textile product has other ingredients conventionally used in the processing of textile products ( For example, an antistatic agent, an antibacterial agent, an acaricide, a flame retardant, a hydrophilic agent, a moisture absorbent, a humectant, an antiallergic agent, and the like) can be used.

  As described above, according to the aroma therapy composition of the present invention (sedation / sleeping composition), aroma therapy material (sedation / sleeping material), and a scented product according to the present invention, the linalool it emits Parasympathetic nerve activity is enhanced (excited) by the stimulation of the scent of the sympathetic nerve and the sympathetic nerve activity is suppressed. Therefore, the present invention provides a body improvement action based on dominating the parasympathetic nerve activity based on odor stimulation, specifically, an action of relaxing the mind and body and relaxing the mind and body (relaxation action) In addition, it is possible to exert an action (slumbering action, sleep improving action) that smoothes sleep and reduces the frequency of awakening during sleep.

  In addition, the body improvement effect caused by the hypersympathetic nerve activation (excitement) or suppression of sympathetic nerve activity caused by the scent of linalool stimulates the sense of smell includes the action of promoting appetite, the action of promoting energy accumulation, and nutrition Examples thereof include an action for improving defects, an action for promoting healing of tissue damage, an action for improving hyperglycemic state of diabetes, an action for lowering blood pressure, an action for improving immunity, and an action for enhancing metabolism of skin.

  In other words, aroma therapy compositions (sedation / sleeping compositions), aroma therapy materials (sedation / sleeping materials), and scented products, based on the scent of linalool, suppress sympathetic nerves and have a sedative effect. It is expressed and increases the activity of the vagus nerve (parasympathetic nerve) to promote digestion and enhance anabolism, so it can be used for sedation or sleep, while improving anorexia, chronic wasting disease and Effective for improvement of energy wasting diseases such as chronic infectious diseases and cachexia, improvement of sputum, improvement of nutritional disorders, promotion of healing repair of tissue damage, recovery of physical strength after surgery, post-disease and pre-partum delivery Can be used. Furthermore, aroma therapy compositions (sedation / sleeping compositions), aroma therapy materials (sedation / sleeping materials), and scented products improve the immunity of the body based on the smell of linalool, and Because it can enhance the metabolism of the skin, it is used for sedation or restful sleep, and at the same time it has a decreased or decreased immunity (including post-operative, post-disease and postpartum subjects), young Improving immunity for the elderly and the elderly, can be used effectively to prevent infection and morbidity of pathogenic bacteria (including viruses), etc., early cure of the disease, and rejuvenate skin age (fresh skin) (Recovery and maintenance of sheath elasticity), and can be used effectively to suppress or improve wrinkles and pigmentation.

  Hereinafter, the present invention will be described with reference to an experiment conducted using linalool as a test substance. However, the present invention is not limited to these experimental examples. In the following experimental examples, (±) -linalool ((±) -3,7-Dimethyl-3-hydroxy-1,6-octadiene) [dl-linalool (dl-3,7-Dimethyl-3) -hydroxy-1,6-octadiene)] (synthetic product, purity 97% or more) (Aldrich Chem. Co., Milwaukee), or (+)-linalool ((+)-3,7-Dimethyl-3-hydroxy- 1,6-octadiene) [S-linalool (S-(+)-3,7-Dimethyl-3-hydroxy-1,6-octadiene)] (available from San-Ei Gen FFI Co., Ltd.) Acquired by precision fractionation after steam distillation (purity 99% or more).

Experimental Example 1 Effect of linalool on lipolysis reaction by odor stimulation First, we investigated how linalool odor stimulation affects the lipolysis reaction in the body.

  As a method for measuring lipolysis of mammals at the individual level, there can be mentioned a method of measuring the blood concentration of free fatty acid or glycerol produced by the degradation of neutral fat accumulated in adipose tissue by lipase. At this time, the free fatty acid generated by decomposition can be used as a substrate for the synthesis of neutral fat in adipose tissue on the spot, but glycerol needs to be phosphorylated once in the liver in order to be used for fat synthesis. Therefore, in order to measure the lipolysis reaction in individual subjects (test animals) with higher accuracy, it is preferable to use a method of measuring the glycerol concentration in blood. Therefore, in this experiment, the blood glycerol concentration (plasma glycerol concentration) was measured, and the influence of the odor stimulation of linalool ((±) -linalool) on the lipolysis reaction in the body was examined.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 250 to 300 g) as test animals. Rats are light for 1 week, 24 ± 1 ° C, 12 hour cycle (lighting 80 lx, 7: 00-19: 00)
In the dark period (19: 00-7: 00), the animals were housed one by one in individual plastic cages, and were fed with free feed (MF type; Oriental Yeast) and water. However, no food was given immediately before the start of the experiment until the end of blood collection. Three days before the start of each experiment, a heart catheter made of SILASTIC (Dow Corning, Midland MI) and PE-50 (Clay Adams, Parsippany, NJ) was inserted into the right atrium under pentobarbital anesthesia (35 mg / kg). .

3. Experiment and result <Experiment>
On the day of the experiment, the rats were divided into two groups (each group: 5 animals), and the odor stimulation by linalool was given to the rats of the first group without anesthesia in the following manner. The second group of rats is the control group. Note that linalool was suspended in 15,000 times volume of distilled deionized water (diluted 15,000 times).

Group 1 (Linalool odor stimulating group): Linalool suspension (diluted 15,000 times) is fully absorbed into 7.5 cm square medical non-woven gauze (100% rayon, 1 g weight, Neogauze, Kawamoto Sangyo Co., Ltd.) The test rat was placed on the top lid (made of metal) containing the test rat, and the cage was covered with a nylon cloth from above.
Group 2 (control group): 7.5 cm square medical non-woven gauze (100% rayon, 1 g in weight, Neogauze, Kawamoto Sangyo Co., Ltd.) fully absorbs distilled deionized water and contains a test cage The cage was placed on an upper mesh lid (made of metal) and covered with a nylon cloth from above.

For each group of rats, immediately after placing the gauze (0 minutes), 15 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after placing the gauze, blood (0.3 ml each) was inserted from the heart catheter inserted into the right atrium. ) Was collected. 10 μl each of EDTA (300 nmol / 10 μl) was added to the collected blood, centrifuged to obtain plasma, and immediately measured for glycerol concentration in plasma. The glycerol concentration in plasma was determined using an enzyme method glycerol measurement kit (F-kit glycerol, JK International, Tokyo) using enzymes of glycerokinase, pyruvate kinase and lactate dehydrogenase and substrates of NADH, ATP and phosphoenolpyruvate. It was measured.

<Result>
The results are shown in FIG. In addition, the data of a figure are shown by the average value +/- standard error. The numbers in parentheses in the figure mean the number of test rats. In the figure,-●-indicates the results of the rats in the first group (linalool odor stimulation group), and --- ○-indicates the results of the rats in the second group (control group). As shown in FIG. 1, the glycerol concentration in the plasma of the first group (linalool odor stimulation group) (-●-) is significant compared to the second group (control group) (--- ○ ---). [P <0.0005 (F = 14.7) by ANOVA].

<Discussion>
This experimental result shows that the increase in blood glycerol concentration is suppressed by the scent stimulation of linalool. That is, this result shows that lipolysis in the body is suppressed by inhaling the scent of linalool, that is, the scent stimulation of linalool works to suppress energy consumption in the body (enhance energy storage).

Experimental Example 2 Effects of linalool odor stimulation on changes in food intake, body weight and tissue weight 1. Introduction The result of Experimental Example 1 shows that odor stimulation by linalool suppresses lipolysis in adipose tissue. Therefore, if the energy consumption is reduced due to the suppression of lipolysis due to the odor stimulation of linalool, the adipose tissue weight may increase and the body weight may increase. Therefore, in this experiment, the effect of odor stimulation of linalool ((±) -linalool) on food intake, body weight and tissue weight was examined.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g) as test animals. Rats are light for 1 week, 24 ± 1 ° C, 12 hour cycle (lighting 80 lx, 7: 00-19: 00)
In the dark period (19: 00-7: 00), the animals were reared in individual cages with free access to feed (MF type; Oriental Yeast) and water.

3. Experiments, results and discussion <Experiment>
Rats were divided into 2 groups (Group 1 and Group 2) (each group: 4 animals), and the rats of Group 1 were given odor stimulation for 15 minutes under anesthesia every day from 13:00 in the following manner. . The second group of rats is a control group. Food consumption and body weight were measured once a week for each group of rats. After another 6 weeks of breeding, the animals are decapitated and the heart, liver, spleen, kidney, white adipose tissue (mesentery, accessory testicle and perirenal adipose tissue) and pancreas are collected and the weight of each organ and tissue is measured. It was measured. In addition, linalool was suspended in 30,000 times volume of distilled deionized water and used (diluted 30,000 times).

Group 1 (Linalool odor stimulating group): Linalool suspension (diluted 30,000 times) is fully absorbed into a 7.5 cm square medical non-woven gauze (100% rayon, 1 g weight, Neogauze, Kawamoto Sangyo Co., Ltd.) The test rat was placed on the top lid (made of metal) containing the test rat, and the cage was covered with a nylon cloth from above.
Group 2 (control group): 7.5 cm square medical non-woven gauze (100% rayon, 1 g in weight, Neogauze, Kawamoto Sangyo Co., Ltd.) fully absorbs distilled deionized water and contains a test cage The cage was placed on an upper mesh lid (made of metal) and covered with a nylon cloth from above.

<Result>
The results are shown in FIGS. In addition, the data of each figure are shown by the average value +/- standard error. The numbers in parentheses in the figure mean the number of test rats. In the figure,-●-indicates the results of the rats in the first group (linalool odor stimulation group), and --- ○-indicates the results of the rats in the second group (control group).

As shown in FIG. 2, the daily food intake (g / day / rat) per rat in each week is about 22g in the second group (control group) (--- ○ ---). The first group (Linalool odor stimulation group) (-●-) showed an increasing trend in the second half of the experiment (weeks 4-6) [0.05 <P <0.1 (F = 3.509) by
ANOVA]. FIG. 3 shows the weight change of the rat at this time. Body weight increased in both groups, but in the first group (Linalool smell stimulation group) (-●-) over the whole period compared to the second group (control group) (--- ○ ---) There was a tendency for weight gain [0.05 <P <0.1 (F = 2.991) by ANOVA;]. Figure 4 shows tissue weights (heart, liver, spleen, kidney, white adipose tissue (mesentery, accessory testicles and kidneys) when linalool odor stimulation or water odor stimulation was given as a control experiment every day for 6 weeks. Surrounding adipose tissue), pancreas). Compared with the second group (control group) (□ column), the first group (linalool odor stimulation group) (■ column) tended to increase the weight of any tissue (however, liver and white adipose tissue) There was no statistically significant difference for [mesentery, accessory testicles and perirenal adipose tissue].

<Discussion>
These experimental results suggest that scent stimulation with linalool increases appetite and increases body weight. Although no statistically significant difference was observed, linalool odor stimulation tended to increase the weight of liver and white adipose tissue. For this reason, linalool odor stimulation can anabolically alter the body's metabolism.

Experimental Example 3 Effects of odor stimulation on autonomic nerve activity 1. Introduction From the experimental results of Experimental Examples 1 and 2 above, odorol stimulation by linalool may affect lipolysis, weight gain and tissue weight gain (tissue protein increase accumulation) through changes in autonomic nerve activity. Was considered. Therefore, in this experiment, sympathetic nerves [paratesticular adipose tissue (white adipose tissue), interscapular (dorsal side) brown fat given by the odor stimulation of linalool (using (±) -linalool) using anesthetized rats. We examined the effects of the sympathetic nerves that innervate tissues and adrenal glands on the electrical activity of the parasympathetic nerve (vagus nerve that innervates the stomach).

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g, 5 animals) as test animals. In addition, one rat is preliminarily maintained for one week at 24 ± 1 ° C in a 12-hour light period (lighting 80 lx, 7: 00-19: 00) and dark period (19: 00-7: 00). Each individual cage was raised with free access to feed (MF type; Oriental Yeast) and water.

3. Experiments, results and discussion <Experiment>
In the experiment, the rats were divided into 2 groups (group 1 and group 2) (5 animals in each group), and laparotomy was performed under urethane anesthesia (1 g / kg aqueous urethane solution was intraperitoneally administered) after 6 hours fasting. Thereafter, odor stimulation was given for 10 minutes by the following method, and the change in electrical activity was measured for the distal branch of each autonomic nerve (see FIG. 5).
Group 1 (Linalool Smell Stimulation Group): Suspend linalool in 100-fold volume of distilled deionized water (diluted 100-fold), absorb it well with filter paper, and place it on the bottom of a glass beaker with a diameter of 5 cm and a depth of 6 cm. The rat's nose was placed in a beaker to give odor stimulation.
Group 2 (control group): Distilled deionized water was sufficiently absorbed by the filter paper and placed on the bottom of the beaker as in Group 1, and the nose of the rat was placed in the beaker to give odor stimulation. .

  Specifically, the electrical activity of each autonomic nerve (centrifugal branch) was measured by picking up the centrifugal branch of each autonomic nerve of an opened rat with a silver recording electrode under a stereomicroscope. In order to prevent drying, the electrode was previously sufficiently immersed in a mixture of liquid paraffin and petroleum jelly. The obtained nerve electrical activity was amplified with a condenser-type differential amplifier, monitored with an oscilloscope, and recorded on a magnetic tape. All neural activity was analyzed after converting the raw data into standard pulses using a slicer and window discriminator to separate it from background noise. The discharge frequency was displayed on a pen recorder by a late meter with a reset time of 5 seconds. Electrical activity was recorded for over 90 minutes.

<Result>
Autonomic nerves [sympathetic nerves innervating paratesticular adipose tissue (white adipose tissue), sympathetic nerves innervating interscapular (dorsal) brown adipose tissue, sympathetic nerves innervating the adrenal gland, innervating the stomach FIG. 6 shows representative results showing changes in the nerve activity (electric activity) of the distal branch of the vagus nerve (parasympathetic nerve). FIG. 6 shows, in order from the left in FIG. 6, the results of nerve activity by the odor stimulation of the second group (control group) and the first group (linalool odor stimulation group).

  As can be seen from the results, the second group (control group) with distilled water is used for the activities of sympathetic nerves that control white adipose tissue, brown adipose tissue and adrenal glands, and parasympathetic nerves that control the stomach (vagus nerve). ) Did not change anything. On the other hand, the first group (the linalool smell stimulation group) that smelled linalool reduces the activity of sympathetic nerves that control white fat (cold testicular) adipose tissue, brown adipose tissue and adrenal gland, and controls the stomach. Increased parasympathetic (vagal) activity.

<Discussion>
These experimental results show that sympathetic nerve activity governing white adipose tissue, brown adipose tissue and adrenal gland is suppressed by the scent stimulation of linalool.

  From these facts, it is possible to theoretically explain the results of Experimental Example 1 in which lipolysis is suppressed (accumulation of energy accumulation) by the scent stimulation of linalool. When the sympathetic nerve of white adipose tissue is excited, hormone sensitive lipase is activated and neutral fat is decomposed into fatty acid and glycerin, whereas when the sympathetic nerve is suppressed, the decomposition of the neutral fat is suppressed, It is known that fat synthesis is increased. Brown adipose tissue is found in newborn humans but is not visible to adults. However, it is known that uncoupling protein 1-3 (UCP1-3, hereinafter referred to as “UCP protein”) having a heat production function exists in adipose tissue, muscle, and the like even in adults. When the adipose tissue (corresponding to brown adipocytes) and muscle sympathetic nerves are excited, the amount and function of the UCP protein are increased, and heat production is increased. On the other hand, when the sympathetic nerves are suppressed, It has been shown that heat production is reduced. Therefore, the results obtained in the above experimental example show that the odor stimulation by linalool suppresses lipolysis in white adipose tissue and suppresses heat production (energy consumption) in adipose tissue and muscle where UCP protein exists. It shows that it acts to store energy.

  In addition, if the activity of the sympathetic nerve that governs the adrenal gland is suppressed, it is known that the secretion of adrenaline that causes sympathetic excitation is suppressed in the blood and the excitation of the sympathetic nerve is suppressed. The lipolysis inhibiting action and the energy storage promoting action are further enhanced.

  Moreover, the above experimental results suggest that parasympathetic nerve activity innervating the intestinal tract is enhanced by the odor stimulation of linalool. In general, the higher the activity of parasympathetic nerves that innervate the intestine, the higher the digestive and absorptive function of the intestine, and this is linked to an increase in appetite. The enhancement of appetite (increased food intake) by linalool odor stimulation shown in Experimental Example 2 is that the odor stimulation excites the olfactory nerve via the odor receptor on the nasal mucosa, and the information is the piriform cortex of the brain This is thought to be caused by a change in the neural activity of the hypothalamus. And the result of the said Experimental example 3 has suggested that the digestive absorption ability in an intestinal tract increases in that case (at the time of the odor stimulation by a linalool). From this point, the above results indicate that the absorption of energy is enhanced by the scent stimulation of linalool, and the storage of energy and protein in the tissue is enhanced.

Experimental Example 4 Effects of (+)-linalool odor stimulation on autonomic nervous activity (±) -linalool and (+)-linalool (both suspended in 100 volumes of distilled deionized water) (100 times) In the same manner as in Experimental Example 3, the effect of linalool odor stimulation on the nerve activity (electrical activity) of the sympathetic nerve (sympathetic adrenal branch) that innervates the adrenal gland was examined. The result of (±) -linalool is shown in FIG. 7 (A), and the result of (+)-linalool is shown in FIG. 7 (B).

<Result>
As shown in FIG. 7, both (±) -linalool odor stimulation and (+)-linalool odor stimulation decreased the activity of the sympathetic nerves governing the adrenal glands. It is known that when the activity of the sympathetic nerve that governs the adrenal gland is suppressed, secretion of adrenaline that causes sympathetic excitation into the blood is suppressed, thereby suppressing the excitation of the sympathetic nerve. Therefore, from the above results, regardless of isomers, linalool odor stimulation suppresses adrenaline secretion (suppression of sympathetic nerves) and causes various physiological phenomena (sedation (relaxation), restful sleep). Conceivable.

Experimental Example 5 Effects of linalool on sympathetic nerve activity and blood pressure by odor stimulation 1. Introduction From the experimental results of Experimental Example 3 above, the scent stimulation of linalool is caused by the activity of sympathetic nerves that innervate the epididymal adipose tissue (white adipose tissue), interscapular (dorsal) brown adipose tissue and adrenal gland in anesthetized rats. It has been shown to suppress and suppress the activity of the vagus nerve (parasympathetic nerve) that innervates the stomach. This suggests that linalool odor stimulation may also affect the activity of the sympathetic nerve that innervates the kidney. Moreover, since the sympathetic nerve also controls blood pressure, the scent stimulation of linalool may simultaneously affect the blood pressure. Therefore, in this experiment, the effects of odor stimulation by linalool ((±) -linalool) on renal sympathetic nerve activity and blood pressure in urethane anesthetized rats were examined.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g) as test animals. Rats are light for 1 week, 24 ± 1 ° C, 12 hour cycle (lighting 80 lx, 7: 00-19: 00)
In the dark period (19: 00-7: 00), the animals were reared in individual cages with free access to feed (MF type; Oriental Yeast) and water.

3. Experiment and result <Experiment>
The rats were divided into two groups (Group 1 and Group 2) (each group: 5 animals), then fasted for 6 hours and then under urethane anesthesia (1 g / kg urethane aqueous solution was administered intraperitoneally). The sympathetic nerve activity was measured for 10 minutes by measuring the change in the electrical activity of the sympathetic nerve branch that controls the kidney (see FIG. 5). According to the method described in Nagai and Kaneko et al. (In vivo 17: 213-218 (2003)), a catheter was inserted into the femoral artery, and an open method using a transducer was used.

Group 1 (Linalool Smell Stimulation Group): Suspend linalool in 100-fold volume of distilled deionized water (diluted 100-fold), absorb it well with filter paper, and place it on the bottom of a glass beaker with a diameter of 5 cm and a depth of 6 cm. The rat's nose was placed in a beaker to give odor stimulation.
Group 2 (control group): Distilled deionized water was sufficiently absorbed by the filter paper and placed on the bottom of the beaker as in Group 1, and the nose of the rat was placed in the beaker to give odor stimulation. .

  The measurement of the sympathetic nerve activity was carried out in the same manner as in Experimental Example 3 with the centrifugal branch of the kidney-dominated sympathetic nerve of the laparotomized rat being picked up on a silver recording electrode under a stereomicroscope (FIG. 5). reference). The discharge frequency was displayed on a pen recorder by a late meter with a reset time of 5 seconds. Electrical activity was recorded for over 90 minutes.

<Result>
Changes in renal sympathetic nerve activity and blood pressure during scent stimulation with linalool are shown in FIGS. 8 and 9, respectively. The experimental results are shown as a percentage (%) calculated with the blood pressure value before odor stimulation in each group as 100%. The data in each figure is shown as an average value ± standard error. The numbers in parentheses in the figure mean the number of test rats. In the figure,-●-indicates the results of the rats in the first group (linalool odor stimulation group), and --- ○-indicates the results of the rats in the second group (control group).

  As can be seen from this figure, linalool odor stimulation significantly suppresses the activity of the sympathetic nerve that controls the kidney [P <0.0005 (F = 140) by ANOVA], and also significantly lowers blood pressure [P <0.0005 (F = 32.3) by ANOVA].

  By the way, in Experimental Example 3 described above, it was shown that the scent stimulation of linalool suppresses the sympathetic nerve activity governing the adrenal gland, and this decrease in the activity of the adrenal sympathetic nerve suppresses the secretion of adrenaline from the adrenal medulla, and as a result It is known to cause a decrease. In other words, the above experimental results indicate that linalool odor stimulation, along with the suppression of sympathetic nerve activity governing the adrenal gland, also inhibits the activity of the sympathetic nerve governing the kidney and has a blood pressure lowering effect. It is.

Experimental Example 6 Glucose tolerance promoting effect of streptozotocin diabetic rats by odor stimulation 1. Introduction In Experimental Example 3, it was shown that the scent stimulation of linalool suppresses the activity of the sympathetic nerve that controls the adrenal gland. By the way, adrenaline secreted from the adrenal medulla is also involved in blood glucose regulation. Therefore, the scent stimulation of linalool may have the effect of reducing blood glucose levels in diabetic animals as a result of suppressing adrenal sympathetic nerves and suppressing adrenaline secretion. Streptozotocin diabetic rats (STZ diabetic rats) were used as diabetic animals, and the effect of the odor stimulation of linalool ((±) -linalool) on the increase in blood glucose during glucose loading in the diabetic rats was examined.

2. Test animals The following experiment was conducted using streptozotocin diabetic rats (male, Wistar rat, 250-300 g) as test animals. Diabetic rats were prepared by intraperitoneally administering streptozotocin (60 mg / kg). The rats are preliminarily kept for 1 week at 24 ± 1 ° C in a 12-hour light period (lighting 80 lx, 7: 00-19: 00) and dark period (19: 00-7: 00). In individual cages, they were raised with free access to feed (MF type; Oriental Yeast) and water. However, no food was given from 2 hours before the start of the experiment until the end of blood collection. Three days before the start of the experiment, SILASTIC (Dow Corning, Midland MI) and PE-50 (Clay Adams, under pentobarbital anesthesia (35 mg / kg)
A cardiac catheter consisting of Parsippany, NJ) was inserted into the right atrium.

3. Experiment and result <Experiment>
On the day of the experiment, the rats were divided into two groups (each group: 5 animals), and the odor stimulation by linalool was given to the rats of the first group without anesthesia in the following manner. The second group of rats is the control group. Note that linalool was suspended in 15,000 times volume of distilled deionized water (diluted 15,000 times).

Group 1 (Linalool Smell Stimulation Group): 0.5 g of glucose per 300 g of body weight is orally administered to rats using a needle and syringe for intragastric administration and simultaneously absorbs linalool suspension (15,000-fold dilution) A 7.5 cm square medical non-woven gauze (100% rayon, 1 g in weight, Neo Gauze, Kawamoto Sangyo Co., Ltd.) is placed on the top lid (metal) of the plastic cage containing the rat, and the gauge is nylon cloth from above. Covered with odor stimulation for 15 minutes.
Group 2 (control group): A 7.5 cm square medical non-woven fabric in which 0.5 g of glucose per 300 g of body weight was orally administered to rats using a needle and syringe for intragastric administration and simultaneously absorbed with distilled deionized water Place gauze (100% rayon, 1 g in weight, Neo Gauze, Kawamoto Sangyo Co., Ltd.) on the upper lid (metal) of the plastic cage containing the rat, cover the gauge with a nylon cloth from above, and stimulate the smell for 15 minutes Gave.

For each group of STZ diabetic rats, blood (0.3 ml each) was drawn from the heart catheter inserted into the right atrium immediately before placing the gauze (0 minutes), 30 minutes, 60 minutes, 90 minutes and 120 minutes after placing the gauze. Collected. 10 μl each of EDTA (300 nmol / 10 μl) was added to the collected blood, centrifuged to obtain plasma, and immediately measured for glucose concentration in plasma. The plasma glucose concentration was measured using a biochemical test system (Fuji Dri-chem System: glucose oxidase).
(Fuji Film).

<Result>
The results are shown in FIG. In addition, the data of a figure are shown by the average value +/- standard error. The numbers in parentheses in the figure mean the number of test rats. In the figure,-●-indicates the results of STZ diabetic rats in the first group (linalool odor stimulation group) and --- ○-indicates the results of STZ diabetic rats in the second group (control group), respectively. As shown in FIG. 10, the first group (linalool odor stimulation group) (-●-) compared to the second group (control group) (--- ○ ---), blood at the time of oral glucose load. The increase in the concentration of medium glucose was significantly suppressed [P <0.05 (F = 5.23) by ANOVA; the values after 30 to 60 minutes were compared as a group].

4). Discussion These experimental results show that linalool odor stimulation improves glucose tolerance in diabetic rats. In other words, this result indicates that stimulation by the odor of linalool is effective in the treatment of diabetes.

Experimental Example 7 Effect of odor stimulation on immune nerve activity INTRODUCTION Sympathetic nerves are distributed in areas closely related to immune responses such as the cortex of the thymus, the lymphocyte sheath around the central artery of the white pulp of the spleen, and the paracortex of the lymph nodes. Therefore, in this experiment, to elucidate how the stimulation by the scent of linalool is related to the immune activity of the living body, using anesthetized rats, the centrifugal branch of the parasympathetic nerve that controls the thymus (vagus thymus branch) and The effects of linalool odor stimulation on the electrical activity of the sympathetic branch (sympathetic spleen branch) that controls the spleen were examined. In addition, (±) -linalool was used as linalool.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g) as test animals. The rats were preliminarily fed for 1 week at 24 ± 1 ° C in a 12-hour light period (lighting 80 lx, 7: 00-19: 00) and dark period (19: 00-7: 00). MF type; Oriental Yeast) and water.

3. Experiments, results and discussion <Experiment>
The rats were divided into 2 groups (Group A and Group B), fasted for 6 hours and then opened under urethane anesthesia (1 g / kg aqueous urethane solution administered intraperitoneally). And the change in electrical activity was measured for the distal branch of each autonomic nerve (see FIG. 9).

Group A: Vagus thymus branch measurement group Linalool is suspended in 100-fold volume of distilled deionized water (diluted 100-fold), absorbed sufficiently on filter paper, and placed on the bottom of a glass beaker with a diameter of 5 cm and a depth of 6 cm. The rat's nose was placed in a beaker to give odor stimulation.

Group B: Sympathetic spleen branch measurement group Linalool was suspended in 100-fold volume of distilled deionized water (diluted 100-fold), fully absorbed by filter paper, and placed on the bottom of a glass beaker with a diameter of 5 cm and a depth of 6 cm. The rat's nose was placed in a beaker to give odor stimulation.

  Specifically, the electrical activity of each autonomic nerve (centrifugal branch) was measured by picking up the centrifugal branch of each autonomic nerve of an opened rat with a silver recording electrode under a stereomicroscope. In order to prevent drying, the electrode was previously sufficiently immersed in a mixture of liquid paraffin and petroleum jelly. The obtained nerve electrical activity was amplified with a condenser-type differential amplifier, monitored with an oscilloscope, and recorded on a magnetic tape. All neural activity was analyzed after converting the raw data into standard pulses using a slicer and window discriminator to separate it from background noise. The discharge frequency was displayed on a pen recorder by a late meter with a reset time of 5 seconds. Electrical activity was recorded for 90 minutes or longer (see FIG. 9B).

<Result>
FIG. 11 (A) shows the change in the nerve activity (electric activity) of the vagus nerve thymus branch by the scent stimulation of linalool, and FIG. 11 (B) shows the change of the nerve activity (electric activity) of the sympathetic nerve spleen branch by the scent stimulation of linalool. Respectively. (2) of FIG. 11 (B) is a graph showing changes in the direct neural activity (electrical activity) of the sympathetic nerve spleen branch by linalool odor stimulation ((1) of FIG. 11 (B)).

  As can be seen from these results, the scent stimulation of linalool increased the activity of the vagus nerve (parasympathetic nerve) that controls the thymus and decreased the activity of the sympathetic nerve that controls the spleen.

<Discussion>
It is known that thymic vagus nerve excitation increases lymphocyte release from the thymus, and splenic sympathetic nerve activity increases NK (natural killer) activity, resulting in immune activation. (A. Niijima and MMMeguid, ”Influence of systemic arginine-lysine on immune organ function: an electrophysiological study. Brain Res. Bull. 45: 437-441 (1998)). The result is that linalool odor stimulation acts to excite the thymus vagus nerve to increase lymphocyte release and decrease splenic sympathetic activity to increase lymphocyte NK activity, i.e. It shows that it acts on the immune activation of the living body.

Experimental Example 8 Effects of odor stimulation on skin nerve activity 1. Introduction In this experiment, using anesthetized rats, the effect of stimulation by the scent of linalool ((±) -linalool) on the electrical activity of the distal branch of the sympathetic nerve (skin sympathetic nerve) that controls the skin was examined. .

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g) as test animals. The rats were preliminarily fed for 1 week at 24 ± 1 ° C in a 12-hour light period (lighting 80 lx, 7: 00-19: 00) and dark period (19: 00-7: 00). MF type; Oriental Yeast) and water.

3. Experiments, results and discussion <Experiment>
The rats were divided into two groups (Group 1 and Group 2), fasted for 6 hours, and then opened under urethane anesthesia (1 g / kg aqueous solution of urethane intraperitoneally). Odor stimulation was applied, and changes in neural activity (electrical activity) were measured for the distal branch of the skin sympathetic nerve (see FIG. 5). The electrical activity of the skin sympathetic nerve (centrifugal branch) was measured according to the method described in Experimental Example 7.
Linalool odor stimulant group: Suspend linalool in 100-fold volume of distilled deionized water (diluted 100-fold), absorb it well on filter paper, place it on the bottom of a glass beaker with a diameter of 5 cm and a depth of 6 cm. This part was placed in a beaker to give odor stimulation.

<Result>
FIG. 12A shows changes in nerve activity (electrical activity) of the skin sympathetic nerve due to linalool odor stimulation. FIG. 12B is a graph of the results shown in FIG. As can be seen from this result, the scent stimulation of linalool reduced the activity of the sympathetic nerve that governs the skin.

<Discussion>
It is known that the blood vessel contraction of the skin is determined by the activity of the sympathetic nerve, and the blood flow volume of the skin increases when the activity of the sympathetic nerve of the skin decreases. As skin blood flow increases, the amount of oxygen and nutrients delivered to the skin increases accordingly, and as a result, skin turnover is promoted. Therefore, the results obtained in the above experimental example show that the scent stimulation of linalool acts to reduce skin sympathetic nerve activity and increase blood flow, thereby promoting skin metabolism (turnover). Is shown. When the metabolism of the skin is promoted, the functions inherent to the skin are pulled out to restore the moisture and elasticity of the healthy skin, and the skin wrinkles, pigmentation dullness, spots and sparrow spots are suppressed or Expected to be improved.

Experimental Example 9 Effect of linalool on rhythm behavior by odor stimulation 1. Introduction From the above experimental results, it was shown that linalool odor stimulation suppressed various sympathetic nerve activities and increased parasympathetic nerve activity. In particular, the result of Experimental Example 4 is that, according to the scent stimulation of linalool ((±) -linalool, (+)-linalool), the sympathetic nerves that innervate the adrenal gland that controls the secretion of adrenaline are suppressed. This shows that the tension of the mind and body is reduced. Therefore, in this experiment, the influence of the odor stimulation of linalool ((±) -linalool) on the daily rhythmic behavior of rats was examined.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 250 to 300 g) as test animals. Rats are light for 1 week, 24 ± 1 ° C, 12 hour cycle (lighting 80 lx, 7: 00-19: 00)
In the dark period (19: 00-7: 00), the animals were reared in individual cages with free access to feed (MF type; Oriental Yeast) and water.

3. Experiment and result <Experiment> (see FIGS. 13A and 13B)
Rats were divided into 2 groups (1st group, 2nd group) (each group: 4 animals) and each cage containing rats (Fig. 13, reference numeral 1) pyroelectric infrared sensor module (reference numeral 3) It was placed in an animal breeding device (Koitotron EA type; manufactured by Koito Kogyo Co., Ltd.) (FIG. 13, reference numeral 2). The temperature in the animal breeding device should be adjusted to 24 ± 1 ℃, and the light period (lighting 80lx, 7: 00-19: 00) and dark period (19: 00-7: 00) will come in a 12-hour cycle. Set to. The pyroelectric infrared sensor module (reference numeral 3) installed in the animal breeding apparatus is an infrared sensor module that employs a Fresnel lens having 9 faces and 18 zones, and can detect movement within a range of more than 5 m.

First group (linalool odor stimulation group): Fabric prepared in Example 2 described later [fabric (100% cotton) with linalool microencapsulated (aromatic therapy material: Example 1) attached, size: 30cm x 30cm, linalool impregnation amount: 0.11% by weight with respect to 100% by weight of the dough before adhering microcapsules] (1) is placed in an animal breeding apparatus with (4) attached to one side of the wall The whole day activity (movement) was counted over 13 days. (See FIG. 13B)
The second group (control group): a fabric (100% cotton) to which nothing is attached, size: 30cm x 30cm] in an animal breeding device affixed to one side of the wall, a cage containing a rat (one animal) All day activity (movement) was counted over 13 days.

<Result>
Fig. 14 shows the total daily activity (13 days) of rats in Group 1 (Linalool Smell Stimulation Group) (-●-) and Group 2 (Control Group) (--- ■ ---). ). FIG. 15 also shows the light period of the rats in the first group (Linalool odor stimulation group) (-●-) and the second group (control group) (--- ■ ---) relative to the total daily activity. The ratio of the activity amount (lighting 80 lx, 7: 00-19: 00, 720 minutes) is calculated with the total daily activity amount being 100% (light activity) (13 days). Since rats are nocturnal animals that are active in the dark period and sleep in the light period, the light period corresponds to the bedtime. A result is shown by the average value of four rats.

  FIG. 16 (A) shows the results of comparing the average value of the total daily activity for 13 days between the first group (linalool smell stimulation group) and the second group (control group), and FIG. 16 (B). Shows the result of comparing the average value for 13 days of the ratio of the light activity amount to the daily activity amount in the first group (linalool smell stimulation group) and the second group (control group).

  As can be seen from these results, it was shown that the daily activity of rats was reduced (sedated) by linalool odor stimulation. Furthermore, since the activity at bedtime was greatly reduced, it was shown that the wakefulness frequency during sleep was reduced by linalool odor stimulation, that is, it was well sleeping at bedtime. From the above, it was found that linalool smell stimulation can calm the mind and body and bring about a good night's sleep.

Experimental Example 10 Sleeping effect by scent stimulation of linalool A pillow cover (50cm x 30cm) was made with the fabric (cotton fabric) prepared in Example 2, and it was used for pillows at bedtime for both adults and men. confirmed. The evaluation was (5) a good sleep, (4) a better sleep than usual, (3) a normal change, (2) a normal sleep, and (1) no sleep at all. The survey was conducted.
The results are shown in Table 1.

この結果から、リナロール（実施例１：鎮静・安眠材）を付着させた枕カバーの使用により、普段と変わらないか普段よりよく眠れる傾向が認められ、リナロールの匂い刺激によって安眠効果が得られることが確認できた。

From this result, the use of a pillow cover to which linalool (Example 1: sedative / hypnotic material) is attached is found to have a tendency to sleep better than usual or better than usual, and a sympathetic stimulation of linalool provides a sleep-sleeping effect. Was confirmed.

Reference Experimental Example 1 Effect of odor stimulation on autonomic nerve activity Introduction From the above experimental results, scent stimulation by linalool leads to lipolysis suppression (energy consumption suppression), increased food intake and body weight, decreased blood pressure, decreased blood sugar, sedation / sedation through changes in autonomic nerve activity It became clear. The action mechanism of the above-mentioned scent stimulation by linalool includes the case where odor information is processed by the brain via the nasal mucosa odor receptor and the autonomic nerve is changed, and the odor is absorbed from the nasal mucosa and lungs to reduce blood flow. There are two cases where the autonomic nerve is changed via In this experiment, it will be clarified whether the action mechanism of the odor stimulation is one of the above.

2. Test animals The following experiments were conducted using rats (male, Wistar rat, 200 to 250 g) as test animals. The rats are preliminarily kept for 1 week at 24 ± 1 ° C in a 12-hour light period (lighting 80 lx, 7: 00-19: 00) and dark period (19: 00-7: 00). In individual cages, they were raised with free access to feed (MF type; Oriental Yeast) and water.

3. Experiment and result <Experiment>
The rats were divided into 4 groups (Groups 1 to 4), and after 6 hours fasting, under the urethane anesthesia (1 g / kg urethane aqueous solution was administered intraperitoneally), the essential oil containing linalool for 10 minutes (lavender essential oil) by the following method The change in the electrical activity of the parasympathetic nerve that governs the stomach was measured. The lavender essential oil containing linalool is a suspension of 100-fold volume of distilled deionized water (diluted 100-fold). This is absorbed into the filter paper, and is a glass beaker with a diameter of 5 cm and a depth of 6 cm. Prepared by placing on the bottom (beaker with essential oil absorbing filter paper).

Group 1 (tracheal odor stimulation group): The trachea is incised at the neck of the test rat, a tube is inserted into the trachea toward the lung, and the end of the tube is placed toward the bottom of a beaker containing essential oil absorbing filter paper. The essential oil did not go to the nasal mucosa but went directly to the lungs to give an odor stimulus, and the change in the electrical activity of the parasympathetic nerve governing the stomach was measured (see FIG. 17 (1)).
Second group (nasal pumping odor stimulation group): The trachea is incised in the neck of the test rat, the trachea toward the lungs is opened to allow breathing, and a syringe is inserted into the trachea toward the nasal cavity. Place a beaker containing essential oil absorption filter paper at the tip of the nose, pump the smell of lavender essential oil absorbed into the filter paper with a syringe, stimulate the nasal mucosa to smell and measure changes in the electrical activity of the parasympathetic nerve that governs the stomach (See FIG. 17 (2)).
Group 3: Record the electrical activity of the gastric parasympathetic nerve while giving the test rat a lavender suspension (100
0.1 ml) and 0.5 ml subcutaneously at intervals. Next, as in the second group, the nasal mucosa was stimulated with lavender essential oil for 10 minutes (nasal pumping odor stimulation) (see FIG. 18 (3)).
Group 4: When recording electrical activity of the gastric parasympathetic nerve, stimulate the nasal mucosa with lavender essential oil for 10 minutes in the same manner as in Group 2 (nasal pumping odor stimulation). 2% xylocaine was injected into 0.2 ml nasal cavity to examine the effects of local anesthesia. Furthermore, after local anesthesia, nasal pumping odor stimulation was performed again for 10 minutes in the same manner as described above (see FIG. 18 (4)).

  Specifically, the measurement of the electrical activity of the parasympathetic nerve governing the stomach was specifically performed by centrifugation of the gastric parasympathetic nerve of a rat that had been fasted for 6 hours and then opened under urethane anesthesia (1 g / kg urethane aqueous solution was intraperitoneally administered). The branches were picked up by silver recording electrodes under a stereomicroscope, and the same procedure as in Experimental Example 3 was performed (see FIG. 5). The discharge frequency was displayed on a pen recorder by a late meter with a reset time of 5 seconds. Electrical activity was recorded for over 90 minutes.

<Result>
FIG. 17 (1) and (2) show the experimental results of the first group and the second group. When the odor component of lavender essential oil was inhaled toward the lungs of the first group (first group), the activity of the gastric parasympathetic nerve did not increase, but it was forced to use the syringe toward the nasal cavity. When the scent of lavender essential oil was inhaled (second group), the activity of the gastric parasympathetic nerve increased. This fact shows that at least the odor component of lavender essential oil acts in the nasal cavity. (3) and (4) of FIG. 18 show the experimental results of the third group and the fourth group.

  As shown in FIG. 18 (3), the activity of the gastric parasympathetic nerve did not increase even when the lavender suspension was administered subcutaneously, but the activity of the gastric parasympathetic nerve increased when the smell of lavender essential oil was inhaled. Further, as shown in FIG. 18 (4), it was recognized that the activity of the gastric parasympathetic nerve increased by odor stimulation to the nasal cavity by lavender essential oil was rapidly reduced by local anesthesia of the nasal cavity by injecting xylocaine. Moreover, after local anesthesia, gastric parasympathetic nerve activity did not increase even when odor stimulation was applied to the nasal cavity with lavender essential oil. These facts support the above findings.

4). DISCUSSION These facts indicate that the odor component including linalool transmits odor information into the brain via the odor receptor of the nasal mucosa, thereby changing the autonomic nervous activity that innervates peripheral tissues (white fat Tissue, brown adipose tissue, adrenal glands, kidneys, spleen, and sympathetic nerves that control the skin, and parasympathetic nerves that control the stomach and thymus), resulting in lipolysis suppression, energy accumulation, blood pressure reduction, blood sugar Decrease, immunostimulation, skin metabolism increase, sedation / hypnosis, etc. occur, and on the other hand, the odor component including linalool is transmitted to the feeding regulation center in the hypothalamus via the odor receptor of the nasal mucosa This suggests that the appetite is improved (FIG. 19).

<Example>
A perfumed product containing the aroma therapy composition of the present invention shown in the following examples was prepared. However, the perfumed product is only an example of a perfumed product targeted by the present invention. In addition, as the following linalool, (±) -linalool (dl-3,7Dimethyl-3-hydroxy-1,6-octadiene, Aldrich Chem. Co., Milwaukee) (synthetic product, purity 97% or more) or (+) -Linalool (obtained from Saneigen FFI Co., Ltd., extracted and purified from coriander, purity 99% or more) was used.

Example 1 : Aroma therapy material (sedation / sleep material)
100 g of (±) -linalool is added to 100 g of a 5 wt% aqueous solution (pH 4) obtained by dissolving a styrene-maleic anhydride copolymer (Crobax 400: trade name, manufactured by Nihon Gosei Co., Ltd.) with a small amount of sodium hydroxide. And emulsified with stirring ((±) -linalool emulsion). On the other hand, a mixed solution of 10 g of melamine, 25 g of 37% formalin and 65 g of water was adjusted to pH 9 with sodium hydroxide, heated to 60 ° C. and stirred for 15 minutes to prepare a melamine-formaldehyde initial condensate. This melamine-formaldehyde initial condensate was added to the above (±) -linalool emulsion, stirred for 30 minutes while maintaining the liquid temperature at 60 ° C., filtered through filter paper, and then air-dried, with a linalool inclusion rate of 70%, An aroma therapy material (sedative / sleep material) having a microcapsule form with an average particle size of about 8 μm was obtained.

Example 2 : Textile product A mixture of scoured, bleached and mercerized 100% cotton fabrics with a basis weight of 150 g / m ² containing microcapsules prepared in Example 1 [0.18% by weight microcapsules (fragrance therapy material), It was immersed in 2% by weight silicon binder (TF3500, manufactured by Kitahiro Chemical Co., Ltd., 97.82% by weight water). After soaking, the taken-out woven fabric was squeezed with a mangle roll (squeezing ratio: 60%), dried at 100 ° C. for 2 minutes, and then heat treated at 150 ° C. to obtain a fiber product (fabric, woven fabric).

Example 3 : Liquid air freshener (±) -linalool (or (+)-linalool) 1.0 (3.0) wt%
Alcohol solvent (Solfit: Kuraray) 6.0
Polyoxyethylene lauryl ether 4.5
Polyoxyethylene alkyl ether 0.5
Ion exchange water balance
Total 100.00% by weight.

Example 4 : Gel fragrance (±) -linalool (or (+)-linalool) 1.0 (3.0) wt%
Gellan Gum 0.8
Calcium lactate 0.05
Polyoxyethylene lauryl ether 6.0
Polyoxyethylene alkyl ether 0.5
Ion exchange water balance
Total 100.00% by weight.

Example 5 : Fragrance aerosol (±) -linalool (or (+)-linalool) 0.17 (0.5) wt%
Ethanol 19.8
LPG remainder
Total 100.00% by weight.

Example 6 : Air freshener (±) -linalool (or (+)-linalool) 30 (88.2) wt%
Isoparaffin remaining
Total 100.00% by weight
A mixture of linalool (or lavender essential oil) and isoparaffin was impregnated in a support (calcium silicate), and placed in an unglazed container to prepare a fragrance.

Example 7 : Liquid fragrance for inhalation (±) -linalool (or (+)-linalool) 1.0 (3.0) wt%
Ethanol 50.0
Polyoxyethylene lauryl ether 2.25
Polyoxyethylene alkyl ether 2.25
Ion exchange water balance
Total 100.00% by weight.

Example 8 : Massage oil (±) -linalool (or (+)-linalool) 0.5 (1.5)
Jojoba oil remaining
Total 100.00% by weight.

Example 9 : Massage cream (±) -linalool (or (+)-linalool) 1 (3.0)
Beeswax 10.0
Liquid paraffin 50.0
Borax 1.0
Purified water balance
Total 100.00% by weight.

Example 10 : Gum (±) -linalool (or (+)-linalool) 0.01 (0.03)
Reduced maltose 20.0
Reduced maltose starch syrup 5.0
The rest of the gum base
Total 100.0% by weight.

It is a figure which shows the influence with respect to the plasma glycerol (plasma glycerol) density | concentration of the smell stimulation of a linalool (Experimental example 1). In the figure,-●-is the rat of the first group (Linalool odor stimulation group) (indicated as "Linalool" in the figure), --- ○ --- is the rat of the second group (control group) (in the figure, “Water” is displayed). Data are shown as mean ± standard error (the same applies to the following figures). The numbers in parentheses in the figure mean the number of test rats (the same applies to the following figures). The horizontal axis shows the elapsed time (min) after placing the gauze impregnated with the test sample on the cage, and the vertical axis shows the glycerol concentration (%) in plasma. It is a figure which shows the influence with respect to the food intake of the smell stimulation of linalool (Experimental example 2). In the figure,-●-is the rat of the first group (Linalool odor stimulation group) (indicated as "Linalool" in the figure), --- ○ --- is the rat of the second group (control group) (in the figure, “Water” is displayed). The horizontal axis represents the elapsed time (weeks) after placing the gauze impregnated with the test sample on the cage, and the vertical axis represents the amount of food consumed per day (g / day / rat) per rat. It is a figure which shows the influence with respect to the body weight of the smell stimulation of a linalool (Experimental example 2). In the figure,-●-is the rat of the first group (Linalool odor stimulation group) (indicated as "Linalool" in the figure), --- ○ --- is the rat of the second group (control group) (in the figure, “Water” is displayed). The horizontal axis shows the elapsed time (days) after placing the gauze impregnated with the test sample on the cage, and the vertical axis shows the weight (g) of one rat. Tissue weight of linalool smell [from right, heart, liver, liver, spleen, kidney, white adipose tissue [(mesenteric adipose tissue (Mesenteric), abdominal testis fat It is a figure which shows the influence with respect to a structure | tissue (Epididymal, perirenal adipose tissue (Perirenal)], and pancreas (Pancreas)] (Experimental example 2) In the figure, ■ column is a rat of the 1st group (linalool smell stimulation group) ( In the figure, “Linalool” is displayed), and □ column indicates the results of the rats in the second group (control group) (indicated as “Water” in the figure). It is a figure which shows the experimental method in Experimental example 3-5, 7-8, and the reference experimental example 1. FIG. A is a schematic diagram showing a method for giving an odor stimulus to a test rat, and B is a schematic diagram showing a method for measuring the electrical activity of each nerve centrifuge branch of the test rat. Each autonomic nerve by odor stimulation [From the top, the sympathetic nerve innervating the paratesticular fat tissue (white adipose tissue), the sympathetic nerve innervating the interscapular (dorsal) brown adipose tissue, and the sympathetic nerve innervating the adrenal gland It is a figure which shows the change of the nerve activity (electrical activity) of the centrifugal branch of the vagus nerve (parasympathetic nerve) which innervates the stomach. In order from the left in FIG. 6, the results of nerve activity by the odor stimulation in the control group and the linalool odor stimulation group are shown. In addition, the horizontal line on each figure shows the provision period (10 minutes) of each odor stimulus. (±) -linalool (FIG. A) and (+)-linalool (FIG. B) are diagrams showing changes in neural activity (electrical activity) of the distal branch of the sympathetic nerve innervating the adrenal gland by odor stimulation (FIG. B). Experimental example 4). It is a figure which shows the change (%) of the renal sympathetic nerve activity (renal sympathetic nerve activity) at the time of the odor stimulation by a linalool (experimental example 5). The experimental results are shown as percentages calculated with the value of renal sympathetic nerve activity before odor stimulation in each test group as 100%. In the figure,-●-indicates the first group (Linalool odor stimulation group) (indicated as "Linalool" in the figure), --- ○ --- indicates the second group (control group) (in the figure, "Water") Display) results. It is a figure which shows the change (%) of the blood pressure (mean arterial pressure) at the time of the odor stimulation by a linalool (Experimental example 5). The experimental results are shown as a percentage calculated with the blood pressure value before odor stimulation in each test group as 100%. In the figure,-●-indicates the first group (Linalool odor stimulation group) (indicated as "Linalool" in the figure), --- ○ --- indicates the second group (control group) (in the figure, "Water") Display) results. It is a figure which shows the result investigated about the influence which the odor stimulation of a linalool exerts on the blood glucose rise at the time of the glucose load with respect to the streptozotocin diabetic rat (experimental example 6). In the figure,-●-indicates the plasma glucose concentration (mg / dl) of the first group (linalool odor stimulation group) (indicated as "Linalool" in the figure) after glucose loading, and --- ○ --- indicates the first The plasma glucose concentration (mg / dl) after glucose loading in group 2 (control group) (shown as “Water” in the figure) is shown. Neuronal activity (electrical activity) of the cranial branch of the autonomic nerve [(A) parasympathetic nerve (vagus nerve thymus branch) innervating thymus, (B) sympathetic nerve (sympathetic nerve spleen branch) innervating spleen] by linalool odor stimulation ) Is a diagram showing a change in (Experimental Example 7). In addition, the horizontal line on each figure shows the provision period (10 minutes) of each odor stimulus. (A) is a figure which shows the change of the nerve activity (electrical activity) of the efferent branch of the autonomic nerve [sympathetic nerve which innervates skin] by a linalool smell stimulation (Experimental example 8). (B) is a graph of this. It is a figure which shows the animal breeding apparatus (code | symbol 2) (FIG. B) with the cage (code | symbol 1) (FIG. A) used for the rhythm action test (experimental example 9) and the pyroelectric infrared sensor module (code | symbol 3). In FIG. B, reference numeral 4 denotes a fabric to which a fragrance therapeutic material (Example 1) in which linalool is microencapsulated is attached, or a fabric to which nothing is attached. Group 1 (Linalool odor stimulation group) (-●-) (shown as “Linalool” in the figure) and Group 2 (control group) (--- ■ ---) (shown as “Water” in the figure) ) Is a graph showing the daily total activity (13 days) of rats. The results are shown as the average value of 4 rats. Group 1 (Linalool odor stimulation group) (-●-) (shown as “Linalool” in the figure) and Group 2 (control group) (--- ■ ---) (shown as “Water” in the figure) ) Rat's total activity amount in the light period (lighting 80 lx, 7: 00-19: 00, 720 minutes) is calculated as the total daily activity amount being 100%. Indicates (light activity) (13 days). The results are shown as the average value of 4 rats. (A) shows the average value of the total daily activity for 13 days as the first group (linalool smell stimulation group) (displayed as “Linalool”) and the second group (control group) (displayed as “Water”). (B) shows the average value for the 13 days of the ratio of the light activity to the total daily activity, the first group (Linalool smell stimulation group) (displayed as “Linalool”) And the result compared with the 2nd group (control group) (it displays with "Water") is shown. It is a figure which shows the influence by the pulmonary (tracheal) stimulation and nasal cavity stimulation of the lavender essential oil with respect to the gastric parasympathetic nerve activity of a urethane anesthesia rat (reference experiment example 1). The upper graph shows the effects of subcutaneous administration of lavender essential oil and nasal stimulation on gastric parasympathetic nerve activity in urethane anesthetized rats. The lower graph shows the effect of nasal mucosal local anesthesia on the stimulating effect of lavender essential oil on the gastric parasympathetic nerve activity of urethane anesthetized rats by nasal stimulation (Reference Experimental Example 1). It is the figure which summarized the influence which the scent stimulation of linalool has on the autonomic nerve.

Claims (5)

A composition for sedation and sleep, comprising (+)-linalool or (±) -linalool as an active ingredient. A sedative / sleeping material obtained by encapsulating (+)-linalool or (±) -linalool in a resin shell. A sedative / hypnotic scented product containing the sedative / hypnotic composition according to claim 1 or the sedative / hypnotic material according to claim 2. The scented product according to claim 3, which is a textile product. The scented product according to claim 4, wherein the textile product is a bedding product.

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