JP2005178244A - Laminated film for medical container, medical container using the film, and its production method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a laminated film for a medical container which can obtain the medial container high in transparency and excellent in heat resistance, flexibility, and bag making properties, the medical container using the film, and its production method. <P>SOLUTION: The laminated film for the medical container is a tubular inflation laminated film formed by coextrusion. An outer layer is formed from polypropylene incorporated with 5-50 wt.% of polyethylene, and an inner layer is formed from polyethylene. The ratio (Mw/Mn) between the weight average molecular weight (Mw) and number (Mn) average molecular weight of the polypropylene forming the outer layer is 3.0 or below, and the ratio (Mw/Mn) between the weight average molecular weight and number average molecular weight of the polyethylene forming the outer layer is 3.5 or below. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a laminated film for medical containers for storing and storing an infusion solution, a medical container using the laminated film, and a method for producing the same.

Conventionally, glass containers have been used as medical containers for storing and storing infusion solutions, dialysis solutions, organ preservation solutions, and the like.
However, glass containers are heavy and bulky, are vulnerable to impacts and are easily damaged, and have problems such as contamination due to elution of glass components. Therefore, recently, in consideration of convenience during transportation and use, a container made of a polyolefin-based synthetic resin represented by polyethylene or polypropylene is often used, and a medical container made of a polyolefin-based synthetic resin is often used. Many proposals have been made (for example, see Patent Documents 1 and 2).
However, the synthetic resin container is inferior in transparency as compared with the glass container, and therefore there is a problem that it is difficult to confirm the presence or absence of a foreign substance in the content liquid or to confirm the change.

As a method for solving such problems, high-pressure low-density polyethylene-based, linear low-density polyethylene-based, and polypropylene-based materials, which are highly transparent materials, are used for the material film forming the medical container. There is a method to use.
However, in general, high-pressure method low-density polyethylene and linear low-density polyethylene are inferior in heat resistance and transparency, and polypropylene is excellent in heat resistance, but there is a problem in flexibility and bag-making property.

  Therefore, in order to achieve both heat resistance and flexibility, a method of laminating a polypropylene-based and linear low-density polyethylene-based resin (see, for example, Patent Documents 3 and 4), or a polypropylene-based resin manufactured with a metallocene-based catalyst. (For example, see Patent Documents 5 to 7). However, when a bag is made into a medical container, it is difficult to achieve both sealing strength and appearance.

JP-A-5-293168 JP-A-9-75444 JP-A-6-169974 JP-A-7-164604 JP-A-9-99036 JP 2000-178319 A JP 2001-172451 A

  The present invention has been made to solve the above-described problems of the prior art, and can provide a medical container having high transparency and excellent heat resistance, flexibility, and bag-making property. It is intended to provide a laminated film for medical containers, a medical container using the laminated film, and a method for producing the same.

The invention according to claim 1 is a tubular inflation laminated film formed by coextrusion, wherein the outer layer is formed from polypropylene mixed with polyethylene in a proportion of 5 to 50% by weight, and the inner layer is formed from polyethylene. The ratio (Mw / Mn) of the weight average molecular weight (Mw) and the number average molecular weight (Mn) of the polypropylene constituting the outer layer is 3.0 or less, and the weight average molecular weight (Mw) of the polyethylene constituting the outer layer And a number average molecular weight (Mn) ratio (Mw / Mn) of 3.5 or less.
The invention according to claim 2 relates to the laminated film for medical containers according to claim 1, wherein the polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.

In the invention according to claim 3, the inner surfaces of the tube-like inflation laminated film formed by coextrusion are heat-sealed in a predetermined contour shape, and the laminated film is cut or punched along the heat-sealed portion. A medical container in which a cap is attached to a formed main body, wherein the laminated film is formed of polypropylene in which polyethylene is mixed at a ratio of 5 to 50% by weight of the outer layer, and the inner layer is formed of polyethylene. The ratio (Mw / Mn) of the weight average molecular weight (Mw) and the number average molecular weight (Mn) of the polypropylene constituting the outer layer is 3.0 or less, and the weight average molecular weight (Mw) of the polyethylene constituting the outer layer And a ratio of the number average molecular weight (Mn) (Mw / Mn) to a medical container, wherein the ratio is 3.5 or less
The invention according to claim 4 relates to the medical container according to claim 3, wherein the polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.

The invention according to claim 5 is formed by coextrusion, the outer layer is made of polypropylene mixed with polyethylene in a proportion of 5 to 50% by weight, the inner layer is made of polyethylene, and the polypropylene constituting the outer layer is made of polypropylene. The ratio of the weight average molecular weight (Mw) to the number average molecular weight (Mn) (Mw / Mn) is 3.0 or less, the ratio of the weight average molecular weight (Mw) and the number average molecular weight (Mn) of the polyethylene constituting the outer layer. (Mw / Mn) is 3.5 or less, the inner surfaces of the blown laminated film are heat-sealed in a predetermined contour shape, and the laminated film is cut or punched along the heat-sealed portion. The present invention relates to a method for manufacturing a medical container, wherein a stopper is inserted, and the main body and the plug are welded by heating from the outer surface side of the main body.
The invention according to claim 6 relates to the method for producing a medical container according to claim 5, wherein the polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.

Since it is a tube-like inflation laminated film formed by co-extrusion of polyethylene and polypropylene, it is possible to prevent contamination during production because the inner surface is heated without being exposed to the outside air during production.
Since the polyethylene forming the inner layer of the laminated film is a polyethylene having a narrow molecular weight distribution width, for example, a polyethylene polymerized by a metallocene catalyst, transparency is satisfied without lowering the density, and elution of low molecular weight components is also small. It is possible to have high heat seal strength.
In addition, since the polypropylene forming the outer layer of the laminated film is a polypropylene having a narrow molecular weight distribution width, for example, a polypropylene polymerized randomly by a metallocene catalyst, it is excellent in flexibility while maintaining high transparency and heat resistance. Furthermore, compatibility with the inner layer polyethylene is also excellent by mixing polypropylene with a narrow molecular weight distribution, such as polyethylene polymerized with a metallocene catalyst.
By co-extrusion of these polyethylene and polypropylene, it is possible to obtain a tubular inflation laminated film having high transparency, excellent heat resistance and flexibility, a medical container using the laminated film, and a method for producing the same.

The best mode for carrying out the present invention will be described below with reference to the drawings.
FIG. 1 is a schematic perspective view showing a first embodiment of a laminated film for medical containers according to the present invention.
The laminated film for medical containers (1) according to the first embodiment is a tubular inflation laminated film, and as shown in the enlarged circle, an inner layer (2) made of polyethylene and an outer layer (3) made of polypropylene, It has a two-layer structure.
The laminated film (1) having such an inner layer (2) and an outer layer (3) is formed in a tube shape by coextrusion by an inflation method. The coextrusion method may be either an air-cooled inflation method or a water-cooled inflation method.

  In general, in the blown film formation of polypropylene, in the air-cooled inflation method, transparency and gloss are significantly deteriorated as compared with the water-cooled method. Even with the air cooling method, a film having transparency and gloss equivalent to that of the water cooling method can be obtained. Therefore, it becomes possible to improve production efficiency using the air-cooled inflation method. In addition, when the air-cooled inflation method is used, it is easy to widen the film width, so that many medical containers can be taken in the width direction, and the manufacturing cost can be reduced.

The thickness of the inflation film formed in a tube shape can be appropriately set according to the material of the film and the like, but is preferably 50 to 400 μm, more preferably 100 to 300 μm.
In the present invention, by using polypropylene randomly polymerized with a metallocene catalyst as will be described later, a higher strength can be obtained as compared with a film using conventional polypropylene. For example, a thickness of about 200 to 300 μm is conventionally increased in strength. What is required can be reduced to about 150 μm.

The ratio (Mw / Mn) of the weight average molecular weight (Mw) and the number average molecular weight (Mn) of polyethylene (L-LDPE) forming the inner layer (2) of the laminated film (1) is 3.5 or less, more preferably The ratio (Mw / Mn) of the weight average molecular weight (Mw) and the number average molecular weight (Mn) of polypropylene (random PP) forming the outer layer (3) of the laminated film (1) is 3.0 or less. It is 0 or less, more preferably 2.8 or less.
Polyethylene and polypropylene forming such an inner layer (2) can be obtained, for example, by polymerization using a metallocene catalyst.
Polyethylene or polypropylene polymerized by a metallocene catalyst has few branching of side chains, has a uniform molecular weight and comonomer distribution, and provides high transparency, rigidity, heat resistance, and heat seal strength.

Thus, a laminated film formed by using polyethylene and polypropylene having a small ratio (Mw / Mn) of weight average molecular weight (Mw) to number average molecular weight (Mn) and a narrow molecular weight distribution range, specifically, metallocene The laminated film (1) having polyethylene polymerized by the catalyst in the inner layer and polypropylene polymerized randomly by the metallocene catalyst in the outer layer has high transparency and flexibility on the inner layer side, and is high on the outer layer side. Since it has transparency, heat resistance and rigidity, a laminated film excellent in high transparency, heat resistance and flexibility can be obtained and can be suitably used as a medical container.
In addition, by making the polypropylene with high heat resistance into the outer layer (outer surface), it is possible to prevent appearance defects caused by softening due to heat when heat-sealing at the time of bag making, and to obtain a bag-made product with good appearance. Become.

In addition, the polypropylene forming the outer layer (3) includes a polyethylene having a ratio (Mw / Mn) of weight average molecular weight (Mw) to number average molecular weight (Mn) of 3.5 or less, more preferably 3.0 or less. Preferably, polyethylene polymerized with a metallocene catalyst is mixed. This is because compatibility with the inner layer (2) is improved by polymerizing polyethylene with a metallocene catalyst.
The proportion of polyethylene is 5 to 50% by weight, more preferably 5 to 40% by weight, based on the entire mixed resin.
When the proportion of polyethylene is less than 5%, the compatibility with the inner layer (2) becomes poor, and interfacial delamination is likely to occur when heat-sealing, and when it exceeds 50%, the heat resistance during bag making is reduced. Because it invites.

  In the laminated film (1) of the first embodiment having such a two-layer structure, the thickness ratio between the outer layer and the inner layer is preferably 3 to 9 when the outer layer is 1. This is because if the inner layer is too thin, the rigidity is increased, whereas if the inner layer is too thick, the heat resistance is lowered, which is not preferable in either case.

FIG. 2 is a schematic perspective view showing a second embodiment of the laminated film for medical containers according to the present invention.
The laminated film for medical containers (1) according to the second embodiment is a tubular inflation laminated film, and as shown in the enlarged circle, an inner layer (2) made of polyethylene and an intermediate layer (4) made of polyethylene, And a three-layer structure composed of an outer layer (3) made of polypropylene.
The laminated film (1) provided with such an inner layer (2), an intermediate layer (4) and an outer layer (3) is formed in a tube shape by coextrusion by an inflation method. The co-extrusion method may be either an air-cooled inflation method or a water-cooled inflation method, but it is more preferable to use the air-cooled inflation method. The reason is as described in the description of the first embodiment.

In the laminated film (1) according to the second embodiment, for the inner layer (2) made of polyethylene and the outer layer (3) made of polypropylene, the inner layer (2) and the outer layer (3 used in the laminated film of the first embodiment) ) Exactly the same configuration can be adopted.
That is, the polyethylene forming the inner layer (2) of the laminated film (1) has a ratio (Mw / Mn) of weight average molecular weight (Mw) to number average molecular weight (Mn) of 3.5 or less, more preferably 3.0. The polypropylene that is polymerized by, for example, a metallocene catalyst and forms the outer layer (3) of the laminated film (1) is a ratio of the weight average molecular weight (Mw) to the number average molecular weight (Mn). (Mw / Mn) is 3.0 or less, more preferably 2.8 or less, for example, random polymerization with a metallocene catalyst.

Moreover, polyethylene is mixed with the polypropylene forming the outer layer (3), and the ratio of the mixed polyethylene is 5 to 50% by weight, more preferably 5 to 40% by weight of the entire mixed resin.
And what was superposed | polymerized by the metallocene catalyst is used for the polyethylene mixed with the polypropylene which forms the said outer layer (3).

  As described above, for the inner layer (2) made of polyethylene and the outer layer (3) made of polypropylene, the same configuration as the inner layer (2) and outer layer (3) used in the laminated film of the first embodiment should be adopted. As a result, the same excellent effects as those described in the description of the first embodiment can be obtained, which is extremely suitable as a laminated film for medical containers.

The point that the laminated film (1) according to the second embodiment is different from that of the first embodiment is that an intermediate layer (2) made of polyethylene is interposed between an inner layer (2) made of polyethylene and an outer layer (3) made of polypropylene. 4) is interposed.
As the polyethylene forming the middle layer (4), polyethylene (L-LDPE) polymerized with a conventional Ziegler catalyst may be used.
Thus, by interposing the middle layer (4) made of polyethylene between the inner layer (2) made of polyethylene and the outer layer (3) made of polypropylene, compared to the laminate film of the first embodiment, It will be excellent in flexibility while ensuring heat resistance.

  In the laminated film (1) of the second embodiment having such a three-layer structure, the thickness ratio of the outer layer, the middle layer, and the inner layer is 2-5 for the inner layer and 1-2 for the inner layer when the outer layer is 1. Preferably there is. This is because if the middle layer is too thin, the flexibility is inferior, if it is too thick, the heat resistance is inferior, if the inner layer is too thin, the heat seal strength is lowered, and if it is too thick, the transparency is lowered, which is not preferable in either case. Because.

In the present invention, in the laminated film of the second embodiment, polyethylene (L-LDPE) polymerized with a metallocene catalyst instead of polyethylene (L-LDPE) polymerized with a conventional Ziegler catalyst as the middle layer (4). LDPE or the like can also be used.
Moreover, it is also possible to form a laminated film having a multilayer structure of four or more layers as a whole by forming the middle layer (4) into two or more layers.

The above is a structure and manufacturing method of the laminated film for medical containers which concerns on this invention, and the medical container which concerns on this invention is manufactured using an above described laminated film.
That is, the medical container according to the present invention uses the tubular inflation laminated film (1) of the first embodiment or the second embodiment, and the inner surfaces of the laminated film (1) (the inner surfaces of the tubes). Is manufactured by cutting or punching the laminated film along the heat seal portion (5) after heat sealing in accordance with a predetermined contour shape, that is, a desired container outer shape.

In the present invention, when the width of the laminated film (1) is set sufficiently wider than the width of the desired container so that a plurality of containers can be taken in the width direction of the laminated film (1), the productivity is increased. From the viewpoint of
After forming the heat seal part (5) which matched the several desired container external shape simultaneously in the width direction of the laminated film (1) (refer FIG. 3), laminated film (1) along this heat seal part (5) The body (6) of the medical container is obtained by cutting or punching (see FIG. 4).

  The main body (6) of the medical container thus obtained has an internal space at the center (7) and the peripheral edge (8) is sealed by heat sealing. A punched through hole (9) is provided at the center in the width direction of the upper part of the heat-sealed peripheral edge (8), and the inner space of the central part is not heat-sealed at the lower end of the peripheral edge (8). An opening (10) in communication with is provided.

A stopper (11) is attached to the opening (10) by thermal welding, thereby completing the medical container (12) (see FIG. 5).
A known material can be used for the plug (11), and for example, medium density polyethylene (MDPE) or high density polyethylene (HDPE) can be used.
As the heat welding method, known heat seals such as those disclosed in Japanese Utility Model Laid-Open No. 61-194638, Japanese Patent Application Laid-Open No. 3-49762, Japanese Patent Application Laid-Open No. 3-268925, Japanese Patent Application Laid-Open No. 7-16956, and the like. The method can be used.

Conventionally, a mouth plug (11) made of high-density polyethylene (HDPE) or the like is inserted into an opening (10) of a medical container made of a laminated film of polyethylene and polypropylene and welded by heat sealing by external heating. It was difficult. This is because the outer layer polypropylene may be melted by heat of heat sealing.
Therefore, in the past, it has been unavoidable to adopt an inefficient method in which the plug (11) is heated at a high temperature to melt the surface, and then inserted into the opening and welded. Since the outer layer of 1) is made of polypropylene randomly polymerized with a metallocene catalyst having a high melting point (about 135 ° C.), the plug (11) is heated at a lower temperature than the conventional one and the opening of the main body (6) Even if it is inserted in (10), the heating temperature from the outer surface side of the main body can be increased, the plug and the main body can be surely fused and fixed, and the production efficiency is excellent.

Hereinafter, the effects of the present invention will be made clearer by showing examples and comparative examples according to the present invention. However, the present invention is not limited to the following examples.
1. Production of laminated film (Example 1)
Random PP (MFR 7.0, density 0.900 g) whose outer layer is polymerized with a metallocene catalyst in a three-layer air-cooled inflation film molding machine (made by Modern Machinery, outer layer machine 55 mmφ, middle layer machine 65 mmφ, inner layer machine 55 mmφ, die 450φ) / Cm ³ ) (hereinafter abbreviated as PP-1) and L-LDPE (MFR 3.5, density 0.880 g / cm ³ ) (hereinafter abbreviated as PE-1) polymerized with a metallocene catalyst at 90:10. L-LDPE (MFR2.0, density 0.910 g / cm ³ ) polymerized with a Ziegler catalyst, and the inner layer polymerized with a metallocene catalyst (MFR2.0). , A density of 0.921 g / cm ³ ) (hereinafter abbreviated as PE-3) was produced.
The molding temperature was 185 ° C., and the obtained film had a thickness of 210 μm, a width of 740 mm, and a thickness ratio of each layer: outer layer: middle layer: inner layer = 1: 5: 1.
(Example 2)
In Example 1, a three-layer laminated film was produced under the same conditions as in Example 1 except that the mixing ratio of PP-1 and PE-1 forming the outer layer was 80:20.

(Comparative Example 1)
In Example 1, a three-layer laminated film was produced under the same conditions as in Example 1 except that the outer layer was formed only from PP-1.
(Comparative Example 2)
Example 1 except that in Example 1, the outer layer was formed by mixing random PP (MFR 7.0, density 0.900 g / cm ³ ) polymerized with a Ziegler catalyst and PE-1 at a ratio of 90:10. A three-layer laminated film was produced under the same conditions.

(Comparative Example 3)
In Example 1, except that the outer layer was formed by mixing PP-1 and L-LDPE (MFR 0.8, density 0.900 g / cm ³ ) polymerized with a Ziegler catalyst at a ratio of 90:10. A three-layer laminated film was produced under the same conditions as in Example 1.
(Comparative Example 4)
In Example 1, a three-layer laminated film was produced under the same conditions as in Example 1 except that the mixing ratio of PP-1 and PE-1 forming the outer layer was 40:60.
(Comparative Example 5)
In Example 1, the same conditions as in Example 1 were used except that L-LDPE (MFR 2.0, density 0.924 g / cm ³ ) (hereinafter abbreviated as PE-4) polymerized with a Ziegler catalyst was used for the inner layer. A three-layer laminated film was produced.
(Comparative Example 6)
In Example 1, a three-layer laminated film was produced under the same conditions as in Example 1 except that PE-4 was used for the outer layer.

The configurations of the laminated films of Examples 1-2 and Comparative Examples 1-6 are summarized in Table 1.
In Table 1, random PP polymerized with a metallocene catalyst is “PP-M”, random PP polymerized with a Ziegler catalyst is “PP-Z”, and polyethylene polymerized with a metallocene catalyst is “PE-M”. Polyethylene polymerized with a Ziegler catalyst was abbreviated as “PE-Z”.

The characteristics of the films obtained in Examples and Comparative Examples were evaluated.
The evaluation method is as follows.
-Transparency: Haze value was measured according to JIS K7105.
Heat resistance: The obtained film inner layer side and the high-density polyethylene spigot are overlapped and heat sealed (conditions: seal temperature 180 ° C., seal time 1.2 seconds, seal pressure 0.8 MPa), seal part The appearance was visually judged.
Criteria for visual appearance of seal part: ○ (normal seal part), × (wrinkle of seal part, deformation)
-Seal strength: The seal part of the heat seal product used in the above heat resistance evaluation was cut out with a width of 1.5 cm, and the seal strength was measured.
-Flexibility: The tensile elastic modulus was measured according to JIS K7161.

  The results are shown in Table 2.

評価項目の単位は、へーズ（％）、シール強度（N／15mm）、引張弾性率（MPa）である。

The units of evaluation items are haze (%), seal strength (N / 15 mm), and tensile modulus (MPa).

As shown in Table 2, the laminated films obtained in Examples 1 and 2 are excellent in transparency and flexibility, excellent in heat seal strength and heat resistance during bag making, and required for medical container films. It had excellent characteristics in all evaluation items of transparency, flexibility, heat resistance (appearance) and bag-making property (seal strength).
On the other hand, the laminated film obtained by the comparative example satisfies all the evaluation items of transparency, flexibility, heat resistance (appearance) and bag-making property (seal strength) required for the medical container film. There was nothing.
Specifically, in Comparative Example 1 in which the outer layer is composed only of polypropylene, the transparency and flexibility were low, and in Comparative Example 2 in which the polypropylene forming the outer layer was polymerized with a Ziegler catalyst, the transparency and heat resistance were low. . Further, in Comparative Example 3 in which polyethylene mixed with polypropylene forming the outer layer was polymerized with a Ziegler catalyst, the transparency and flexibility were low, and the ratio of polyethylene mixed with polypropylene forming the outer layer was high (over 50%). In Comparative Example 4, the heat resistance was low. Further, Comparative Example 5 in which the polyethylene forming the inner layer was polymerized with a Ziegler catalyst had low transparency and sealing strength, and Comparative Example 6 in which the outer layer was formed only from polyethylene had low transparency and heat resistance.

  The present invention can be suitably used for medical containers for storing and storing infusion solutions, dialysis solutions, organ preservation solutions, and the like.

It is a schematic perspective view which shows 1st embodiment of the laminated film for medical containers which concerns on this invention. It is a schematic perspective view which shows 2nd embodiment of the laminated | multilayer film for heavy packaging bags which concerns on this invention. It is a schematic plan view which shows the heat seal process which is a part of manufacturing process of the medical container which concerns on this invention. It is a figure which shows the state which cut or punched the main body of the medical container which concerns on this invention from a laminated film. It is an external view which shows an example of the medical container which concerns on this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Inflation laminated film 2 Inner layer 3 Outer layer 4 Middle layer 5 Heat seal part 6 Main body of medical container 12 Medical container

Claims (6)

  A tube-like inflation laminated film formed by coextrusion, wherein the outer layer is made of polypropylene mixed with polyethylene in a proportion of 5 to 50% by weight, and the inner layer is made of polyethylene, and constitutes the outer layer. Ratio (Mw / Mn) of weight average molecular weight (Mw) and number average molecular weight (Mn) of polypropylene is 3.0 or less, and weight average molecular weight (Mw) and number average molecular weight (Mn) of polyethylene constituting the outer layer A laminated film for medical containers, wherein the ratio (Mw / Mn) is 3.5 or less.   The laminated film for medical containers according to claim 1, wherein the polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.   The inner surface of the tube-like inflation laminated film formed by coextrusion is heat sealed to a predetermined contour shape, and the body is formed by cutting or punching the laminated film along the heat seal portion. The laminated film has an outer layer made of polypropylene in which polyethylene is mixed at a ratio of 5 to 50% by weight, and an inner layer made of polyethylene, and constitutes the outer layer. Ratio (Mw / Mn) of weight average molecular weight (Mw) and number average molecular weight (Mn) of polypropylene is 3.0 or less, and weight average molecular weight (Mw) and number average molecular weight (Mn) of polyethylene constituting the outer layer The medical container, wherein the ratio (Mw / Mn) is 3.5 or less.   The medical container according to claim 3, wherein polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.   The outer layer is formed by coextrusion, the outer layer is made of polypropylene mixed with polyethylene in a proportion of 5 to 50% by weight, the inner layer is made of polyethylene, and the weight average molecular weight (Mw) and number of the polypropylene constituting the outer layer. The ratio (Mw / Mn) to the average molecular weight (Mn) is 3.0 or less, and the ratio (Mw / Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) of the polyethylene constituting the outer layer is 3. Heat-sealing the inner surfaces of the inflation laminated film having a thickness of 5 or less into a predetermined contour shape, inserting a plug into the main body obtained by cutting or punching the laminated film along the heat-sealed portion, A method for producing a medical container, wherein the main body and the plug are welded by heating from the outer surface side.   6. The method for producing a medical container according to claim 5, wherein the polypropylene and polyethylene constituting the outer layer are polymerized by a metallocene catalyst.

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