JP2007151844A - Multi-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a multi-chamber container where a composition of a housed drug is not changed by dividing and housing a plurality of drugs, and where the respective drugs can be mixed sanitarily in a closed state when they are used. <P>SOLUTION: In the multi-chamber container 1, a space formed by superimposing two laminate sheets 2 so that sealant layers 21 may face each other and sealing the periphery parts of both of the sheets are partitioned by separable weak seal parts 7a and 7b. Each sealant layer of both of one laminate sheet and the other laminate sheet contains annular polyolefin-based resin of ≥Tg100°C in an amount of ≥50 mass%. In the one laminate sheet and the other laminate sheet, a tensile elastic modulus measured based on JIS-K7161 is ≤500 MPa. At least one chambers 6a, 6b and 6c contains a very small quantity of a solution including vitamines of ≤30 ml in total. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a multi-chamber container for storing a small amount of solution of 30 ml or less, and more specifically, a plurality of contents having at least one content containing vitamins are stored in separate storage rooms separated from each other. In addition, in use, it relates to a flexible multi-chamber container suitable for aseptically mixing and discharging the plurality of contents by breaking or peeling off the isolation part (weak seal part). .

In the medical field, it is common practice to administer a plurality of drug components to a patient in a mixed state, but various methods are employed depending on the combination of the drug components to be mixed. For example, in the case of infusion preparations, chemicals containing amino acids and glucose are likely to be altered by the Maillard reaction, so each component is stored in a separate closed storage room and mixed immediately before administration to the patient. To be administered.
In this case, the mixing operation is performed in an aseptically closed state (closed system), and in order to facilitate the mixing operation, a multi-chamber container having a plurality of storage chambers is used, and different drugs are stored in the storage chambers. A method is adopted in which the components are stored, and the storage chamber fractionated immediately before use is communicated in the closed system by some means and mixed.

  Here, when a drug is administered to a patient, it is not preferable that the drug composition changes due to the influence of the container. For example, when an administration drug containing trace elements (such as manganese), vitamins, isosorbate nitrate, etc. as an active ingredient is contained in a container in which polyethylene or polypropylene is used as the material for the inner wall of the container, a medical injection For example, when high-pressure steam sterilization is performed, these components are adsorbed on the inner wall of the container and the composition of the administered drug changes, and the active ingredient is not completely administered to the patient for use. May occur.

  In order to solve such a problem, for example, Patent Document 1: No. 99/039679 proposes a container using a cyclic olefin copolymer in a layer structure. However, this container has a layer structure of polyolefin, cyclic olefin copolymer, and polyolefin in that order from the inside. By setting the thickness of the polyolefin itself in direct contact with the content liquid to be thin, adsorption and sorption of the content liquid component is small. Although the content of the liquid components can be reduced to the above, the adsorption and sorption of the components of the contents will remain.

Patent Document 2: JP-A-2001-157704 and Patent Document 3: JP-A-2001-157705 include polyethylene, α-olefin polymer, ethylene / α-olefin copolymer, ethylene / α-olefin, A mixture of another olefinic monomer terpolymer and a cyclic olefin ring-opening polymer or a hydrogenated product thereof, or an infusion solution constituting an intermediate layer using a cyclic olefin ring-opening polymer or a hydrogenated product thereof. Packaging materials have been proposed. However, in these packaging materials, an olefin resin other than the cyclic polyolefin resin such as LDPE or LLDPE is used as the innermost layer that comes into contact with the contents when forming the container. There is no change in wearing.
A plurality of drugs that are not desirable to be mixed in advance can be stored separately, the composition of the drugs to be stored is not changed, and each drug can be easily mixed without touching the outside environment at the time of use. The development of a container that can be used has been desired.

  By the way, since post-operative patients of gastrointestinal surgery are often unable to be taken orally, nutritional management of such patients is generally performed by administering high calorie infusion (IVH) from the central vein. Has been done. IVH usually contains carbohydrates (glucose) and amino acids, which are nutrient sources, and an electrolyte component. Here, when IVH is administered over a relatively long period of time, trace elements not included in the infusion preparation, vitamin deficiencies, and the like are regarded as problems. Therefore, IVH includes glucose, amino acids, and electrolyte components. In addition, it is essential to add trace elements and vitamins.

  Here, since vitamins generally lack storage stability, they are exclusively used in the form of mixed vitamin preparations or multivitamin preparations (that is, a form in which a stabilizer is added to vitamins to improve storage stability). Vitamin-containing IVH is administered to the patient by mixing the formulation into the IVH formulation immediately before the IVH formulation is administered to the patient. However, such a mixing operation is cumbersome and involves the risk of bacterial contamination during the mixing operation. In particular, since the development of pneumonia due to nosocomial infections in elderly patients is fatal, the person in charge is required to be both efficient and cautious, which places a heavy burden on the person in charge. is the current situation.

  As a method for easily performing the above mixing operation, a method using a multi-chamber container has been proposed. For example, in Patent Document 4: Japanese Patent Laid-Open No. 6-209979 and Patent Document 5: Japanese Patent Laid-Open No. 8-709, fat and sugar are stored in one of the two chambers, and amino acid and electrolyte are stored in the other. At the same time, there has been proposed a method using a multi-chamber container in which various vitamins to be administered are stored in any one of them.

  However, IVH formulations disclosed in these documents further contain fat from the viewpoint of ensuring the storage stability of vitamins to be administered. The administration of such fat is not necessarily tolerated by all patients. For example, administration of large amounts of fat is contraindicated for patients with hyperlipidemia, liver damage, thrombosis, diabetes, and the like. Further, although fat is a kind of nutrient source, the optimum dose varies depending on the patient, and it is essentially desired to control the dose by single administration.

Patent Document 6: Japanese Patent Application Laid-Open No. 11-158061 discloses that a medicine container is divided into three chambers, a solution A containing vitamin B1 and reducing sugar, and a solution containing folic acid (a kind of vitamin) and an amino acid. There has been proposed a multi-chamber container containing B and a solution C containing fat-soluble vitamins and vitamin C separately, and further containing IVH preparations in which the pH of each solution is adjusted to a specific range. However, even in this case, each of the three compartments contains only a specific drug that constitutes the IVH preparation and a vitamin that can be stably stored correspondingly. It is hard to say that the degree of freedom of control is wide and applicable.
Furthermore, since vitamins do not have a large dose, it is desirable to store them in a small amount. However, when cyclic polyolefin or the like is used in order to ensure the storage stability of vitamins, there is a problem that the container becomes hard and it is difficult to discharge a predetermined amount.
Therefore, the development of a storage container that can store specific vitamins independently, has a wide degree of freedom in dose control, communicates and mixes in a closed system, and reliably discharges a predetermined amount. Was demanded.

No. 99/039679 JP 2001-157704 A Japanese Patent Laid-Open No. 2001-157705 Japanese Patent Application Laid-Open No. 6-209979 JP-A-8-709 Japanese Patent Laid-Open No. 11-158061

  This invention is made | formed in view of the said situation, and can isolate | separate and accommodate the some chemical | medical agent containing vitamins which it is not desirable to mix beforehand, and changes the property and active ingredient amount of the chemical | medical agent to accommodate. It is possible to contain specific vitamins independently, and at the time of use, each drug can be easily mixed hygienically in a closed state. It aims at providing the multi-chamber container which can discharge | emit predetermined amount reliably.

  As a result of intensive studies to achieve the above object, the present inventor constituted a multi-chamber container using a laminated sheet comprising a sealant layer mainly composed of a specific resin, and the tensile modulus of the laminated sheet. In addition to reducing the risk of vitamins being adsorbed on the sealant layer as much as possible, by adding flexibility to the container, it is possible to improve the discharge ability to reliably discharge a predetermined amount. A chamber container can be realized, and preferably, the storage stability of vitamins contained in the at least one chamber can be improved by blending a specific component into the sealant layer. As a result, the inventors have made the present invention.

That is, the present invention provides the following multi-chamber container.
Claim 1:
Both laminated sheets are superimposed such that the sealant layer surface of one laminated sheet provided with at least one sealant layer faces the sealant layer surface of another laminated sheet provided with at least one sealant layer, A space formed by sealing the peripheral edge and the peripheral edge of another laminated sheet is a multi-chamber container that contains a small amount of solution with a total content of 30 ml or less partitioned by a weakly peelable peelable part. There,
Both the sealant layers of the one laminated sheet and the other laminated sheet each contain 50% by mass or more of a cyclic polyolefin resin having a glass transition point of 100 ° C. or higher,
The tensile modulus measured according to JIS-K7161 of the one laminated sheet and / or the other laminated sheet is 500 MPa or less,
A multi-chamber container characterized in that a content containing vitamins is stored in at least one of the chambers partitioned by the weak seal portion.
Claim 2:
The multi-chamber container according to claim 1, wherein the multi-chamber container is partitioned into three chambers by the weak seal portion.
Claim 3:
The one laminated sheet and / or the other laminated sheet is a laminated sheet having a sealant layer on one side and a base material layer on the other side, and the glass transition temperature of the cyclic polyolefin resin is 100 to 170 ° C. The multi-chamber container according to claim 1, wherein the base material layer has a melting point of 110 to 220 ° C. and contains 50 mass% or more of a polyolefin resin other than the cyclic polyolefin resin.
Claim 4:
The multi-chamber container according to claim 3, wherein the polyolefin resin contained in the base material layer is a propylene copolymer composition containing the following component (A).
Component (A): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 15 mass% to 50 mass% and the proportion of elution at 60 ° C. to 90 ° C. is the total amount of elution. A propylene-based copolymer that is 5% by mass or more and less than 15% by mass with respect to.
Claim 5:
The multi-chamber container according to claim 4, wherein the propylene-based copolymer composition further comprises the following component (B).
Component (B): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass, and the proportion of elution at 60 ° C. to 90 ° C. is the total amount eluted. A propylene-based copolymer that is 15% by mass or more and 70% by mass or less based on the weight.
Claim 6:
The multi-chamber container according to any one of claims 1 to 5, wherein the cyclic polyolefin resin is one or a combination of two or more polynorbornene resins obtained by polymerizing norbornene monomers.
Claim 7:
Either of the one laminated sheet and the other laminated sheet is a laminated sheet formed by laminating each constituent layer constituting the laminated sheet without using an adhesive and an anchor agent. The multi-chamber container according to item 1.
Claim 8:
The multi-chamber container according to any one of claims 1 to 7, wherein the sealant layer of the one laminated sheet and / or the sealant layer of the other laminated sheet contains vitamin E in a range of 50 to 1000 ppm (mass). .

  According to the present invention, it is possible to isolate and contain a plurality of medicines containing vitamins that are not desirable to be mixed in advance, without changing the properties of the medicines to be contained and the amount of active ingredients, and the specific vitamins Thus, a multi-chamber container is provided that can contain a small amount of solution that can be stored independently and can be easily mixed in a closed state in a sanitary manner. Such a multi-chamber container is suitable as a container for storing, for example, an infusion preparation (IVH) for central intravenous administration and contents containing vitamins mixed therewith. In addition, since the multi-chamber container of the present invention has a specific tensile elastic modulus for the laminated sheet constituting the container, the work of communicating the weak seal portion and the discharge of mixed contents are good, and the total content liquid is Even in the case of 30 ml or less, a predetermined amount can be reliably discharged. Moreover, since the sealant layer of the laminated sheet constituting the container is a specific resin, it is excellent in heat sealability of the inner wall of the container made of cyclic polyolefin resin, and is required for a medical injection, for example, 100 ° C. or more This is a multi-chamber container capable of realizing a form in which the container is not deformed even when the high-pressure steam sterilization treatment is performed, and liquid leakage does not occur even when the contents are liquid.

Hereinafter, the present invention will be described in more detail. FIG. 1 is a plan view of a multi-chamber container 1 showing an example of an embodiment of the multi-chamber container of the present invention, FIG. 2 is an XX cross-sectional view of the multi-chamber container 1 shown in FIG. 1, and FIG. It is YY sectional drawing of the multiple chamber container 1 shown.
The multi-chamber container 1 shown in FIGS. 1 to 3 is a port having two laminated sheets 2 composed of a sealant layer 21, an intermediate layer 22, and a surface layer 23, a sealing member (not shown), and a boat-shaped weld base 31. Part 3. That is, in the multi-chamber container 1, the sheets 2 and 2 are overlapped so that the sealant layers 21 face each other so that the welding base 31 of the port portion 3 is held at a predetermined position, The position is thermocompression-bonded to provide a strong seal portion 4 (welding between both sheets), a strong seal portion 5 (welding between the sheet 2 and the welding base 31), and further providing the strong seal portions 4 and 5. Is formed by providing weak seal portions 7a and 7b that divide the space formed between the two sheets into three chambers 6a, 6b, and 6c. The chambers 6a, 6b, and 6c contain contents (not shown) 8a, 8b, and 8c, respectively, and at least one of the contents 8a, 8b, and 8c contains vitamins.

  In the multi-chamber container 1, the chamber 6c and the chamber 6a, or the chamber 6c and the chamber 6b are formed adjacent to each other, and the chamber 6c and the chamber 6a are isolated from each other by being blocked by the weak seal portion 7a. The chamber 6b is isolated by being cut off by a weak seal portion 7b. The multi-chamber container 1 is configured such that the chambers 6a, 6b, and 6c can communicate with each other in a sealed environment by breaking (peeling) the weak seal portions 7a and 7b. It is comprised so that discharge | emission from the port part 3 to the container exterior is possible.

When the multi-chamber container 1 is used, first, for example, the chamber 6a for accommodating the contents 8a and 8b in a state where the flow path communicating the inside and outside of the container of the port portion 3 is sealed by the sealing member (not shown). The weak seal portions 7a, 7b are peeled off sequentially or simultaneously by gripping the 6b portion or the like, and the chambers 6a, 6b, 6c are connected integrally to obtain a mixed product of the contents 8a, 8b, 8c. Thereafter, the sealing of the port portion 3 is released, and the mixed product is discharged out of the container. In FIG. 1, since the discharge port of the port part 3 is shape | molded in the shape of a needle | hook, it can also be used as it is as a part of infusion kit.
In the multi-chamber container 1 of the present embodiment, the shape of the chambers 6a and 6b is formed so as to expand from the vicinity of the boundary position with the chamber 6c toward the inside of the chambers 6a and 6b. , 8b can be reliably guided to the chamber 6c, and the remaining contents are reduced.

  Here, on the basis of the above-described embodiment, it is possible to appropriately change the design of the shape and components of the multi-chamber container 1 as long as the object of the present invention is not impaired. The thickness of the sheets constituting the multi-chamber container, the number of content storage chambers (the number of chambers may be two or four or more), the presence / absence of the port portion, and the form (including the form of the weld base) ), The number, the sealing mode of the port portion, the opening method, and the like are not particularly limited. The multi-chamber container of the present invention may be opened by cutting the corners or the like of the flexible container with a scissors or the like without using a port member, or may be peel-opened by sealing a film lid. A port member whose one end is closed in advance may be used to fold (break open), or a lid member may be detachably fitted or screwed to seal the port portion, and the lid The material may be removed so as to be resealable.

  As a sealing method of both sheets, either a method using an adhesive or a method of heat welding can be employed, and a method of inserting an easy peel tape may be used to form a weak seal portion. By setting the sealing conditions (adhesive type, pressure bonding temperature conditions at the time of heat welding, pressure bonding time conditions, pressure bonding pressure conditions, etc.) and the material of the sealant layer provided on the inner surface of the container, the strong seal part and weak seal part can be It is also possible to make them separately.

  Moreover, it is also possible to previously form a recess having an appropriate depth at the sheet position forming the inner wall surface of each chamber by drawing. The shape of such a recess in plan view is not particularly limited, and may be rectangular or circular in plan view. However, from the viewpoint of good dischargeability, the recess is a shallow recess having an elliptical shape in plan view. Is preferred.

  Further, the intermediate layer of the laminated sheet may be a layer for adhering the inner and outer layers, but is a layer for improving light shielding properties and gas barrier properties such as a metal foil and an ethylene-vinyl alcohol copolymer resin layer. There may be a plurality of layers. Furthermore, as will be described later, the intermediate layer may be omitted.

  The method for filling the multi-chamber container with the contents is not particularly limited. A weak seal part is prepared so that the peripheral part of the sheet is strongly sealed in advance and a container having a port part that can be opened and closed is prepared, and after the first contents are accommodated in the container through the port part, the first contents are sealed. The inside and outside of the container communicate with each other when the process of repeating the process of partitioning the inside of the container and storing the second contents into the container through the port part as many times as necessary, or when providing a strong seal part at the periphery of the sheet. After the possible unsealed part is provided and the shape of the container is adjusted (after the predetermined chamber is formed in the container), the predetermined content is filled into the predetermined chamber through the unsealed part, and then unsealed A method of sealing a portion, further, forming a recess in one sheet or both sheets in advance and filling the recess with the contents, and then superimposing both sheets, etc. it can.

  In general, when crystalline olefin resin such as polyethylene or polypropylene is used as the material for the inner wall of the container, and vitamins and trace elements are stored, the rate of adsorption and sorption of drug components on the inner wall of the container is high. And the content of each of these components is significantly reduced. In particular, when vitamins and the like are stored in a small amount, the area of the sealant layer that comes into contact with a unit amount of vitamins and the like increases, and the content thereof greatly decreases with time. In the present invention, the inner wall surface of the multi-chamber container is composed of a specific resin (containing 50% by mass or more of a cyclic polyolefin resin having a glass transition point of 100 ° C. or higher). This realizes a multi-chamber container in which the extent to which the adsorption and sorption occurs is reduced as much as possible. In addition, since a cyclic polyolefin resin having a glass transition temperature of 100 ° C. or higher is used as a main component for the sealant layer, the container is deformed even when subjected to high-pressure steam sterilization at 100 ° C. or higher, which is required for medical injections. Or the possibility of leakage of contents due to bag breakage is reduced as much as possible.

  In general, when a cyclic polyolefin resin is used, the container becomes hard, making it difficult to deform the container, and hurting hands and fingers due to the hardness of the container when discharging the contents. There is a risk of In the present invention, since at least one of the laminated sheets is a sheet having a tensile modulus of elasticity of 500 MPa or less, preferably 400 MPa or less, more preferably 350 MPa or less, the contents can be easily discharged, and a predetermined predetermined amount is ensured. Therefore, when the mixed medicine is further poured into an infusion bag or the like and mixed, the mixing ratio of the medicine becomes accurate. Further, it is easy to fold the container in half or to squeeze the container by hand, so that the weak seal portion can be easily communicated. When a sheet having a tensile modulus of elasticity exceeding 500 MPa is used for both, there is a possibility that such a discharge operation or communication operation of the contents becomes difficult, and there is a problem that a hand or a finger is damaged during the operation. By limiting the tensile elastic modulus of at least one of the laminated sheets to the above range, even if the total container capacity (ml) of the multi-chamber container of the present invention is 30 ml or less, In the multi-chamber container of the invention, it is possible to ensure the ease of discharging contents and communicating between the chambers.

  The glass transition point of the cyclic polyolefin resin contained in the sealant layer is 100 ° C. or higher, preferably 105 ° C. or higher, more preferably 120 ° C. or higher, from the heat resistance when the high-pressure steam sterilization is performed. Since the base material may be softened during heat sealing, the upper limit is usually 170 ° C. or lower, preferably 165 ° C. or lower. The proportion of the cyclic polyolefin resin contained in the sealant layer is 50% by mass or more, preferably 70% by mass or more, more preferably 80% by mass or more, and may be 100% by mass. If it is less than 50% by mass, the performance of preventing the adsorption and sorption of the active ingredient of the drug is lowered. In the present invention, “glass transition temperature” means a value measured according to JIS K7121 (DSC).

The one laminated sheet and / or other laminated sheet in the present invention is preferably a laminated sheet having a sealant layer on one side and a base material layer on the other side.
Here, although there is no restriction | limiting in particular as a base material layer, It is preferable that it is melting | fusing point 110-220 degreeC and is 50 mass% or more of polyolefin resin which is not cyclic polyolefin resin. By using such a base material layer, even when a sealant layer containing a cyclic polyolefin resin having a glass transition temperature of 100 ° C. or higher as a main component is also employed, heat sealing for constituting the container without deforming the container The sealant layer can be thermally welded without any inconvenience such as opening a hole in a part of the container by heat at the time of sealing. That is, conventionally, when a sealant layer mainly composed of a cyclic polyolefin resin having a glass transition temperature of 100 ° C. or higher is employed, the sealing properties between the laminated films for forming the container or between the laminated film and the port member are remarkably inferior. In some cases, the sealing portion may be deformed at the time of sealing, or the sealing edge portion (the root of the sealing portion) may be broken. However, in the present invention, as a base material, a polyolefin resin other than a cyclic polyolefin resin having a melting point of 110 to 220 ° C is used as a main component, and a sealant containing a cyclic polyolefin resin having a glass transition temperature of 100 ° C or higher as a main component. By using in combination with the layer, the inconvenience that the seal part is deformed or the seal edge part is broken at the time of sealing for forming the container is eliminated. In addition, when combining the base material and the sealant layer, the base material may melt. Therefore, it is preferable to set the melting point of the base material to be higher than the glass transition temperature of the sealant layer. preferable. And since polyolefin-based resins other than cyclic polyolefin-based resins are superior in flexibility compared to cyclic polyolefin-based resins, the heat sealability of the sealant layer is also improved without impairing flexibility when used as a laminated film. It becomes possible to heat seal with the sealing strength. From the viewpoint of flexibility, it is preferable not to use an adhesive layer during lamination. The multi-chamber container of the present invention formed of a laminated film combining such a sealant layer and a base material layer has sufficient heat resistance during container sterilization (retort sterilization), and also has flexibility and drop strength. It will be an excellent container.

Here, the method for sealing the laminated sheets to each other in the present invention is not particularly limited, but the one laminated sheet and / or the other laminated sheet is provided with a sealant layer on one side, and the base material layer is provided on the other side. A polyolefin sheet other than a cyclic polyolefin resin having a glass transition temperature of 100 to 170 ° C. and a melting point of 110 to 220 ° C. In the case of a laminated sheet containing at least mass%, it is preferable to employ the following sealing conditions in order to ensure the shape and strength of the container.
(Ii) Sealing conditions (thermal welding conditions) between the peripheral edge of one laminated sheet and the peripheral edge of another laminated sheet
Temperature: Usually 180-240 ° C, preferably 190-220 ° C
Pressure: Usually 0.1 to 0.8 MPa, preferably 0.2 to 0.6 MPa
Time: Usually 2 to 12 seconds, preferably 4 to 10 seconds (I-ii) Sealing conditions of the peelable weak seal portion (thermal welding conditions)
Temperature: Usually 160 to 230 ° C, preferably 180 to 210 ° C
Pressure: Usually 0.1 to 0.6 MPa, preferably 0.2 to 0.4 MPa
Time: Usually 3 to 10 seconds, preferably 4 to 8 seconds

  In addition, as a ratio which polyolefin resin other than cyclic polyolefin resin of melting | fusing point 110-220 degreeC occupies for the said base material layer, it is 80 mass% or more normally, Preferably it is 100 mass%. If the ratio is less than 80% by mass, the seal portion edge may be deformed or broken.

When the polyolefin resin contained in the base material layer is a propylene copolymer composition containing the following component (A), the heat resistance, flexibility, and transparency of the multi-chamber container of the present invention are compatible. This is preferable.
Component (A): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 15 mass% to 50 mass% and the proportion of elution at 60 ° C. to 90 ° C. is the total amount of elution. A propylene-based copolymer that is 5% by mass or more and less than 15% by mass with respect to.

Moreover, when the said propylene-type copolymer composition contains the following (B) component further, the stickiness of the container surface of the multi-chamber container of this invention can be reduced, and moderate firmness can be provided. Is preferred.
Component (B): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass, and the proportion of elution at 60 ° C. to 90 ° C. is the total amount eluted. A propylene-based copolymer that is 15% by mass or more and 70% by mass or less based on the weight.

  Here, temperature rising elution fractionation (TREF) is a known method for analyzing the composition distribution of a polymer, and in principle, since each polymer component has a different crystal structure, In this method, the composition distribution of the polymer is analyzed by utilizing the fact that the deposition rate or dissolution rate of the polymer is different for each polymer. That is, when a polymer is completely dissolved in a solvent at a high temperature and then gradually cooled in the presence of an inert carrier, first, a highly crystalline polymer component that is easily crystallized first precipitates on the surface of the inert carrier. A polymer layer is formed, and then a low crystalline or amorphous polymer component that is difficult to crystallize is deposited to form a polymer layer. Next, after the polymer layer is formed in this way, when the temperature is raised continuously or stepwise, the low crystalline or amorphous polymer component is eluted, and the high crystalline polymer component is finally eluted. Become. That is, it is possible to analyze the polymer composition distribution from the elution curve drawn by the elution amount and elution temperature at each temperature. In the present invention, o-dichlorobenzene is used as a solvent used in the temperature rising elution fractionation method, and a temperature range of 0 to 140 ° C. is employed.

  In the present invention, the proportion of the (A) component eluted at 0 ° C. is usually 15% by mass or more, preferably 18% by mass or more, and the upper limit is usually 50% by mass or less, preferably It is 40 mass% or less. If the ratio is too small, the flexibility of the propylene-based copolymer composition may be reduced, the contents may not be easily discharged, and the created multi-chamber container has a strong feel, The drop strength tends to be inferior. On the other hand, if the ratio is too large, a sticky feeling may occur on the outer surface of the multi-chamber container when sterilization is performed at 100 ° C. or higher, and sticking occurs with other multi-chamber containers during sterilization. There is. This tendency becomes more prominent when sterilization at 121 ° C. is performed.

  Moreover, as a ratio which the elution amount in 60 degreeC or more and 90 degrees C or less of the said (A) component occupies with respect to the total elution amount, it is 5 mass% or more normally, Preferably it is 6 mass% or more, Usually, less than 15 mass% as an upper limit, Preferably it is 10 mass% or less. If the proportion is too small, the transparency of the propylene-based copolymer composition may be inferior. On the other hand, if the proportion is too large, the heat resistance of the propylene-based copolymer composition is inferior, and the resulting multi-chamber is obtained. The container may be deformed during sterilization at 100 ° C. This tendency becomes more prominent when sterilization at 121 ° C. is performed. Further, the seal part may be deformed or the seal edge part may be broken during sealing for forming the multi-chamber container.

  In the present invention, the proportion of the (B) component eluted at 0 ° C. is usually 0% by mass or more, preferably 2% by mass or more, and the upper limit is usually 25% by mass or less, preferably It is 15 mass% or less. When the ratio is too large, a sticky feeling may occur on the surface of the multi-chamber container when sterilization is performed at 100 ° C. or higher.

  Further, the proportion of the elution amount of the component (B) at 60 ° C. or more and 90 ° C. or less to the total elution amount is usually 15% by mass or more, preferably 20% by mass or more, and the upper limit is usually 70% by mass or less. Preferably it is 60 mass% or less. If the ratio is too small, the multi-chamber container may not have a proper stiffness. On the other hand, if the ratio is too large, the heat resistance of the propylene-based copolymer composition is inferior, and the created container However, the multi-chamber container may be deformed during sterilization at 100 ° C or higher. This tendency becomes more prominent when sterilization at 121 ° C. is performed.

  The propylene-based copolymer composition in the present invention preferably contains the component (A) as a main component (50% by mass or more, preferably 55% by mass or more), and the component (A) alone However, it is also suitable to use the component (B) together with the component (A). The component (A) is a component excellent in heat resistance and flexibility, and the component (B) is a component excellent in heat resistance and capable of giving an appropriate stiffness to the outermost layer. The handleability in the post process can be improved. By blending component (B) with component (A), there was no stickiness even after sterilization of the resulting multi-chamber container at 100 ° C. or higher, and it had transparency, flexibility and stiffness. It is possible to maintain the state.

  In addition, as a ratio for which the (B) component accounts in the said propylene-type copolymer composition, it is 50 mass% or less normally, Preferably it is 45 mass% or less. When the blending ratio of the component (B) exceeds 50% by mass, the multi-chamber container becomes hard, the contents are poorly discharged, and may not be suitable as a multi-chamber container.

  The compounding ratio of the component (A) to the component (B) is usually (A) component: (B) component = 100: 0-50: 50 (mass ratio), preferably 98: 2-55: 45, More preferably, the ratio is 90:10 to 60:40 (mass ratio). If the compounding ratio of the component (A) is too small, the flexibility of the resulting multi-chamber container will be reduced, and the risk of bag breakage will increase in subsequent processes such as transportation and outer layer packaging, and there will be problems with the discharge properties. There is a case.

The propylene copolymer of the component (A) and the component (B) is a propylene copolymer composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms.
Here, examples of the α-olefin having 4 to 8 carbon atoms include butene-1, 3-methylbutene-1, pentene-1, 4-methylpentene-1, hexene-1, octene-1, and the like. These can be used alone or in combination of two or more.

  More specifically, as the propylene-based copolymer component in the present invention, a copolymer component composed of propylene and ethylene, or a propylene-based copolymer composed of propylene, ethylene, and an α-olefin having 4 to 8 carbon atoms. It is preferable that it is a component, and it is preferable to employ butene-1 as the α-olefin having 4 to 8 carbon atoms.

Examples of the method for producing the propylene copolymer of the component (A) and the component (B) include the following methods (i) to (iii):
(I) When performing sequential polymerization of at least two stages, a random copolymer by introducing propylene homopolymer or propylene and a small amount of ethylene and / or an α-olefin having 4 to 8 carbon atoms at the first stage polymerization A process for producing a random copolymer of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms in the presence of the polymer obtained in the previous stage after the second stage polymerization.
(Ii) Propylene homopolymer, or random copolymer of propylene and a small amount of ethylene and / or an α-olefin having 4 to 8 carbon atoms, and ethylene and an α-olefin having 4 to 8 carbon atoms A blending method,
(Iii) Propylene homopolymer, or a random copolymer of propylene and a small amount of ethylene and / or an α-olefin having 4 to 8 carbon atoms, and random copolymer of ethylene and / or 4 to 8 carbon atoms and propylene A blending method,
Can be adopted. Among these, it is preferable to use the method (i) from the viewpoint of economy.

  Although it does not specifically limit as a catalyst used for the sequential polymerization of said (i), It consists of an organic aluminum compound and the solid component which essentially needs a titanium atom, a magnesium atom, a halogen atom, and an electron-donating compound. Those are preferred.

Examples of the organoaluminum compound include a general formula R ¹ _m AlX _(3-m) (wherein R ¹ represents a hydrocarbon residue having 1 to 12 carbon atoms, X represents a halogen atom, and m represents 1 to 3). Is used). Specific examples of such organoaluminum compounds include trialkylaluminum halides such as trimethylaluminum chloride and triethylaluminum chloride, dialkylaluminum halides such as dimethylaluminum chloride and diethylaluminum chloride, alkyls such as methylaluminum sesquichloride and ethylaluminum sesquichloride. Examples include aluminum sesquihalides, alkylaluminum dihalides such as methylaluminum dichloride and ethylaluminum dichloride, and alkylaluminum hydrides such as diethylaluminum hydride.

In addition, as a solid component essentially including the above titanium atom, magnesium atom, halogen atom, and electron donating compound, those known in this kind of polymerization can be used, and as a titanium compound serving as a titanium atom supply source, For example, the general formula Ti (OR ² ) _(4-n) X _n (wherein R ² represents a hydrocarbon residue having 1 to 10 carbon atoms, X represents a halogen atom, and n is a number from 0 to 4). ) Is used. Of these, titanium tetrachloride, tetraethoxy titanium, tetrabutoxy titanium and the like are preferably used.

  Examples of the magnesium compound that serves as a supply source of the magnesium atom include dialkyl magnesium, magnesium dihalide, dialkoxy magnesium, and alkoxy magnesium halide. Among these, magnesium dihalide is preferable. Examples of the halogen atom include fluorine, chlorine, bromine and iodine. Among them, chlorine is preferable. The halogen atom is usually supplied from the above-described titanium compound or magnesium compound, but may be supplied from another halogen source such as an aluminum halide, a silicon halide, or a tungsten halide.

  Examples of the electron donating compound include alcohols, phenols, ketones, aldehydes, carboxylic acids, oxygen-containing compounds such as organic acids or inorganic acids and derivatives thereof, ammonia, amines, nitriles, isocyanates, and the like. Nitrogen-containing compounds and the like can be mentioned, among which inorganic acid esters, organic acid esters, and organic acid halides are preferable, and silicic acid esters, phthalic acid esters, acetic acid cellosolve esters, and phthalic acid halides are particularly preferable.

Here, as said silicic acid ester, for example, R ³ R ⁴ _(3-p) Si (OR ⁵ ) _p (wherein R ³ is a branch having 3 to 20 carbon atoms (preferably 4 to 10). An aliphatic hydrocarbon residue or a cyclic aliphatic hydrocarbon residue having 5 to 20 carbon atoms (preferably 6 to 10 carbon atoms), wherein R ⁴ is a branched or branched group having 1 to 20 carbon atoms (preferably 1 to 10 carbon atoms); A straight-chain aliphatic hydrocarbon residue, R ⁵ represents an aliphatic hydrocarbon residue having 1 to 10 carbon atoms (preferably 1 to 4 carbon atoms, and p is a number of 1 to 3). Organic silicon compounds. Specific examples of such organosilicon compounds include t-butyl-methyl-dimethoxysilane, t-butyl-methyl-diethoxysilane, cyclohexyl-methyl-dimethoxysilane, and cyclohexyl-methyl-diethoxysilane.

  When the production method (i) is employed in producing the propylene copolymer of the component (A) and the component (B) in the present invention, propylene or propylene and a small amount of ethylene and / Or an α-olefin having 4 to 8 carbon atoms is supplied, and in the presence of the catalyst as described above, a polymerization temperature of 50 to 150 ° C., preferably 50 to 100 ° C., a partial pressure of propylene of 0.5 to 4.5 MPa, The polymerization is preferably carried out under the conditions of 1.0 to 3.5 MPa, and subsequently, in the second stage polymerization, propylene and ethylene and / or carbon atoms of 4 to 8 in the presence of the polymer obtained by the first stage polymerization. In the presence of the catalyst at a temperature of 50 to 150 ° C., preferably 50 to 100 ° C., and a partial pressure of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, respectively. 3～4.5MPa, preferably be as a condition of 0.5～3.5MPa, performing copolymerization.

  In this case, the polymerization method may be any of batch, continuous, and semi-batch methods, but the first and second polymerizations are preferably carried out in the gas phase or liquid phase. The residence time of the stages can usually be 0.5 to 10 hours, preferably 1 to 5 hours, respectively. In addition, when there is a problem such as stickiness in the powder particles of the composition produced by such a method, the second-stage polymerization is performed after the first-stage polymerization for the purpose of imparting fluidity to the powder particles. Active hydrogen in the range of 100 to 1000 times mol of titanium atoms in the solid component of the catalyst and 2 to 5 times mol of the organoaluminum compound of the catalyst before the start of the polymerization or during the second stage polymerization It is preferable to add a containing compound. Examples of such active hydrogen-containing compounds include water, alcohols, phenols, aldehydes, carboxylic acids, acid amides, ammonia, amines and the like.

  The propylene-based copolymer as the component (A) and the component (B) in the present invention is an elution fraction at 0 ° C. in temperature rising elution fractionation between 0 ° C. and 140 ° C. using o-dichlorobenzene as a solvent. In addition, the ratio of the amount of elution at 60 ° C. or more and 90 ° C. or less is adjusted to be in a specific range. Control of crystallinity of propylene polymer by multi-stage copolymerization of ethylene and / or α-olefin having 4 to 8 carbon atoms, and control of stereoregularity of propylene polymer by selecting catalyst The method of doing is mentioned.

  From the viewpoint of improving heat sealability, the sealant layer in the present invention is preferably used in combination with a cyclic polyolefin resin having a glass transition temperature of 100 ° C. or higher and a cyclic polyolefin resin having a glass transition temperature of less than 100 ° C. It is. In the present invention, the proportion of the cyclic polyolefin resin having a glass transition temperature of less than 100 ° C. in the entire material constituting the sealant layer is usually 50% by mass or less, preferably 30% by mass or less, more preferably 25% by mass or less, More preferably, it is 20 mass% or less. If the amount of the component is too large, the sealing property is improved, but sufficient heat resistance cannot be maintained during sterilization, and the container may be deformed and the object of the present invention may not be achieved.

  In the present invention, the cyclic polyolefin resin means a polymer obtained by polymerizing a monomer composition containing a cyclic olefin monomer, or a derivative thereof. Here, the “derivative” means a hydrogenated product of a resin obtained by polymerizing a monomer composition containing a cyclic olefin monomer.

  Examples of the cyclic olefin monomer include norbornene, norbornadiene, methylnorbornene, dimethylnorbornene, ethylnorbornene, chlorinated norbornene, chloromethylnorbornene, trimethylsilylnorbornene, phenylnorbornene, cyanonorbornene, dicyanonorbornene, methoxycarbonylnorbornene, pyridylnorbornene, nadic anhydride Products, bicyclic cycloolefins such as nadic imides; tricyclocycloolefins such as dicyclopentadiene, dihydrodicyclopentadiene and their alkyl, alkenyl, alkylidene, and aryl substituents; dimethanohexahydronaphthalene, dimethanooctahydronaphthalene, Tetracyclic cycloolefins such as alkyl, alkenyl, alkylidene and aryl substituents Pentacyclic cycloolefins such as tricyclopentadiene; and hexacyclic cycloolefins such as hexamethylene cycloheptanone decene and the like. Further, dinorbornene, a compound in which two norbornene rings are bonded by a hydrocarbon chain or an ester group, and a compound containing a norbornene ring such as an alkyl or aryl substituent thereof can be used. These may be used alone or in combination of two or more. When two or more types are used, a resin having various physical properties can be obtained by appropriately combining a monomer having one double bond to be a thermoplastic resin and a monomer having a plurality of double bonds to be a thermosetting resin. In addition, compared with the case where a single monomer is used, the range in which the monomer can be handled as a liquid may be expanded due to the freezing point depression, which is preferable.

  Among them, examples of the cyclic olefin monomer suitably used in the present invention include norbornene monomers such as dicyclopentadiene, norbornene, and tetracyclododecene (here, “norbornene-based” means that the molecular skeleton includes a norbornene skeleton. Means).

  In addition, from the viewpoint of reducing the interaction with trace components in the contents as much as possible and further improving the water impermeability, it is preferable to use only those that do not contain polar groups as much as possible, Depending on the contents, a monomer having a partial polar group may be used in combination as long as the object of the present invention is not impaired. As such a monomer, for example, a substituent obtained by introducing a halogen group such as chlorine or bromine or an ester group into the above-described norbornene-based monomer can be given. However, the proportion of the monomer having such a polar group in the total amount of the cyclic olefin monomer is usually 30% or less.

  Moreover, in the said monomer composition, it is also possible to use another monomer together with the said cyclic olefin monomer in the range which does not impair the objective of this invention.

  Examples of such other monomers include α-olefins having 2 or more carbon atoms, and more specifically, ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 3-methyl-1- Butene, 3-methyl-1-pentene, 3-ethyl-1-pentene, 4-methyl-1-pentene, 4-methyl-1-hexene, 4,4-dimethyl-1-hexene, 4,4-dimethyl- 1-pentene, 4-ethyl-1-hexene, 3-ethyl-1-hexene, 1-octene, 1-decene, 1-dodecene, 1-tetradecene, 1-hexadecene, 1-octadecene, 1-eicocene, etc. It is done. These can be used alone or in combination. Of these, ethylene or propylene is preferable, and ethylene is particularly preferable.

  The compounding ratio when the cyclic olefin monomer and other monomer are used in combination is not particularly limited, but is usually 98/2 to 30 / as (cyclic olefin monomer) / (other monomer) (mass ratio). 70, preferably 95/5 to 40/60. If the amount of the cyclic olefin monomer is too large, sufficient sealing properties may not be obtained. On the other hand, if the amount is too small, the non-adsorbability of the content components may be impaired.

  In addition, as a polymerization method and a polymerization mechanism in the case of using a plurality of types of monomers in combination, a known method can be used, and the copolymerization may be performed by blending at the time of the monomer, or the block may be blended after polymerization to some extent. It may be copolymerized. Further, it may be ring-opening polymerization or addition polymerization.

  The cyclic polyolefin resin in the present invention is one or a combination of two or more polynorbornene resins obtained by polymerizing one or more of the norbornene monomers, or the norbornene-based resin. It is a combination of one or two or more of hydrogenated polynorbornene resins obtained by polymerizing one or more monomers, and has a good heat-sealing property. It is suitable from the viewpoint of realizing a multi-chamber container that can be used for medical purposes such as a medical container that contains elements and the like.

  As a specific structure of the cyclic polyolefin-based resin, for example, a structural formula represented by the following general formula (1) or (2) can be shown.

（式中、Ｒ⁶，Ｒ⁷，Ｒ⁸，Ｒ⁹は互いに同一又は異種の炭素数１〜２０の有機基を示し、また、Ｒ⁶とＲ⁷、及び／又はＲ⁸とＲ⁹は互いに環を形成していてもよい。ｍ，ｐは０または１以上の整数を示す。ｌ，ｎは１以上の整数を示す。）

(In the formula, R ⁶ , R ⁷ , R ⁸ and R ⁹ are the same or different organic groups having 1 to 20 carbon atoms, and R ⁶ and R ⁷ and / or R ⁸ and R ⁹ are (The ring may form a ring. M and p represent 0 or an integer of 1 or more. L and n represent an integer of 1 or more.)

  More specifically, examples of the organic group having 1 to 20 carbon atoms include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, t-butyl, i-pentyl, t-pentyl, n-hexyl, n-heptyl, n-octyl, t-octyl (1,1-dimethyl-3,3-dimethylbutyl), 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, Alkyl groups such as pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, icosyl; cycloalkyl groups such as cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl; 1-methylcyclopentyl, 1-methylcyclohexyl, 1-methyl-4-i-propyl Alkylcycloalkyl groups such as cyclohexyl; Alkenyl groups such as phenyl, propenyl, butenyl, 2-butenyl, hexenyl, cyclohexenyl; aryl groups such as phenyl, naphthyl, methylphenyl, methoxyphenyl, biphenyl, phenoxyphenyl, chlorophenyl, and sulfophenyl An aralkyl group such as a benzyl group, a 2-phenylethyl group (phenethyl group), an α-methylbenzyl group, an α, α-dimethylbenzyl group, and the like, but is not limited thereto. These may be used alone or in combination of two or more.

  The glass transition temperature of such a cyclic polyolefin can be appropriately adjusted by appropriately selecting the values of l, m, n, and p in the above general formulas (1) and (2), or substituents. . The glass transition temperatures of the cyclic polyolefins other than the above general formulas (1) and (2) are also arbitrarily adjusted by appropriately setting the monomer species to be used, the blending ratio of the monomer species, the monomer arrangement, the type of substituents, and the like. be able to.

  Commercially available products can be used as the cyclic polyolefin represented by the general formula (1), and for example, ZEONEX and ZEONOR manufactured by ZEON CORPORATION can be suitably used.

  As the cyclic polyolefin represented by the general formula (2), a commercially available product can be used. For example, Appel manufactured by Mitsui Chemicals, Inc. and TOPAS manufactured by TICONA can be preferably used.

In addition, it is more suitable to add vitamin E (tocopherol) in the range of 50-1000 ppm (mass ratio) to the said sealant layer in this invention. Addition of vitamin E to the sealant layer can prevent deterioration of the fat-soluble vitamins over time, particularly when the content contains fat-soluble vitamins.
So far, a multi-chamber container containing fat-soluble vitamins has been proposed, but there has been inconvenience such as mixing with fat and containing it. Moreover, when accommodating vitamins with a small quantity, since the area of the sealant layer which contacts with the unit quantity of vitamins becomes large, the content falls significantly with time. In the present invention, fat-soluble vitamins, especially vitamin D, which are easily taken into polyethylene and polypropylene among vitamins, and whose content greatly decreases with time when stored in a polyethylene or polypropylene container, It is intended to provide a container that can suppress a decrease in vitamin D content as much as possible even when accommodated in a small amount. Moreover, the stability of vitamin D can be improved by blending the specific additive into the sealant layer. The multi-chamber container of the present invention has a great medical value in the sense of maintaining the stability of the content components.
In addition, as addition amount of vitamin E, it is 50-1000 ppm (mass ratio) normally in a sealant layer, Preferably it is 100-800 ppm (mass ratio). If the amount added is less than 50 ppm, the effect of inhibiting the denaturation of vitamin D may not be sufficiently exhibited. On the other hand, if it exceeds 1000 ppm, elution of vitamin E into the contents may be a problem.

  In the present invention, a method for forming a laminated sheet, that is, a laminating method is not particularly limited, and a known method can be used. Both the one laminated sheet and the other laminated sheet constitute each laminated sheet. A laminated sheet formed by laminating the constituent layers without using an adhesive and an anchor agent may allow low molecular weight components to elute from the container side to the contents side (contamination of the contents). It is suitable from the viewpoint of reducing as much as possible. As a method of laminating without using an adhesive and an anchor agent, for example, a co-extrusion film forming method or a melt lamination method using a melt-type adhesive resin (extrusion laminating an adhesive resin melted between two films) A so-called sandwich lamination method) or a method of extruding and laminating one of a base material layer and a sealant layer.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

Examples 1 to 4 and Comparative Examples 1 and 2
A laminated sheet having a surface layer and optionally an intermediate layer and a sealant layer with the constituent materials shown in Table 1 was prepared by a multilayer coextrusion method. Using these laminated sheets, a multi-chamber container having the form shown in FIG. The created multi-chamber container has a port portion made of the same material as the sealant layer, and has a width of 80 mm, a height of 165 mm, and a seal width of 3 to 5 mm except for a wide seal portion near the port. is there. The sealing conditions shown in Table 1 were adopted as the sealing conditions for the container outer periphery sealing portion and the weak sealing portion.
About the obtained multi-chamber container, while measuring the external appearance and heat seal strength after sealing of the outer peripheral seal portion and the weak seal portion, 2.2 ml of vitamin D was added to the chamber 6a shown in FIG. The chamber 6b and the chamber 6c were each filled with 2.2 ml of water and filled with 6.6 ml of total liquid, and then sterilized under the predetermined sterilization conditions shown in Table 1, and a predetermined pressure was applied after the sterilization. In this case, it was evaluated whether or not liquid leakage occurred, and then a part of the container was pressed from the outside with a stronger pressure to evaluate the patency of the weak seal portion, and the results are shown in Table 1. Furthermore, for the contents after sterilization, in accordance with the weight loss rate and the 14th revised Japanese Pharmacopoeia plastic drug container test method (plastic water injection container 1. polyethylene or polypropylene water injection container), It was also evaluated whether it satisfied. The results are shown in Table 1. In addition, the evaluation of the discharge performance of the weak seal part, after mixing the chemical liquid, as a chemical liquid discharge auxiliary tool, cover the port portion with a round cylindrical discharge auxiliary tool, and fold it vertically from the weak seal part, Folding it horizontally from the weak seal part so as to cover the discharge assisting tool and grasping it, the chemical solution was discharged. As a result, the contents could be discharged smoothly with almost no remaining content.

Surface layer constituent material a: The following (A) alone b: The following (A): (B) = 90: 10
c: (A) :( B) below = 70: 30
d: High density polyethylene (Novatec, manufactured by Nippon Polyethylene Co., Ltd.)

Component (A): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 15 mass% to 50 mass% and the proportion of elution at 60 ° C. to 90 ° C. is the total amount of elution. Polymeric polypropylene TPO manufactured by Mitsubishi Chemical Corporation, which is a propylene-based copolymer having a content of 5% by mass or more and less than 15% by mass.
Component (B): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass, and the proportion of elution at 60 ° C. to 90 ° C. is the total amount eluted. Propylene-based copolymer manufactured by Mitsubishi Chemical Co., Ltd. with respect to 15% by mass to 70% by mass.

Intermediate layer composition material e: Adhesive resin (Modic manufactured by Mitsubishi Chemical Corporation)

Sealant layer constituent material I: cyclic polyolefin layer having a glass transition temperature (hereinafter referred to as Tg) of 136 ° C. (manufactured by Nippon Zeon Co., Ltd .: ZEONOR 1420R)
II: 20% by mass of cyclic polyolefin (manufactured by ZEON Corporation: ZEONOR 1020R) having a Tg of 105 ° C., and 80% by mass of cyclic polyolefin (manufactured by ZEON Corporation: ZEONOR 1410R) having a Tg of 136 ° C. Mixed cyclic polyolefin mixed layer III: 20% by mass of cyclic polyolefin having a Tg of 75 ° C. (manufactured by ZEON Corporation: ZEONOR 750R) and cyclic polyolefin having a Tg of 136 ° C. (manufactured by ZEON Corporation: ZEONOR 1420R) Mixed layer IV mixed at a ratio of 80%: Cyclic polyolefin layer having a Tg of 60 ° C. (Mitsui Chemicals, Inc .: APL 8008T manufactured by Apel)
V: Linear low density polyethylene layer (Nippon Polyethylene Co., Ltd .: Harmolex)

Appearance after sealing ○: Good ×: Significant deformation and / or fracture from the edge of the seal
Seal part strength Heat seal strength (180 ° peel strength) of MD direction sample based on JIS Z 0238.
Openability ○: Opened.
×: not opened and / or the outer peripheral part is broken first
The Japanese Pharmacopoeia Test 14th revision Japanese Pharmacopoeia plastic drug container test method (plastic water-based injection container 1. polyethylene or polypropylene water-based injection container).

  According to the present invention, in a multi-chamber container partitioned into multi-chambers that can stably store vitamins for a long period of time, when in use, the weak drugs are communicated to mix the plurality of drugs in a closed state. A multi-chamber container suitable for is provided. In particular, there is provided a multi-chamber container, particularly a multi-chamber container for IVH, which can be easily discharged even with a small volume of medicine and does not reduce the content of vitamin D among vitamins. The above values are tremendous.

It is a top view which shows an example of the multiple chamber container of this invention. It is XX sectional drawing of the multi-chamber container shown in FIG. It is YY sectional drawing of the multi-chamber container shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Multi-chamber container 2 Laminated sheet 21 Sealant layer 22 Intermediate layer 23 Surface layer 3 Port part 31 Welding base part 4,5 Strong seal part 6a, 6b, 6c Chamber 7a, 7b Weak seal part

Claims (8)

Both laminated sheets are superimposed such that the sealant layer surface of one laminated sheet provided with at least one sealant layer faces the sealant layer surface of another laminated sheet provided with at least one sealant layer, A space formed by sealing the peripheral edge and the peripheral edge of another laminated sheet is a multi-chamber container that contains a small amount of solution with a total content of 30 ml or less partitioned by a weakly peelable peelable part. There,
Both the sealant layers of the one laminated sheet and the other laminated sheet each contain 50% by mass or more of a cyclic polyolefin resin having a glass transition point of 100 ° C. or higher,
The tensile modulus measured according to JIS-K7161 of the one laminated sheet and / or the other laminated sheet is 500 MPa or less,
A multi-chamber container characterized in that a content containing vitamins is stored in at least one of the chambers partitioned by the weak seal portion. The multi-chamber container according to claim 1, wherein the multi-chamber container is partitioned into three chambers by the weak seal portion.   The one laminated sheet and / or the other laminated sheet is a laminated sheet having a sealant layer on one side and a base material layer on the other side, and the glass transition temperature of the cyclic polyolefin resin is 100 to 170 ° C. The multi-chamber container according to claim 1, wherein the base material layer has a melting point of 110 to 220 ° C. and contains 50 mass% or more of a polyolefin resin other than the cyclic polyolefin resin. The multi-chamber container according to claim 3, wherein the polyolefin resin contained in the base material layer is a propylene copolymer composition containing the following component (A).
Component (A): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 15 mass% to 50 mass% and the proportion of elution at 60 ° C. to 90 ° C. is the total amount of elution. A propylene-based copolymer that is 5% by mass or more and less than 15% by mass with respect to. The multi-chamber container according to claim 4, wherein the propylene-based copolymer composition further comprises the following component (B).
Component (B): a propylene copolymer component composed of propylene and ethylene and / or an α-olefin having 4 to 8 carbon atoms, and a temperature rising elution fractionation method (temperature: 0 to 140 ° C., solvent: o -Dichlorobenzene), the proportion of elution at 0 ° C. is 0% to 25% by mass, and the proportion of elution at 60 ° C. to 90 ° C. is the total amount eluted. A propylene-based copolymer that is 15% by mass or more and 70% by mass or less based on the weight.   The multi-chamber container according to any one of claims 1 to 5, wherein the cyclic polyolefin resin is one or a combination of two or more polynorbornene resins obtained by polymerizing norbornene monomers.   Either of the one laminated sheet and the other laminated sheet is a laminated sheet formed by laminating each constituent layer constituting the laminated sheet without using an adhesive and an anchor agent. The multi-chamber container according to item 1.   The multi-chamber container according to any one of claims 1 to 7, wherein the sealant layer of the one laminated sheet and / or the sealant layer of the other laminated sheet contains vitamin E in a range of 50 to 1000 ppm (mass). .

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