JP2005091216A - Analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a compact and maintenance-free analyzer that can cope with an analysis having complex procedures without using tubular piping to the utmost. <P>SOLUTION: The analyzer comprises a manifold block B1, where a plurality of channels in which fluid flows internally are formed; at least one valve device for connecting each end section of either pair of channels formed in the manifold block B1; and a printed-circuit board W, having a function for controlling at least one valve device. The manifold block B1 comprises a first perpendicular outer surface S1 that is a nearly perpendicular surface; and a second perpendicular outer surface S2 that is a nearly perpendicular surface and is not adjacent to the first perpendicular outer surface S1. At least one valve device is mounted to the side of the first perpendicular outer surface S1, and the printed-circuit board W is arranged along the second perpendicular outer surface S2. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  This idea relates to the structure of an analyzer that sucks a sample fluid such as liquid or gas from the outside and analyzes the properties and specific components of the sample fluid by a chemical, physical, or optical method.

As a conventional analyzer, a plurality of parts such as a sample introduction part, a pretreatment part, a reagent addition part, a reaction part, a measurement part, and a waste liquid part are connected via piping tubes, valve devices, etc. It is the mainstream that has a separate control unit for operating in accordance with a predetermined procedure.
An analyzer using such a pipe has an advantage that it is easy to assemble and can easily cope with even a complicated analysis method.
However, it is easy to increase the size to secure the space for the piping tube, there is a risk of leakage due to aging of the tube, deterioration of the tube connection part, etc., the tube must be replaced regularly, etc. There was a problem.

Therefore, instead of piping using tubes, a flow path is formed in a block made of transparent plastic member such as acrylic resin or glass, and a part of this flow path functions as a measurement cell, a stirring tank, etc. Analyzes that are designed to be simplified have also been proposed (for example, Non-Patent Document 1).
"Development of a dioxin measurement system in a flue using BioMEMS, report on the results (first year)", New Energy and Industrial Technology Development Organization, March 2002

  However, any of the analyzers such as the above-mentioned Patent Document 1 can only deal with an analysis of an extremely simple procedure using only the flow path in the block. Therefore, in order to deal with the analysis of complicated procedures such as opening and closing a large number of valve devices according to the time chart, in addition to the blocks with flow paths, tube-like piping must be used together as usual. As a result, it has been difficult to reduce the overall size.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a compact and easy-to-maintain analyzer that can handle analysis of complicated procedures without using tubular piping as much as possible. .

According to a first aspect of the present invention, there is provided a manifold block in which a plurality of flow paths through which a fluid flows is formed, and one or more valve devices that connect each end of any pair of flow paths formed in the manifold block. A printed circuit board having a function of controlling at least the one or more valve devices, and the manifold block includes a first vertical outer surface that is a substantially vertical surface, and a first vertical outer surface that is a substantially vertical surface. And the second vertical outer surface not adjacent to each other, the one or more valve devices are attached to the first vertical outer surface side, and the printed circuit board is disposed along the second vertical outer surface. Provide an analyzer.
In the first invention, a temperature adjusting mechanism may be disposed between the manifold block and the printed board.

  A second invention includes a manifold block in which a plurality of flow paths through which a fluid flows is formed, a light source and a light receiving element, and the manifold block is a first slope formed obliquely with respect to a vertical plane. A cell having an outer surface, a second inclined outer surface formed obliquely with respect to a vertical surface on the opposite side above the first inclined outer surface, and a straight line portion extending from the first inclined outer surface to the second inclined outer surface An analyzer is provided, wherein one of the light source and the light receiving element is disposed on the first inclined outer surface side and the other is disposed on the second inclined outer surface side.

  According to a third aspect of the present invention, there is provided a manifold block in which a plurality of flow paths through which a fluid flows is formed, and one or more valve devices that connect each end of any pair of flow paths formed in the manifold block. A printed circuit board having a function of controlling at least the one or more valve devices, a light source and a light receiving element, wherein the manifold block has a first vertical outer surface which is a substantially vertical surface, and a substantially vertical surface. A second vertical outer surface not adjacent to the first vertical outer surface, a first inclined outer surface formed obliquely with respect to the vertical surface, and an inclined side with respect to the vertical surface on the opposite side above the first inclined outer surface And the one or more valve devices are provided on the first vertical outer surface side. The second inclined outer surface is formed on the first inclined outer surface, and the cell channel has a straight line portion extending from the first inclined outer surface to the second inclined outer surface. The printed circuit board is attached to the second lead Are arranged along the outer surface, one said first inclined outer surface of the light source and the light receiving element, to provide a spectrometer, characterized in that the other is disposed on the second inclined outer surface.

  In the second and third inventions, the cell channel has an opening end on the second inclined outer surface, and is connected to a light source or a light receiving element provided on the second inclined outer surface side at the opening end. It is preferable that a light guide to be inserted is inserted.

    According to a fourth aspect of the present invention, there is provided a manifold block in which a plurality of flow paths through which a fluid flows is formed, and one or more valve devices that connect each end of any pair of flow paths formed in the manifold block. A printed circuit board having a function of controlling at least the one or more valve devices, and the manifold block has a first outer surface and a second outer surface located above the first outer surface. The one or more valve devices are attached to a first outer surface side, and the printed circuit board is disposed along the second outer surface.

  In each of the above inventions, it is preferable that one or more liquid inlets and / or liquid outlets are open on the bottom surface of the manifold block.

According to the first and third inventions, since the valve device and the printed circuit board are arranged on different vertical outer surface sides of the manifold block, a liquid leak should occur between the valve device and the flow path of the manifold block. However, the printed circuit board which is an electrical component is not damaged.
According to the second and third aspects of the invention, it is possible to avoid arranging one of the light source and the light receiving element on the bottom surface of the manifold block by arranging the cell flow paths obliquely. Therefore, even if liquid leakage occurs, neither of them damages the light source and the light receiving element which are electrical parts.
According to the fourth invention, since the printed circuit board is disposed above the valve device, even if liquid leakage occurs between the valve device and the flow path of the manifold block, the printed circuit board which is an electrical component Will not be damaged.
Further, according to each of the above-described inventions, it is possible to provide a compact and easy-to-maintain analyzer that can cope with an analysis of a complicated procedure without using a lot of tube-like piping.

  FIG. 1 is a perspective view showing a main part of a silica analyzer according to an embodiment of the present invention. As shown in FIG. 1, the silica analyzer of this embodiment includes a manifold block B1 in which a plurality of flow paths through which fluid flows are formed, a plurality of valve devices, a printed circuit board W, and a light source L1 (L2). And a light receiving element D1.

The manifold block B1 is made of a transparent acrylic resin and has a first vertical outer surface S1 on the front side of the drawing, a second vertical outer surface S2 on the rear side of the drawing (printed circuit board W side), and a first side surface S3 on the left side of the drawing that connects these surfaces. A second side surface S4 on the right side of the drawing, a bottom surface S5, a top surface S6, a first inclined outer surface S7 formed obliquely between the first side surface S3 and the bottom surface S5, a second side surface S4 and a top surface S6. The second inclined outer surface S8 formed diagonally between the two outer surfaces is formed into a substantially rectangular thick plate shape.
The manifold block B1 is installed with the bottom surface S5 facing downward so that the first vertical outer surface S1 and the second vertical outer surface S2 are substantially vertical surfaces.
In the present invention, the term “substantially vertical plane” is a concept including not only a complete vertical plane but also a plane slightly inclined with respect to the vertical plane as long as the effects of the present invention are not impaired.

As the plurality of valve devices, on-off valves SV1, SV2, SV5 to SV13, and manual valves MV1, MV2 for flow rate adjustment are provided. The on-off valves SV1, SV2, SV5 to SV13 are all attached to the first vertical outer surface S1 side so as to connect a pair of flow paths whose ends open on the first vertical outer surface S1 of the manifold block B1. The manual valves MV1 and MV2 are attached to the first vertical outer surface S1 side so as to connect a pair of flow paths in the manifold block B1.
The printed circuit board W is disposed on the second vertical outer surface S2 side. The light source L1 (L2) is disposed to face the first inclined outer surface S7, and the light receiving element D1 is disposed to face the second inclined outer surface S8. The light source L1 is an LED having a wavelength of 820 nm, the light source L2 is an LED having a wavelength of 374 nm, and the wavelength selection mirror M (see FIG. 6) is used so that light from one of the light sources enters the first inclined outer surface S7. It has become. The light receiving element D1 is a silicon photocell.

A recess 21 is formed on the upper left of the first vertical outer surface S1 in the drawing. Moreover, the recessed part 22 is formed in the position which substantially opposes the recessed part 21 of 2nd perpendicular | vertical outer surface S2.
As shown in FIG. 2, the air pump P is fitted into the recess 21 via an o-ring r <b> 1. An air introduction space 21a corresponding to the thickness of the o-ring r1 is formed between the air pump P and the manifold block B1. In addition, a heater HT1 is fitted into the recess 22 via an o-ring r2. A heating space 22a corresponding to the thickness of the o-ring r2 is formed between the heater HT1 and the manifold block B1.
Further, a recess 23 is formed on the lower right side of the second vertical outer surface S2 in the drawing. As shown in FIG. 3, a heater HT2 is fitted in the recess 23 via an o-ring r3. A heating space 23a corresponding to the thickness of the o-ring r3 is formed between the heater HT2 and the manifold block B1.
Moreover, the recessed part 24 for attaching light source L1 (L2) is formed in 1st inclination outer surface S7 adjacent to the lower end of the cell flow path C. As shown in FIG.
Further, a recess 25 is formed on the first vertical outer surface S1 recess 21. A pressure adjustment valve R of an air pressure controller is fitted in the recess 25.
Further, screw holes 31 and 32 are formed in the bottom surface S1, and screw holes 3 and 34 are formed in the top surface S6.

A plurality of flow paths including the cell flow path C are formed inside the manifold block B1.
The cell flow path C is connected to the straight portion C1 linearly formed in the direction from the vicinity of the first inclined outer surface S7 to the second inclined outer surface S8, and is connected to the straight portion C1 and extends in the same direction as the second inclined surface. A light guide insertion portion C2 having an open end on the outer surface S8, a reagent introduction path C3 having an open end connected to the vicinity of the lower end of the light guide insertion portion C2 and extending upward, and a light guide insertion portion C2 The overflow pipe C4 is connected to the vicinity of the open end of the pipe and extends downward.

  Each of the portions constituting the cell channel C has a substantially circular cross section. The light guide insertion part C2 and the reagent introduction path C3 have a larger diameter than the straight part C1, the light guide insertion part C2 has a light guide G that guides light to the light receiving element D1, and the reagent introduction path C3 has nozzles N1 to N3. Are each inserted. The overflow pipe C4 has a smaller diameter than the straight part C1.

Ports 1 to 9 are opened on the bottom surface S1 side of the manifold block B1. Further, the ports 10 to 12 are opened on the upper surface S6 side, and the port 13 is opened on the second side surface S4 side. These ports 1 to 13 are all liquid or gas inlets and / or outlets.
A flow path f <b> 1 is formed between the port 1 and the heating space 22 a of the recess 22. A flow path f2 is formed between the port 2 and one end side of the on-off valve SV11. A flow path f3 is formed between the port 3 and one end side of the on-off valve SV12. A flow path f4 is formed between the port 4 and the heating space 23a of the recess 23. A flow path f5 is formed between the port 5 and one end side of the on-off valve SV6.
A flow path f6 is formed between the port 6 and one end side of the on-off valve SV10. A flow path f7 is formed between the port 7 and one end side of the on-off valve SV7. A flow path f8 is formed between the port 8 and one end side of the on-off valve SV8. A flow path f9 is formed between the port 9 and one end side of the on-off valve SV9.
A flow path f10 is formed between the port 10 and the other end side of the on-off valve SV7. A flow path f11 is formed between the port 11 and the other end side of the on-off valve SV8. A flow path f12 is formed between the port 12 and the other end side of the on-off valve SV9. A flow path f13 is formed between the port 13 and the other end side of the on-off valve SV2.
A flow path f15 is formed between the other end side of the on-off valve SV6 and the overflow pipe C4.

Near the lower end of the cell flow path C, a flow path f21 communicating therewith is formed, and the other end side is connected to the other end side of the on-off valve SV10. Further, a flow path f22 communicating with the cell flow path C is formed near the lower end of the cell flow path C, and the other end side is connected to one end side of the on-off valve SV5. A flow path f23 is formed between the other end side of the on-off valve SV5 and the heating space 23a. Further, in the vicinity of the lower end of the cell channel C, a channel f24 communicating with the cell channel C is formed.
A flow path f25 that communicates in a branched manner is formed in the middle of the flow path f22, and the other end side is connected to one end side of the on-off valve SV1. A flow path f26 is formed between the other end side of the on-off valve SV1 and the manual valve MV1. On the other end side of the manual valve MV1, a flow path f27 communicating with the middle of the flow path f1 is formed.
A flow path f28 communicating with the middle of the flow path f24 is formed on the other end side of the on-off valve SV11. Further, on the other end side of the on-off valve SV12, a flow path f29 communicating with the middle of the flow path f24 is formed.

A flow path f31 is formed between the recess 21 and the heating space 22a. A flow path f32 is formed between the recess 25 and the heating space 22a. A flow path f33 is formed between the middle of the flow path f32 and the other end side of the on-off valve SV13.
Further, a flow path f34 is formed between the middle of the flow path f33 and one end side of the manual valve MV2. A flow path f35 is formed between the other end side of the manual valve MV2 and the other end side of the on-off valve SV2.

  The printed circuit board W incorporates a control device that controls the valve devices to open and close at a predetermined timing, and controls the heaters HT1, HT2, the light sources L1, L2, L3, the light receiving elements D1, D3, and the like. It is. In addition, a memory for storing the output of the light receiving element D1, an arithmetic unit for calculating the silica concentration based on the output value, and the like are also incorporated.

As shown in FIGS. 4 and 5, the silica analyzer of the present embodiment further includes a transparent acrylic resin tube connection block B2 and a relay block B3.
As shown in FIG. 4, through-holes 51 to 59 corresponding to the ports 1 to 9 of the manifold block B1 are formed in the tube connection block B2, and a pipe tube is inserted into each of the tube connection blocks B2. The upper end portions of the through-holes 51 to 59 each have an enlarged diameter, and an o-ring is inserted into this portion, so that the ports 1 to 9 and the piping tubes inserted into the through-holes 51 to 59 can communicate in a liquid-tight manner. It is like that.
Further, screw through holes 61 and 62 are formed. The screw 63 is screwed into the screw hole 31 through the screw through hole 61, and the screw 64 is screwed into the screw hole 32 through the screw through hole 62. Thus, the tube connection block B2 is fixed to the manifold block B1.

As shown in FIG. 5, the relay block B3 has ports 70 to 72 that open corresponding to the ports 10 to 12 of the manifold block B1, and ports 75 to 76 that open to correspond to the opening end of the reagent introduction path C3. have. A flow path f50 is formed between the port 70 and the port 75, a flow path f51 is formed between the port 71 and the port 76, and a flow path f52 is formed between the port 72 and the port 77. Nozzles N1 to N3 are inserted into the ports 75 to 76, respectively.
That is, the port 10 and the nozzle N1 of the manifold block B1, the port 11 and the nozzle N2, and the port 12 and the nozzle N3 are connected to each other via the relay block B3.
The ports 10 to 12 of the manifold block B1 have enlarged diameters at the upper ends of the flow paths f10 to f12, respectively, and o-rings are inserted into these portions to make the ports 10 to 12 and the ports 70 to 71 liquid-tight. You can communicate.
Further, screw through holes 81 and 82 are formed, and the screw 83 is screwed into the screw hole 33 through the screw through hole 81, and the screw 84 is screwed into the screw hole 34 through the screw through hole 82. Thus, the relay block B3 is fixed to the manifold block B1.

FIG. 6 shows a schematic configuration of the silica analyzer of the present embodiment. In FIG. 6, the same components as those in FIG. 1 are denoted by the same reference numerals as those in FIG. 1, and detailed descriptions thereof are omitted. In FIG. 6, α and α ′ and β and β ′ are connected to each other.
As shown in FIG. 6, the silica analyzer of this embodiment further includes a filter F. The filter F has a double cylinder structure including a filter cylinder F2 in an outer cylinder F1 whose top and bottom are closed. Between the outer cylinder F1 and the filtration cylinder F2, a sample liquid introduction pipe t1 is connected to the bottom face or the vicinity thereof, and a sample liquid discharge pipe t2 is connected to the upper face or the vicinity thereof. Further, an air introduction tube t3 is connected in the vicinity of the center in the height direction. A sample solution outlet tube t4 is connected to the bottom surface in the filter cylinder F2. An open / close valve SV3 is interposed in the sample liquid introduction pipe t1, and an open / close valve SV4 is interposed in the sample liquid discharge pipe t2. The other end side of the air introduction pipe t3 is connected to the port 13 of the manifold block B1. The other end of the sample solution outlet tube t4 is connected to the port 4 of the manifold block B1.

As shown in FIG. 6, the silica analyzer of this embodiment further includes a light source L3 and a light receiving element D3 for detecting the liquid level. The light source L3 is an LED having a wavelength of 600 nm, and the light receiving element D1 is a silicon photocell. The light source L3 and the light receiving element D3 may be installed so as to be embedded in the manifold block B1, or may be installed outside the manifold block B1.
The level 1 liquid level can be detected by the light guide G, and the level 2 liquid level can be detected by the light source L3 and the light receiving element D3. The level 1 liquid surface is almost the upper end of the straight portion C1 of the cell channel C. The level 2 liquid level is above level 1 and below the position where the overflow pipe C4 is connected to the light guide insertion portion C2.
In addition, the front-end | tip of the light guide G is made into the shape cut | disconnected diagonally with respect to the axial direction so that it may become a substantially vertical surface in an installation state body.

Based on FIG. 6, the connection destination of the piping tube connected to the ports 1 to 9 of the manifold block B1 will be described.
First, the piping tube connected to the port 1 is branched into a plurality of piping tubes on the way, a tank w1 for storing reagent 1 (ammonium molybdate), a tank w2 for storing reagent 2 (tartaric acid), and a reagent 3 (ascorbine). Acid)), a tank w4 for storing a standard solution, and a tank w5 for storing a cleaning solution. Thereby, the air supplied from the air pump P is supplied to each tank, and the liquid in each tank can be pumped.

The piping tube connected to the port 2 is inserted into the standard solution in the tank w4. As a result, the standard solution can be supplied to the cell channel C via the on-off valve SV11. The piping tube connected to the port 3 is inserted into the cleaning liquid in the tank w5. As a result, the cleaning liquid can be supplied to the cell channel C via the on-off valve SV12.
The piping tube connected to the port 5 is for drainage, and can discharge liquid from the overflow pipe C4. Further, the pipe tube connected to the port 6 is also used for drainage, and the liquid can be discharged from the vicinity of the lower end of the straight portion C1 of the cell flow path C.

  The piping tube connected to the port 7 is inserted into the reagent 1 of the tank w1. Thereby, the reagent 1 can be supplied to the reagent introduction path C3 of the cell flow path C through the on-off valve SV7 and the nozzle N1. The piping tube connected to the port 8 is inserted into the reagent 2 of the tank w2. Thereby, the reagent 2 can be supplied to the reagent introduction path C3 via the opening / closing valve SV8 and the nozzle N2. The piping tube connected to the port 9 is inserted into the reagent 3 of the tank w3. Accordingly, the reagent 3 can be supplied to the reagent introduction path C3 via the opening / closing valve SV9 and the nozzle N3.

  Below, the measurement procedure of the silica using the silica analyzer of this embodiment is demonstrated, referring FIG. It should be noted that specific numerical values such as capacity and temperature in the following description are merely shown for convenience of description, and do not limit the technical scope of the present invention.

(Sample solution measurement)
First, the on-off valve SV13 is opened to supply air from the air pump P to the cell flow path C, and the on-off valves SV6 and SV10 are opened to discharge the liquid in the cell flow path C from the ports 5 and 6.
In addition, the on-off valves SV3 and SV4 are opened in advance, and the sample liquid is allowed to flow from the sample liquid introduction pipe t1 to the sample liquid discharge pipe t2 via the filter F. When the water pressure of the sample solution is insufficient, a liquid feed pump or the like is used as appropriate. When the sample solution is sufficiently filled in the filter F, the on-off valves SV3 and SV4 are closed.

Next, the on-off valve SV3 is opened, air from the air pump P is supplied to the filter F through the air introduction pipe t3, and the on-off valve SV5 is opened. Thereby, the sample liquid filtered through the filter cylinder F2 is pushed to the sample liquid outlet pipe t4. This sample solution enters the manifold block B1 from the port 4, is heated to 45 to 50 ° C. by the heater HT1, and is then introduced into the cell channel C.
At this time, the light from the light source L1 is detected by the light receiving element D through the light guide G. When the sample liquid reaches a liquid level (level 1) at which the tip of the light guide G is submerged and the amount of light detected by the light receiving element D changes significantly, the open / close valve SV5 is closed. Thereby, a fixed amount (for example, about 5 mL) of the sample liquid is measured in the cell channel C.
Since the tip of the light guide G has a shape that is obliquely cut so as to be a substantially vertical surface in the installation state, it is difficult for air bubbles to be involved when submerged.

Next, the open / close valve SV7 is opened for a certain time, and about 0.6 mL of reagent 1 (ammonium molybdate solution) in the tank w1 is injected into the cell channel C from the nozzle N1 by the air pressure supplied from the air pump P. Next, the open / close valve SV13 is opened to send air bubbles into the cell channel C, and the sample solution and the reagent 1 are stirred.
At this time, since the cell flow path C is disposed so as to be inclined with respect to the vertical plane, the sent air bubbles are quickly discharged to the upper part of the cell flow path C without staying.
Next, the opening / closing valve SV8 is opened for a certain period of time, and about 0.6 mL of reagent 2 (tartaric acid) in the tank w2 is injected into the cell channel C from the nozzle N2 by the air pressure supplied from the air pump P. Next, the open / close valve SV13 is opened to send air bubbles into the cell channel C, and the reagent 1, the sample liquid after reaction, and the reagent 2 are stirred.
Here, light of 820 nm of the light source L1 is measured by the light receiving element D1, and this output is stored in a memory (not shown) as a blank value.

Next, the open / close valve SV9 is opened for a certain time, and about 0.6 mL of reagent 3 (ascorbic acid) in the tank w3 is injected into the cell channel C from the nozzle N3 by the air pressure supplied from the air pump P. Here, the open / close valves SV2 and SV5 are opened to add the sample solution to the cell channel C. When the sample liquid reaches the liquid level of level 2 and the amount of light from the light source L3 detected by the light receiving element D3 changes, the open / close valves SV2 and SV5 are closed. Thereby, even if the injection volume of each reagent 1-3 is not exactly 0.6 mL, the liquid volume in the cell flow path C can be made constant (for example, about 7 mL).
Next, the open / close valve SV13 is opened to send air bubbles into the cell channel C, and the reagent 2, the sample liquid after reaction, and the reagent 3 are stirred.
Here, 820 nm light of the light source L1 is measured by the light receiving element D1, and the blank value stored in the memory is subtracted from this output to obtain the absorbance of molybdenum blue due to the reaction between the sample solution and the reagent.

After the measurement, the on-off valve SV13 is opened to supply air from the air pump P to the cell flow path C, and the on-off valves SV6 and SV10 are opened to discharge the liquid in the cell flow path C from the ports 5 and 6. . Then, the on-off valve SV12 is opened to introduce the cleaning liquid in the tank w5 into the cell flow path C.
By repeating the above operation, the sample solution can be measured intermittently.

(Standard solution measurement)
First, the on-off valve SV13 is opened to supply air from the air pump P to the cell flow path C, and the on-off valves SV6 and SV10 are opened to discharge the liquid in the cell flow path C from the ports 5 and 6.
Next, the on-off valve SV11 is opened, and the standard solution in the tank w4 is introduced into the cell channel C.
At this time, the light from the light source L1 is detected by the light receiving element D through the light guide G. When the sample liquid reaches a liquid level (level 1) at which the tip of the light guide G is submerged and the amount of light detected by the light receiving element D changes significantly, the open / close valve SV11 is closed. Thereby, a fixed amount (for example, about 5 mL) of the standard solution is measured in the cell flow path C.

Next, the open / close valve SV7 is opened for a certain time, and about 0.6 mL of reagent 1 (ammonium molybdate solution) in the tank w1 is injected into the cell channel C from the nozzle N1 by the air pressure supplied from the air pump P. Next, the opening / closing valve SV13 is opened to send air bubbles into the cell channel C, and the standard solution and the reagent 1 are stirred.
Next, the opening / closing valve SV8 is opened for a certain period of time, and about 0.6 mL of reagent 2 (tartaric acid) in the tank w2 is injected into the cell channel C from the nozzle N2 by the air pressure supplied from the air pump P. Next, the opening / closing valve SV13 is opened to send air bubbles into the cell channel C, and the reagent 1, the standard solution after the reaction, and the reagent 2 are stirred.
Here, light of 820 nm of the light source L1 is measured by the light receiving element D1, and this output is stored in a memory (not shown) as a blank value.

Next, the open / close valve SV9 is opened for a certain time, and about 0.6 mL of reagent 3 (ascorbic acid) in the tank w3 is injected into the cell channel C from the nozzle N3 by the air pressure supplied from the air pump P. Here, the open / close valve SV11 is opened to add the standard solution to the cell flow path C. When the sample liquid reaches the liquid level of level 2 and the amount of light from the light source L3 detected by the light receiving element D3 changes, the open / close valve SV11 is closed. Thereby, even if the injection volume of each reagent 1-3 is not exactly 0.6 mL, the liquid volume in the cell flow path C can be made constant (for example, about 7 mL).
Next, the open / close valve SV13 is opened to send air bubbles into the cell channel C, and the reagent 2, the standard solution after reaction, and the reagent 3 are stirred.
Here, 820 nm light of the light source L1 is measured by the light receiving element D1, and the blank value stored in the memory is subtracted from this output to obtain the absorbance of molybdenum blue due to the reaction between the standard solution and the reagent.

After the measurement, the on-off valve SV13 is opened to supply air from the air pump P to the cell flow path C, and the on-off valves SV6 and SV10 are opened to discharge the liquid in the cell flow path C from the ports 5 and 6. . Then, the on-off valve SV12 is opened to introduce the cleaning liquid in the tank w5 into the cell flow path C.
With the above operation, it is possible to measure a standard solution necessary for calibration of the silica analyzer.

According to the silica analyzer of the present embodiment, a complicated analysis procedure can be performed in the block, and the entire apparatus can be miniaturized. Moreover, since the printed circuit board is arranged so as to overlap the block, the entire apparatus can be easily accommodated in one housing. Further, the electrical system such as the printed circuit board and the light source is arranged at a position that is not easily affected by water leakage or the like, so that safety is high.
Further, since the valve device or the like is disposed on the substantially vertical surface instead of the bottom surface, maintenance work or the like is easy.
In addition, since the cell channel is arranged obliquely, bubbles are not easily convected in the cell channel, and a high agitation effect is obtained by air.

In the present embodiment, the heaters HT1 and HT2 are used as the temperature adjusting mechanism. However, a flat heating plate or cooling plate may be sandwiched between the manifold block B1 and the printed board W.
In the present embodiment, the sample liquid and the like are measured by optically detecting the level 1 and level 2 liquid surfaces, but other measuring means such as a metering pump may be used. In this case, the light source D3 and the light receiving element D3 can be omitted.
Further, a display mechanism such as a liquid crystal display device may be provided on the opposite side of the printed circuit board W from the manifold block B1.
In addition, a diaphragm and an ultrasonic transmitting element that block the fluid but not the ultrasonic wave are embedded in the manifold block B1, and ultrasonic waves are irradiated into the cell flow path C through the diaphragm to promote the reaction. May be.
In the present embodiment, a silica analyzer is shown as an example of performing an absorbance analysis. However, the analyzer of the present invention may be an analyzer using other detection means such as an electric conductivity detection electrode.
In the present embodiment, the transparent acrylic resin is used as the manifold block B1, but other materials such as an opaque material may be used as long as the material forms a flow path therein. However, it is preferable to use a transparent material because it is easy to check the internal situation and maintenance is easy. In particular, when an absorbance analyzer is used, a transparent material is preferable. If it is a transparent material, light can be transmitted between the light source or the light receiving element and the internal liquid without using a light transmission member such as a light guide.
Although the silica analyzer is shown as an example for performing the absorbance analysis, the analyzer of the present invention may be an analyzer using other detection means such as an electric conductivity detection electrode.

Further, unlike the above-described embodiment, if the first vertical outer surface S1 is set downward so that the first vertical outer surface S1 and the second vertical outer surface S2 in FIG. 1 are substantially horizontal, the analysis according to the fourth invention is performed. It can be configured as a total.
In this case, the first vertical outer surface S1 and the second vertical outer surface S2 may be installed so as to be completely horizontal, but the second inclined outer surface S8 is slightly higher than the first inclined outer surface S7. It is preferable to install it at a slight angle with respect to the horizontal plane. Thereby, since the cell flow path C is not horizontal but is arranged diagonally, there is an advantage that the internal bubbles are easily removed.

It is a perspective view which shows the principal part of the silica analyzer which concerns on one Embodiment of this invention. It is typical sectional drawing of the recessed part 21 and 22 vicinity of FIG. It is typical sectional drawing of the recessed part 23 vicinity of FIG. It is a disassembled perspective view of tube block B2 vicinity. It is a disassembled perspective view of relay block B3 vicinity. It is a schematic block diagram of the silica analyzer which concerns on one Embodiment of this invention.

Explanation of symbols

B1 ... Manifold block, B2 ... Tube connection block,
B3 ... Relay block, W ... Printed circuit board, L1, L2, L3 ... Light source,
D1, D3... Light receiving element, C... Cell flow path,
S1... First vertical outer surface, S2... Second vertical outer surface,
S3 ... first side, S4 ... second side,
S5... Bottom surface, S6.
S7... First inclined outer surface, S8... Second inclined outer surface,
SV1, SV2, SV5 to SV13... Open / close valve

Claims (7)

A manifold block in which a plurality of flow paths through which fluid flows are formed; one or more valve devices that connect the ends of any pair of flow paths formed in the manifold block; and at least the one or more flow paths And a printed circuit board having a function of controlling the valve device,
The manifold block has a first vertical outer surface that is a substantially vertical surface, and a second vertical outer surface that is a substantially vertical surface and is not adjacent to the first vertical outer surface,
The one or more valve devices are attached to a first vertical outer surface side, and the printed circuit board is disposed along a second vertical outer surface.   The analyzer according to claim 1, wherein a temperature adjustment mechanism is disposed between the manifold block and the printed circuit board. A manifold block having a plurality of flow paths through which fluid flows, a light source and a light receiving element;
The manifold block includes a first inclined outer surface formed obliquely with respect to the vertical surface, and a second inclined outer surface formed obliquely with respect to the vertical surface on the opposite side above the first inclined outer surface; A cell flow path having a straight portion from the first inclined outer surface toward the second inclined outer surface;
One of the light source and the light receiving element is disposed on the first inclined outer surface side, and the other is disposed on the second inclined outer surface side. A manifold block in which a plurality of flow paths through which fluid flows are formed; one or more valve devices that connect the ends of any pair of flow paths formed in the manifold block; and at least the one or more flow paths A printed circuit board having a function of controlling the valve device, a light source and a light receiving element;
The manifold block includes a first vertical outer surface that is a substantially vertical surface, a second vertical outer surface that is a substantially vertical surface and is not adjacent to the first vertical outer surface, and is formed obliquely with respect to the vertical surface. 1 inclined outer surface, a second inclined outer surface formed obliquely with respect to the vertical surface on the opposite side above the first inclined outer surface, and a straight line portion extending from the first inclined outer surface toward the second inclined outer surface A cell flow path having
The one or more valve devices are attached to a first vertical outer surface, and the printed circuit board is disposed along a second vertical outer surface;
One of the light source and the light receiving element is disposed on the first inclined outer surface side, and the other is disposed on the second inclined outer surface side.   The cell channel has an opening end on the second inclined outer surface, and a light guide connected to a light source or a light receiving element provided on the second inclined outer surface side is inserted into the opening end. The analyzer according to 3 or 4. A manifold block in which a plurality of flow paths through which fluid flows are formed; one or more valve devices that connect the ends of any pair of flow paths formed in the manifold block; and at least the one or more flow paths And a printed circuit board having a function of controlling the valve device,
The manifold block has a first outer surface and a second outer surface located above the first outer surface,
The one or more valve devices are attached to a first outer surface side, and the printed circuit board is disposed along a second outer surface. The analyzer according to any one of claims 1 to 6, wherein one or more liquid inlets and / or liquid outlets are opened at a bottom surface of the manifold block.

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