JP2005029566A - Base for external gel preparation - Google Patents
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- JP2005029566A JP2005029566A JP2004171734A JP2004171734A JP2005029566A JP 2005029566 A JP2005029566 A JP 2005029566A JP 2004171734 A JP2004171734 A JP 2004171734A JP 2004171734 A JP2004171734 A JP 2004171734A JP 2005029566 A JP2005029566 A JP 2005029566A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000341 volatile oil Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 15
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 claims abstract description 15
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 15
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 15
- 239000003921 oil Substances 0.000 claims abstract description 5
- 241000220317 Rosa Species 0.000 claims abstract description 4
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims abstract description 4
- 239000010665 pine oil Substances 0.000 claims abstract description 4
- 235000005979 Citrus limon Nutrition 0.000 abstract description 4
- 244000131522 Citrus pyriformis Species 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 abstract description 2
- 235000009024 Ceanothus sanguineus Nutrition 0.000 abstract description 2
- 241000723346 Cinnamomum camphora Species 0.000 abstract description 2
- 240000004784 Cymbopogon citratus Species 0.000 abstract description 2
- 235000017897 Cymbopogon citratus Nutrition 0.000 abstract description 2
- 244000166675 Cymbopogon nardus Species 0.000 abstract description 2
- 235000018791 Cymbopogon nardus Nutrition 0.000 abstract description 2
- 240000003553 Leptospermum scoparium Species 0.000 abstract description 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract description 2
- 244000246386 Mentha pulegium Species 0.000 abstract description 2
- 235000016257 Mentha pulegium Nutrition 0.000 abstract description 2
- 235000004357 Mentha x piperita Nutrition 0.000 abstract description 2
- 244000178231 Rosmarinus officinalis Species 0.000 abstract description 2
- 229960000846 camphor Drugs 0.000 abstract description 2
- 229930008380 camphor Natural products 0.000 abstract description 2
- 235000001050 hortel pimenta Nutrition 0.000 abstract description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 abstract description 2
- 239000009637 wintergreen oil Substances 0.000 abstract description 2
- 244000004281 Eucalyptus maculata Species 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 26
- 239000008213 purified water Substances 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 4
- 240000003538 Chamaemelum nobile Species 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 4
- 244000166124 Eucalyptus globulus Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 description 3
- 240000002657 Thymus vulgaris Species 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 229940060184 oil ingredients Drugs 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000001585 thymus vulgaris Substances 0.000 description 3
- 244000166652 Cymbopogon martinii Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- 235000010676 Ocimum basilicum Nutrition 0.000 description 2
- 240000007926 Ocimum gratissimum Species 0.000 description 2
- 235000017304 Ruaghas Nutrition 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000010628 chamomile oil Substances 0.000 description 2
- 229960001193 diclofenac sodium Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960000905 indomethacin Drugs 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 description 2
- 229960002702 piroxicam Drugs 0.000 description 2
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 2
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 240000005020 Acaciella glauca Species 0.000 description 1
- 240000006054 Agastache cana Species 0.000 description 1
- 235000003717 Boswellia sacra Nutrition 0.000 description 1
- 235000012035 Boswellia serrata Nutrition 0.000 description 1
- 240000007551 Boswellia serrata Species 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 235000018782 Dacrydium cupressinum Nutrition 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 235000010695 Eucalyptus radiata Nutrition 0.000 description 1
- 240000003060 Eucalyptus radiata Species 0.000 description 1
- 239000001293 FEMA 3089 Substances 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 241000208152 Geranium Species 0.000 description 1
- 244000308760 Helichrysum petiolatum Species 0.000 description 1
- 235000010650 Hyssopus officinalis Nutrition 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 241000721662 Juniperus Species 0.000 description 1
- 235000010658 Lavandula latifolia Nutrition 0.000 description 1
- 244000178860 Lavandula latifolia Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000078639 Mentha spicata Species 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 235000013697 Pinus resinosa Nutrition 0.000 description 1
- 235000011751 Pogostemon cablin Nutrition 0.000 description 1
- 240000002505 Pogostemon cablin Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000000222 aromatherapy Methods 0.000 description 1
- 235000001053 badasse Nutrition 0.000 description 1
- 235000019480 chamomile oil Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 244000056931 lavandin Species 0.000 description 1
- 235000009606 lavandin Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- -1 pH adjusters Substances 0.000 description 1
- 229940081310 piperonal Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000008132 rose water Substances 0.000 description 1
- 229940043266 rosin Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
本発明は、外用ゲル剤用基剤に関する。さらに詳しくは、脂溶性精油成分を含有する透明な外用ゲル剤用基剤に関する。 The present invention relates to a base for external gel. In more detail, it is related with the base for transparent external preparations containing a fat-soluble essential oil component.
現在、消炎鎮痛剤を配合した外用ゲル剤は多く市販されている。そして、外用消炎鎮痛剤に香料として精油を0.01〜0.1％含有し、消炎鎮痛作用に加えて、アロマテラピー効果を狙った外用消炎鎮痛剤が開示されている（特許文献１）。実施例には、固化した外用消炎鎮痛剤が例示されている。 At present, many external gels containing anti-inflammatory analgesics are commercially available. Further, an external anti-inflammatory analgesic containing 0.01 to 0.1% of essential oil as a fragrance in an external anti-inflammatory analgesic and targeting an aromatherapy effect in addition to the anti-inflammatory analgesic is disclosed (Patent Document 1). In the examples, solidified external anti-inflammatory analgesics are exemplified.
しかしながら、脂溶性精油成分を配合した外用ゲル剤の具体的な記載はなく、しかも透明な外用ゲル剤用基剤の開示は全く無い。 However, there is no specific description of an external gel containing a fat-soluble essential oil component, and there is no disclosure of a transparent base for external gel.
本発明は、通常より脂溶性精油成分を多く含有する透明な外用ゲル剤用基剤を提供するものである。 The present invention provides a transparent base for external gel containing more fat-soluble essential oil components than usual.
外用ゲル剤用基剤に、脂溶性精油成分を0.1重量％以上配合する場合、ゲル剤が白く濁ることが判明した。 It was found that when the fat-soluble essential oil component was blended in an amount of 0.1% by weight or more in the external gel base, the gel became white and cloudy.
そこで、本発明者らは、鋭意研究の結果、驚くべきことに、脂溶性精油成分を0.1重量％以上配合する場合に、ヒドロキシプロピルセルロース、低級アルコール及び水をある特定な範囲で配合すると、透明な外用ゲル剤用基剤となることを見出し、本発明を完成した。 Therefore, as a result of intensive studies, the inventors have surprisingly found that when blending a fat-soluble essential oil component in an amount of 0.1% by weight or more, when hydroxypropylcellulose, lower alcohol and water are blended in a certain range, And the present invention was completed.
本発明により、脂溶性精油成分を0.1〜0.5重量％含有し、商品性を向上した透明な外用ゲル剤用基剤を提供することができる。 According to the present invention, it is possible to provide a transparent base for gel for external use containing 0.1 to 0.5% by weight of a fat-soluble essential oil component and having improved commercial properties.
本発明は、
(A)脂溶性精油成分を0.1〜0.5重量％、
(B)ヒドロキシプロピルセルロースを2〜5重量％、
(C)低級アルコールを45〜80重量％及び
(D)水を15〜50重量％
を配合する外用ゲル剤用基剤である。
The present invention
(A) 0.1-0.5% by weight of fat-soluble essential oil component,
(B) 2-5% by weight of hydroxypropyl cellulose,
(C) 45-80% by weight of lower alcohol and
(D) 15 to 50% by weight of water
Is a base for external gel formulation.
本発明で脂溶性精油成分とは、ベルガモット油、ラベンダー油、パイン油、ローズオットー油、ウィンターグリーン油、シトロネラ、ティートリー、ペパーミント、レモン、レモングラス、レモンユーカリ、ローズマリーカンファー、クローブ、ゼラニウム・ブルボン、マジョラム・スイート、ラバンジン、ローズウッド、パルマローザ、プチゴレン、サイプレス、シナモン、ジュニパー、オレンジ・スイート、スパイクラベンダー、タイムチモール、タイムリナロール、バジル、ヒソップ、ヘリクリサム、マンダリン、ユーカリデイビス、ヨーロッパアカマツ、ラバンサラアロマティカ、レモンバーベナ、レモンバーム、ローマンカモミール、イランイラン、カモミールジャーマン、カモミールローマン、カユプテ、クラリセージ、グレープフルーツ、サンダルウッド、シダーウッドアトラス、シダーウッドバージニア、ジャスミン・アブソリュート、スペアミント、タイムツヤノール、ニアウリ・シネオール、ネロリ、バジル・スイート、パチュリー、パルマローザ、フェンネルスイート、プチグレン、フランキンセンス、ユーカリ・グロブルス、ユーカリ・ラジアタ、ラバンサラ、カミツレ油、ケイヒ油、シンナムアルデヒド、チョウジ油、ハッカ油、ピペロナール、ユーカリ油、ロジン、ローズ水、ローマカミツレ油、オレンジ油及びテレピン油から選ばれる群の１種以上の精油であり、好ましくは、ベルガモット油、ラベンダー油、パイン油、ローズオットー油から選ばれる群の1種以上の精油、更に好ましくはベルガモット油である。 In the present invention, fat-soluble essential oil components are bergamot oil, lavender oil, pine oil, rose otto oil, winter green oil, citronella, tea tree, peppermint, lemon, lemongrass, lemon eucalyptus, rosemary camphor, clove, geranium bourbon , Marjoram sweet, lavandin, rosewood, palmarosa, petit goren, cypress, cinnamon, juniper, orange sweet, spike lavender, thyme thymol, thyme linalool, basil, hyssop, helichrysum, mandarin, eucalyptus davis, european red pine, lavansara aroma Tika, Lemon Verbena, Lemon Balm, Roman Chamomile, Ylang Ylang, Chamomile German, Chamomile Roman, Cayupute, Clarisage, Gray Fruit, sandalwood, cedarwood atlas, cedarwood virginia, jasmine absolute, spearmint, thyme tyanol, nearuri cineole, neroli, basil sweet, patchouli, palmarosa, fennel sweet, petitgren, frankincense, eucalyptus globulus, eucalyptus radiata, One or more essential oils selected from the group selected from Labansara, chamomile oil, cinnamon oil, cinnamaldehyde, clove oil, mint oil, piperonal, eucalyptus oil, rosin, rose water, roman chamomile oil, orange oil and turpentine oil, preferably Is one or more essential oils of the group selected from bergamot oil, lavender oil, pine oil and rose otto oil, more preferably bergamot oil.
低級アルコールとは、エタノール、プロパノール、プロピレングリコール、１，３−ブチレングリコールなどであり、好ましくは、エタノールである。 The lower alcohol is ethanol, propanol, propylene glycol, 1,3-butylene glycol, etc., preferably ethanol.
また、本発明の外用ゲル剤のよれを更に防止するためには、グリセリン、多価アルコール（例えば１，３−ブタンジオール）を配合する。また、皮膚への付着性を更に向上させるためには、ポリビニルピロリドンやポリビニルアルコールを配合する。 Moreover, in order to further prevent the external gel of the present invention from shaking, glycerin and a polyhydric alcohol (for example, 1,3-butanediol) are blended. In order to further improve the adhesion to the skin, polyvinyl pyrrolidone or polyvinyl alcohol is blended.
脂溶性精油成分の配合量は、0.1〜0.5重量％、好ましくは0.1〜0.3重量％である。0.5重量％以上配合すると精油成分の香りが強くなり、使用感が悪くなる。 The compounding quantity of a fat-soluble essential oil component is 0.1 to 0.5 weight%, Preferably it is 0.1 to 0.3 weight%. When 0.5% by weight or more is blended, the scent of the essential oil component becomes strong and the feeling of use becomes worse.
ヒドロキシプロピルセルロースの配合量は、2〜5重量％、好ましくは2.5〜3.5重量％である。 The amount of hydroxypropylcellulose is 2 to 5% by weight, preferably 2.5 to 3.5% by weight.
低級アルコールの配合量は、45〜80重量％、好ましくは50〜70重量％である。 The blending amount of the lower alcohol is 45 to 80% by weight, preferably 50 to 70% by weight.
水の配合量は、15〜50重量％、好ましくは25〜47重量％である。 The amount of water is 15 to 50% by weight, preferably 25 to 47% by weight.
（低級アルコールの配合量）／（水の配合量）は、好ましくは、1.0〜2.8である。 The amount of (lower alcohol) / (water) is preferably 1.0 to 2.8.
本発明の外用ゲル剤用基剤は、通常用いられる方法（例えば、第１４改正日本薬局方に規定する方法など）に従って、調製することができる。また、ゲル剤の透明度を失わせない範囲で、その他の有効成分、ｐＨ調整剤、高分子などの通常ゲル剤に配合される成分を加えることができる。 The base for external gel preparation of the present invention can be prepared according to a commonly used method (for example, a method defined in the 14th revised Japanese pharmacopoeia). In addition, other active ingredients, pH adjusters, and other components that are usually blended in gels can be added within a range that does not lose the transparency of the gel.
本発明の外用ゲル剤用基剤は、外用薬として使用されている種々の薬物の外用ゲル剤の基剤として使用することができるが、インドメタシン、ピロキシカム及びジクロフェナクナトリウム等の消炎鎮痛薬の外用ゲル剤用基剤として有用である。インドメタシン、ピロキシカム及びジクロフェナクナトリウム等の消炎鎮痛薬を使用する際は、その配合量が、通常0.1〜5.0重量％、好ましくは0.5〜2.0重量％である。 The base for external gel of the present invention can be used as a base for external gels of various drugs used as external drugs, but external gels for anti-inflammatory analgesics such as indomethacin, piroxicam and diclofenac sodium It is useful as an agent base. When using anti-inflammatory analgesics such as indomethacin, piroxicam and diclofenac sodium, the blending amount is usually 0.1 to 5.0% by weight, preferably 0.5 to 2.0% by weight.
以下、実施例及び試験例を挙げて、本発明を具体的に説明するが、本発明は何ら実施例に限定されるものではない。 EXAMPLES Hereinafter, although an Example and a test example are given and this invention is demonstrated concretely, this invention is not limited to an Example at all.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ４６．９ｇ
エタノール ５０ｇ
ベルガモット油 ０．１ｇ
製造方法：
精製水４６．９ｇにヒドロキシプロピルセルロース３ｇを少量ずつ加えて攪拌して得た溶液とエタノール５０ｇにベルガモット油０．１ｇを加えて攪拌して得た溶液を混合して攪拌して、外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
46.9g of purified water
50g ethanol
Bergamot oil 0.1g
Production method:
A solution obtained by adding 3 g of hydroxypropylcellulose to 46.9 g of purified water in small portions and stirring and a solution obtained by adding 0.1 g of bergamot oil to 50 g of ethanol and stirring the mixture are stirred to obtain a gel for external use. A base for use was obtained.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ４６．７ｇ
エタノール ５０ｇ
ベルガモット油 ０．３ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
46.7g of purified water
50g ethanol
Bergamot oil 0.3g
Production method:
In the same manner as in Example 1, an external gel base was obtained.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ３６．７ｇ
エタノール ６０ｇ
ベルガモット油 ０．３ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
36.7g of purified water
Ethanol 60g
Bergamot oil 0.3g
Production method:
In the same manner as in Example 1, an external gel base was obtained.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ４６．５ｇ
エタノール ５０ｇ
ベルガモット油 ０．５ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
46.5g of purified water
50g ethanol
Bergamot oil 0.5g
Production method:
A base for external gel was obtained in the same manner as Example 1.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ３６．５ｇ
エタノール ６０ｇ
ベルガモット油 ０．５ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
36.5g of purified water
Ethanol 60g
Bergamot oil 0.5g
Production method:
A base for external gel was obtained in the same manner as Example 1.
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ２６．５ｇ
エタノール ７０ｇ
ベルガモット油 ０．５ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Formula:
Hydroxypropylcellulose 3g
26.5g of purified water
70g ethanol
Bergamot oil 0.5g
Production method:
In the same manner as in Example 1, an external gel base was obtained.
比較例１
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ５６．９ｇ
エタノール ４０ｇ
ベルガモット油 ０．１ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Comparative Example 1
Formula:
Hydroxypropylcellulose 3g
56.9 g of purified water
Ethanol 40g
Bergamot oil 0.1g
Production method:
A base for external gel was obtained in the same manner as Example 1.
比較例２
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ５６．７ｇ
エタノール ４０ｇ
ベルガモット油 ０．３ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Comparative Example 2
Formula:
Hydroxypropylcellulose 3g
56.7 g of purified water
Ethanol 40g
Bergamot oil 0.3g
Production method:
A base for external gel was obtained in the same manner as Example 1.
比較例３
処方：
ヒドロキシプロピルセルロース ３ｇ
精製水 ５６．５ｇ
エタノール ４０ｇ
ベルガモット油 ０．５ｇ
製造方法：
実施例１と同様にして外用ゲル剤用基剤を得た。
Comparative Example 3
Formula:
Hydroxypropylcellulose 3g
56.5 g of purified water
Ethanol 40g
Bergamot oil 0.5g
Production method:
In the same manner as in Example 1, an external gel base was obtained.
試験例
実施例１〜６及び比較例１〜３の外用ゲル剤用基剤の性状を肉眼にて判定した。判定は、『×：白濁している、○：透明である』の２つで行った。
Test Example The properties of the external gel bases of Examples 1 to 6 and Comparative Examples 1 to 3 were determined with the naked eye. Judgment was made in two ways: “×: clouded, ○: transparent”.
結果を表１に示した。比較例１〜３は、白濁している性状であったが、実施例１〜６は、透明な性状であった。 The results are shown in Table 1. Comparative Examples 1 to 3 were cloudy, while Examples 1 to 6 were transparent.
Claims (3)
(B)ヒドロキシプロピルセルロースを2〜5重量％、
(C)低級アルコールを45〜80重量％及び
(D)水を15〜50重量％
を配合する外用ゲル剤用基剤。 (A) 0.1-0.5% by weight of fat-soluble essential oil component,
(B) 2-5% by weight of hydroxypropyl cellulose,
(C) 45-80% by weight of lower alcohol and
(D) 15 to 50% by weight of water
A gel base for external use.
The base for external gel preparation according to claim 1, wherein the lower alcohol is ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004171734A JP2005029566A (en) | 2003-06-17 | 2004-06-09 | Base for external gel preparation |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003172571 | 2003-06-17 | ||
| JP2004171734A JP2005029566A (en) | 2003-06-17 | 2004-06-09 | Base for external gel preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2005029566A true JP2005029566A (en) | 2005-02-03 |
Family
ID=34219936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004171734A Pending JP2005029566A (en) | 2003-06-17 | 2004-06-09 | Base for external gel preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2005029566A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008260888A (en) * | 2007-04-13 | 2008-10-30 | Kao Corp | Gellant |
-
2004
- 2004-06-09 JP JP2004171734A patent/JP2005029566A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008260888A (en) * | 2007-04-13 | 2008-10-30 | Kao Corp | Gellant |
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