JP2004537495A5 - - Google Patents
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- JP2004537495A5 JP2004537495A5 JP2002538984A JP2002538984A JP2004537495A5 JP 2004537495 A5 JP2004537495 A5 JP 2004537495A5 JP 2002538984 A JP2002538984 A JP 2002538984A JP 2002538984 A JP2002538984 A JP 2002538984A JP 2004537495 A5 JP2004537495 A5 JP 2004537495A5
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- sustained release
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Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7090668B1 (en) * | 1999-10-29 | 2006-08-15 | Cytori Therapeutics, Inc. | Time-released substance delivery device |
| US8403954B2 (en) | 2001-05-22 | 2013-03-26 | Sanostec Corp. | Nasal congestion, obstruction relief, and drug delivery |
| JP2005530561A (ja) * | 2002-06-21 | 2005-10-13 | ジェンズィム コーポレーション | 薬剤送達用シリコーン混合物及び複合体 |
| JP4503930B2 (ja) * | 2003-01-30 | 2010-07-14 | オリンパス株式会社 | 医療装置 |
| US9445901B2 (en) * | 2003-03-12 | 2016-09-20 | Deger C. Tunc | Prosthesis with sustained release analgesic |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US20040229878A1 (en) * | 2003-05-13 | 2004-11-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of P38 kinase |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7553827B2 (en) * | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| US7429378B2 (en) * | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US8361467B2 (en) * | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| US7255713B2 (en) * | 2003-12-18 | 2007-08-14 | Malek Michel H | Systems and methods for agent delivery |
| US20050158365A1 (en) * | 2003-12-22 | 2005-07-21 | David Watson | Drug delivery device with mechanical locking mechanism |
| US20070053963A1 (en) * | 2004-01-13 | 2007-03-08 | Hotchkiss Robert N | Drug delivery to a joint |
| US20050256540A1 (en) * | 2004-02-26 | 2005-11-17 | Silver Theodore A | Apparatus and method for movement of electricity or fluid into and out of the body |
| FR2869390B1 (fr) * | 2004-04-27 | 2006-07-14 | Siemens Vdo Automotive Sas | Corps d'une bougie de prechauffage comprenant un capteur de pression |
| CN101370634A (zh) * | 2005-02-16 | 2009-02-18 | 亚历山大·R·瓦卡若 | 供植入与药物传递的再吸收中空装置 |
| WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
| WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| US20070179613A1 (en) * | 2006-01-30 | 2007-08-02 | Sdgi Holdings, Inc. | Passive lubricating prosthetic joint |
| US20070178138A1 (en) * | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
| ES2540059T3 (es) | 2006-04-26 | 2015-07-08 | Micell Technologies, Inc. | Recubrimientos que contienen múltiples fármacos |
| GB0623065D0 (en) * | 2006-11-18 | 2006-12-27 | Smith & Nephew | Annular ring |
| US20090005869A1 (en) * | 2006-12-15 | 2009-01-01 | University Of Virginia Patent Foundation | Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof |
| CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| GB0702974D0 (en) * | 2007-02-15 | 2007-03-28 | Jagotec Ag | Method and apparatus for producing a tablet |
| US20080275567A1 (en) * | 2007-05-01 | 2008-11-06 | Exploramed Nc4, Inc. | Extra-Articular Implantable Mechanical Energy Absorbing Systems |
| US20080275403A1 (en) * | 2007-05-04 | 2008-11-06 | Armand Maaskamp | Dual syringe assembly |
| US7910123B2 (en) * | 2007-09-05 | 2011-03-22 | Warsaw Orthopedic | Methods of treating a trauma or disorder of the knee joint by local administration and sustained-delivery of a biological agent |
| US20090062922A1 (en) * | 2007-09-05 | 2009-03-05 | Mckay William F | Method and apparatus for delivering treatment to a joint |
| US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| EP2052700A1 (en) * | 2007-09-26 | 2009-04-29 | Microchips, Inc. | Drug delivery device and method for use with prosthetic device implantation |
| US9247973B2 (en) | 2007-09-28 | 2016-02-02 | DePuy Synthes Products, Inc. | Anti-microbial implant |
| US8029478B2 (en) * | 2007-10-31 | 2011-10-04 | Warsaw Orthopedic, Inc. | Implantable device and method for delivering drug depots to a site beneath the skin |
| US20090162351A1 (en) * | 2007-12-21 | 2009-06-25 | Depuy Spine, Inc. | Transdiscal administration of inhibitors of p38 MAP kinase |
| US8986696B2 (en) * | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| US20090177229A1 (en) * | 2008-01-03 | 2009-07-09 | New York Society Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Suture anchor with drug/growth factor delivery reservoir |
| CN102083397B (zh) | 2008-04-17 | 2013-12-25 | 米歇尔技术公司 | 具有生物可吸收层的支架 |
| US20090263456A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Methods and Compositions for Reducing Preventing and Treating Adhesives |
| US8257407B2 (en) * | 2008-04-23 | 2012-09-04 | Aryan Henry E | Bone plate system and method |
| JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ，インク． | 薬物送達医療デバイス |
| JP2012500056A (ja) * | 2008-08-13 | 2012-01-05 | スメド−ティーエイ／ティーディー・エルエルシー | 薬物送達インプラント |
| EP2198796A1 (de) * | 2008-12-19 | 2010-06-23 | Sepitec Foundation | Knochenschraube |
| CA2756386C (en) | 2009-03-23 | 2019-01-15 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2010120552A2 (en) | 2009-04-01 | 2010-10-21 | Micell Technologies, Inc. | Coated stents |
| EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
| US20100274295A1 (en) * | 2009-04-24 | 2010-10-28 | Warsaw Orthopedic, Inc. | Medical implant configured to deliver a therapeutic substance |
| WO2010124276A2 (en) | 2009-04-24 | 2010-10-28 | Vanderbilt Universtiy | Anti-tgf-beta induction of bone cell function and bone growth |
| EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | MEDICAL DEVICE DISPENSING MEDICINE |
| US8221396B2 (en) | 2009-08-27 | 2012-07-17 | Silver Bullet Therapeutics, Inc. | Bone implants for the treatment of infection |
| US10265435B2 (en) | 2009-08-27 | 2019-04-23 | Silver Bullet Therapeutics, Inc. | Bone implant and systems and coatings for the controllable release of antimicrobial metal ions |
| US9821094B2 (en) | 2014-06-11 | 2017-11-21 | Silver Bullet Therapeutics, Inc. | Coatings for the controllable release of antimicrobial metal ions |
| US9114197B1 (en) | 2014-06-11 | 2015-08-25 | Silver Bullett Therapeutics, Inc. | Coatings for the controllable release of antimicrobial metal ions |
| US8927004B1 (en) | 2014-06-11 | 2015-01-06 | Silver Bullet Therapeutics, Inc. | Bioabsorbable substrates and systems that controllably release antimicrobial metal ions |
| EP2475316B8 (en) | 2009-09-10 | 2016-07-13 | Woodwelding AG | Device to be implanted in a human or animal body for signal delivery or acquisition within the body |
| US9078701B2 (en) * | 2009-11-09 | 2015-07-14 | Centinel Spine, Inc. | System and method for stabilizing a posterior fusion over motion segments |
| EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| EP2560576B1 (en) | 2010-04-22 | 2018-07-18 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| WO2012009684A2 (en) | 2010-07-16 | 2012-01-19 | Micell Technologies, Inc. | Drug delivery medical device |
| EP3037066B1 (en) | 2010-11-12 | 2017-08-16 | Silver Bullet Therapeutics Inc. | Bone implant that controllably releases silver |
| CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| US9364273B2 (en) * | 2012-08-15 | 2016-06-14 | DePuy Synthes Products, Inc. | Drug eluting surgical screw |
| RU2676102C2 (ru) | 2012-09-27 | 2018-12-26 | Аллерган, Инк. | Биодеградируемые системы доставки лекарственных средств для долговременного высвобождения белков |
| KR20150143476A (ko) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
| BR112015024234B1 (pt) | 2013-03-21 | 2022-11-16 | Eupraxia Pharmaceuticals USA LLC | Composição farmacêutica de liberação sustentada injetável, uso da mesma para diminuir inflamação ou controlar dor e método para formar micropartículas revestidas |
| HK1222313A1 (zh) | 2013-05-15 | 2017-06-30 | Micell Technologies, Inc. | 可生物吸收的生物医学植入物 |
| US9452242B2 (en) | 2014-06-11 | 2016-09-27 | Silver Bullet Therapeutics, Inc. | Enhancement of antimicrobial silver, silver coatings, or silver platings |
| US10080877B2 (en) | 2014-07-25 | 2018-09-25 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a drug cartridge |
| US9775978B2 (en) | 2014-07-25 | 2017-10-03 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
| US10278986B2 (en) | 2014-08-14 | 2019-05-07 | The Regents Of The University Of Colorado, A Body Corporate | Antibody-siRNA conjugates and uses therefor |
| WO2016172026A1 (en) | 2015-04-20 | 2016-10-27 | The Board Of Regents Of The University Of Texas System | Clec11a is a bone growth agent |
| US10449055B2 (en) | 2015-04-23 | 2019-10-22 | Disc Fix L.L.C. | Systems and methods for treatment of intervertebral disc derangements |
| DK3206672T3 (en) | 2015-10-27 | 2018-06-18 | Eupraxia Pharmaceuticals Inc | Formulations for sustained release of local anesthetics |
| US10076650B2 (en) | 2015-11-23 | 2018-09-18 | Warsaw Orthopedic, Inc. | Enhanced stylet for drug depot injector |
| USD802757S1 (en) | 2016-06-23 | 2017-11-14 | Warsaw Orthopedic, Inc. | Drug pellet cartridge |
| US11045242B2 (en) * | 2016-09-22 | 2021-06-29 | Globus Medical, Inc. | Systems and methods for intramedullary nail implantation |
| US10434261B2 (en) | 2016-11-08 | 2019-10-08 | Warsaw Orthopedic, Inc. | Drug pellet delivery system and method |
| US10646345B2 (en) | 2017-06-02 | 2020-05-12 | Howmedica Osteonics Corp. | Implant with hole having porous structure for soft tissue fixation |
| CN110151290A (zh) * | 2018-02-12 | 2019-08-23 | 香港科能有限公司 | 可释放药物的植入物和制造及使用方法 |
| EP3978065A1 (de) | 2020-10-02 | 2022-04-06 | Heraeus Medical GmbH | Implantat zur lokalen wirkstofffreisetzung |
| US12310928B2 (en) | 2020-11-16 | 2025-05-27 | University Of Utah Research Foundation | Enthesis healing |
| CA3208483A1 (en) * | 2021-01-15 | 2022-07-21 | Diffusion RX, Inc. | Joint implant with constant and continuous release of therapeutic agent |
| EP4417243A1 (de) | 2023-02-15 | 2024-08-21 | Heraeus Medical GmbH | Implantat zur verzögerten wirkstofffreisetzung |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4927687A (en) * | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
| CH670381A5 (https=) * | 1986-05-05 | 1989-06-15 | Sulzer Ag | |
| WO1988006023A1 (en) * | 1987-02-20 | 1988-08-25 | Klaus Draenert | Suction drainage-bone screw |
| EP0550641B1 (en) * | 1990-09-28 | 1994-05-25 | Pfizer Inc. | Dispensing device containing a hydrophobic medium |
| US5868711A (en) * | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
| US5433718A (en) * | 1992-08-20 | 1995-07-18 | Brinker; Mark | Antibiotic eluding intramedullary nail apparatus |
| US6051576A (en) * | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
| EP0956079A4 (en) * | 1995-06-07 | 2001-04-25 | American Cyanamid Co | IMPLANT DART SYSTEM |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5871484A (en) * | 1995-11-09 | 1999-02-16 | General Orthopedics | Apparatus and method for administering a biologically active substance to a bone |
| US5902598A (en) * | 1997-08-28 | 1999-05-11 | Control Delivery Systems, Inc. | Sustained release drug delivery devices |
| TW577758B (en) * | 1997-10-27 | 2004-03-01 | Ssp Co Ltd | Intra-articular preparation for the treatment of arthropathy |
| AUPP830499A0 (en) * | 1999-01-22 | 1999-02-18 | Cryptych Pty Ltd | Method and apparatus for delivering bio-active compounds to specified sites in the body |
-
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- 2001-11-02 AU AU2002232399A patent/AU2002232399A1/en not_active Abandoned
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- 2001-11-02 AR ARP010105145A patent/AR031880A1/es unknown
- 2001-11-02 US US09/985,319 patent/US20020169162A1/en not_active Abandoned
- 2001-11-02 JP JP2002538984A patent/JP2004537495A/ja not_active Withdrawn
- 2001-11-02 IL IL15547901A patent/IL155479A0/xx unknown
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