JP2004536900A - [ポリ(dA−dT)]2バインダーの小溝としての新規なシアニン染料の合成と評価 - Google Patents
[ポリ(dA−dT)]2バインダーの小溝としての新規なシアニン染料の合成と評価 Download PDFInfo
- Publication number
- JP2004536900A JP2004536900A JP2002587511A JP2002587511A JP2004536900A JP 2004536900 A JP2004536900 A JP 2004536900A JP 2002587511 A JP2002587511 A JP 2002587511A JP 2002587511 A JP2002587511 A JP 2002587511A JP 2004536900 A JP2004536900 A JP 2004536900A
- Authority
- JP
- Japan
- Prior art keywords
- dye
- bebo
- arh
- methyl
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCNC([*+])c1ccc(cc(-c(cc2)ccc2C(N)=[N+]*)[n]2)c2c1 Chemical compound CCNC([*+])c1ccc(cc(-c(cc2)ccc2C(N)=[N+]*)[n]2)c2c1 0.000 description 2
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Polyesters Or Polycarbonates (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101651A SE519116C2 (sv) | 2001-05-10 | 2001-05-10 | Syntes och utvärdering av nya cyaninfärgämnen som binder till minor groove |
| PCT/SE2002/000860 WO2002090443A1 (en) | 2001-05-10 | 2002-05-10 | Synthesis and evaluation of new cyanine dyes as minor groove of [poly(da-dt)]2 binders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536900A true JP2004536900A (ja) | 2004-12-09 |
| JP2004536900A5 JP2004536900A5 (https=) | 2005-12-22 |
Family
ID=20284061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587511A Ceased JP2004536900A (ja) | 2001-05-10 | 2002-05-10 | [ポリ(dA−dT)]2バインダーの小溝としての新規なシアニン染料の合成と評価 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7378240B2 (https=) |
| EP (1) | EP1390433B1 (https=) |
| JP (1) | JP2004536900A (https=) |
| AT (1) | ATE289337T1 (https=) |
| AU (1) | AU2002303054B2 (https=) |
| CA (1) | CA2446982C (https=) |
| DE (1) | DE60203005T2 (https=) |
| SE (1) | SE519116C2 (https=) |
| WO (1) | WO2002090443A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008540578A (ja) * | 2005-05-11 | 2008-11-20 | モレキュラー プローブス インコーポレイテッド | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE519116C2 (sv) | 2001-05-10 | 2003-01-14 | Lightup Technologies Ab | Syntes och utvärdering av nya cyaninfärgämnen som binder till minor groove |
| US7776567B2 (en) | 2005-03-17 | 2010-08-17 | Biotium, Inc. | Dimeric and trimeric nucleic acid dyes, and associated systems and methods |
| US7601498B2 (en) * | 2005-03-17 | 2009-10-13 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection and associated technology |
| US9433700B2 (en) | 2009-04-27 | 2016-09-06 | Medibeacon Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| US8877437B1 (en) | 2009-12-23 | 2014-11-04 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection |
| CN105765066B (zh) * | 2013-11-29 | 2018-12-14 | 宝生物工程株式会社 | 用于定量腺伴随病毒的方法 |
| CN108165045B (zh) * | 2018-01-15 | 2021-03-16 | 广东工业大学 | 核酸染料化合物及其制备方法和应用 |
| WO2023086970A2 (en) | 2021-11-12 | 2023-05-19 | Arna Genomics Us Incorporated | Methods and compositions for analyzing nucleic acids and nucleases in a body fluid as indicators of disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656449A (en) * | 1995-03-06 | 1997-08-12 | Molecular Probes, Inc. | Neutral unsymmetrical cyanine dyes |
| SE519172C2 (sv) | 2000-06-07 | 2003-01-21 | Lightup Technologies Ab | Fastfas syntes av cyaninfärgämnen |
| SE519116C2 (sv) | 2001-05-10 | 2003-01-14 | Lightup Technologies Ab | Syntes och utvärdering av nya cyaninfärgämnen som binder till minor groove |
-
2001
- 2001-05-10 SE SE0101651A patent/SE519116C2/sv unknown
-
2002
- 2002-05-10 AU AU2002303054A patent/AU2002303054B2/en not_active Ceased
- 2002-05-10 CA CA002446982A patent/CA2446982C/en not_active Expired - Fee Related
- 2002-05-10 EP EP02731046A patent/EP1390433B1/en not_active Expired - Lifetime
- 2002-05-10 JP JP2002587511A patent/JP2004536900A/ja not_active Ceased
- 2002-05-10 WO PCT/SE2002/000860 patent/WO2002090443A1/en not_active Ceased
- 2002-05-10 DE DE60203005T patent/DE60203005T2/de not_active Expired - Fee Related
- 2002-05-10 AT AT02731046T patent/ATE289337T1/de not_active IP Right Cessation
-
2003
- 2003-11-10 US US10/605,961 patent/US7378240B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008540578A (ja) * | 2005-05-11 | 2008-11-20 | モレキュラー プローブス インコーポレイテッド | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
| JP2013060448A (ja) * | 2005-05-11 | 2013-04-04 | Molecular Probes Inc | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| SE519116C2 (sv) | 2003-01-14 |
| CA2446982C (en) | 2009-01-13 |
| WO2002090443A1 (en) | 2002-11-14 |
| CA2446982A1 (en) | 2002-11-14 |
| SE0101651L (sv) | 2002-11-11 |
| HK1060895A1 (en) | 2004-08-27 |
| DE60203005T2 (de) | 2006-05-11 |
| AU2002303054B2 (en) | 2006-12-07 |
| DE60203005D1 (de) | 2005-03-24 |
| SE0101651D0 (sv) | 2001-05-10 |
| US7378240B2 (en) | 2008-05-27 |
| EP1390433A1 (en) | 2004-02-25 |
| EP1390433B1 (en) | 2005-02-16 |
| ATE289337T1 (de) | 2005-03-15 |
| US20040132046A1 (en) | 2004-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Karlsson et al. | Syntheses and DNA-binding studies of a series of unsymmetrical cyanine dyes: structural influence on the degree of minor groove binding to natural DNA | |
| US8153802B2 (en) | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | |
| CN101535412B (zh) | 新型双链dna结合荧光染料 | |
| Karlsson et al. | Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly (dA-dT)] 2 | |
| US20230124451A1 (en) | Novel quencher and reporter dye combinations | |
| EP1390433B1 (en) | Synthesis and evaluation of new cyanine dyes as minor groove of poly(da-dt)] 2 binders | |
| AU2002303054A1 (en) | Synthesis and evaluation of new cyanine dyes as minor groove of [POLY(DA-DT)]2 binders | |
| HK1060895B (en) | Synthesis and evaluation of new cyanine dyes as minor groove of poly(da-dt)) 2 binders | |
| RU2795062C2 (ru) | Новые комбинации гасителя и репортерного красителя | |
| JP4114958B2 (ja) | 核酸ハイブリッド体の検出方法及びそれに用いるプローブ | |
| JP4291557B2 (ja) | 多重鎖核酸の光学的検出法 | |
| HK1135719B (en) | New ds dna binding fluorescent dyes | |
| HK1135719A (en) | New ds dna binding fluorescent dyes | |
| BR112020017959B1 (pt) | Sonda, método para detectar ou quantificar uma molécula de ácido nucleico alvo em uma amostra por reação em cadeia da polimerase, kits e composição |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050425 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20071213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071218 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080318 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080326 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080416 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080423 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080515 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080805 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081031 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20081210 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090319 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090428 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20090528 |
|
| A045 | Written measure of dismissal of application [lapsed due to lack of payment] |
Free format text: JAPANESE INTERMEDIATE CODE: A045 Effective date: 20090917 |