JP2004535795A5 - - Google Patents

Info

Publication number

JP2004535795A5

JP2004535795A5 JP2002589630A JP2002589630A JP2004535795A5 JP 2004535795 A5 JP2004535795 A5 JP 2004535795A5 JP 2002589630 A JP2002589630 A JP 2002589630A JP 2002589630 A JP2002589630 A JP 2002589630A JP 2004535795 A5 JP2004535795 A5 JP 2004535795A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acid

nucleic acid

activity

Prior art date

2002-05-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 229920001184 polypeptide Polymers 0.000 claims 26
• 102000004196 processed proteins & peptides Human genes 0.000 claims 26
• 108090000765 processed proteins & peptides Proteins 0.000 claims 26
• 125000003275 alpha amino acid group Chemical group 0.000 claims 14
• 102000039446 nucleic acids Human genes 0.000 claims 13
• 108020004707 nucleic acids Proteins 0.000 claims 13
• 150000007523 nucleic acids Chemical class 0.000 claims 13
• 102000004127 Cytokines Human genes 0.000 claims 9
• 108090000695 Cytokines Proteins 0.000 claims 9
• 230000000694 effects Effects 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 9
• 125000003729 nucleotide group Chemical group 0.000 claims 9
• 150000001413 amino acids Chemical class 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 150000001875 compounds Chemical class 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 230000027455 binding Effects 0.000 claims 4
• 239000005557 antagonist Substances 0.000 claims 3
• 230000002708 enhancing effect Effects 0.000 claims 2
• 230000004890 epithelial barrier function Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 206010009887 colitis Diseases 0.000 claims 1
• 210000000981 epithelium Anatomy 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 230000004968 inflammatory condition Effects 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000000968 intestinal effect Effects 0.000 claims 1
• 210000004347 intestinal mucosa Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1