JP2004533405A5 - - Google Patents
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- JP2004533405A5 JP2004533405A5 JP2002524451A JP2002524451A JP2004533405A5 JP 2004533405 A5 JP2004533405 A5 JP 2004533405A5 JP 2002524451 A JP2002524451 A JP 2002524451A JP 2002524451 A JP2002524451 A JP 2002524451A JP 2004533405 A5 JP2004533405 A5 JP 2004533405A5
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- 239000008194 pharmaceutical composition Substances 0.000 description 60
- 108091033319 polynucleotide Proteins 0.000 description 29
- 102000040430 polynucleotide Human genes 0.000 description 29
- 239000002157 polynucleotide Substances 0.000 description 29
- 238000003556 assay Methods 0.000 description 17
- 108091006146 Channels Proteins 0.000 description 15
- 239000012634 fragment Substances 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 206010003658 Atrial Fibrillation Diseases 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 239000013603 viral vector Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 230000002107 myocardial effect Effects 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 5
- 102000010970 Connexin Human genes 0.000 description 4
- 108050001175 Connexin Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 102000002067 Protein Subunits Human genes 0.000 description 3
- 108010001267 Protein Subunits Proteins 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 230000036279 refractory period Effects 0.000 description 3
- 206010003662 Atrial flutter Diseases 0.000 description 2
- 102000034573 Channels Human genes 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 108091006027 G proteins Proteins 0.000 description 2
- 102000030782 GTP binding Human genes 0.000 description 2
- 108091000058 GTP-Binding Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 210000001992 atrioventricular node Anatomy 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 210000005003 heart tissue Anatomy 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002336 repolarization Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 230000008728 vascular permeability Effects 0.000 description 2
- 206010047302 ventricular tachycardia Diseases 0.000 description 2
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 208000006808 Atrioventricular Nodal Reentry Tachycardia Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 102100030540 Gap junction alpha-5 protein Human genes 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 101000944277 Homo sapiens Inward rectifier potassium channel 2 Proteins 0.000 description 1
- 102100033114 Inward rectifier potassium channel 2 Human genes 0.000 description 1
- 208000007888 Sinus Tachycardia Diseases 0.000 description 1
- 206010040741 Sinus bradycardia Diseases 0.000 description 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003668 atrial tachycardia Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 108010014510 connexin 40 Proteins 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 208000015700 familial long QT syndrome Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23031100P | 2000-09-06 | 2000-09-06 | |
| US60/230,311 | 2000-09-06 | ||
| US29588901P | 2001-06-05 | 2001-06-05 | |
| US60/295,889 | 2001-06-05 | ||
| PCT/US2001/027623 WO2002019966A2 (en) | 2000-09-06 | 2001-09-06 | Cardiac arrhythmia treatment methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533405A JP2004533405A (ja) | 2004-11-04 |
| JP2004533405A5 true JP2004533405A5 (https=) | 2008-11-13 |
| JP5106738B2 JP5106738B2 (ja) | 2012-12-26 |
Family
ID=26924110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524451A Expired - Fee Related JP5106738B2 (ja) | 2000-09-06 | 2001-09-06 | 心不整脈治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US7034008B2 (https=) |
| EP (2) | EP2363152A1 (https=) |
| JP (1) | JP5106738B2 (https=) |
| AU (2) | AU8880701A (https=) |
| CA (1) | CA2421584C (https=) |
| IL (1) | IL154769A0 (https=) |
| WO (1) | WO2002019966A2 (https=) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0928135B1 (en) * | 1996-07-17 | 2006-06-14 | Medtronic, Inc. | System for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment |
| WO2002087419A2 (en) * | 2001-04-27 | 2002-11-07 | Johns Hopkins University | Biological pacemaker |
| WO2002019966A2 (en) * | 2000-09-06 | 2002-03-14 | Johns Hopkins University | Cardiac arrhythmia treatment methods |
| US20090175790A1 (en) * | 2000-09-06 | 2009-07-09 | The Johns Hopkins University | Cardiac arrhythmia treatment methods and biological pacemaker |
| US7294333B1 (en) * | 2000-10-20 | 2007-11-13 | Genegrafts Ltd. | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues |
| US7699790B2 (en) | 2000-12-20 | 2010-04-20 | Ev3, Inc. | Debulking catheters and methods |
| US7927784B2 (en) | 2000-12-20 | 2011-04-19 | Ev3 | Vascular lumen debulking catheters and methods |
| WO2002098287A2 (en) * | 2001-06-06 | 2002-12-12 | The Trustees Of Columbia University In The City Of New York | A high throughput biological heart rate monitor that is molecularly determined |
| US6849611B2 (en) * | 2001-06-06 | 2005-02-01 | The Trustees Of Columbia University In The City Of New York | Implantation of biological pacemaker that is molecularly determined |
| US6783979B2 (en) * | 2001-06-06 | 2004-08-31 | The Trustees Of Columbia University In The City Of New York Research Foundation Of State University Of New York | Vectors encoding HCN channels and MiRP1 |
| CN1612691A (zh) | 2001-11-08 | 2005-05-04 | 加利福尼亚大学董事会 | 纠正心脏传导障碍的方法和组合物 |
| US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| US6811777B2 (en) | 2002-04-13 | 2004-11-02 | Allan Mishra | Compositions and minimally invasive methods for treating incomplete connective tissue repair |
| WO2003095016A1 (en) * | 2002-05-08 | 2003-11-20 | The Regents Of The University Of California | System and method for forming a non-ablative cardiac conduction block |
| US8003618B2 (en) * | 2002-10-02 | 2011-08-23 | The John Hopkins University | Focal calcium channel modulation |
| US7627373B2 (en) | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
| WO2004078065A2 (en) | 2003-03-03 | 2004-09-16 | Sinus Rhythm Technologies, Inc. | Electrical conduction block implant device |
| US20070021375A1 (en) | 2003-04-25 | 2007-01-25 | Vinod Sharma | Genetic modification of targeted regions of the cardiac conduction system |
| US8013133B2 (en) * | 2003-04-25 | 2011-09-06 | Medtronic, Inc. | Genetic modification of targeted regions of the cardiac conduction system |
| US20050021089A1 (en) * | 2003-07-24 | 2005-01-27 | Medtronic, Inc. | Compositions and methods for treating cardiac dysfunction |
| ITRM20030376A1 (it) * | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| JP2007520259A (ja) * | 2003-11-10 | 2007-07-26 | シンフォニー メディカル， インコーポレイテッド | 心房細動患者における心室速度を制御するための方法 |
| SE526861C2 (sv) | 2003-11-17 | 2005-11-15 | Syntach Ag | Vävnadslesionsskapande anordning samt en uppsättning av anordningar för behandling av störningar i hjärtrytmregleringssystemet |
| WO2005047500A1 (ja) * | 2003-11-17 | 2005-05-26 | Eisai Co., Ltd. | hERGチャネル発現細胞 |
| WO2005062857A2 (en) * | 2003-12-24 | 2005-07-14 | The Trustees Of Columbia University In The City Of New York | Creation of a biological atrioventricular bypass to compensate for atrioventricular block |
| US20060128647A1 (en) * | 2003-12-24 | 2006-06-15 | Daniel Sigg | Novel oligonucleotides and treating cardiac disorders by using the same |
| US8859273B2 (en) * | 2003-12-24 | 2014-10-14 | Medtronic, Inc. | Methods of using HCN genes to treat cardiac arrhythmias |
| WO2005082424A1 (en) * | 2004-02-26 | 2005-09-09 | Merck & Co., Inc. | Biological assay |
| US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| US9398967B2 (en) | 2004-03-02 | 2016-07-26 | Syntach Ag | Electrical conduction block implant device |
| US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
| US7729761B2 (en) | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
| EP1781371A4 (en) * | 2004-07-19 | 2007-12-19 | Univ Columbia | ASSAY SYSTEM FOR MONITORING THE EFFECTS OF GENETICALLY MANUFACTURED CELLS TO CHANGE THE FUNCTION OF A SYNCYTIUM |
| EP1829526B1 (en) * | 2004-11-02 | 2016-01-20 | National University Corporation Tokyo Medical and Dental University | Liposome and method of injecting substance into cell by using the same |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| WO2006084322A1 (en) * | 2005-02-09 | 2006-08-17 | Craig Steven Mclachlan | Treatment method for modifying tissue passive electrical conductance |
| US8565898B2 (en) * | 2005-04-28 | 2013-10-22 | Medtronic, Inc. | Rate control during AF using cellular intervention to modulate AV node |
| EP1917350A4 (en) * | 2005-07-29 | 2009-04-22 | Univ Columbia | BIOLOGICAL BYPASS BRIDGE WITH SODIUM CHANNELS, CALCIUM CHANNELS AND / OR KALIUM CHANNELS FOR COMPENSATING A LEAD BLOCK IN THE HEART |
| US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
| EP1942946A4 (en) * | 2005-10-14 | 2009-11-25 | Univ Johns Hopkins | BIOLOGICALLY AVAILABLE CELLS |
| US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
| US7989207B2 (en) | 2006-02-17 | 2011-08-02 | Tyco Healthcare Group Lp | Testing lumenectomy samples for markers of non-vascular diseases |
| GB2437893A (en) * | 2006-07-25 | 2007-11-07 | Celladon Corp | Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy |
| US20080082415A1 (en) * | 2006-09-20 | 2008-04-03 | Vishwanath Shastry | Listing generation and advertising management utilizing catalog information |
| US8825677B2 (en) | 2006-09-20 | 2014-09-02 | Ebay Inc. | Listing generation utilizing catalog information |
| WO2008079412A2 (en) * | 2006-12-22 | 2008-07-03 | The Trustees Of Columbia University In The City Of New York | Methods and compositions to treat arrhythmias |
| US20100150887A1 (en) * | 2007-01-25 | 2010-06-17 | Duff Henry J | Tissue Progenitor Cells That Overexpress ERG |
| US20090047703A1 (en) * | 2007-08-17 | 2009-02-19 | University Of Maryland, Baltimore | ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease |
| US8311620B2 (en) * | 2007-08-22 | 2012-11-13 | Cardiac Pacemakers, Inc. | Methods and apparatus to treat and prevent atrial tachyarrhythmias |
| US20090054828A1 (en) * | 2007-08-22 | 2009-02-26 | Cardiac Pacemakers, Inc. | Systems for transient conduction control |
| WO2009036220A2 (en) | 2007-09-12 | 2009-03-19 | The Regents Of The University Of California | Compositions and methods for improving the functional efficacy of stem cell-derived cardiomyocytes |
| US20090233991A1 (en) * | 2007-11-01 | 2009-09-17 | Hee Cheol Cho | Generation of biological pacemaker activity |
| WO2009105135A1 (en) | 2008-02-19 | 2009-08-27 | Celladon Corporation | Compositions for enhanced uptake of viral vectors in the myocardium |
| US20110256112A2 (en) * | 2008-03-07 | 2011-10-20 | The Trustees Of Columbia University In The City Of New York | Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein |
| WO2009120082A2 (en) * | 2008-03-27 | 2009-10-01 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing electrical activity of cells |
| WO2010042658A1 (en) | 2008-10-07 | 2010-04-15 | Bioparadox, Llc | Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities |
| EP2493547A4 (en) * | 2009-10-27 | 2013-06-19 | Cedars Sinai Medical Center | EXTERNAL MAGNETIC POWER FOR TARGETED CELL RELIEF WITH REINFORCED CELL RESERVATION |
| US9393198B2 (en) * | 2010-03-22 | 2016-07-19 | Signpath Pharma Inc. | Intravenous curcumin and derivatives for treatment of neurodegenerative and stress disorders |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US10695432B2 (en) * | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9271950B2 (en) | 2010-10-29 | 2016-03-01 | Infirst Healthcare Limited | Compositions for treating chronic inflammation and inflammatory diseases |
| US9308213B2 (en) | 2010-10-29 | 2016-04-12 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
| US11730709B2 (en) | 2010-10-29 | 2023-08-22 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US10695431B2 (en) | 2010-10-29 | 2020-06-30 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
| US8639323B2 (en) | 2010-11-01 | 2014-01-28 | Medtronic, Inc. | System and apparatus to monitor biopacemaker maturation |
| WO2012068385A2 (en) | 2010-11-18 | 2012-05-24 | Medtronic, Inc. | Implantable medical device with swappable headers |
| US9592398B2 (en) | 2011-05-12 | 2017-03-14 | Medtronic, Inc. | Leadless implantable medical device with osmotic pump |
| US10532045B2 (en) | 2013-12-18 | 2020-01-14 | Signpath Pharma, Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
| US10449193B2 (en) | 2011-06-03 | 2019-10-22 | Signpath Pharma Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies |
| EP3326616B1 (en) | 2011-06-03 | 2021-07-28 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current |
| US12004868B2 (en) | 2011-06-03 | 2024-06-11 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
| US10349884B2 (en) | 2011-06-03 | 2019-07-16 | Sighpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel |
| US8753674B2 (en) | 2011-06-03 | 2014-06-17 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current |
| US10238602B2 (en) | 2011-06-03 | 2019-03-26 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies |
| US10117881B2 (en) | 2011-06-03 | 2018-11-06 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies |
| US9681836B2 (en) | 2012-04-23 | 2017-06-20 | Cyberonics, Inc. | Methods, systems and apparatuses for detecting seizure and non-seizure states |
| US9884076B2 (en) | 2012-06-05 | 2018-02-06 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| CA2882978A1 (en) | 2012-08-31 | 2014-03-06 | Signpath Pharma Inc. | Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy |
| GB201309882D0 (en) * | 2013-06-03 | 2013-07-17 | Isis Innovation | Prevention and treatment of atrial fibrillation |
| US20140356893A1 (en) | 2013-06-04 | 2014-12-04 | Allan Mishra | Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation |
| US10087436B2 (en) | 2014-02-06 | 2018-10-02 | The Regents Of The University Of California | Electrophysiologically mature cardiomyocytes and methods for making same |
| AU2015269699B2 (en) | 2014-06-03 | 2020-08-13 | Avanti Polar Lipids, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, EGPG, LysoPG and LysoPC against drugs that cause channelopathies |
| EP4494699A3 (en) | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| EP3206702A1 (en) * | 2014-10-16 | 2017-08-23 | Academisch Medisch Centrum | Nk3 agonist for use in the treatment of a patient suffering from atrial arrhythmia or fibrillation |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| AU2017257496B2 (en) | 2016-04-27 | 2020-05-07 | Signpath Pharma, Inc. | Prevention of drug-induced atrio-ventricular block |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
| US12098385B2 (en) | 2017-09-20 | 2024-09-24 | The Regents Of The University Of California | Gene therapy strategy to restore cardiac electrical and structural function in arrhythmogenic right ventricular cardiomyopathy |
| ES2976559T3 (es) | 2017-09-20 | 2024-08-05 | Univ California | Terapia génica con conexina 43 para restaurar la función eléctrica y cardíaca y la estructura cardíaca, en la miocardiopatía arritmogénica del ventrículo derecho |
| KR20240145085A (ko) | 2017-10-19 | 2024-10-04 | 사인패스 파마 인코포레이티드 | 채널병증을 야기하는 약물에 대한 DMPC, DMPG, DMPC/DMPG, LysoPG 및 LysoPC의 보호 효과 |
| WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| WO2020206103A1 (en) * | 2019-04-04 | 2020-10-08 | University Of Massachusetts | Ventricular arrhythmias and related methods |
| CN117024557B (zh) * | 2023-10-10 | 2024-01-30 | 天津外泌体科技有限公司 | 14-3-3蛋白theta异构体作为细胞外囊泡支架蛋白的应用和细胞外囊泡 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
| US5163950A (en) * | 1990-08-24 | 1992-11-17 | Medical Engineering Corporation | Balloon catheter and endoscope kit |
| EP0745134A1 (en) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| US5662585A (en) * | 1994-05-05 | 1997-09-02 | Imagyn Medical, Inc. | Endoscope with protruding member and method of utilizing the same |
| US5836905A (en) * | 1994-06-20 | 1998-11-17 | Lemelson; Jerome H. | Apparatus and methods for gene therapy |
| US5824550A (en) * | 1994-10-28 | 1998-10-20 | Barnes-Jewish Hopital | Voltage-gated calcium channel and antisense oligonucleotides thereto |
| WO1996028537A1 (en) | 1995-03-09 | 1996-09-19 | University Of Utah Research Foundation | Long qt genes and method for diagnosing or preventing the occurrence of long qt syndrome |
| US6605274B1 (en) * | 1995-04-11 | 2003-08-12 | The Regents Of The University Of California | Method for in vivo regulation of cardiac muscle contractility |
| DK0876491T3 (da) * | 1995-12-22 | 2009-07-06 | Univ Utah Res Found | Langt QT-syndrom-gen, der koder for KVLQT1 og dets association med minK |
| US5944710A (en) * | 1996-06-24 | 1999-08-31 | Genetronics, Inc. | Electroporation-mediated intravascular delivery |
| AU734576B2 (en) * | 1996-08-02 | 2001-06-14 | Elan Pharmaceuticals, Inc. | Voltage-gated calcium channel antagonist and methods |
| US20020009772A1 (en) * | 1997-02-28 | 2002-01-24 | Terry P. Snutch | Novel human calcium channels and related probes, cell lines and mehtods |
| US6086582A (en) * | 1997-03-13 | 2000-07-11 | Altman; Peter A. | Cardiac drug delivery system |
| US6123699A (en) * | 1997-09-05 | 2000-09-26 | Cordis Webster, Inc. | Omni-directional steerable catheter |
| US6183444B1 (en) * | 1998-05-16 | 2001-02-06 | Microheart, Inc. | Drug delivery module |
| AU1520599A (en) | 1997-11-07 | 1999-05-31 | Johns Hopkins University, The | Somatic transfer of modified genes to predict drug effects |
| US6703485B2 (en) * | 1997-12-23 | 2004-03-09 | The Trustees Of Columbia University In The City Of New York | Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof |
| US6776987B1 (en) * | 1998-01-13 | 2004-08-17 | Massachusetts Institute Of Technology | Enhancement of cardiac chronotropy |
| US5965396A (en) * | 1998-01-13 | 1999-10-12 | Zeneca Limited | Human lymph node derived GTPase |
| US6207422B1 (en) * | 1998-04-17 | 2001-03-27 | The Metrohealth System | Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same |
| US6623474B1 (en) * | 1998-06-04 | 2003-09-23 | Biosense Webster, Inc. | Injection catheter with needle stop |
| US6365337B1 (en) * | 1998-07-27 | 2002-04-02 | University Of Iowa Research Foundation | Genes encoding neuronal voltage-gated calcium channel gamma subunits |
| WO2000018903A2 (en) * | 1998-09-29 | 2000-04-06 | The Johns Hopkins University | Inducible genetic suppression of cellular excitability |
| EP1139751A4 (en) * | 1998-12-28 | 2003-03-19 | Arch Dev Corp | EFFICIENT AND STABLE -I (IN VIVO) GENE TRANSFER TO CARDIOMYCETS USING RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS |
| AU2732000A (en) | 1999-01-19 | 2000-08-01 | Children's Hospital Of Philadelphia, The | Reverse gene therapy |
| WO2002019966A2 (en) * | 2000-09-06 | 2002-03-14 | Johns Hopkins University | Cardiac arrhythmia treatment methods |
| WO2002087419A2 (en) * | 2001-04-27 | 2002-11-07 | Johns Hopkins University | Biological pacemaker |
| US6992070B2 (en) * | 2000-10-13 | 2006-01-31 | The Johns Hopkins University | Methods and compositions for nucleic acid delivery |
| US7294333B1 (en) * | 2000-10-20 | 2007-11-13 | Genegrafts Ltd. | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues |
| WO2002098287A2 (en) * | 2001-06-06 | 2002-12-12 | The Trustees Of Columbia University In The City Of New York | A high throughput biological heart rate monitor that is molecularly determined |
| US6783979B2 (en) * | 2001-06-06 | 2004-08-31 | The Trustees Of Columbia University In The City Of New York Research Foundation Of State University Of New York | Vectors encoding HCN channels and MiRP1 |
| US8003618B2 (en) * | 2002-10-02 | 2011-08-23 | The John Hopkins University | Focal calcium channel modulation |
| CA2526841A1 (en) * | 2003-05-28 | 2005-04-14 | Synta Pharmaceuticals Corp. | Novel calcium channels and uses thereof |
| CN101090632A (zh) * | 2004-08-02 | 2007-12-19 | 约翰·霍普金斯大学 | 利用新颖工程方法调节生物电性节律 |
| US9116846B2 (en) | 2013-06-10 | 2015-08-25 | Veeam Software Ag | Virtual machine backup from storage snapshot |
-
2001
- 2001-09-06 WO PCT/US2001/027623 patent/WO2002019966A2/en not_active Ceased
- 2001-09-06 US US09/947,953 patent/US7034008B2/en not_active Expired - Fee Related
- 2001-09-06 IL IL15476901A patent/IL154769A0/xx unknown
- 2001-09-06 AU AU8880701A patent/AU8880701A/xx active Pending
- 2001-09-06 EP EP10185602A patent/EP2363152A1/en not_active Withdrawn
- 2001-09-06 CA CA2421584A patent/CA2421584C/en not_active Expired - Fee Related
- 2001-09-06 JP JP2002524451A patent/JP5106738B2/ja not_active Expired - Fee Related
- 2001-09-06 EP EP20010968567 patent/EP1324780A4/en not_active Withdrawn
- 2001-09-06 AU AU2001288807A patent/AU2001288807B2/en not_active Ceased
-
2004
- 2004-05-28 US US10/855,989 patent/US20040266717A1/en not_active Abandoned
- 2004-05-28 US US10/855,892 patent/US20040266716A1/en not_active Abandoned
- 2004-05-28 US US10/855,805 patent/US20050107323A1/en not_active Abandoned
-
2006
- 2006-08-24 US US11/508,957 patent/US20070048284A1/en not_active Abandoned
-
2014
- 2014-09-15 US US14/486,020 patent/US20150183842A1/en not_active Abandoned
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