JP2004533405A5 - - Google Patents
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- JP2004533405A5 JP2004533405A5 JP2002524451A JP2002524451A JP2004533405A5 JP 2004533405 A5 JP2004533405 A5 JP 2004533405A5 JP 2002524451 A JP2002524451 A JP 2002524451A JP 2002524451 A JP2002524451 A JP 2002524451A JP 2004533405 A5 JP2004533405 A5 JP 2004533405A5
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- 239000008194 pharmaceutical composition Substances 0.000 description 60
- 108091033319 polynucleotide Proteins 0.000 description 29
- 102000040430 polynucleotide Human genes 0.000 description 29
- 239000002157 polynucleotide Substances 0.000 description 29
- 238000003556 assay Methods 0.000 description 17
- 108091006146 Channels Proteins 0.000 description 15
- 239000012634 fragment Substances 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 206010003658 Atrial Fibrillation Diseases 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 239000013603 viral vector Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 230000002107 myocardial effect Effects 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 5
- 102000010970 Connexin Human genes 0.000 description 4
- 108050001175 Connexin Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- 102000002067 Protein Subunits Human genes 0.000 description 3
- 108010001267 Protein Subunits Proteins 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 230000036279 refractory period Effects 0.000 description 3
- 206010003662 Atrial flutter Diseases 0.000 description 2
- 102000034573 Channels Human genes 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 108091006027 G proteins Proteins 0.000 description 2
- 102000030782 GTP binding Human genes 0.000 description 2
- 108091000058 GTP-Binding Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 210000001992 atrioventricular node Anatomy 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 210000005003 heart tissue Anatomy 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002336 repolarization Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 230000008728 vascular permeability Effects 0.000 description 2
- 206010047302 ventricular tachycardia Diseases 0.000 description 2
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- 208000006808 Atrioventricular Nodal Reentry Tachycardia Diseases 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 102100030540 Gap junction alpha-5 protein Human genes 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 101000944277 Homo sapiens Inward rectifier potassium channel 2 Proteins 0.000 description 1
- 102100033114 Inward rectifier potassium channel 2 Human genes 0.000 description 1
- 208000007888 Sinus Tachycardia Diseases 0.000 description 1
- 206010040741 Sinus bradycardia Diseases 0.000 description 1
- 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003668 atrial tachycardia Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 108010014510 connexin 40 Proteins 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 208000015700 familial long QT syndrome Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23031100P | 2000-09-06 | 2000-09-06 | |
| US60/230,311 | 2000-09-06 | ||
| US29588901P | 2001-06-05 | 2001-06-05 | |
| US60/295,889 | 2001-06-05 | ||
| PCT/US2001/027623 WO2002019966A2 (en) | 2000-09-06 | 2001-09-06 | Cardiac arrhythmia treatment methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533405A JP2004533405A (ja) | 2004-11-04 |
| JP2004533405A5 true JP2004533405A5 (https=) | 2008-11-13 |
| JP5106738B2 JP5106738B2 (ja) | 2012-12-26 |
Family
ID=26924110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002524451A Expired - Fee Related JP5106738B2 (ja) | 2000-09-06 | 2001-09-06 | 心不整脈治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US7034008B2 (https=) |
| EP (2) | EP1324780A4 (https=) |
| JP (1) | JP5106738B2 (https=) |
| AU (2) | AU8880701A (https=) |
| CA (1) | CA2421584C (https=) |
| IL (1) | IL154769A0 (https=) |
| WO (1) | WO2002019966A2 (https=) |
Families Citing this family (105)
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| US6849611B2 (en) * | 2001-06-06 | 2005-02-01 | The Trustees Of Columbia University In The City Of New York | Implantation of biological pacemaker that is molecularly determined |
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| US8859273B2 (en) | 2003-12-24 | 2014-10-14 | Medtronic, Inc. | Methods of using HCN genes to treat cardiac arrhythmias |
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-
2001
- 2001-09-06 EP EP20010968567 patent/EP1324780A4/en not_active Withdrawn
- 2001-09-06 IL IL15476901A patent/IL154769A0/xx unknown
- 2001-09-06 AU AU8880701A patent/AU8880701A/xx active Pending
- 2001-09-06 AU AU2001288807A patent/AU2001288807B2/en not_active Ceased
- 2001-09-06 JP JP2002524451A patent/JP5106738B2/ja not_active Expired - Fee Related
- 2001-09-06 WO PCT/US2001/027623 patent/WO2002019966A2/en not_active Ceased
- 2001-09-06 CA CA2421584A patent/CA2421584C/en not_active Expired - Fee Related
- 2001-09-06 EP EP10185602A patent/EP2363152A1/en not_active Withdrawn
- 2001-09-06 US US09/947,953 patent/US7034008B2/en not_active Expired - Fee Related
-
2004
- 2004-05-28 US US10/855,805 patent/US20050107323A1/en not_active Abandoned
- 2004-05-28 US US10/855,892 patent/US20040266716A1/en not_active Abandoned
- 2004-05-28 US US10/855,989 patent/US20040266717A1/en not_active Abandoned
-
2006
- 2006-08-24 US US11/508,957 patent/US20070048284A1/en not_active Abandoned
-
2014
- 2014-09-15 US US14/486,020 patent/US20150183842A1/en not_active Abandoned
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